Gene gun bombardment with DNA-coated gold particles is a potential alternative to hydrodynamics-based transfection for delivering genes into superficial hepatocytes

Human Gene Therapy

Volumn 19, Issue 4, 2008, Pages 391-395

  Chang, Ming Ling ^a,c   Chen, Jeng Chang ^b   Yeh, Chau Ting ^a,c   Chang, Ming Yu ^b   Liang, Chun Kai ^a,c   Chiu, Cheng Tang ^a,c   Lin, Deng Yn ^a,c   Liaw, Yun Fan ^a,c  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG CHILDREN S HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENHANCED GREEN FLUORESCENT PROTEIN; GALACTOSIDASE; GOLD; GOLD DNA COMPLEX; PHOSPHATE BUFFERED SALINE; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE GUN; GENETIC CODE; GENETIC TRANSFECTION; HEPATITIS; HYDRODYNAMICS; IN VIVO STUDY; LIVER CELL; LIVER NECROSIS; MALE; MATERIAL COATING; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM;

ANIMALS; BIOLISTICS; DNA; GOLD; HEPATOCYTES; LIVER; MALE; MICE; MICROSPHERES; POLYMERS; TRANSFECTION;

MURINAE;

EID: 42549115708     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2007.152     Document Type: Article

References (12)

1. AZZAM, T., and DOMB, A.J. (2004). Current developments in gene transfection agents. Curr. Drug Deliv. 1, 165-193.
2. DOBSON, J. (2006). Gene therapy progress and prospects: Magnetic nanoparticle-based gene delivery. Gene Ther. 13, 283-287.
3. JOHNSTON, S.A., and TANG, D.C. (1994). Gene gun transfection of animal cells and genetic immunization. Methods Cell Biol. 43, 353-365.
4. NISHIKAWA, M., and HUANG, L. (2001). Nonviral vectors in the new millennium: Delivery barriers in gene transfer. Hum. Gene Ther. 12, 861-870.
5. PEACHMAN, K.K., RAO, M., and ALVING, C.R. (2003). Immunization with DNA through the skin. Methods 31, 232-242.
6. ROBACZEWSKA, M., GUERRET, S., REMY, J.S., CHEMIN, I., OFFENSPERGER, W.B., CHEVALLIER, M., BEHR, J.P., PODHAJSKA, A.J., BLUM, H.E., TREPO, C., and COVA, L. (2001). Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver. Gene Ther. 8, 874-881.
7. WELLS, D.J. (2004). Gene therapy progress and prospects: electroporation and other physical methods. Gene Ther. 11, 1363-1366.
8. WOLFF, J.A., and BUDKER, V. (2005). The mechanism of naked DNA uptake and expression. Adv. Genet. 54, 3-20.
9. YANG, P.L., ALTHAGE, A., CHUNG, J., and CHISARI, F.V. (2002). Hydrodynamic injection of viral DNA: A mouse model of acute hepatitis B virus infection. Proc. Natl. Acad. Sci. U.S.A. 99, 13825-13830.
10. ZHANG, G., BUDKER, V., and WOLFF, J.A. (1999). High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum. Gene Ther. 10, 1735-1737.
11. ZHANG, G., GAO, X., SONG, Y.K., VOLLMER, R., STOLZ, D.B., GASIOROWSKI, J.Z., DEAN, D.A., and LIU, D. (2004). Hydroporation as the mechanism of hydrodynamic delivery. Gene Ther. 11, 675-682.
12. ZOU, S.M., ERBACHER, P., REMY, J.S., and BEHR, J.P. (2000). Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse. J. Gene Med. 2, 128-134.