Lack of 'tissue' transglutaminase protein cross-linking leads to leakage of macromolecules from dying cells: Relationship to development of autoimmunity in MRLlpr/lpr mice

Cell Death and Differentiation

Volumn 4, Issue 6, 1997, Pages 463-472

  Piredda, Lucia ^a   Amendola, Alessandra ^a   Colizzi, Vittorio ^a   Davies, Peter J A ^b   Farrace, Maria Grazia ^a   Fraziano, Maurizio ^a   Gentile, Vittorio ^c   Uray, Ivan ^d   Piacentini, Mauro ^a   Fesus, Laszlo ^d  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Apoptosis; Autoantibody; Follicular dendritic cells; LDH; Lymph nodes; TNF

Indexed keywords

EID: 14044258854     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400267     Document Type: Article

References (45)

1. 2+ sensitivity by tissue transglutaminase. Biochem. Biophys. Res. Commun. 163: 944-950
2. Brigati DJ, Myerson D, Leary JJ, Spalholz B, Travis SZ, Fong CKY, Hsiung GD and Ward DC (1983) Detection of viral genomes in cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes. Virology 126: 32-50
3. Burton K (1956) A study of conditions and mechanisms of a diphenylamine reaction for a colorimetric estimation of deoxyribonucleic acid. Biochem. J. 62: 315-322
4. Buttyan R, Zakeri Z, Lockshin R and Wolgemuth D (1988) Cascade induction of c-fos c-myc and heat shock 70K transcripts during regression of the rat ventral prostate gland. Mol. Endocrinol. 2: 650-657
5. Casthelhano AL, Billedeau R, Pliura DH, Bonaventura B and Kranz A (1988) Synthesis, chemistry and absolute configuration of novel transglutaminase inhibitors containing a 3-halo-4,5-dihydroisoxazole. J. Bioorg. Chem. 16: 335-349
6. Cohen PL and Eisenberg RA (1991) Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9: 243-269
7. Fesus L and Arato G (1986) Quantitation of tissue transglutaminase by a sandwich ELISA system. J. Immunol. Methods 94: 131-138
8. Fesus L, Davies PJA and Piacentini M (1991) Apoptosis: Molecular mechanism in programmed cell death. Eur. J. Cell Biol. 56: 170-177
9. Fesus L, Tarcsa E, Kedei N, Autuori F and Piacentini M (1991) Degradation of cells dying by apoptosis leads to accumulation of ε(γ-glutamyl)lysine isopeptide in culture fluid and blood. FEBS Lett. 284: 109-112
10. Fesus L, Thomazy V, Autuori F, Cerù MP, Tarcsa E and Piacentini M (1989) Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action. FEBS Lett. 245: 150-154
11. Folk JE (1980) Transglutaminases. Ann. Rev. Biochem. 49: 517-531
12. Gemma R, Suzuki Y, Tanaka I, Taminato T, Yoshimi T and Kanno T (1992) Lactate dehydrogenase (LDH)-linked immunoglobulin in a patient with Graves' disease treated with methimazole. Intern-.Med. 31 (3): 377-379
13. Gentile V, Thomazy V, Piacentini M, Fesus L and Davies PJA (1992) Expression of tissue transglutaminase in BALB-C 3T3 fibroblasts: effects on cellular morphology and adhesion. J. Cell Biol. 119: 463-474
14. Harsfalvi J, Tarcsa E, Udvardy M, Zajka G, Szarvas T and Fesus L (1992) Presence and possible origin of ε(γ-glutamyl) lysine isopeptide in human plasma Thromb. Haemost. 67: 60-62
15. Howell BF, McCune S and Schaffer R (1979) Lactate-to-pyruvate reaction: Arrhenius relationships for lactate dehydrogenase: a re-examination. Clin. Chem. 23: 269-272
16. Hsu HC, Seibold JR and Thomas TJ (1994) Regulation of ornithine decarboxylase in the kidney of autoimmune mice with the lpr gene. Autoimmunity 19: 253-264
17. Ibrahim MAA, Chain BM and Katz DR (1995) The injured cell: the role of dentritic cell system as a sentinel receptor pathway. Immunol. Today 16: 181-186
18. Ikai K, Shimizu K, Kanauchi H, Ando Y, Furukawa F and Immamuira S (1992) The presence of autoantibody to lipocortin 1 in autoimmune-prone MRL mice. Autoimmunity 12: 239
19. Izui S, Kelley VE, Masuda K, Yoshida H, Roths JB and Murphy ED (1984) Induction of various autoantibodies by mutand gene lpr in several strains of mice. J. Immunol. 133: 227-233
