Fracture vascularity and bone healing: A systematic review of the role of VEGF

Injury

Volumn 39, Issue SUPPL.2, 2008, Pages

  Keramaris, N C ^a   Calori, G M ^b   Nikolaou, V S ^a   Schemitsch, E H ^c   Giannoudis, P V ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF MILAN   (Italy)

^c ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Angiogenesis; Bone; Fracture; Healing; VEGF

Indexed keywords

ADENOVIRUS VECTOR; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; PLASMID DNA; VASCULOTROPIN; VASCULOTROPIN 165; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE DEFECT; BONE DEVELOPMENT; BONE MINERALIZATION; CELL DIFFERENTIATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG POTENTIATION; FRACTURE HEALING; GENE THERAPY; GENE TRANSFER; HUMAN; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; SYSTEMATIC REVIEW;

ANIMALS; BONE AND BONES; FRACTURE HEALING; FRACTURES, BONE; FRACTURES, UNUNITED; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; RABBITS; RATS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 51849093548     PISSN: 00201383     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-1383(08)70015-9     Document Type: Article

References (64)

1. Dimitriou R., Tsiridis E., Carr I., et al. The role of inhibitory molecules in fracture healing. Injury 37 Suppl 1 (2006) S20-S29
2. Giannoudis P.V., Einhorn T.A., and Marsh D. Fracture healing: the diamond concept. Injury 38 Suppl 4 (2007) S3-S6
3. Tsiridis E., Upadhyay N., and Giannoudis P. Molecular aspects of fracture healing: which are the important molecules?. Injury 38 Suppl 1 (2007) S11-S25
4. Calori G.M., D'Avino M., Tagliabue L., et al. An ongoing research for evaluation of treatment with BMPs or AGFs in long bone non-union: protocol description and preliminary results. Injury 37 Suppl 3 (2006) S43-S50
5. Karamitros A.E., Kalentzos V.N., and Soucacos P.N. Electric stimulation and hyperbaric oxygen therapy in the treatment of nonunions. Injury 37 Suppl 1 (2006) S63-S73
6. Ronga M., Baldo F., Zappala G., et al. Recombinant human bone morphogenetic protein-7 for treatment of long bone non-union: an observational, retrospective, non-randomized study of 105 patients. Injury 37 Suppl 3 (2006) S51-S56
7. Soucacos P.N., Dailiana Z., and Beris A.E. Vascularised bone grafts for the management of non-union. Injury 37 Suppl 1 (2006) S41-S50
8. Tzioupis C., and Giannoudis P.V. Prevalence of long-bone non-unions. Injury 38 Suppl 2 (2007) S3-S9
9. Axelrad T.W., Kakar S., and Einhorn T.A. New technologies for the enhancement of skeletal repair. Injury 38 Suppl 1 (2007) S49-S62
10. Carano R.A., and Filvaroff E.H. Angiogenesis and bone repair. Drug Discov Today 8 (2003) 980-989
11. Bielby R., Jones E., and McGonagle D. The role of mesenchymal stem cells in maintenance and repair of bone. Injury 38 Suppl 1 (2007) S26-S32
12. Gerstenfeld L.C., Cullinane D.M., Barnes G.L., et al. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88 (2003) 873-884
13. Senger D.R., Galli S.J., Dvorak A.M., et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219 (1983) 983-985
14. Ferrara N., and Henzel W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161 (1989) 851-858
15. Augustin G., Antabak A., and Davila S. The periosteum. Part 1: anatomy, histology and molecular biology. Injury 38 (2007) 1115-1130
16. Ferrara N., and Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 18 (1997) 4-25
17. Giannoudis P., Psarakis S., and Kontakis G. Can we accelerate fracture healing? A critical analysis of the literature. Injury 38 Suppl 1 (2007) S81-S89
18. Giannoudis P.V., Tzioupis C.C., and Tsiridis E. Gene therapy in orthopaedics. Injury 37 Suppl 1 (2006) S30-S40
