메뉴 건너뛰기




Volumn 18, Issue 1, 2012, Pages 1-14

Progress and outlook of inorganic nanoparticles for delivery of nucleic acid sequences related to orthopedic pathologies: A review

Author keywords

[No Author keywords available]

Indexed keywords

AGING POPULATION; CELL BIOLOGY; CLINICAL MEDICINE; IMMUNE RESPONSE; IMPLANT DEVICES; INORGANIC MATERIALS; INORGANIC NANOPARTICLE; MEDICAL NEEDS; MOLECULAR GENETICS; NONVIRAL; ORTHOPEDIC APPLICATIONS; PARTICLE-BASED METHODS; POSSIBLE FUTURES; TREATMENT DURATION; VIRAL VECTORS;

EID: 84856151412     PISSN: 19373368     EISSN: 19373376     Source Type: Journal    
DOI: 10.1089/ten.teb.2011.0081     Document Type: Review
Times cited : (20)

References (193)
  • 1
    • 0033021062 scopus 로고    scopus 로고
    • Localized, direct plasmid genedelivery in vivo: Prolonged therapy results in reproducible tissue regeneration
    • Bonadio, J., Smiley, E., Patil, P., and Goldstein, S. Localized, direct plasmid genedelivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat Med 5, 753, 1999.
    • (1999) Nat Med , vol.5 , pp. 753
    • Bonadio, J.1    Smiley, E.2    Patil, P.3    Goldstein, S.4
  • 2
    • 70349433901 scopus 로고    scopus 로고
    • Tissue engineering of bone tissue. Principles and clinical applications
    • Schmidt-Rohlfing, B., Tzioupis, C., Menzel, C., and Pape, H. Tissue engineering of bone tissue. Principles and clinical applications. Unfallchirurg 112, 785, 2009.
    • (2009) Unfallchirurg , vol.112 , pp. 785
    • Schmidt-Rohlfing, B.1    Tzioupis, C.2    Menzel, C.3    Pape, H.4
  • 3
    • 67650459934 scopus 로고    scopus 로고
    • Novel gene-activated matrix with embedded chitosan/ plasmidDNAnanoparticles encoding PDGF for periodontal tissue engineering
    • Peng, L., Cheng, X., Zhuo, R., Lan, J., Wang, Y., Shi, B., et al. Novel gene-activated matrix with embedded chitosan/plasmidDNAnanoparticles encoding PDGF for periodontal tissue engineering. J Biomed Mat Res A 90A, 564, 2009.
    • (2009) J Biomed Mat Res A , vol.90 A , pp. 564
    • Peng, L.1    Cheng, X.2    Zhuo, R.3    Lan, J.4    Wang, Y.5    Shi, B.6
  • 4
    • 77649269524 scopus 로고    scopus 로고
    • The repair of critical-sized bone defects using expedited, autologous BMP-2 gene-activated fat implants
    • Betz, O., Betz, V., Abdulazim, A., Penzkofer, R., Schmitt, B., Schroeder, C., et al. The repair of critical-sized bone defects using expedited, autologous BMP-2 gene-activated fat implants. Tissue Eng Part A 16, 1093, 2010.
    • (2010) Tissue Eng Part A , vol.16 , pp. 1093
    • Betz, O.1    Betz, V.2    Abdulazim, A.3    Penzkofer, R.4    Schmitt, B.5    Schroeder, C.6
  • 5
    • 70449134628 scopus 로고    scopus 로고
    • Cell recruitment and transfection in gene activated collagen matrix
    • Orsi, S., Capua, A., Guarnieri, D., Marasco, D., and Netti, P. Cell recruitment and transfection in gene activated collagen matrix. Biomaterials 31, 570, 2010.
    • (2010) Biomaterials , vol.31 , pp. 570
    • Orsi, S.1    Capua, A.2    Guarnieri, D.3    Marasco, D.4    Netti, P.5
  • 6
    • 40149095754 scopus 로고    scopus 로고
    • Gene therapy applications for fracture-healing
    • Carofino, B.C., and Lieberman, J.R. Gene therapy applications for fracture-healing. J Bone Joint Surg Am 90, 99, 2008.
    • (2008) J Bone Joint Surg Am , vol.90 , pp. 99
    • Carofino, B.C.1    Lieberman, J.R.2
  • 7
    • 33947174799 scopus 로고    scopus 로고
    • Evolving gene therapy approaches for osteosarcoma using viral vectors: Review
    • Witlox, M.A., Lamfers, M.L., Wuisman, P.I.J.M., Curiel, D.T., and Siegal, G.P. Evolving gene therapy approaches for osteosarcoma using viral vectors: review. Bone 40, 797, 2007.
    • (2007) Bone , vol.40 , pp. 797
    • Witlox, M.A.1    Lamfers, M.L.2    Wuisman, P.I.J.M.3    Curiel, D.T.4    Siegal, G.P.5
  • 8
    • 33745230179 scopus 로고    scopus 로고
    • Bone tissue engineering by gene delivery
    • Kofron, M.D., and Laurencin, C.T. Bone tissue engineering by gene delivery. Adv Drug Deliv Rev 58, 555, 2006.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 555
    • Kofron, M.D.1    Laurencin, C.T.2
  • 9
    • 34748876874 scopus 로고    scopus 로고
    • Genetic engineering for skeletal regenerative medicine
    • Gersbach, C., Phillips, J., and Garcia, A. Genetic engineering for skeletal regenerative medicine. Annu Rev Biomed Eng 9, 87, 2007.
    • (2007) Annu Rev Biomed Eng , vol.9 , pp. 87
    • Gersbach, C.1    Phillips, J.2    Garcia, A.3
  • 11
    • 33644805061 scopus 로고    scopus 로고
    • Biological approaches to bone regeneration by gene therapy
    • Franceschi, R.T. Biological approaches to bone regeneration by gene therapy. J Dent Res 84, 1093, 2005.
    • (2005) J Dent Res , vol.84 , pp. 1093
    • Franceschi, R.T.1
  • 12
    • 16244411961 scopus 로고    scopus 로고
    • The ABCs of BMPs
    • Boden, S. The ABCs of BMPs. Orthop Nurs 24, 49, 2005.
    • (2005) Orthop Nurs , vol.24 , pp. 49
    • Boden, S.1
  • 13
    • 34948872003 scopus 로고    scopus 로고
    • Bone formation following OP-1 implantation is improved by addition of autogenous bone marrow cells in a canine femur defect model
    • Takigami, H., Kumagai, K., Latson, L., Togawa, D., Bauer, T., Powell, K., et al. Bone formation following OP-1 implantation is improved by addition of autogenous bone marrow cells in a canine femur defect model. J Orthop Res 25, 1333, 2007.
    • (2007) J Orthop Res , vol.25 , pp. 1333
    • Takigami, H.1    Kumagai, K.2    Latson, L.3    Togawa, D.4    Bauer, T.5    Powell, K.6
  • 14
    • 75149162762 scopus 로고    scopus 로고
    • High-dose bone morphogenetic proteininduced ectopic abdomen bone growth
    • Deutsch, H. High-dose bone morphogenetic proteininduced ectopic abdomen bone growth. Spine J 10, e1, 2010.
    • (2010) Spine J , vol.10
    • Deutsch, H.1
  • 15
    • 53149131019 scopus 로고    scopus 로고
    • A comprehensive review of the safety profile of bone morphogenetic protein in spine surgery
    • Benglis, D., Wang, M.Y., and Levi, A.D. A comprehensive review of the safety profile of bone morphogenetic protein in spine surgery. Neurosurgery 62, 423, 2008.
    • (2008) Neurosurgery , vol.62 , pp. 423
    • Benglis, D.1    Wang, M.Y.2    Levi, A.D.3
  • 17
    • 54449094771 scopus 로고    scopus 로고
    • Neurologic impairment from ectopic bone in the lumbar canal: A potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2)
    • Wong, D.A., Kumar, A., Jatana, S., Ghiselli, G., and Wong, K. Neurologic impairment from ectopic bone in the lumbar canal: a potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2). Spine J 8, 1011, 2008.
    • (2008) Spine J , vol.8 , pp. 1011
    • Wong, D.A.1    Kumar, A.2    Jatana, S.3    Ghiselli, G.4    Wong, K.5
  • 19
    • 63649145843 scopus 로고    scopus 로고
    • Orthopedic gene therapy in 2008
    • Evans, C., Ghivizzani, S., and Robbins, P. Orthopedic gene therapy in 2008. Mol Ther 17, 231, 2009.
    • (2009) Mol Ther , vol.17 , pp. 231
    • Evans, C.1    Ghivizzani, S.2    Robbins, P.3
  • 20
    • 0003008343 scopus 로고    scopus 로고
    • Synthetic DNA delivery systems
    • Luo, D., and Saltzman, W.M. Synthetic DNA delivery systems. Nat Biotechnol 18, 33, 2000.
    • (2000) Nat Biotechnol , vol.18 , pp. 33
    • Luo, D.1    Saltzman, W.M.2
  • 21
    • 0032487387 scopus 로고    scopus 로고
    • Key issues in non-viral gene delivery
    • Pouton, C., and Seymour, L. Key issues in non-viral gene delivery. Adv Drug Deliv Rev 34, 3, 1998.
    • (1998) Adv Drug Deliv Rev , vol.34 , pp. 3
    • Pouton, C.1    Seymour, L.2
  • 22
    • 39849106393 scopus 로고    scopus 로고
    • Inorganic nanoparticles as carriers of nucleic acids into cells
    • Sokolova, V., and Epple, M. Inorganic nanoparticles as carriers of nucleic acids into cells. Angew Chem Int Ed Engl 47, 1382, 2008.
    • (2008) Angew Chem Int Ed Engl , vol.47 , pp. 1382
    • Sokolova, V.1    Epple, M.2
  • 23
    • 0033856380 scopus 로고    scopus 로고
    • Tissue engineering via local gene delivery
    • Bonadio, J. Tissue engineering via local gene delivery. J Mol Med 78, 303, 2000.
    • (2000) J Mol Med , vol.78 , pp. 303
    • Bonadio, J.1
  • 24
    • 68149160162 scopus 로고    scopus 로고
    • Nanotechnology controlled drug delivery for treating bone diseases
    • Yang, L., and Webster, T. Nanotechnology controlled drug delivery for treating bone diseases. Expert Opin Drug Deliv 6, 851, 2009.
