Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides

Advanced Drug Delivery Reviews

Volumn 57, Issue 4 SPEC.ISS., 2005, Pages 637-651

  Gupta, Bhawna ^a   Levchenko, Tatiana S ^a   Torchilin, Vladimir P ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Cell penetrating peptides; Fusion proteins; Gene delivery; Imaging agents; Intracellular delivery; Liposomes; Particles; Toxins

Indexed keywords

ANTIBODIES; CELL MEMBRANES; CONTROLLED DRUG DELIVERY; DNA; GENE TRANSFER; IMMUNOLOGY; MEDICAL IMAGING; POLYPEPTIDES; TUMORS; VACCINES;

CELL-PENETRATING PEPTIDES (CPP); CELLULAR IMAGING; CELLULAR MEMBRANES; IMMUNOTHERAPY;

PROTEINS;

ANTENNAPEDIA PROTEIN; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; APOPTOSIS REPRESSOR WITH CASPASE RECRUITMENT DOMAIN; DENDRITIC CELL VACCINE; DIPHTHERIA TOXIN; GLYCYLLEUCYLPHENYLALANYLGLUTAMYLALANYLLEUCYLLEUCYLGLUTAMYLLEUCYLLEUCYL GLUTAMYLSERYLLEUCYLTRYPTOPHYLGLUTAMYLLEUCYLLEUCYLLEUCYLGLUTAMYLALANINE; HEPATITIS B ANTIGEN; HERPES SIMPLEX VACCINE; HYBRID PROTEIN; LIPOSOME; LYSYLLEUCYLLEUCYLLYSYLLEUCYLLEUCYLLEUCYLLYSYLLEUCYLTRYPTOPHYLLEUCYLLYSYL LEUCYLLEUCYLLYSYLLEUCYLLEUCYLLEUCINE; NANOPARTICLE; NEUROPROTECTIVE AGENT; PEPTIDE; POLYPEPTIDE; PROLYLTHREONYLASPARTIC ACID 4; PROLYLTHREONYLASPARTIC ACID 5; PROTEIN; PROTEIN BCL XL; PROTEIN VP22; RADIOPHARMACEUTICAL AGENT; SIGNAL PEPTIDE; THREONYLALANYLTHREONYLPROLYLTHREONYLASPARTYLPHENYLALANYLASPARAGINYLLYSINE; THYMIDINE KINASE; TRANSACTIVATOR PROTEIN; TRYPTOPHYLGLUTAMYLALANYLLYSYLLEUCYLALANYLLYSYLALANYLLEUCYLALANYLLYSYL ALANYLLEUCYLALANYLLYSYLHISTIDYLLEUCYLALANYLLYSYLALANYLLEUCYLALANYLLYSYLALANYL LEUCYLLYSYLALANYLCYSTEINYLGLUTAMYLALANINE; UNCLASSIFIED DRUG; VACCINE; VIRUS PROTEIN;

ALPHA HELIX; ANTIGEN PRESENTING CELL; ARTHRITIS; BRAIN CELL; CANCER IMMUNOTHERAPY; CARCINOMA; CELL MEMBRANE PERMEABILITY; CELLULAR IMMUNITY; CYTOLOGY; DENDRITIC CELL; DNA PROTEIN COMPLEX; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; ENDOCYTOSIS; EXPERIMENTAL MOUSE; EXTRACELLULAR MATRIX; GENE TARGETING; GERBIL; IMAGING; IMMUNOMODULATION; INTRACELLULAR TRANSPORT; LIPOPHILICITY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE HOMING; MACROMOLECULE; MAMMAL CELL; MOLECULAR WEIGHT; MUSCLE CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN TARGETING; PROTEIN TRANSPORT; REVIEW; SKELETAL MUSCLE; SPLEEN CELL; SUICIDE GENE THERAPY; T LYMPHOCYTE ACTIVATION; TEMPERATURE DEPENDENCE; TRANSCYTOSIS; TUMOR SUPPRESSOR GENE; VACCINATION;

EID: 13844298046     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2004.10.007     Document Type: Review

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