Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 13, 1999, Pages 7388-7393

  Karpuj, Marcela V ^a   Garren, Hideki ^b   Slunt, Hilda ^d   Price, Donald L ^d   Gusella, James ^c   Becher, Mark W ^e   Steinman, Lawrence ^a,b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b STANFORD UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; HUNTINGTIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL NUCLEUS INCLUSION BODY; CROSS LINKING; ELECTROPHORESIS; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; PRIORITY JOURNAL; PROTEIN AGGREGATION;

ADULT; AGED; AGED, 80 AND OVER; BRAIN; CELL NUCLEUS; CROSS-LINKING REAGENTS; DIMERIZATION; ENZYME ACTIVATION; HUMANS; HUNTINGTON DISEASE; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; TRANSGLUTAMINASES;

EID: 0033594894     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.13.7388     Document Type: Article

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