    • (2009) Expert Opin Drug Deliv , vol.6 , pp. 851
    • Yang, L.1    Webster, T.2
  • 26
    • 0034670057 scopus 로고    scopus 로고
    • Tissue engineering via local gene delivery: Update and future prospects for enhancing the technology
    • Bonadio, J. Tissue engineering via local gene delivery: update and future prospects for enhancing the technology. Adv Drug Deliv Rev 44, 185, 2000.
    • (2000) Adv Drug Deliv Rev , vol.44 , pp. 185
    • Bonadio, J.1
  • 27
    • 0032077625 scopus 로고    scopus 로고
    • Regional gene therapy with a BMP-2 producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents
    • Lieberman, J., Le, L., Wu, L., Finerman, G., Berk, A., Witte, O., et al. Regional gene therapy with a BMP-2 producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J Orthop Res 16, 330, 1998.
    • (1998) J Orthop Res , vol.16 , pp. 330
    • Lieberman, J.1    Le, L.2    Wu, L.3    Finerman, G.4    Berk, A.5    Witte, O.6
  • 28
    • 34250886203 scopus 로고    scopus 로고
    • Review: Gene-and stem cell-based therapeutics for bone regeneration and repair
    • Kimelman, N., Pelled, G., Helm, G.A., Huard, J., Schwarz, E.M., and Gazit, D. Review: gene-and stem cell-based therapeutics for bone regeneration and repair. Tissue Eng 13, 1135, 2007.
    • (2007) Tissue Eng , vol.13 , pp. 1135
    • Kimelman, N.1    Pelled, G.2    Helm, G.A.3    Huard, J.4    Schwarz, E.M.5    Gazit, D.6
  • 29
    • 13844280288 scopus 로고    scopus 로고
    • Orthopaedic applications of gene therapy
    • Kofron, M.D., and Laurencin, C.T. Orthopaedic applications of gene therapy. Curr Gene Ther 5, 37, 2005.
    • (2005) Curr Gene Ther , vol.5 , pp. 37
    • Kofron, M.D.1    Laurencin, C.T.2
  • 31
    • 84856185169 scopus 로고    scopus 로고
    • Comparison of Healos/bone marrow to INFUSE(rhBMP-2acs) with a collagen-ceramic sponge bulking agent as graft substitutes for lumbar spine fusion
    • Boden, S., Kraiwattanapong, C., Louis-Ugbo, J., Barnes, B., and Hutton, W. Comparison of Healos/bone marrow to INFUSE(rhBMP-2acs) with a collagen-ceramic sponge bulking agent as graft substitutes for lumbar spine fusion. Proceedings of the NASS 19th Annual Meeting. Spine J 4, 24S, 2004.
    • (2004) Proceedings of the NASS 19th Annual Meeting. Spine J 4 , vol.24 S
    • Boden, S.1    Kraiwattanapong, C.2    Louis-Ugbo, J.3    Barnes, B.4    Hutton, W.5
  • 32
    • 0037587239 scopus 로고    scopus 로고
    • Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: A comparison of adenoviral vectors and liposomes
    • Park, J., Ries, J., Gelse, K., Kloss, F., von der Mark, K., Wiltfang, J., et al. Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes. Gene Ther 10, 1089, 2003.
    • (2003) Gene Ther , vol.10 , pp. 1089
    • Park, J.1    Ries, J.2    Gelse, K.3    Kloss, F.4    Von Der Mark, K.5    Wiltfang, J.6
  • 33
    • 46449095585 scopus 로고    scopus 로고
    • Osteogenic gene regulation and relative acceleration of healing by adenoviral-mediated transfer of human BMP-2 or-6 in equine osteotomy and ostectomy models
    • Ishihara, A., Shields, K., Litsky, A., Mattoon, J., Weisbrode, S., Bartlett, J., et al. Osteogenic gene regulation and relative acceleration of healing by adenoviral-mediated transfer of human BMP-2 or-6 in equine osteotomy and ostectomy models. J Orthop Res 26, 764, 2008.
    • (2008) J Orthop Res , vol.26 , pp. 764
    • Ishihara, A.1    Shields, K.2    Litsky, A.3    Mattoon, J.4    Weisbrode, S.5    Bartlett, J.6
  • 34
    • 0032866489 scopus 로고    scopus 로고
    • The effect of regional gene therapy with bone morphogenetic protein-2-producing bonemarrow cells on the repair of segmental femoral defects in rats
    • Lieberman, J., Daluiski, A., Stevenson S., Wu, L., McAllister, P., Lee, Y.P., et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bonemarrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg Am 81, 905, 1999.
    • (1999) J Bone Joint Surg Am , vol.81 , pp. 905
    • Lieberman, J.1    Daluiski, A.2    Stevenson, S.3    Wu, L.4    McAllister, P.5    Lee, Y.P.6
  • 35
  • 36
    • 21344464386 scopus 로고    scopus 로고
    • Combined bone morphogenetic protein-2 and-7 enhances osteoblastic differentiation and spine fusion in a rodent model
    • Zhu, W., Rawlins, B., Boachie-Adjei, O., Myers, E., Arimizu, J., Choi, E., et al. Combined bone morphogenetic protein-2 and-7 enhances osteoblastic differentiation and spine fusion in a rodent model. J Bone Miner Res 19, 2021, 2004.
    • (2004) J Bone Miner Res , vol.19 , pp. 2021
    • Zhu, W.1    Rawlins, B.2    Boachie-Adjei, O.3    Myers, E.4    Arimizu, J.5    Choi, E.6
  • 37
    • 0028288203 scopus 로고
    • Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing
    • Nakase, T., Nomura, S., Yoshikawa, H., Hashimoto, J., Hirota, S., Kitamura, Y., et al. Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing. J Bone Miner Res 9, 651, 1994.
    • (1994) J Bone Miner Res , vol.9 , pp. 651
    • Nakase, T.1    Nomura, S.2    Yoshikawa, H.3    Hashimoto, J.4    Hirota, S.5    Kitamura, Y.6
  • 38
    • 13644267079 scopus 로고    scopus 로고
    • Structural and functional healing of critical-size segmental bone defects by trasduced muscle-derived cells expressing BMP4
    • Shen, H., Peng, H., Usas, A., Gearhart, B., Fu, F., and Huard, J. Structural and functional healing of critical-size segmental bone defects by trasduced muscle-derived cells expressing BMP4. J Gene Med 6, 984, 2004.
    • (2004) J Gene Med , vol.6 , pp. 984
    • Shen, H.1    Peng, H.2    Usas, A.3    Gearhart, B.4    Fu, F.5    Huard, J.6
  • 39
    • 0036738338 scopus 로고    scopus 로고
    • Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4
    • Peng, H., Wright, V., Usas, A., Gearhart, B., Shen, H., Cummins, J., et al. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest 110, 751, 2002.
    • (2002) J Clin Invest , vol.110 , pp. 751
    • Peng, H.1    Wright, V.2    Usas, A.3    Gearhart, B.4    Shen, H.5    Cummins, J.6
  • 40
    • 40549106124 scopus 로고    scopus 로고
    • Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat
    • Rundle, C., Strong, D., Chen, S., Linkhart, T., Sheng, M., Wergedal, J., et al. Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat. J Gene Med 10, 229, 2008.
    • (2008) J Gene Med , vol.10 , pp. 229
    • Rundle, C.1    Strong, D.2    Chen, S.3    Linkhart, T.4    Sheng, M.5    Wergedal, J.6
  • 41
    • 0142124749 scopus 로고    scopus 로고
    • In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4
    • Rundle, C., Miyakoshi, N., Kasukawa, Y., Chen, S., Sheng, M., Wergedal, J., et al. In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4. Bone 32, 591, 2003.
    • (2003) Bone , vol.32 , pp. 591
    • Rundle, C.1    Miyakoshi, N.2    Kasukawa, Y.3    Chen, S.4    Sheng, M.5    Wergedal, J.6
  • 42
    • 15444381040 scopus 로고    scopus 로고
    • Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4)
    • Huang, Y., Simmons, C., Kaigler, D., Rice, K., and Mooney, D. Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther 12, 418, 2005.
    • (2005) Gene Ther , vol.12 , pp. 418
    • Huang, Y.1    Simmons, C.2    Kaigler, D.3    Rice, K.4    Mooney, D.5
  • 43
    • 67651163639 scopus 로고    scopus 로고
    • Treatment of rabbit femoral defect by firearm with BMP-4 gene combined with TGF-beta1
    • Li, B.C., Zhang, J.J., Xu, C., Zhang, J.Y., and Zhao, H. Treatment of rabbit femoral defect by firearm with BMP-4 gene combined with TGF-beta1. J Trauma 66, 450, 2009.
    • (2009) J Trauma , vol.66 , pp. 450
    • Li, B.C.1    Zhang, J.J.2    Xu, C.3    Zhang, J.Y.4    Zhao, H.5
  • 45
    • 4844223862 scopus 로고    scopus 로고
    • Adenoviral-mediated transfer of human BMP-6 gene accelerates healing in a rabbit ulnar osteotomy model
    • Bertone, A., Pittman, D., Bouxsein, M., Li, J., Clancy, B., and Seeherman, H. Adenoviral-mediated transfer of human BMP-6 gene accelerates healing in a rabbit ulnar osteotomy model. J Orthop Res 22, 1261, 2004.
    • (2004) J Orthop Res , vol.22 , pp. 1261
    • Bertone, A.1    Pittman, D.2    Bouxsein, M.3    Li, J.4    Clancy, B.5    Seeherman, H.6
  • 46
    • 0032941836 scopus 로고    scopus 로고
    • Gene-enhanced tissue engineering: Applications for bone healing using cultured periosteal cells transduced retrovirally with the BMP-7 gene
    • Breitbart, A.S., Grande, D.A., Mason, J.M., Barcia, M., James, T., and Grant, R.T. Gene-enhanced tissue engineering: applications for bone healing using cultured periosteal cells transduced retrovirally with the BMP-7 gene. Ann Plast Surg 42, 488, 1999.
