Biochemistry: The widespread impact of mammalian microRNAs on mRNA repression and evolution

Science

Volumn 310, Issue 5755, 2005, Pages 1817-1821

  Farh, Kyte Kai How ^a   Grimson, Andrew ^a   Jan, Calvin ^a   Lewis, Benjamin P ^a,b   Johnston, Wendy K ^a   Lim, Lee P ^c   Burge, Christopher B ^b   Bartel, David P ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c ROSETTA INPHARMATICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN MESSENGER RNA; MESSAGES; MICRORNA (MIRNA); TEMPORAL SPECIFICITIES;

BIOCHEMISTRY; GENES; TISSUE;

RNA;

MESSENGER RNA; MICRORNA; NUCLEOTIDE;

RNA;

3' UNTRANSLATED REGION; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CEREBELLUM; DEVELOPMENTAL STAGE; GENE EXPRESSION; LIVER; MAMMAL; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; T LYMPHOCYTE; ANIMAL; ANTIBODY SPECIFICITY; CELL DIFFERENTIATION; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUSCLE CELL; RAT; RNA STABILITY; SPECIES DIFFERENCE; UNTRANSLATED REGION; ZEBRA FISH;

ANIMALIA; MAMMALIA;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MAMMALS; MICE; MICRORNAS; MOLECULAR SEQUENCE DATA; MUSCLE FIBERS; ORGAN SPECIFICITY; RATS; RNA STABILITY; RNA, MESSENGER; SPECIES SPECIFICITY; UNTRANSLATED REGIONS; ZEBRAFISH;

EID: 29144505309     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1121158     Document Type: Article

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25. We thank C. Ruby, M. Axtell, and H. Chang for helpful discussions. Supported by predoctoral fellowships from the Department of Energy (B.P.L.) and NSF (C.J.) and a postdoctoral fellowship and grants from the NIH (A.G., C.B.B., D.P.B.). D.P.B. is a Howard Hughes Medical Institute Investigator.