19. Gerber H.P., Vu T.H., Ryan A.M., et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5 (1999) 623-628
20. Schmidmaier G., Schwabe P., Wildemann B., et al. Use of bone morphogenetic proteins for treatment of non-unions and future perspectives. Injury 38 Suppl 4 (2007) S35-S41
21. Tsiridis E., and Giannoudis P.V. Transcriptomics and proteomics: advancing the understanding of genetic basis of fracture healing. Injury 37 Suppl 1 (2006) S13-S19
22. Wang Y.Q., Luk J.M., Chu A.C., et al. TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells. Biochem Biophys Res Commun 341 (2006) 239-244
23. Clarke S.A., Hoskins N.L., Jordan G.R., et al. Healing of an ulnar defect using a proprietary TCP bone graft substitute, JAX, in association with autologous osteogenic cells and growth factors. Bone 40 (2007) 939-947
24. Eckardt H., Bundgaard K.G., Christensen K.S., et al. Effects of locally applied vascular endothelial growth factor (VEGF) and VEGF-inhibitor to the rabbit tibia during distraction osteogenesis. J Orthop Res 21 (2003) 335-340
25. Eckardt H., Ding M., Lind M., et al. Recombinant human vascular endothelial growth factor enhances bone healing in an experimental nonunion model. J Bone Joint Surg Br 87 (2005) 1434-1438
26. Fang T.D., Salim A., Xia W., et al. Angiogenesis is required for successful bone induction during distraction osteogenesis. J Bone Miner Res 20 (2005) 1114-1124
27. Geiger F., Bertram H., Berger I., et al. Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res 20 (2005) 2028-2035
28. Geiger F., Lorenz H., Xu W., et al. VEGF producing bone marrow stromal cells (BMSC) enhance vascularization and resorption of a natural coral bone substitute. Bone 41 (2007) 516-522
29. Hausman M.R., Schaffler M.B., and Majeska R.J. Prevention of fracture healing in rats by an inhibitor of angiogenesis. Bone 29 (2001) 560-564
30. Hiltunen M.O., Ruuskanen M., Huuskonen J., et al. Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo. FASEB J 17 (2003) 1147-1149
31. Huang Y.C., Kaigler D., Rice K.G., et al. Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration. J Bone Miner Res 20 (2005) 848-857
32. Kaigler D., Wang Z., Horger K., et al. VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects. J Bone Miner Res 21 (2006) 735-744
33. Katsube K., Bishop A.T., Simari R.D., et al. Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone. J Orthop Res 23 (2005) 469-474
34. Kleinheinz J., Stratmann U., Joos U., et al. VEGFactivated angiogenesis during bone regeneration. J Oral Maxillofac Surg 63 (2005) 1310-1316
35. Leach J.K., Kaigler D., Wang Z., et al. Coating of VEGFreleasing scaffolds with bioactive glass for angiogenesis and bone regeneration. Biomaterials 27 (2006) 249-255
36. Maes C., Carmeliet P., Moermans K., et al. Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Mech Dev 111 (2002) 61-73
37. Mori S., Yoshikawa H., Hashimoto J., et al. Antiangiogenic agent (TNP-470) inhibition of ectopic bone formation induced by bone morphogenetic protein-2. Bone 22 (1998) 99-105
38. Murphy W.L., Simmons C.A., Kaigler D., et al. Bone regeneration via a mineral substrate and induced angiogenesis. J Dent Res 83 (2004) 204-210
39. Peng H., Usas A., Olshanski A., et al. VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis. J Bone Miner Res 20 (2005) 2017-2027
40. Peng H., Wright V., Usas A., et al. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest 110 (2002) 751-759
41. Sipola A., Ilvesaro J., Birr E., et al. Endostatin inhibits endochondral ossification. J Gene Med 9 (2007) 1057-1064