    • (1999) Ann Plast Surg , vol.42 , pp. 488
    • Breitbart, A.S.1    Grande, D.A.2    Mason, J.M.3    Barcia, M.4    James, T.5    Grant, R.T.6
  • 47
    • 0141813683 scopus 로고    scopus 로고
    • Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7 expressing bone marrow cells and allograft bone
    • Hidaka, C., Goshi, K., Rawlins, B., Boachie-Adjei, O., and Crystal, R. Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7 expressing bone marrow cells and allograft bone. Spine 28, 2049, 2003.
    • (2003) Spine , vol.28 , pp. 2049
    • Hidaka, C.1    Goshi, K.2    Rawlins, B.3    Boachie-Adjei, O.4    Crystal, R.5
  • 48
    • 1342279195 scopus 로고    scopus 로고
    • Osteogenesis in rats induced by a novel recombinant helper-dependent bone morphogenetic protein-9 (BMP-9) adenovirus
    • Li, J., Hankins, G., Kao, C., Li, H., Kammauff, J., and Helm, G. Osteogenesis in rats induced by a novel recombinant helper-dependent bone morphogenetic protein-9 (BMP-9) adenovirus. J Gene Med 5, 748, 2003.
    • (2003) J Gene Med , vol.5 , pp. 748
    • Li, J.1    Hankins, G.2    Kao, C.3    Li, H.4    Kammauff, J.5    Helm, G.6
  • 49
    • 0034127731 scopus 로고    scopus 로고
    • Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent
    • Helm, G.A., Alden, T.D., Beres, E.J., Hudson, S.B., Das, S., Engh, J.A., et al. Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent. J Neurosurg 92, 191, 2000.
    • (2000) J Neurosurg , vol.92 , pp. 191
    • Helm, G.A.1    Alden, T.D.2    Beres, E.J.3    Hudson, S.B.4    Das, S.5    Engh, J.A.6
  • 50
    • 0035831609 scopus 로고    scopus 로고
    • Morphologic analysis of BMP-9 gene therapyinduced osteogenesis
    • Varaday, P., Li, J., Cunningham, M., Beres, M., Das, S., Engh, J., et al. Morphologic analysis of BMP-9 gene therapyinduced osteogenesis. Hum Gene Ther 12, 697, 2001.
    • (2001) Hum Gene Ther , vol.12 , pp. 697
    • Varaday, P.1    Li, J.2    Cunningham, M.3    Beres, M.4    Das, S.5    Engh, J.6
  • 51
    • 0032215597 scopus 로고    scopus 로고
    • Single local injection of recombinant fibroblast growth factor-2 stimulates healing of segmental bone defects in rabbits
    • Kato, T., Kawaguchi, H., Hanada, K., Aoyama, I., Hiyama, Y., Nakamura, T., et al. Single local injection of recombinant fibroblast growth factor-2 stimulates healing of segmental bone defects in rabbits. J Orthop Res 16, 654, 1998.
    • (1998) J Orthop Res , vol.16 , pp. 654
    • Kato, T.1    Kawaguchi, H.2    Hanada, K.3    Aoyama, I.4    Hiyama, Y.5    Nakamura, T.6
  • 52
    • 0031781483 scopus 로고    scopus 로고
    • Recombinant human fibroblast growth factor accelerates fracture healing by enhancing callus remodeling in experimental dog tibial fracture
    • Nakamura, T., Hara, Y., Tagawa, M., Tamura, M., Yuge, T., and Fukuda, H. Recombinant human fibroblast growth factor accelerates fracture healing by enhancing callus remodeling in experimental dog tibial fracture. J Bone Miner Res 13, 942, 1998.
    • (1998) J Bone Miner Res , vol.13 , pp. 942
    • Nakamura, T.1    Hara, Y.2    Tagawa, M.3    Tamura, M.4    Yuge, T.5    Fukuda, H.6
  • 53
    • 0037097976 scopus 로고    scopus 로고
    • FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
    • Ornitz, D., and Marie, P. FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Gene Dev 16, 1446, 2002.
    • (2002) Gene Dev , vol.16 , pp. 1446
    • Ornitz, D.1    Marie, P.2
  • 54
    • 33749540127 scopus 로고    scopus 로고
    • Bone regeneration with active angiogenesis by basic fibroblast growth factor gene transfected mesenchymal stem cells seeded on porous beta-TCP ceramic scaffolds
    • Guo, X., Zheng, Q., Kulbatski, I., Yuan, Q., Yang, S., Shao, Z., et al. Bone regeneration with active angiogenesis by basic fibroblast growth factor gene transfected mesenchymal stem cells seeded on porous beta-TCP ceramic scaffolds. Biomed Mater 1, 93, 2006.
    • (2006) Biomed Mater , vol.1 , pp. 93
    • Guo, X.1    Zheng, Q.2    Kulbatski, I.3    Yuan, Q.4    Yang, S.5    Shao, Z.6
  • 55
    • 0036771653 scopus 로고    scopus 로고
    • Systematically administered mesenchymal stromal cells transduced with insulin-like growth factor-I localize to a fracture site and potentiate healing
    • Shen, F.H., Visger, J.M., Balian, G., Hurwitz, S.R., and Diduch, D.R. Systematically administered mesenchymal stromal cells transduced with insulin-like growth factor-I localize to a fracture site and potentiate healing. J Orthop Trauma 16, 651, 2002.
    • (2002) J Orthop Trauma , vol.16 , pp. 651
    • Shen, F.H.1    Visger, J.M.2    Balian, G.3    Hurwitz, S.R.4    Diduch, D.R.5
  • 56
    • 66149096522 scopus 로고    scopus 로고
    • Adenovirus encoding human plateletderived growth factor-B delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use
    • Chang, P.C., Cirelli, J.A., Jin, Q., Seol, Y.J., Sugai, J.V., D'Silva, N.J., et al. Adenovirus encoding human plateletderived growth factor-B delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use. Hum Gene Ther 20, 486, 2009.
    • (2009) Hum Gene Ther , vol.20 , pp. 486
    • Chang, P.C.1    Cirelli, J.A.2    Jin, Q.3    Seol, Y.J.4    Sugai, J.V.5    D'Silva, N.J.6
  • 57
    • 0025138534 scopus 로고
    • Transforming growth factor-beta stimulates bone matrix apposition and bone cell replication in cultured fetal rat carvariae
    • Hock, J., Canalis, E., and Centrella, M. Transforming growth factor-beta stimulates bone matrix apposition and bone cell replication in cultured fetal rat carvariae. Endocrinology 126, 421, 1990.
    • (1990) Endocrinology , vol.126 , pp. 421
    • Hock, J.1    Canalis, E.2    Centrella, M.3
  • 58
    • 0025340885 scopus 로고
    • Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur
    • Joyce, M., Roberts, A., Sporn, M., and Bolander, M. Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 110, 2195, 1990.
    • (1990) J Cell Biol , vol.110 , pp. 2195
    • Joyce, M.1    Roberts, A.2    Sporn, M.3    Bolander, M.4
  • 59
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • Gerber, H., Vu, T., Ryan, A., Kowalski, J., Werb, Z., and Ferrara, N. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5, 623, 1999.
    • (1999) Nat Med , vol.5 , pp. 623
    • Gerber, H.1    Vu, T.2    Ryan, A.3    Kowalski, J.4    Werb, Z.5    Ferrara, N.6
  • 60
    • 0037162547 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover
    • Street, J., Bao, M., deGuzman, L., Bunting, S., Peale, F., Ferrara, N., et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA 99, 9656, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9656
    • Street, J.1    Bao, M.2    De Guzman, L.3    Bunting, S.4    Peale, F.5    Ferrara, N.6
  • 61
    • 51849093548 scopus 로고    scopus 로고
    • Fracture vascularity and bone healing: A systematic review of the role of VEGF
    • Keramaris, N., Calori, N., Nikolaou, V., Schemitsch, E., and Giannoudis, P. Fracture vascularity and bone healing: a systematic review of the role of VEGF. Injury 39, S45, 2008.
    • (2008) Injury , vol.39
    • Keramaris, N.1    Calori, N.2    Nikolaou, V.3    Schemitsch, E.4    Giannoudis, P.5
  • 62
    • 20144387650 scopus 로고    scopus 로고
    • Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy
    • Ito, H., Koefoed, M., Tiyapatanaputi, P., Gromov, K., Goater, J.J., Carmouche, J., et al. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med 11, 291, 2005.
    • (2005) Nat Med , vol.11 , pp. 291
    • Ito, H.1    Koefoed, M.2    Tiyapatanaputi, P.3    Gromov, K.4    Goater, J.J.5    Carmouche, J.6
  • 63
    • 58149271034 scopus 로고    scopus 로고
    • Effect of cell-based VEGF gene therapy on healing of a segmental bone defect
    • Li, R., Stewart, D., von Schroeder, H., Mackinnon, E., and Schemitsch, E. Effect of cell-based VEGF gene therapy on healing of a segmental bone defect. J Orthop Res 27, 8, 2009.
    • (2009) J Orthop Res , vol.27 , pp. 8
    • Li, R.1    Stewart, D.2    Von Schroeder, H.3    MacKinnon, E.4    Schemitsch, E.5
  • 64
    • 27444447463 scopus 로고    scopus 로고
    • Vascular endothelial growth factor gene activated-matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects
    • Geiger, F., Bertram, H., Berger, I., Lorenz, H., Wall, O., Eckhardt, C., et al. Vascular endothelial growth factor gene activated-matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res 20, 2028, 2005.
    • (2005) J Bone Miner Res , vol.20 , pp. 2028
    • Geiger, F.1    Bertram, H.2    Berger, I.3    Lorenz, H.4    Wall, O.5    Eckhardt, C.6
  • 65
    • 0344289637 scopus 로고    scopus 로고
    • Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues
    • Tarkka, T., Sipola, A., Jamsa, T., Soini, Y., Yla-Herttuala, S., Tuukkanen, J., et al. Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues. J Gene Med 5, 560, 2003.
    • (2003) J Gene Med , vol.5 , pp. 560
    • Tarkka, T.1    Sipola, A.2    Jamsa, T.3    Soini, Y.4    Yla-Herttuala, S.5    Tuukkanen, J.6
  • 66
    • 0031755753 scopus 로고    scopus 로고
    • LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation
    • Boden, S., Liu, Y., Hair, G., Helms, J., Hu, D., and Racine, M. LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation. Endocrinology 139, 5125, 1998.
