Evidence for seeding of β-amyloid by intracerebral infusion of Alzheimer brain extracts in β-amyloid precursor protein-transgenic mice

Journal of Neuroscience

Volumn 20, Issue 10, 2000, Pages 3606-3611

  Kane, Michael D ^a   Lipinski, William J ^a   Callahan, Michael J ^a   Bian, Feng ^a   Durham, Robert A ^a   Schwarz, Roy D ^a   Roher, Alex E ^b   Walker, Lary C ^a  

^a PFIZER INC   (United States)

^b SUN HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

Alzheimer's disease; Amyloid; Angiopathy; Animal model; A ; Conformational disease; Neu roinflammation; Neurodegeneration; Prion; Seeding; Transgenic

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

ADOLESCENT; AGED; ALZHEIMER DISEASE; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SENILE PLAQUE; TRANSGENIC MOUSE; VASCULAR DISEASE;

EID: 0034657130     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-10-03606.2000     Document Type: Article

References (36)

1. Atwood CS, Moir RD, Huang X, Scarpa RC, Bacarra NME, Romano DM, Hartshorn MA, Tanzi RE, Bush AI (1998) Dramatic aggregation of Alzheimer Aβ by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem 273:12817-12826.
2. Baker HF, Ridley RM, Duchen LW, Crow TJ, Bruton CJ (1994) Induction of β(A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Mol Neurobiol 8:25-39.
3. Brown P, Gajdusek DC (1991) The human spongiform encephalopathies: Kuru, Creutzfeld-Jakob disease, and the Gerstmann-Straussler-Scheinker syndrome Curr Top Microbiol Immunol 172:1-20.
4. Carrell RW, Lomas DA (1997) Conformational discase. Lancet 350:134-138.
5. Findeis MA, Molineaux SM (1999) Design and testing of inhibitors of fibril formation. Methods Enzymol 309:476-488.
6. Franklin KBJ, Paxinos G (1997) The mouse brain in stereotaxic coordinates. San Diego: Academic.
7. Frautschy SA, Cole GM, Baird A (1992) Phagocytosis and deposition of vascular β-amyloid in rat brains injected with Alzheimer β-amyloid. Am J Pathol 140:1389-1399.
8. Frautschy SA, Yang F, Calderon L, Cole GM (1996) Rodent models of Alzheimer's disease: Rat Aβ infusion approaches to amyloid deposits. Neurobiol Aging 17:311-321.
9. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM (1998) Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 152:307-317.
10. Gajdusek DC (1994) Spontaneous generation of infectious nucleating amyloids in the transmissible and nontransmissihlc cerebral amyloidoses. Mol Neurobiol 8:1-13.
11. Godec MS, Asher DM, Kozachuk WE, Masters CL, Ruhi JU, Payne JA, Rubi-Villa DJ, Wagner EE, Rapoport SI, Schapiro MB (1994) Blood buffy coat from Alzheimer's disease patients and their relatives does not transmit spongiform encephalopathy to hamsters. Neurology 44:1111-1115.
12. Goudsmit J, Morrow CH, Asher DM, Yanagihara RT, Masters CL, Gibbs CJ Jr, Gajdusek DC (1980) Evidence for and against the transmissibility of Alzheimer's disease. Neurology 30:945-950.
13. Hardy J, Duff K, Gwinn Hardy K, Perez-Tur J, Hutton M (1998) Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nat Neurosci 1:355-358.
14. Harper JD, Lansbury PT (1997) Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. Annu Rev Biochem 66:385-407.
15. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Aβ elevation, and amyloid plaques in transgcnic mice. Science 274:99-102.
16. Hsiao K, Pogemiller L, Clark HB (1997) Age-related neuropathology in transgenic mice with human mutant APP. Soc Neurosci Abstr 23:1647.
