Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 14, 2007, Pages 6072-6077

  Son, Marjatta ^a   Puttaparthi, Krishna ^a   Kawamata, Hibiki ^b   Rajendran, Bhagya ^a   Boyer, Philip J ^a   Manfredi, Giovanni ^b   Elliott, Jeffrey L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Aggregation; Amyotrophic lateral sclerosis; Motor neuron; Neurodegeneration; Transgenic

Indexed keywords

CHAPERONE; COPPER CHAPERONE; COPPER PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; COPPER; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; CYTOSOL; DISEASE COURSE; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE OVEREXPRESSION; MOTONEURON; MOUSE; MOUSE STRAIN; NERVE DEGENERATION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; SURVIVAL; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; CROSS BREEDING; ENZYMOLOGY; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MITOCHONDRION; MOLECULAR CLONING; MOUSE MUTANT; PATHOLOGY; SPINAL CORD; ULTRASTRUCTURE;

MUS; MUS MUSCULUS;

ANIMALS; CELL FRACTIONATION; CLONING, MOLECULAR; COPPER; CROSSES, GENETIC; DISEASE PROGRESSION; DNA, COMPLEMENTARY; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, NEUROLOGIC MUTANTS; MICE, TRANSGENIC; MITOCHONDRIA; MOTOR NEURONS; SPINAL CORD; SUBCELLULAR FRACTIONS; SUPEROXIDE DISMUTASE; SURVIVAL ANALYSIS;

EID: 34347237645     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0610923104     Document Type: Article

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