Cationic silica nanoparticles as gene carriers: Synthesis, characterization and transfection efficiency In vitro and In vivo

Journal of Nanoscience and Nanotechnology

Volumn 4, Issue 7, 2004, Pages 876-881

  Ravi Kumar, M N V ^a,b   Sameti, M ^a   Mohapatra, S S ^d   Kong, X ^d   Lockey, R F ^d   Bakowsky, U ^a,c   Lindenblatt, G ^e   Schmidt, H ^e   Lehr, C M ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

^e INM LEIBNIZ INSTITUTE FOR NEW MATERIALS   (Germany)

Author keywords

DBA 2 Mice; Gene Delivery; In vivo; Silica Nanoparticle; Transfection

Indexed keywords

DBA2/ MICE; GENE DELIVERY; IN VIVO; SILICA NANOPARTICLE; TRANSFECTION;

CELL IMMOBILIZATION; DNA; GENE TRANSFER; POSITIVE IONS; SILICA; SURFACE TREATMENT; SYNTHESIS (CHEMICAL); TOXICITY;

NANOSTRUCTURED MATERIALS;

AMINOHEXYL AMINOPROPYLTRIMETHOXYSILANE; CATION; CHLOROQUINE; SILANE DERIVATIVE; SILICON DIOXIDE; UNCLASSIFIED DRUG; AMINO HEXYL AMINO PROPYLTRI METHOXYSILANE; AMINO-HEXYL-AMINO-PROPYLTRI-METHOXYSILANE; BETA GALACTOSIDASE; DNA; GREEN FLUORESCENT PROTEIN; NANOMATERIAL; NANOTUBE; SILICON;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; CYTOTOXICITY; GENE TRANSFER; GENETIC ANALYSIS; GENETIC TRANSFECTION; HETEROZYGOTE; IN VITRO STUDY; IN VIVO STUDY; LUNG; MOUSE; NANOPARTICLE; NONHUMAN; PARTICLE SIZE; PARTICULATE MATTER; PH; REPORTER GENE; SURFACE PROPERTY; ZETA POTENTIAL; AGAR GEL ELECTROPHORESIS; ANIMAL; ATOMIC FORCE MICROSCOPY; CHEMISTRY; DBA MOUSE; ESCHERICHIA COLI; GENE VECTOR; LIGHT; METABOLISM; METHODOLOGY; NANOTECHNOLOGY; PHOTON; PLASMID; RADIATION SCATTERING; SPECTROPHOTOMETRY;

ANIMALS; BETA-GALACTOSIDASE; CATIONS; CHLOROQUINE; COS CELLS; DNA; ELECTROPHORESIS, AGAR GEL; ESCHERICHIA COLI; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HYDROGEN-ION CONCENTRATION; LIGHT; LUNG; MICE; MICE, INBRED DBA; MICROSCOPY, ATOMIC FORCE; NANOSTRUCTURES; NANOTECHNOLOGY; NANOTUBES; PHOTONS; PLASMIDS; SCATTERING, RADIATION; SILANES; SILICON; SILICON DIOXIDE; SPECTROPHOTOMETRY; TRANSFECTION;

EID: 7944221147     PISSN: 15334880     EISSN: None     Source Type: Journal    
DOI: 10.1166/jnn.2004.120     Document Type: Article

References (22)

1. O. Zelphati, C. Nguyen, M. Ferrari, J. Felgner, Y. Tsai, and P. L. Felgner, Gene Ther. 5, 1272 (1998).
2. S. Gottschalk, J. T. Sparrow, J. Hauer, M. P. Mims, F. E. Leland, S. L. C. Woo, and L. C. Smith, Gene Ther. 3, 448 (1996).
3. T. Blessing, J. S. Remy, and J. P. Behr, Proc. Natl. Acad. Sci. U.S.A. 95, 1427 (1998).
4. V. Vijayanathan, T. Thomas, and T. J. Thomas, Biochemistry 41, 14085 (2002).
5. J. Y. Cherng, P. van de Wetering, H. Talsma, D. J. A. Crommelin, and W. E. Hennink, Pharm. Res. 13, 1038 (1996).
6. W. T. Godbey, K. K. Wu, G. J. Hirasaki, and A. Mikos, Gene Ther. 6, 1380 (1999).
7. O. Boussif, T. Delair, C. Brua, L. Veron, A. Pavirani, and H. V. Kolbe, Bioconj. Chem. 10, 877 (1999).
8. H. Bottcher, C. Jagota, J. Trepte, K. H. Kallies, and H. Haufe, J. Control. Rel. 60, 57 (1999).
9. P. Kortesuo, M. Ahola, S. Karlsson, I. Kangasniemi, A. Yli Urpo, and J. Keisvaara, Biomaterials 21, 193 (2000).
10. C. Kneuer, M. Sameti, U. Bakowsky, T. Schiestel, H. Schirra, H. Schmidt, and C.-M. Lehr, Bioconj. Chem. 11, 926 (2000).
11. C. Kneuer, M. Sameti, E. G. Haltner, T. Schiestel, H. Schirra, H. Schmidt, and C.-M. Lehr, Int. J. Pharm. 196, 257 (2000).
12. M. Sameti, M. N. V. Ravi Kumar, C. Kneuer, U. Bakowsky, M. Nacken, H. Schmidt, and C.-M. Lehr, Int. J. Pharm. 266, 51 (2003).
13. D. Luo, W. M. Saltzman, E. Han, and N. Belcheva, U.S. Pat. No. 6319715, April 21, 2000.
14. Zs. Csõgör, M. Nacken, M. Sameti, C.-M. Lehr, and H. Schmidt, Mater. Sci. Eng. C 23, 93 (2003).
15. X. X. He, K. M. Wang, W. H. Tan, X. Lin, L. Chen, and X. H. Chen, Rev. Adv. Mater. Sci. 5, 375 (2003).
16. M. F. Tai, K. M. Chi, K. H. W. Lau, D. J. Baylink, and S. T. Chen, Rev. Adv. Mater. Sci. 5, 319 (2003).
17. D. Luo and W. M. Saltzman, Nature Biotech. 18, 893 (2000).
18. S. Feng and G. Huang, J. Control. Rel. 71, 53 (2001).
19. V. Bayems and R. Gurny, Pharm. Acta Helv. 72, 191 (1997).
20. M. A. Wolfert and L. W. Seymour, Gene Ther. 5, 409 (1998).
21. K. Tabatt, M. Sameti, C. Olbrich, R. H. Müller, and C.-M. Lehr, Eur. J. Pharm. Biopharm. 57, 155 (2004).
22. N. D. Sonawane, F. C. Szoka, and A. S. Verkman, J. Biol. Chem. 278, 44826 (2003).