42. Street J., Bao M., deGuzman L., et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci USA 99 (2002) 9656-9661
43. Suzuki O., Bishop A.T., Sunagawa T., et al. VEGF-promoted surgical angiogenesis in necrotic bone. Microsurgery 24 (2004) 85-91
44. Tarkka T., Sipola A., Jamsa T., et al. Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues. J Gene Med 5 (2003) 560-566
45. Yang C., Yang S., Du J., et al. Vascular endothelial growth factor gene transfection to enhance the repair of avascular necrosis of the femoral head of rabbit. Chin Med J (Engl) 116 (2003) 1544-1548
46. Zelzer E., McLean W., Ng Y.S., et al. Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development 129 (2002) 1893-1904
47. Zhao D.M., Wang H.B., Yang J.F., et al. Effect of vascular endothelial growth factor 165 gene transfection on bone defects and its mRNA expression in rabbits. Chin Med J (Engl) 120 (2007) 1187-1191
48. Kontakis G.M., Tossounidis T., Weiss K., et al. Fat embolism: special situations bilateral femoral fractures and pathologic femoral fractures. Injury 37 Suppl 4 (2006) S19-S24
49. Jackson W.F., Theologis T.N., Gibbons C.L., et al. Early management of pathological fractures in children. Injury 38 (2007) 194-200
50. Papagelopoulos P.J., Mavrogenis A.F., and Soucacos P.N. Evaluation and treatment of pelvic metastases. Injury 38 (2007) 509-520
51. Carson J.S., and Bostrom M.P. Synthetic bone scaffolds and fracture repair. Injury 38 Suppl 1 (2007) S33-S37
52. Calori G.M., Albisetti W., Agus A., et al. Risk factors contributing to fracture non-unions. Injury 38 Suppl 2 (2007) S11-S18
53. Giannoudis P.V., and Atkins R. Management of long-bone non-unions. Injury 38 Suppl 2 (2007) S1-S2
54. Levin L.S. Early versus delayed closure of open fractures. Injury 38 (2007) 896-899
55. Pountos I., Corscadden D., Emery P., and Giannoudis P.V. Mesenchymal stem cell tissue engineering: techniques for isolation, expansion and application. Injury 38 Suppl 4 (2007) S23-S33
56. Vaibhav B., Nilesh P., Vikram S., et al. Bone morphogenic protein and its application in trauma cases: a current concept update. Injury 38 (2007) 1227-1235
57. Stylios G., Wan T., and Giannoudis P. Present status and future potential of enhancing bone healing using nanotechnology. Injury 38 Suppl 1 (2007) S63-S74
58. DiSilvio L., Jameson J., Gamie Z., et al. In vitro evaluation of the direct effect of estradiol on human osteoblasts (HOB) and human mesenchymal stem cells (h-MSCs). Injury 37 Suppl 3 (2006) S33-S42
59. Giannoudis P., Tzioupis C., Almalki T., et al. Fracture healing in osteoporotic fractures: is it really different? A basic science perspective. Injury 38 Suppl 1 (2007) S90-S99
60. Christodoulakos G., Lambrinoudaki I., Panoulis C., et al. Effect of hormone therapy, tibolone and raloxifene on circulating vascular endothelial growth factor in Greek postmenopausal women. Eur J Endocrinol 151 (2004) 187-192
61. Pufe T., Claassen H., Scholz-Ahrens K.E., et al. Influence of estradiol on vascular endothelial growth factor expression in bone: a study in Gottingen miniature pigs and human osteoblasts. Calcif Tissue Int 80 (2007) 184-191
62. Moonen A.F., Neal T.D., and Pilot P. Peri-operative blood management in elective orthopaedic surgery. A critical review of the literature. Injury 37 Suppl 5 (2006) S11-S16
63. Jaquet K., Krause K., Tawakol-Khodai M., et al. Erythropoietin and VEGF exhibit equal angiogenic potential. Microvasc Res 64 (2002) 326-333
64. Holstein J.H., Menger M.D., Scheuer C., et al. Erythropoietin (EPO): EPO-receptor signaling improves early endochondral ossification and mechanical strength in fracture healing. Life Sci 80 (2007) 893-900