    • (1998) Endocrinology , vol.139 , pp. 5125
    • Boden, S.1    Liu, Y.2    Hair, G.3    Helms, J.4    Hu, D.5    Racine, M.6
  • 67
    • 0032238373 scopus 로고    scopus 로고
    • Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1)
    • Boden, S., Titus, L., Hair, G., Liu, Y., Viggeswarapu, M., Nanes, M., et al. Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1). Spine 23, 2486, 1998.
    • (1998) Spine , vol.23 , pp. 2486
    • Boden, S.1    Titus, L.2    Hair, G.3    Liu, Y.4    Viggeswarapu, M.5    Nanes, M.6
  • 68
    • 52049086443 scopus 로고    scopus 로고
    • Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models
    • Lattanzi, W., Parrilla, C., Retoni, A., Logroscino, G., Straface, G., Pecorini, G., et al. Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models. Gene Ther 15, 1220, 2008.
    • (2008) Gene Ther , vol.15 , pp. 1220
    • Lattanzi, W.1    Parrilla, C.2    Retoni, A.3    Logroscino, G.4    Straface, G.5    Pecorini, G.6
  • 69
    • 0035101195 scopus 로고    scopus 로고
    • Adenoviral delivery of LIM mineralization protein-1 induces new-bone formation in vitro and in vivo
    • Viggeswarapu, M., Boden, S., Liu, Y., Hair, G., Louis-Ugbo, J., Murakami, H., et al. Adenoviral delivery of LIM mineralization protein-1 induces new-bone formation in vitro and in vivo. J Bone Joint Surg Am 83A, 364, 2001.
    • (2001) J Bone Joint Surg Am , vol.83 A , pp. 364
    • Viggeswarapu, M.1    Boden, S.2    Liu, Y.3    Hair, G.4    Louis-Ugbo, J.5    Murakami, H.6
  • 70
    • 0009660825 scopus 로고    scopus 로고
    • Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): A mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro
    • Yasuda, H., Shima, N., Nakagawa, N., Mochizuki, S., Yano, K., Fujise, N., et al. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology 139, 1329, 1998.
    • (1998) Endocrinology , vol.139 , pp. 1329
    • Yasuda, H.1    Shima, N.2    Nakagawa, N.3    Mochizuki, S.4    Yano, K.5    Fujise, N.6
  • 71
    • 0034510162 scopus 로고    scopus 로고
    • Osteoprotegerin and its ligand: A new paradigm for regulation of osteoclastogenesis and bone resorption
    • Aubin, J.E., and Bonnelye, E. Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption. Osteoporos Int 11, 905, 2000.
    • (2000) Osteoporos Int , vol.11 , pp. 905
    • Aubin, J.E.1    Bonnelye, E.2
  • 72
    • 39749106932 scopus 로고    scopus 로고
    • Local osteoprotegerin gene transfer to periodontal tissue inhibits liopopolysaccharaide-induced alveolar bone resportion
    • Chen, R., Kanzaki, H., Chiba, M., Nishimura, M., Kanzaki, R., and Igarashi, K. Local osteoprotegerin gene transfer to periodontal tissue inhibits liopopolysaccharaide-induced alveolar bone resportion. J Periodontal Res 43, 237, 2008.
    • (2008) J Periodontal Res , vol.43 , pp. 237
    • Chen, R.1    Kanzaki, H.2    Chiba, M.3    Nishimura, M.4    Kanzaki, R.5    Igarashi, K.6
  • 73
    • 0034980793 scopus 로고    scopus 로고
    • Adenoviral delivery of osteoprotegerin ameloriates bone resorption in a mouse ovariectomy model of osteoporosis
    • Bolon, B., Carter, C., Daris, M., Morony, S., Capparelli, C., Hsieh, A., et al. Adenoviral delivery of osteoprotegerin ameloriates bone resorption in a mouse ovariectomy model of osteoporosis. Mol Ther 3, 197, 2001.
    • (2001) Mol Ther , vol.3 , pp. 197
    • Bolon, B.1    Carter, C.2    Daris, M.3    Morony, S.4    Capparelli, C.5    Hsieh, A.6
  • 74
    • 27744529640 scopus 로고    scopus 로고
    • Osteoprotegerin and RANKL regulate bone resporptoin, density, geometry and strength
    • Kostenuik, P. Osteoprotegerin and RANKL regulate bone resporptoin, density, geometry and strength. Curr Opin Pharmacol 5, 618, 2005.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 618
    • Kostenuik, P.1
  • 75
    • 33645769738 scopus 로고    scopus 로고
    • Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement
    • Kanzaki, H., Chiba, M., Arai, K., Takahashi, I., Haryuama, N., Nishimura, M., et al. Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement. Gene Ther 13, 678, 2006.
    • (2006) Gene Ther , vol.13 , pp. 678
    • Kanzaki, H.1    Chiba, M.2    Arai, K.3    Takahashi, I.4    Haryuama, N.5    Nishimura, M.6
  • 76
    • 0034460993 scopus 로고    scopus 로고
    • Runx2 is a common target of transforming growth factor b1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblasts-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
    • Lee, K., Kim, H., Li, Q., Chi, X., Ueta, C., Komori, T., et al. Runx2 is a common target of transforming growth factor b1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblasts-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20, 8783, 2000.
    • (2000) Mol Cell Biol , vol.20 , pp. 8783
    • Lee, K.1    Kim, H.2    Li, Q.3    Chi, X.4    Ueta, C.5    Komori, T.6
  • 77
    • 37549048980 scopus 로고    scopus 로고
    • Healing cranial defects with AdRunx2-transduced marrow stromal cells
    • Zhao, Z., Wang, Z., Ge, C., Krebsbach, P., and Franceschi, R.T. Healing cranial defects with AdRunx2-transduced marrow stromal cells. J Dent Res 86, 1207, 2007.
    • (2007) J Dent Res , vol.86 , pp. 1207
    • Zhao, Z.1    Wang, Z.2    Ge, C.3    Krebsbach, P.4    Franceschi, R.T.5
  • 78
    • 33645321143 scopus 로고    scopus 로고
    • Effects of Runx2 genetic engineering and in vitro maturation of tissue-engineered constructs on the repair of critical size bone defects
    • Byers, B., Guldberg, R., Hutmacher, D., and Garcia, A. Effects of Runx2 genetic engineering and in vitro maturation of tissue-engineered constructs on the repair of critical size bone defects. J Biomed Mat Res A 76A, 646, 2006.
    • (2006) J Biomed Mat Res A , vol.76 A , pp. 646
    • Byers, B.1    Guldberg, R.2    Hutmacher, D.3    Garcia, A.4
  • 79
    • 34548067391 scopus 로고    scopus 로고
    • Dermal fibroblasts genetically modified to express Runx2/Cbfa1 as a mineralizing cell source for bone tissue engineering
    • Phillips, J., Guldberg, R., and Garcia, A. Dermal fibroblasts genetically modified to express Runx2/Cbfa1 as a mineralizing cell source for bone tissue engineering. Tissue Eng 13, 2029, 2007.
    • (2007) Tissue Eng , vol.13 , pp. 2029
    • Phillips, J.1    Guldberg, R.2    Garcia, A.3
  • 80
    • 33746824572 scopus 로고    scopus 로고
    • Mineralization capacity of Runx2/Cfab1-genetically engineered fibroblasts is scaffold dependent
    • Phillips, J., Hutmacher, D., Guldberg, R., and Garcia, A. Mineralization capacity of Runx2/Cfab1-genetically engineered fibroblasts is scaffold dependent. Biomaterials 27, 5535, 2006.
    • (2006) Biomaterials , vol.27 , pp. 5535
    • Phillips, J.1    Hutmacher, D.2    Guldberg, R.3    Garcia, A.4
  • 81
    • 33745212688 scopus 로고    scopus 로고
    • LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads
    • Sangadala, S., Boden, S., Viggeswarapu, M., Liu, Y., and Titus, L. LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads. J Biol Chem 281, 17212, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 17212
    • Sangadala, S.1    Boden, S.2    Viggeswarapu, M.3    Liu, Y.4    Titus, L.5
  • 82
    • 77955287601 scopus 로고    scopus 로고
    • Gene transfer: How can the biological barriers be overcome?
    • Escoffre, J., Teissie, T., and Rols, M. Gene transfer: how can the biological barriers be overcome? J Membr Biol 236, 61, 2010.
    • (2010) J Membr Biol , vol.236 , pp. 61
    • Escoffre, J.1    Teissie, T.2    Rols, M.3
  • 83
    • 44649117371 scopus 로고    scopus 로고
    • Formulations for DNA delivery via electroporation in vivo
    • Anwer, K. Formulations for DNA delivery via electroporation in vivo. Methods Mol Biol 423, 77, 2008.
    • (2008) Methods Mol Biol , vol.423 , pp. 77
    • Anwer, K.1
  • 84
    • 0032805251 scopus 로고    scopus 로고
    • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
    • Liu, F., Song, Y., and Liu, D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 6, 1258, 1999.
    • (1999) Gene Ther , vol.6 , pp. 1258
    • Liu, F.1    Song, Y.2    Liu, D.3
  • 85
    • 0038745599 scopus 로고    scopus 로고
    • Progress and problems associated with the use of viral vectors for gene therapy
    • Thomas, C., Ehrhardt, A., and Kay, M. Progress and problems associated with the use of viral vectors for gene therapy. Nat Rev Genet 45, 346, 2003.
    • (2003) Nat Rev Genet , vol.45 , pp. 346
    • Thomas, C.1    Ehrhardt, A.2    Kay, M.3
  • 86
    • 15944400651 scopus 로고    scopus 로고
    • Towards safe, non-viral therapeutic gene expression in humans
    • Glover, D., Lipps, H., and Jans, D. Towards safe, non-viral therapeutic gene expression in humans. Nat Rev Genet 6, 299, 2005.
