Adenovirus encoding human platelet-derived growth factor-b delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use

Human Gene Therapy

Volumn 20, Issue 5, 2009, Pages 486-496

  Chang, Po Chun ^a,b   Cirelli, Joni A ^a   Jin, Qiming ^a   Seol, Yang Jo ^a,c   Sugai, James V ^a   D'Silva, Nisha J ^a   Danciu, Theodora E ^a   Chandler, Lois A ^d   Sosnowski, Barbara A ^d   Giannobile, William V ^a,b  

^a UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c Seoul National University   (South Korea)

^d Tissue Repair Company   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; COLLAGEN; PLATELET DERIVED GROWTH FACTOR B;

ALVEOLAR BONE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXILLARY LYMPH NODE; BIOLOGICAL MONITORING; BLOOD CHEMISTRY; BODY WEIGHT; BONE REGENERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG SAFETY; DRUG TISSUE LEVEL; FEMALE; GENETIC CODE; HISTOPATHOLOGY; LOW DRUG DOSE; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PERIODONTAL DISEASE; RAT; TOOTH DEVELOPMENT; VIRAL GENE THERAPY;

ADENOVIRUSES, HUMAN; ALVEOLAR BONE LOSS; ANIMALS; BONE AND BONES; BONE REGENERATION; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; MALE; PROTO-ONCOGENE PROTEINS C-SIS; RATS; RATS, SPRAGUE-DAWLEY; SAFETY; TRANSDUCTION, GENETIC;

ADENOVIRIDAE; RATTUS;

EID: 66149096522     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2008.114     Document Type: Article

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