17. Ishihara T, Hong M, Zhang B, Nakagawa Y, Lee MK, Trojanowski JQ, Lee VM-Y (1999) Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron 24:751-762.
18. Kisilevsky R, Fraser PE (1997) Aβ amyloidogenesis: unique, or variation on a systemic theme? Crit Rev Biochem Mol Biol 32:361-404.
19. Koo EH, Lansbury PT, Kelly JW (1999) Amyloid diseases: abnormal protein aggregation in neurodegeneration. Proc Natl Acad Sci USA 96:9989-9990.
20. Lansbury PT (1997) Structural neurology: are seeds at the root of neuronal degeneration? Neuron 19:1151-1154.
21. Manuelidis EE, Manuelidis L (1991) Search for transmissible agent in Alzheimer's disease: studies of human buffy coat. Curr Top Microbiol Immunol 172:275-280.
22. Olafsson I, Thorsteinsson O, Jensson O (1996) The molecular pathology of hereditary cystatin C amyloid angiopathy causing brain hemorrhage. Brain Pathol 6:121-126.
23. Price DL, Borchelt DR, Walker LC, Sisodia SS (1992) Toxicity of synthetic Aβ peptides and modeling of Alzheimer's disease. Neurobiol Aging 13:623-625.
24. Price DL, Sisodia SS, Borchelt DR (1998) Genetic neurodegenerative diseases: The human illness and transgenic models. Science 282:1079-1083.
25. Prusiner SB (1985) Scrapie prions, brain amyloid, and senile dementia. Curr Top Cell Regul 26:79-95.
26. Prusiner SB (1998) Prions. Proc Natl Acad Sci USA 95:13363-13383.
27. Prusiner SB, Scott M, Foster D, Pan KM, Groth D, Mirenda C, Torchia M, Yang SL, Serhan D, Carlson GA, Hoppe PC, Westaway D, DeArmond SJ (1990) Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prior replication. Cell 63:673-686.
28. Selkoe DJ (1999) Biology of β-amyloid precursor protein and the mechanism of Alzheimer's disease. In: Alzheimer disease, Ed 2 (Terry RD, Katzman R, Bick KL, Sisodia SS, eds), pp 293-310. Philadelphia: Lippincott Williams and Wilkins.
29. Smith DH, Nakamura M, McIntosh TK, Wang J, Rodriguez A, Chen XH, Raghupathi R, Saatman KE, Clemens J, Schmidt ML, Lee VM, Trojanowski JO (1998) Brain trauma induces massive hippocampal neuron death linked to a surge in β-amyloid levels in mice overexpressing mutant amyloid precursor protein. Am J Pathol 153: 1005-1010.
30. Snow AD, Sekiguchi R, Nochlin D, Fraser P, Kimata K, Mizutani A, Arai M, Schreier WA, Morgan DG (1994) An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar Aβ-amyloid in rat brain. Neuron 12:219-234.
31. Trojanowski JQ, Lee VM-Y (1998) Aggregation of neurofilament and α-synuclein proteins in Lewy bodies. Arch Neurol 55:151-152.
32. Vidal R, Frangione B, Rostagno A, Mead S, Revesz T, Plant G, Ghiso J (1999) A stop-codon mutation in the BRI gene associated with familial British dementia. Nature 399:776-781.
33. Wakahayashi K, Hayashi S, Kakita A, Yamada M, Toyoshima Y, Yoshimoto M, Takahashi H (1998) Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy. Acta Neuropathol (Berl) 96:445-452.
34. Walker LC, Lipinski WJ, Callahan MJ, Bian F, Durham RA, Schwarz RD, Roher AE, Kane MD (1999) Induction of β-amyloidosis in βAPP-transgenic mice by the intracerebral injection of Alzheimer brain homogenate. Alzheimer's Reports 2:541.
35. Walker LC, Pahnke J, Madauss M, Vogelgesang S, Pahnke A, Herbst EW, Stausske D, Walther R, Kessler C, Warzok RW (2000) Apolipoprotein E4 promotes the early deposition of Aβ42 and then Aβ40 in the elderly. Acta Neuropathol (Berl), in press.
36. Younkin SG (1995) Evidence that Aβ42 is the real culprit in Alzheimer's disease. Ann Neurol 37:287-288.