    • (2005) Nat Rev Genet , vol.6 , pp. 299
    • Glover, D.1    Lipps, H.2    Jans, D.3
  • 87
    • 0142089747 scopus 로고    scopus 로고
    • Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
    • Raper, S.E., Chirmule, N., Lee, F.S., Wivel, N.A., Bagg, A., Gao, G.P., et al. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab 80, 148, 2003.
    • (2003) Mol Genet Metab , vol.80 , pp. 148
    • Raper, S.E.1    Chirmule, N.2    Lee, F.S.3    Wivel, N.A.4    Bagg, A.5    Gao, G.P.6
  • 91
    • 0037462997 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    • Panyam, J., and Labhasetwar, V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 55, 329, 2003.
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 329
    • Panyam, J.1    Labhasetwar, V.2
  • 92
    • 0035028217 scopus 로고    scopus 로고
    • Cationic polymers for gene delivery: Designs for overcoming barriers to systemic administration
    • Hwang, S., and Davis, M. Cationic polymers for gene delivery: designs for overcoming barriers to systemic administration. Curr Opin Mol Ther 3, 183, 2001.
    • (2001) Curr Opin Mol Ther , vol.3 , pp. 183
    • Hwang, S.1    Davis, M.2
  • 93
    • 33745284997 scopus 로고    scopus 로고
    • Natural polymers for gene delivery and tissue engineering
    • Dang, J., and Leong, K. Natural polymers for gene delivery and tissue engineering. Adv Drug Deliv Rev 58, 487, 2006.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 487
    • Dang, J.1    Leong, K.2
  • 94
    • 4444330267 scopus 로고    scopus 로고
    • Biomaterials: Where we have been and where we are going
    • Ratner, B., and Bryant, S. Biomaterials: where we have been and where we are going. Annu Rev Biomed Eng 6, 41, 2004.
    • (2004) Annu Rev Biomed Eng , vol.6 , pp. 41
    • Ratner, B.1    Bryant, S.2
  • 95
    • 3242796521 scopus 로고    scopus 로고
    • Evaluation of collagen and methylated collagen as gene carriers
    • Wang, J., Lee, I., Lim, W., Chia, S., Yu, H., Leong, K., et al. Evaluation of collagen and methylated collagen as gene carriers. Int J Pharm 279, 115, 2004.
    • (2004) Int J Pharm , vol.279 , pp. 115
    • Wang, J.1    Lee, I.2    Lim, W.3    Chia, S.4    Yu, H.5    Leong, K.6
  • 96
    • 20444409137 scopus 로고    scopus 로고
    • Chitosan: A versatile biopolymer for orthopaedic tissue-engineering
    • DiMartino, A., Sittinger, M., and Risbud, M. Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. Biomaterials 26, 5983, 2005.
    • (2005) Biomaterials , vol.26 , pp. 5983
    • Dimartino, A.1    Sittinger, M.2    Risbud, M.3
  • 97
    • 29444440132 scopus 로고    scopus 로고
    • Bio-functional inorganic materials: An attractive branch of gene-based nano-medicine delivery for 21st century
    • Chowdhury, E.H., and Akaike, T. Bio-functional inorganic materials: an attractive branch of gene-based nano-medicine delivery for 21st century. Curr Gene Ther 5, 669, 2005.
    • (2005) Curr Gene Ther , vol.5 , pp. 669
    • Chowdhury, E.H.1    Akaike, T.2
  • 98
    • 33645223448 scopus 로고    scopus 로고
    • Stabilizing of plasmid DNA in vivo by PEG-modified cationic gold nanoparticles and the gene expression assisted with electrical pulses
    • Kawano, T., Yamagata, M., Takahashi, H., Niidome, Y., Yamada, S., Katayama, Y., et al. Stabilizing of plasmid DNA in vivo by PEG-modified cationic gold nanoparticles and the gene expression assisted with electrical pulses. J Control Release 111, 382, 2006.
    • (2006) J Control Release , vol.111 , pp. 382
    • Kawano, T.1    Yamagata, M.2    Takahashi, H.3    Niidome, Y.4    Yamada, S.5    Katayama, Y.6
  • 99
    • 0032030790 scopus 로고    scopus 로고
    • Antimicrobial effects of metal ions (Ag+, Cu2+, Zn2+) in hydroxyapatite
    • Kim, T., Feng, Q., Kim, J., Wu, J., Wang, H., Chen, G., et al. Antimicrobial effects of metal ions (Ag+, Cu2+, Zn2+) in hydroxyapatite. J Mater Sci Mater M 9, 129, 1998.
    • (1998) J Mater Sci Mater M , vol.9 , pp. 129
    • Kim, T.1    Feng, Q.2    Kim, J.3    Wu, J.4    Wang, H.5    Chen, G.6
  • 100
    • 40149085560 scopus 로고    scopus 로고
    • Nanofibers and nanoparticles for orthopaedic surgery applications
    • Nair, L., and Laurencin, C. Nanofibers and nanoparticles for orthopaedic surgery applications. J Bone Joint Surg Am 90, 128, 2008.
    • (2008) J Bone Joint Surg Am , vol.90 , pp. 128
    • Nair, L.1    Laurencin, C.2
  • 101
    • 3342897529 scopus 로고    scopus 로고
    • Surface-mediated gene transfer from nanocomposites of controlled texture
    • Shen, H., Tan, J., and Saltzman, W.M. Surface-mediated gene transfer from nanocomposites of controlled texture. Nat Mater 3, 569, 2004.
    • (2004) Nat Mater , vol.3 , pp. 569
    • Shen, H.1    Tan, J.2    Saltzman, W.M.3
  • 103
    • 0033898807 scopus 로고    scopus 로고
    • Enhancement of transfection by physical concentration of DNA at the cell surface
    • Luo, D., and Saltzman, W.M. Enhancement of transfection by physical concentration of DNA at the cell surface. Nat Biotechnol 18, 893, 2000.
    • (2000) Nat Biotechnol , vol.18 , pp. 893
    • Luo, D.1    Saltzman, W.M.2
  • 104
    • 7944221147 scopus 로고    scopus 로고
    • Cationic silica nanoparticles as gene carriers: Syn thesis, characterization and transfection efficiency in vitro and in vivo
    • Kumar, M., Sameti, M., Mohapatra, S., Kong, X., Lockey, R., Bakowsky, U., et al. Cationic silica nanoparticles as gene carriers: synthesis, characterization and transfection efficiency in vitro and in vivo. J Nanosci Nanotechnol 4, 876, 2004.
    • (2004) J Nanosci Nanotechnol , vol.4 , pp. 876
    • Kumar, M.1    Sameti, M.2    Mohapatra, S.3    Kong, X.4    Lockey, R.5    Bakowsky, U.6
  • 105
    • 0036727416 scopus 로고    scopus 로고
    • Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
    • Lewis, D., Hagstrom, J., Loomis, A., Wolff, J., and Herweijer, H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet 32, 107, 2002.
    • (2002) Nat Genet , vol.32 , pp. 107
    • Lewis, D.1    Hagstrom, J.2    Loomis, A.3    Wolff, J.4    Herweijer, H.5
  • 106
    • 67649365433 scopus 로고    scopus 로고
    • Transfection by particle bombardment: Delivery of plasmid DNA into mammalian cells using gene gun
    • Uchida, M., Li, X., Mertens, P., and Alpar, H. Transfection by particle bombardment: delivery of plasmid DNA into mammalian cells using gene gun. Biochim Biophys Acta 1790, 754, 2009.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 754
    • Uchida, M.1    Li, X.2    Mertens, P.3    Alpar, H.4
  • 107
    • 42549115708 scopus 로고    scopus 로고
    • Gene gun bombardment with DNA-coated gold particles is a potential alternative to hydrodynamics-based transfection for delivering genes into superficial hepatocytes
    • Chang, M., Chen, J., Yeh, C., Chang, M., Liang, C., Chiu, C., et al. Gene gun bombardment with DNA-coated gold particles is a potential alternative to hydrodynamics-based transfection for delivering genes into superficial hepatocytes. Hum Gene Ther 19, 391, 2008.
    • (2008) Hum Gene Ther , vol.19 , pp. 391
    • Chang, M.1    Chen, J.2    Yeh, C.3    Chang, M.4    Liang, C.5    Chiu, C.6
  • 109
    • 77649160212 scopus 로고    scopus 로고
    • Comparative transfection of DNA into primary and transformed mammalian cells from different lineages
    • Maurisse, R., De Semir, D., Emamekhoo, H., Bedaya, B., Abdolmohammadi, A., Parsi, H., et al. Comparative transfection of DNA into primary and transformed mammalian cells from different lineages. BMC Biotechnol 10, 9, 2010.
    • (2010) BMC Biotechnol , vol.10 , pp. 9
    • Maurisse, R.1    De Semir, D.2    Emamekhoo, H.3    Bedaya, B.4    Abdolmohammadi, A.5    Parsi, H.6
  • 110
    • 71049129937 scopus 로고    scopus 로고
    • In vivo electrical conductivity measurements during and after tumor electroporation: Conductivity changes reflect the treatment outcome
    • Ivorra, A., Al-Sakere, B., Rubinsky, B., and Mir, L. In vivo electrical conductivity measurements during and after tumor electroporation: conductivity changes reflect the treatment outcome. Phys Med Biol 54, 5949, 2009.
    • (2009) Phys Med Biol , vol.54 , pp. 5949
    • Ivorra, A.1    Al-Sakere, B.2    Rubinsky, B.3    Mir, L.4
  • 111
    • 64549134676 scopus 로고    scopus 로고
    • Nonviral vectors for gene delivery
    • Mintzer, M., and Simanek, E. Nonviral vectors for gene delivery. Chem Rev 109, 259, 2009.
    • (2009) Chem Rev , vol.109 , pp. 259
    • Mintzer, M.1    Simanek, E.2
  • 112
    • 27844445222 scopus 로고    scopus 로고
    • Inorganic nanoparticles as carriers for efficient cellular delivery
    • Xu, Z., Zeng, Q., Lu, G., and Yu, A. Inorganic nanoparticles as carriers for efficient cellular delivery. Chem Eng Sci 61, 1027, 2006.