20. Ju ST, Dekruyff RH and Dorf ME (1986) Inducer T-cell-mediated killing of antigen-presenting cells. Cell. Immunol. 101: 613-624
21. Kerr JFR (1995) Neglected opportunity in apoptosis research. Trends Cell Biol. 5: 55-57
22. Killackey JJF, Bonaventura BJ, Castelhano AL, Billedeau RL, Farmer W, Deyoung L, Kranz A and Pliura DH (1989) A new class of mechanism-based inhibitors of transglutaminase enzymes inhibits the formation of cross-linked envelopes by human malignant keratynocytes. Mol. Pharmacol. 35: 701-706
23. Levine J, Hartwell D and Beller DI (1991) Imbalanced cytokine production by machrophages from autoimmune-prone mice. Immunol. Lett. 0: 183-192
24. McKanna JA (1995) Lipocortin 1 in apoptosis: mammary regression. Anat. Rec. 242: 1-10
25. Melino G, Annichiarico-Petruzzelli M, Piredda L, Candi E, Gentile V, Davies PJA and Piacentini M (1994) 'Tissue' Transglutaminase and apoptosis: sense and antisense transfection studies in human neuroblastoma cells. Mol. Cell. Biol. 14: 6584-6592
26. Nagata S and Golstein P (1995) The Fas death factor. Science 267: 1445-1449
27. Nakaoka H, Perez DM, Baek KJ, Das T, Husain A, Mosono IM and Graham RM (1994) Gh: A GTP-binding protein with transgtutaminase activity and receptor signaling function. Science 264: 1593-1596
28. Piacentini M (1995) Tissue' transglutaminase a candidate effector element of physiological cell death. Curr. Top. Microbiol. 200: 163-176
29. Piacentini M, Autuori F, Dini L, Farrace MG, Ghibelli L, Piredda L and Fesus L (1991) Tissue transglutaminase is specifically expressed in neonatal rat liver cells undergoing apoptosis upon epidermal growth factor-stimulation. Cell Tissue Res. 263: 227-235
30. Piacentini M, Davies PJA and Fesus L (1994) Tissue transglutaminase in cells undergoing apoptosis. In Apoptosis II: The molecular basis of apoptosis in disease. L.D. Tomei and F.O. Cope editors. Cold Spring Harbor Lab. Press. 143-165
31. Piacentini M, Farrace MG, Imparato M, Piredda L and Autuori F (1990) Polyamine-dependent post-translational modification of proteins in differentiating mouse epidermal cells. J. Invest. Dermatol. 94: 694-699
32. Piacentini M, Sartori C, Beninati S, Bargagli AM and Argento Cerù MP (1986) Ornithine decarboxilase, transglutaminase, diamine oxidase and total diamines and polyamines in maternal liver and kidney throughout rat pregnancy. Biochem. J. 234: 435-440
33. Polakowska RR and Haake AR (1994) Apoptosis: the skin from a new perspective. Cell Death Differ. 1: 19-31
34. + T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice. J. Exp. Med. 167: 1713-1718
35. Savill J, Fadok V, Henson P and Haslett C (1993) Phagocyte recognition of cell undergoing apoptosis. Immunol. Today 14: 131-136
36. Schulze-Ostoff F, Krammer PH and Droge W (1994) Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J. 13: 4587-4596
37. Steinert PM (1995) A model for the hierarchical structure of the human epidermal cornified cell envelope. Cell Death Differ. 2: 33-40
38. Tang B, Matsuda T, Akira S, Nagata N, Ikehara S, Hirano T and Kishimoto T (1991) Age-associated increase in interleuken 6 in MRL/1 pr mice. Int. Immunol. 3: 273-278
39. Theofilopoulos AN (1995) The basis of autoimmunity: part II genetic predisposition. Immunol. Today 16: 150-159
40. Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462
41. Van Houten N and Budd RC (1992) Accelerated programmed cell death of MRL-lpr/lpr T lymphocytes. J. Immunol. 149: 2513-2517
42. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA and Nagata S (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356: 314-317
43. White E (1996) Life, Death, and pursuit of apoptosis. Genes Dev. 10: 1-15
44. Wyllie AH, Kerr JFR and Currie AR (1980) Cell death the significance of apoptosis. Int. Rev. Cytol. 68: 251-306
45. Yokoyama H, Kreft B and Kelly VR (1995) Biphasic increase in circulating and renal TNF-alpha in MRL-lpr mice with differing regulatory mechanisms. Kidney Int. 47: 122-130