Reversible and competitive cinnamoyl triazole inhibitors of tissue transglutaminase

Chemical Biology and Drug Design

Volumn 72, Issue 3, 2008, Pages 189-196

  Pardin, Christophe ^a   Roy, Isabelle ^a   Lubell, William D ^a   Keillor, Jeffrey W ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Cinnamoyl; Cycloaddition; Enzyme inhibition; Heterocycle; Transglutaminase; Triazole

Indexed keywords

1 (1 BENZHYDRYL 1H 1,2,3 TRIAZOL 4 YL) 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 (1 BENZYL 1H 1,2,3 TRIAZOL 4 YL) 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 (1 CYCLOPENTYL 1H 1,2,3 TRIAZOL 4 YL) 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 [1 (2 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL] 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 [1 (3 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL] 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 [1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOL 4 YL] 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 [1 (4 NITROBENZYL) 1H 1,2,3 TRIAZOL 4 YL] 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 [1 (CYCLOHEXYLMETHYL) 1H 1,2,3 TRIAZOL 4 YL] 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 [1 [(3H 1,2,3 TRIAZOL 4 YL)METHYL] 1H 1,2,3 TRIAZOL 4 YL] 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 [1 [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 1H 1,2,3 TRIAZOL 4 YL] 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 3 (4 NITROPHENYL) 1 (1 OCTYL 1H 1,2,3 TRIAZOL 4 YL)PROP 2 EN 1 ONE; 3 (4 NITROPHENYL) 1 (1H 1,2,3 TRIAZOL 4 YL)PROP 2 EN 1 ONE; 3 (4 NITROPHENYL) 1 (PYRIDIN 3 YL)PROP 2 EN 1 ONE; 3 (4 NITROPHENYL) 1 [1 (1 PHENYLETHYL) 1H 1,2,3 TRIAZOL 4 YL]PROP 2 EN 1 ONE; 3 (4 NITROPHENYL) 1 [1 (PERFLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]PROP 2 EN 1 ONE; 3 (4 NITROPHENYL) 1 [1 [(PYRIDIN 2 YL)METHYL] 1H 1,2,3 TRIAZOL 4 YL]PROP 2 EN 1 ONE; 4 (TERT BUTOXYCARBONYLAMINO)CINNAMOYLBENZOTRIAZOLYL AMIDE; ENZYME INHIBITOR; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CHROMATOGRAPHY; COMPETITIVE INHIBITION; CYCLOADDITION; ENZYME INHIBITION; ENZYME SUBSTRATE; GUINEA PIG; IC 50; LIVER; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALKYNES; ANIMALS; AZIDES; CATALYSIS; CINNAMATES; ENZYME INHIBITORS; GTP-BINDING PROTEINS; GUINEA PIGS; TRANSGLUTAMINASES; TRIAZOLES;

CAVIA;

EID: 50449111031     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2008.00696.x     Document Type: Article

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