    • (2006) Chem Eng Sci , vol.61 , pp. 1027
    • Xu, Z.1    Zeng, Q.2    Lu, G.3    Yu, A.4
  • 113
    • 34547790831 scopus 로고    scopus 로고
    • Inorganic hollow nanoparticles and nanotubes in nanomedicine: Part 1. Drug/gene delivery applications
    • Son, S., Bai, X., and Lee, S. Inorganic hollow nanoparticles and nanotubes in nanomedicine: part 1. Drug/gene delivery applications. Drug Discov Today 12, 650, 2007.
    • (2007) Drug Discov Today , vol.12 , pp. 650
    • Son, S.1    Bai, X.2    Lee, S.3
  • 114
    • 1242316227 scopus 로고    scopus 로고
    • A selfassembled, modular DNA delivery system mediated by silica nanoparticles
    • Luo, D., Han, E., Belcheva, N., and Saltzman, W.M. A selfassembled, modular DNA delivery system mediated by silica nanoparticles. J Control Release 95, 333, 2004.
    • (2004) J Control Release , vol.95 , pp. 333
    • Luo, D.1    Han, E.2    Belcheva, N.3    Saltzman, W.M.4
  • 115
    • 9644270435 scopus 로고    scopus 로고
    • DNA encapsulated magnesium and manganous phosphate nanoparticles: Potential non-viral vectors for gene delivery
    • Bhakta, G., Mitra, S., and Maitra, A. DNA encapsulated magnesium and manganous phosphate nanoparticles: potential non-viral vectors for gene delivery. Biomaterials 26, 2157, 2005.
    • (2005) Biomaterials , vol.26 , pp. 2157
    • Bhakta, G.1    Mitra, S.2    Maitra, A.3
  • 116
    • 32644483914 scopus 로고    scopus 로고
    • Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles
    • Sokolova, V., Radtke, I., Heumann, R., and Epple, M. Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles. Biomaterials 27, 3147, 2006.
    • (2006) Biomaterials , vol.27 , pp. 3147
    • Sokolova, V.1    Radtke, I.2    Heumann, R.3    Epple, M.4
  • 118
    • 60149110939 scopus 로고    scopus 로고
    • RNA-based therapeutics: Ready for delivery?
    • Bonetta, L. RNA-based therapeutics: ready for delivery? Cell 136, 581, 2009.
    • (2009) Cell , vol.136 , pp. 581
    • Bonetta, L.1
  • 119
    • 65749119809 scopus 로고    scopus 로고
    • Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAibased gene therapy
    • Takahashi, Y., Nishikawa, M., and Takakura, Y. Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAibased gene therapy. Adv Drug Deliv Rev 61, 760, 2009.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 760
    • Takahashi, Y.1    Nishikawa, M.2    Takakura, Y.3
  • 120
    • 0029875845 scopus 로고    scopus 로고
    • Gene gun delivery of mRNA in situ results in efficient transgene expression and genetic immunization
    • Qiu, P., Ziegelhoffer, P., Sun, J., and Yang, N.S. Gene gun delivery of mRNA in situ results in efficient transgene expression and genetic immunization. Gene Ther 3, 262, 1996.
    • (1996) Gene Ther , vol.3 , pp. 262
    • Qiu, P.1    Ziegelhoffer, P.2    Sun, J.3    Yang, N.S.4
  • 121
    • 59349116903 scopus 로고    scopus 로고
    • Knocking down barriers: Advances in siRNA delivery
    • Whitehead, K., Langer, R., and Anderson, D. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 8, 129, 2009.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 129
    • Whitehead, K.1    Langer, R.2    Anderson, D.3
  • 122
    • 42049116924 scopus 로고    scopus 로고
    • VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro
    • Mei, J., Gao, Y., Zhang, L., Cai, X., Qian, Z., Huang, H., et al. VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro. Exp Oncol 30, 29, 2008.
    • (2008) Exp Oncol , vol.30 , pp. 29
    • Mei, J.1    Gao, Y.2    Zhang, L.3    Cai, X.4    Qian, Z.5    Huang, H.6
  • 123
    • 48949098577 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Synthetic polymer-based systems
    • Schaffert, D., and Wagner, E. Gene therapy progress and prospects: synthetic polymer-based systems. Gene Ther 15, 1131, 2008.
    • (2008) Gene Ther , vol.15 , pp. 1131
    • Schaffert, D.1    Wagner, E.2
  • 125
    • 57349152290 scopus 로고    scopus 로고
    • Targeted delivery of siRNA by nonviral vectors: Lessons learned from recent advances
    • Li, S., and Huang, L. Targeted delivery of siRNA by nonviral vectors: lessons learned from recent advances. Curr Opin Investig Drugs 9, 1317, 2008.
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 1317
    • Li, S.1    Huang, L.2
  • 127
    • 0028118941 scopus 로고
    • The new frontier: Gene and oligonucleotide therapy
    • Schreier, H. The new frontier: gene and oligonucleotide therapy. Pharm Acta Helv 68, 145, 1994.
    • (1994) Pharm Acta Helv , vol.68 , pp. 145
    • Schreier, H.1
  • 128
    • 0012756249 scopus 로고    scopus 로고
    • RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase
    • Donze, O., and Picard, D. RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase. Nucleic Acids Res 30, e46, 2002.
    • (2002) Nucleic Acids Res , vol.30
    • Donze, O.1    Picard, D.2
  • 129
    • 24144502840 scopus 로고    scopus 로고
    • Effects of base modifications on antisense properties of 2'-o-methoxyethyl and PNA oligonucleotides
    • Sazani, P., Astriab-Fischer, A., and Kole, R. Effects of base modifications on antisense properties of 2'-o-methoxyethyl and PNA oligonucleotides. Antisense Nucleic Acid Drug Dev A 13, 119, 2003.
    • (2003) Antisense Nucleic Acid Drug Dev A , vol.13 , pp. 119
    • Sazani, P.1    Astriab-Fischer, A.2    Kole, R.3
  • 130
    • 33847009448 scopus 로고    scopus 로고
    • Functionalisation of calcium phosphate nanoparticles by oligonucleotides and their application for gene silencing
    • Sokolova, V., Kovtun, A., Prymak, O., Meyer-Zaika, W., Kubareva, E.A., Romanova, E.A., et al. Functionalisation of calcium phosphate nanoparticles by oligonucleotides and their application for gene silencing. J Mater Chem 17, 721, 2007.
    • (2007) J Mater Chem , vol.17 , pp. 721
    • Sokolova, V.1    Kovtun, A.2    Prymak, O.3    Meyer-Zaika, W.4    Kubareva, E.A.5    Romanova, E.A.6
  • 131
    • 34547228805 scopus 로고    scopus 로고
    • Polymer-based siRNA delivery: Perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery
    • Gary, D., Puri, N., and Won, Y. Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery. J Control Release 121, 64, 2007.
    • (2007) J Control Release , vol.121 , pp. 64
    • Gary, D.1    Puri, N.2    Won, Y.3
  • 132
    • 31044444460 scopus 로고    scopus 로고
    • Inhibition of RNAse A family enzymes prevents degradation and loss of silencing activity of siRNAs in serum
    • Haupenthal, J., Baehr, C., Kiermayer, S., Zeuzem, S., and Piiper, A. Inhibition of RNAse A family enzymes prevents degradation and loss of silencing activity of siRNAs in serum. Biochem Pharmacol 71, 702, 2006.
    • (2006) Biochem Pharmacol , vol.71 , pp. 702
    • Haupenthal, J.1    Baehr, C.2    Kiermayer, S.3    Zeuzem, S.4    Piiper, A.5
  • 134
    • 0029979929 scopus 로고    scopus 로고
    • Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA lactosylated polylysine complexes
    • Erbacher, P., Roche, A.C., Monsigny, M., and Midoux, P. Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA lactosylated polylysine complexes. Exp Cell Res 225, 186, 1996.
    • (1996) Exp Cell Res , vol.225 , pp. 186
    • Erbacher, P.1    Roche, A.C.2    Monsigny, M.3    Midoux, P.4
  • 135
    • 33947150969 scopus 로고    scopus 로고
    • Nanostructured materials for applications in drug delivery and tissue engineering
    • Goldberg, M., Langer, R., and Xinqiao, J. Nanostructured materials for applications in drug delivery and tissue engineering. J Biomater Sci Polym Ed 18, 241, 2007.
    • (2007) J Biomater Sci Polym Ed , vol.18 , pp. 241
    • Goldberg, M.1    Langer, R.2    Xinqiao, J.3
  • 136
    • 53849088251 scopus 로고    scopus 로고
    • Dendrimers and DNA: Combinations of two special topologies for nanomaterials and biology
    • Caminade, A.M., Turrin, C.O., and Majoral, J.P. Dendrimers and DNA: combinations of two special topologies for nanomaterials and biology. Chemistry 14, 7422, 2008.
    • (2008) Chemistry , vol.14 , pp. 7422
    • Caminade, A.M.1    Turrin, C.O.2    Majoral, J.P.3
  • 137
    • 67650869003 scopus 로고    scopus 로고
    • Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells
    • Martino, S., Girolamo, I., Tiribuzi, R., D'Angelo, F., Datti, A., and Orlacchio, A. Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells. J Biomed Biotechnol 2009, 410260, 2009.
    • (2009) J Biomed Biotechnol , vol.2009 , pp. 410260
    • Martino, S.1    Girolamo, I.2    Tiribuzi, R.3    D'Angelo, F.4    Datti, A.5    Orlacchio, A.6
  • 138
    • 84856196035 scopus 로고    scopus 로고
    • The effect of formulation parameters on the size of poly-((2- dimethylamino)ethyl methacrylate)-plasmid complexes
    • Cherng, J.Y., Talsma, H., Verrijk, R., Crommelin, D.J.A., and Hennink, W.E. The effect of formulation parameters on the size of poly-((2-dimethylamino) ethyl methacrylate)-plasmid complexes. Eur J Pharm Biopharm 473, 2919, 1999.
    • (1999) Eur J Pharm Biopharm , vol.473 , pp. 2919
    • Cherng, J.Y.1    Talsma, H.2    Verrijk, R.3    Crommelin, D.J.A.4    Hennink, W.E.5
  • 140
    • 27944498250 scopus 로고    scopus 로고
    • Calcium phosphate nanoparticles: Secondgeneration nonviral vectors in gene therapy
    • Maitra, A. Calcium phosphate nanoparticles: secondgeneration nonviral vectors in gene therapy. Expert Rev Mol Diagn 5, 893, 2005.
    • (2005) Expert Rev Mol Diagn , vol.5 , pp. 893
    • Maitra, A.1
  • 141
    • 33745149711 scopus 로고    scopus 로고
    • PH-sensing nano-crystals of carbonate apatite: Effects on intracellular delivery and release of DNA for efficient expression into mammalian cells
    • Chowdhury, E.H., Maruyama, A., Kano, A., Nagaoka, M., Kotaka, M., Hirose, S., et al. pH-sensing nano-crystals of carbonate apatite: effects on intracellular delivery and release of DNA for efficient expression into mammalian cells. Gene 376, 87, 2006.
    • (2006) Gene , vol.376 , pp. 87
    • Chowdhury, E.H.1    Maruyama, A.2    Kano, A.3    Nagaoka, M.4    Kotaka, M.5    Hirose, S.6
  • 142
    • 36749055209 scopus 로고    scopus 로고
    • Nonfunctionalized nanocrystals can exploit a cell's active transport machinery delivering them to specific nuclear and cytoplasmic compartments
    • Nabiev, I., Mitchell, S., Davies, A., Williams, Y., Kelleher, D., Moore, R., et al. Nonfunctionalized nanocrystals can exploit a cell's active transport machinery delivering them to specific nuclear and cytoplasmic compartments. Nano Lett 7, 3452, 2007.
    • (2007) Nano Lett , vol.7 , pp. 3452
    • Nabiev, I.1    Mitchell, S.2    Davies, A.3    Williams, Y.4    Kelleher, D.5    Moore, R.6
  • 145
    • 20744435177 scopus 로고    scopus 로고
    • Nuclear entry of nonviral vectors
    • Dean, D.A., Strong, D.D., and Zimmer, W.E. Nuclear entry of nonviral vectors. Gene Ther 12, 881, 2005.
    • (2005) Gene Ther , vol.12 , pp. 881
    • Dean, D.A.1    Strong, D.D.2    Zimmer, W.E.3
  • 146
    • 33748449331 scopus 로고    scopus 로고
    • Visualizing single molecules interacting with nuclear pore complexes by narrow-field epifluorescence microscopy
    • Yang, W., and Musser, S. Visualizing single molecules interacting with nuclear pore complexes by narrow-field epifluorescence microscopy. Methods 39, 316, 2006.
    • (2006) Methods , vol.39 , pp. 316
    • Yang, W.1    Musser, S.2
  • 147
    • 13844298046 scopus 로고    scopus 로고
    • Intracellular deliveryof largemoleculesandsmallparticles bycell-penetrating proteins and peptides
    • Gupta, B., Levchenko, T., and Torchilin, V. Intracellular deliveryof largemoleculesandsmallparticles bycell-penetrating proteins and peptides. Adv Drug Deliv Rev 57, 637, 2005.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 637
    • Gupta, B.1    Levchenko, T.2    Torchilin, V.3
  • 149
    • 33845315084 scopus 로고    scopus 로고
    • Powering membrane traffic in endocytosis and recycling
    • Soldati, T., and Schliwa, M. Powering membrane traffic in endocytosis and recycling. Nature 7, 897, 2006.
    • (2006) Nature , vol.7 , pp. 897
    • Soldati, T.1    Schliwa, M.2
  • 151
    • 77954505734 scopus 로고    scopus 로고
    • Intranuclear DNA release is a determinant of transfection activity for a non-viral vector: Biocleavable polyrotaxane as a supramolecularly dissociative condenser for efficient intranuclear DNA release
    • Yamada, Y., Nomura, T., Harashima, H., Yamashita, A., Katoono, R., and Yui, N. Intranuclear DNA release is a determinant of transfection activity for a non-viral vector: biocleavable polyrotaxane as a supramolecularly dissociative condenser for efficient intranuclear DNA release. Biol Pharm Bull 33, 1218, 2010.
    • (2010) Biol Pharm Bull , vol.33 , pp. 1218
    • Yamada, Y.1    Nomura, T.2    Harashima, H.3    Yamashita, A.4    Katoono, R.5    Yui, N.6
  • 152
    • 11844271939 scopus 로고    scopus 로고
    • Non-viral gene delivery for local and controlled DNA release
    • Trentin, D., Hubbell, J., and Hall, H. Non-viral gene delivery for local and controlled DNA release. J Control Release 102, 263, 2005.
    • (2005) J Control Release , vol.102 , pp. 263
    • Trentin, D.1    Hubbell, J.2    Hall, H.3
  • 153
    • 79957797244 scopus 로고    scopus 로고
    • Gene therapy for the regeneration of bone
    • Evans, C. Gene therapy for the regeneration of bone. Injury 42, 599, 2011.
    • (2011) Injury , vol.42 , pp. 599
    • Evans, C.1
  • 155
    • 0033847185 scopus 로고    scopus 로고
    • Options for tissue engineering to address challenges of the aging skeleton
    • Hollinger, J.O., Winn, S., and Bonadio, J. Options for tissue engineering to address challenges of the aging skeleton. Tissue Eng 6, 341, 2000.
    • (2000) Tissue Eng , vol.6 , pp. 341
    • Hollinger, J.O.1    Winn, S.2    Bonadio, J.3
  • 157
    • 77649275634 scopus 로고    scopus 로고
    • Hybrid superparamagnetic iron oxide nanoparticle-branched polthylenimin magnetoplexes for gene transfection of vascular endothelial cells
    • Namgung, R., Singha, K., Yu, M.K., John, S., Kim, Y.S., Ahn, Y., et al. Hybrid superparamagnetic iron oxide nanoparticle-branched polthylenimin magnetoplexes for gene transfection of vascular endothelial cells. Biomaterials 31, 4202, 2010.
    • (2010) Biomaterials , vol.31 , pp. 4202
    • Namgung, R.1    Singha, K.2    Yu, M.K.3    John, S.4    Kim, Y.S.5    Ahn, Y.6
  • 158
    • 77949657067 scopus 로고    scopus 로고
    • The effect of static magnetic fields and tat peptides on cellular and nuclear uptake of magnetic nanoparticles
    • Smith, C., Fuente, J., Pelaz, B., Furlani, E., Mullin, M., and Berry, C. The effect of static magnetic fields and tat peptides on cellular and nuclear uptake of magnetic nanoparticles. Biomaterials 31, 4392, 2010.
    • (2010) Biomaterials , vol.31 , pp. 4392
    • Smith, C.1    Fuente, J.2    Pelaz, B.3    Furlani, E.4    Mullin, M.5    Berry, C.6
  • 159
    • 73549120413 scopus 로고    scopus 로고
    • Preparation and characterization of polyethyleniminecoated Fe3O4-MCM-48 nanocomposite particles as a novel agent for magnet-assisted transfection
    • Yiu, H., McBain, S., Lethbridge, Z., Lees, M., and Dobson, J. Preparation and characterization of polyethyleniminecoated Fe3O4-MCM-48 nanocomposite particles as a novel agent for magnet-assisted transfection. J Biomed Mater Res A 92, 386, 2010.
    • (2010) J Biomed Mater Res A , vol.92 , pp. 386
    • Yiu, H.1    McBain, S.2    Lethbridge, Z.3    Lees, M.4    Dobson, J.5
  • 160
    • 66949127647 scopus 로고    scopus 로고
    • Uptake of systemically administered magnetic nanoparticles (MNPs) in areas of experimental spinal cord injury (SCI)
    • Jeffrey, N., McBain, S., Dobson, J., and Chari, D. Uptake of systemically administered magnetic nanoparticles (MNPs) in areas of experimental spinal cord injury (SCI). J Tissue Eng Regen Med 3, 153, 2009.
    • (2009) J Tissue Eng Regen Med , vol.3 , pp. 153
    • Jeffrey, N.1    McBain, S.2    Dobson, J.3    Chari, D.4
  • 161
    • 57449098228 scopus 로고    scopus 로고
    • Magnetic nanoparticles for gene and drug delivery
    • McBain, S.C., Yiu, H.H.P., and Dobson, J. Magnetic nanoparticles for gene and drug delivery. Int J Nanomed 3, 169, 2008.
    • (2008) Int J Nanomed , vol.3 , pp. 169
    • McBain, S.C.1    Yiu, H.H.P.2    Dobson, J.3
  • 164
    • 40149102045 scopus 로고    scopus 로고
    • Ex vivo magnetofection with magnetic nanoparticles: A novel platform for nonviral tissue engineering
    • Yang, S., Sun, J., Tsuang, Y., Chen, L., Hong, C., Yang, H., and Horng, H. Ex vivo magnetofection with magnetic nanoparticles: a novel platform for nonviral tissue engineering. Artif Organs 32, 195, 2007.
    • (2007) Artif Organs , vol.32 , pp. 195
    • Yang, S.1    Sun, J.2    Tsuang, Y.3    Chen, L.4    Hong, C.5    Yang, H.6    Horng, H.7
  • 165
    • 11044222650 scopus 로고    scopus 로고
    • Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    • Gupta, A., and Gupta, M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26, 3995, 2005.
    • (2005) Biomaterials , vol.26 , pp. 3995
    • Gupta, A.1    Gupta, M.2
  • 166
    • 0033652054 scopus 로고    scopus 로고
    • A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro
    • Kneuer, C., Sameti, M., Bakowsky, U., Schiestel, T., Schirra, H., Schmidt, H., et al. A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro. Bioconjug Chem 11, 926, 2000.
    • (2000) Bioconjug Chem , vol.11 , pp. 926
    • Kneuer, C.1    Sameti, M.2    Bakowsky, U.3    Schiestel, T.4    Schirra, H.5    Schmidt, H.6
  • 167
    • 0344530200 scopus 로고    scopus 로고
    • Sodium chloride modified silica nanoparticles as a non-viral vector with a high efficiency of DNA transfer into cells
    • Chen, Y., Xue, Z., Zheng, D., Xia, K., Zhao, Y., Long, Z., et al. Sodium chloride modified silica nanoparticles as a non-viral vector with a high efficiency of DNA transfer into cells. Curr Gene Ther 3, 273, 2003.
    • (2003) Curr Gene Ther , vol.3 , pp. 273
    • Chen, Y.1    Xue, Z.2    Zheng, D.3    Xia, K.4    Zhao, Y.5    Long, Z.6
  • 168
    • 35748941661 scopus 로고    scopus 로고
    • Calcium-doped organosilicate nanoparticles as gene delivery vehicles for bone cells
    • Moudgil, S., and Ying, J. Calcium-doped organosilicate nanoparticles as gene delivery vehicles for bone cells. Adv Mater 19, 3130, 2007.
    • (2007) Adv Mater , vol.19 , pp. 3130
    • Moudgil, S.1    Ying, J.2
  • 169
    • 0037413362 scopus 로고    scopus 로고
    • Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery
    • Roy, I., Mitra, S., Maitra, A., and Mozumdar, S. Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. Int J Pharm 250, 25, 2003.
    • (2003) Int J Pharm , vol.250 , pp. 25
    • Roy, I.1    Mitra, S.2    Maitra, A.3    Mozumdar, S.4
  • 170
    • 0141905056 scopus 로고    scopus 로고
    • Synthesis of mixed monolayer-protected gold clusters from thiol mictures, variation in the tail group, chain length and solvent
    • Choo, H., Cutler, E., and Shon, Y.S. Synthesis of mixed monolayer-protected gold clusters from thiol mictures, variation in the tail group, chain length and solvent. Langmuir 19, 8555, 2003.
    • (2003) Langmuir , vol.19 , pp. 8555
    • Choo, H.1    Cutler, E.2    Shon, Y.S.3
  • 172
    • 0036180065 scopus 로고    scopus 로고
    • Transfection of liver in vivo by biolistic particle delivery: Its use in the investigation of cytochrome P450 gene regulation
    • Muangmoonchai, R., Wong, S.C., Smirlis, D., Phillips, I.R., and Shardl, E.A. Transfection of liver in vivo by biolistic particle delivery: its use in the investigation of cytochrome P450 gene regulation. Mol Biotechnol 22, 145, 2002.
    • (2002) Mol Biotechnol , vol.22 , pp. 145
    • Muangmoonchai, R.1    Wong, S.C.2    Smirlis, D.3    Phillips, I.R.4    Shardl, E.A.5
  • 173
    • 0029075794 scopus 로고
    • Gene gun and other non-viral approaches for cancer gene-therapy
    • Yang, N.S., and Sun, W.H. Gene gun and other non-viral approaches for cancer gene-therapy. Nat Med 1, 481, 1995.
    • (1995) Nat Med , vol.1 , pp. 481
    • Yang, N.S.1    Sun, W.H.2
  • 175
    • 0041923880 scopus 로고    scopus 로고
    • Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells
    • Thomas, M., and Klibanov, A. Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc Natl Acad Sci USA 100, 9138, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9138
    • Thomas, M.1    Klibanov, A.2
  • 176
    • 33646738061 scopus 로고    scopus 로고
    • Oligonucleotide-modified gold nanoparticles for intracellular gene regulation
    • Rosi, N., Giljohann, D., Thaxton, C., Lytton-Jean, A., Han, M., and Mirkin, C. Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science 312, 1027, 2007.
    • (2007) Science , vol.312 , pp. 1027
    • Rosi, N.1    Giljohann, D.2    Thaxton, C.3    Lytton-Jean, A.4    Han, M.5    Mirkin, C.6
  • 177
    • 36048957877 scopus 로고    scopus 로고
    • The potential use of the enhanced nonlinear properties of gold nanospheres in photothermal cancer therapy
    • Huang, X., Qian, W., El-Sayed, I.H., and El-Sayed, M.A. The potential use of the enhanced nonlinear properties of gold nanospheres in photothermal cancer therapy. Lasers Surg Med 39, 747, 2007.
    • (2007) Lasers Surg Med , vol.39 , pp. 747
    • Huang, X.1    Qian, W.2    El-Sayed, I.H.3    El-Sayed, M.A.4
  • 180
    • 67649948599 scopus 로고    scopus 로고
    • MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier
    • Bonoiu, A., Mahajan, S., Ye, L., Kumar, R., Ding, H., Yong, K.T., et al. MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier. Brain Res 1282, 142, 2009.
    • (2009) Brain Res , vol.1282 , pp. 142
    • Bonoiu, A.1    Mahajan, S.2    Ye, L.3    Kumar, R.4    Ding, H.5    Yong, K.T.6
  • 182
    • 33845975678 scopus 로고    scopus 로고
    • Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference
    • Tan, W., Jiang, S., and Zhang, Y. Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference. Biomaterials 28, 1565, 2007.
    • (2007) Biomaterials , vol.28 , pp. 1565
    • Tan, W.1    Jiang, S.2    Zhang, Y.3
  • 183
    • 0029991350 scopus 로고    scopus 로고
    • Transfecting mammalian cells: Optimization of criticial parameters affecting calcium-phosphate precipitate formation
    • Jordan, M., Schallhorn, A., and Wurm, F. Transfecting mammalian cells: optimization of criticial parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res 24, 596, 1996.
    • (1996) Nucleic Acids Res , vol.24 , pp. 596
    • Jordan, M.1    Schallhorn, A.2    Wurm, F.3
  • 184
    • 44349187279 scopus 로고    scopus 로고
    • The importance of particle size and DNA condensation salt for calcium phosphate nanoparticle transfection
    • Pedraza, C.E., Bassett, D., McKee, M., Nelea, V., Gbureck, U., and Barralet, J. The importance of particle size and DNA condensation salt for calcium phosphate nanoparticle transfection. Biomaterials 29, 3384, 2008.
    • (2008) Biomaterials , vol.29 , pp. 3384
    • Pedraza, C.E.1    Bassett, D.2    McKee, M.3    Nelea, V.4    Gbureck, U.5    Barralet, J.6
  • 185
    • 15744393856 scopus 로고    scopus 로고
    • A new technique with calcium phosphate precipitate enhances efficiency of in vivo plasmid DNA gene transfer
    • Kuroda, S., Kondo, H., Ohya, K., and Kasugai, S. A new technique with calcium phosphate precipitate enhances efficiency of in vivo plasmid DNA gene transfer. J Pharmacol Sci 97, 227, 2005.
    • (2005) J Pharmacol Sci , vol.97 , pp. 227
    • Kuroda, S.1    Kondo, H.2    Ohya, K.3    Kasugai, S.4
  • 186
    • 0035972806 scopus 로고    scopus 로고
    • Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection
    • Batard, P., Jordan, M., and Wurm, F. Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection. Gene 270, 61, 2001.
    • (2001) Gene , vol.270 , pp. 61
    • Batard, P.1    Jordan, M.2    Wurm, F.3
  • 187
    • 33846691639 scopus 로고    scopus 로고
    • Tracking the pathway of calcium phosphate/DNA nanoparticles during cell transfection by incorportation of redfluorescing tetramethylrhodamine isothiocyanate-bovine serum albumin into these nanoparticles
    • Sokolova, V., Kovtun, A., Heumann, R., and Epple, M. Tracking the pathway of calcium phosphate/DNA nanoparticles during cell transfection by incorportation of redfluorescing tetramethylrhodamine isothiocyanate-bovine serum albumin into these nanoparticles. J Biol Inorg Chem 12, 174, 2007.
    • (2007) J Biol Inorg Chem , vol.12 , pp. 174
    • Sokolova, V.1    Kovtun, A.2    Heumann, R.3    Epple, M.4
  • 188
    • 10644293770 scopus 로고    scopus 로고
    • PDNA loaded calcium phosphate nanoparticles: Highly efficient non-viral vector for gene delivery
    • Bisht, S., Bhakta, G., Mitra, S., and Maitra, A. pDNA loaded calcium phosphate nanoparticles: highly efficient non-viral vector for gene delivery. Int J Pharm 288, 157, 2005.
    • (2005) Int J Pharm , vol.288 , pp. 157
    • Bisht, S.1    Bhakta, G.2    Mitra, S.3    Maitra, A.4
  • 190
    • 39749105456 scopus 로고    scopus 로고
    • Calcium phosphate-DNA nanocomposites: Morphological studies and their bile duct infusion for liver-direced gene therapy
    • Singh, R., Saxena, A., and Mozumdar, S. Calcium phosphate-DNA nanocomposites: morphological studies and their bile duct infusion for liver-direced gene therapy. Int J Appl Ceram Tec 51, 1, 2008.
    • (2008) Int J Appl Ceram Tec , vol.51 , pp. 1
    • Singh, R.1    Saxena, A.2    Mozumdar, S.3
  • 191
    • 70349873525 scopus 로고    scopus 로고
    • The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimize intracellular calcium disturbance during transfection
    • Neumann, S., Kovtun, A., Dietzel, I., Epple, M., and Heumann, R. The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimize intracellular calcium disturbance during transfection. Biomaterials 30, 6794, 2009.
    • (2009) Biomaterials , vol.30 , pp. 6794
    • Neumann, S.1    Kovtun, A.2    Dietzel, I.3    Epple, M.4    Heumann, R.5
  • 192
    • 4043151371 scopus 로고    scopus 로고
    • Transfection of cells with custom-made calcium phosphate nanoparticles coated with DNA
    • Welzel, T., Radtke, I., Meyer-Zaika, W., Heumann, R., and Epple, M. Transfection of cells with custom-made calcium phosphate nanoparticles coated with DNA. J Mater Chem 14, 2213, 2004.
    • (2004) J Mater Chem , vol.14 , pp. 2213
    • Welzel, T.1    Radtke, I.2    Meyer-Zaika, W.3    Heumann, R.4    Epple, M.5
  • 193
    • 34548618928 scopus 로고    scopus 로고
    • Coating of human mesenchymal cells in 3D culture with bioinorganic nanoparticles promotes osteoblastic differentiation and gene transfection
    • Gonzalez-McQuire, R., Green, D., Partridge, K., Oreffo, R., Mann, S., and Davis, S. Coating of human mesenchymal cells in 3D culture with bioinorganic nanoparticles promotes osteoblastic differentiation and gene transfection. Adv Mater 19, 2236, 2007.
    • (2007) Adv Mater , vol.19 , pp. 2236
    • Gonzalez-Mcquire, R.1    Green, D.2    Partridge, K.3    Oreffo, R.4    Mann, S.5    Davis, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.