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Volumn 67, Issue 4, 2011, Pages 867-874

Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin

Author keywords

Anti tumour agents; Apoptosis; Conjugates; Doxorubicin; Multi drug resistance; Thymoquinone

Indexed keywords

CASPASE 3; DOXORUBICIN; REACTIVE OXYGEN METABOLITE; THYMOQUINONE;

EID: 79954440155     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-010-1386-x     Document Type: Article
Times cited : (127)

References (31)
  • 1
    • 67650675111 scopus 로고    scopus 로고
    • Impact of natural products on developing new anti-cancer agents
    • 19422222 10.1021/cr900019j 1:CAS:528:DC%2BD1MXlsFCns7Y%3D
    • GM Cragg PG Grothaus DJ Newman 2009 Impact of natural products on developing new anti-cancer agents Chem Rev 109 3012 3043 19422222 10.1021/cr900019j 1:CAS:528:DC%2BD1MXlsFCns7Y%3D
    • (2009) Chem Rev , vol.109 , pp. 3012-3043
    • Cragg, G.M.1    Grothaus, P.G.2    Newman, D.J.3
  • 2
    • 38949179532 scopus 로고    scopus 로고
    • Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: From synthetic organic chemistry to compounds with anticancer potential
    • DOI 10.1039/b715270a
    • MA Colucci CJ Moody GD Couch 2008 Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential Org Biomol Chem 6 637 656 18264564 10.1039/b715270a 1:CAS:528:DC%2BD1cXhs1yksb4%3D (Pubitemid 351972602)
    • (2008) Organic and Biomolecular Chemistry , vol.6 , Issue.4 , pp. 637-656
    • Colucci, M.A.1    Couch, G.D.2    Moody, C.J.3
  • 4
    • 0001984256 scopus 로고    scopus 로고
    • Anthracyclines
    • L.B. Grochow M.M. Ames (eds). pharmacokinetic and pharmacodynamics Williams & Wilkins, Baltimore
    • Robert J (1998) Anthracyclines. In: Grochow LB, Ames MM (eds) A clinician′s guide to chemotherapy. pharmacokinetic and pharmacodynamics, Williams & Wilkins, Baltimore, pp 93-173
    • (1998) A Clinician′s Guide to Chemotherapy , pp. 93-173
    • Robert, J.1
  • 5
    • 0035237915 scopus 로고    scopus 로고
    • Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis
    • 11531013 1:CAS:528:DC%2BD3MXmvV2ksrY%3D
    • OA Badary AM Gamal El-Din 2001 Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis Cancer Detect Prev 25 362 368 11531013 1:CAS:528:DC%2BD3MXmvV2ksrY%3D
    • (2001) Cancer Detect Prev , vol.25 , pp. 362-368
    • Badary, O.A.1    Gamal El-Din, A.M.2
  • 6
    • 33646202807 scopus 로고    scopus 로고
    • Thymoquinone: A promising anti-cancer drug from natural sources
    • 16314136 10.1016/j.biocel.2005.10.009 1:CAS:528:DC%2BD28XksVGgsro%3D
    • H Gali-Muhtasib A Roessner R Schneider-Stock 2006 Thymoquinone: A promising anti-cancer drug from natural sources Int J Biochem Cell Biol 38 1249 1253 16314136 10.1016/j.biocel.2005.10.009 1:CAS:528:DC%2BD28XksVGgsro%3D
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 1249-1253
    • Gali-Muhtasib, H.1    Roessner, A.2    Schneider-Stock, R.3
  • 8
    • 13244285843 scopus 로고    scopus 로고
    • Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via p53-dependent mechanism
    • 15375533 1:CAS:528:DC%2BD2cXovFWlurY%3D
    • H Gali-Muhtasib M Diab-Assaf C Boltze J Al-Hmaira R Hartig A Roessner R Schneider-Stock 2004 Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via p53-dependent mechanism Int J Oncol 25 857 866 15375533 1:CAS:528:DC%2BD2cXovFWlurY%3D
    • (2004) Int J Oncol , vol.25 , pp. 857-866
    • Gali-Muhtasib, H.1    Diab-Assaf, M.2    Boltze, C.3    Al-Hmaira, J.4    Hartig, R.5    Roessner, A.6    Schneider-Stock, R.7
  • 9
    • 26444457920 scopus 로고    scopus 로고
    • Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
    • DOI 10.1002/ijc.21205
    • MA El-Mahdy Q Zhu QE Wang G Wani AA Wani 2005 Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells Int J Cancer 117 409 417 15906362 10.1002/ijc.21205 1:CAS:528:DC%2BD2MXhtFant7rF (Pubitemid 41429564)
    • (2005) International Journal of Cancer , vol.117 , Issue.3 , pp. 409-417
    • El-Mahdy, M.A.1    Zhu, Q.2    Wang, Q.-E.3    Wani, G.4    Wani, A.A.5
  • 10
    • 67651083705 scopus 로고    scopus 로고
    • Effects of thymoquinone-fatty acid conjugates on cancer cells
    • 19322799 1:CAS:528:DC%2BD1MXls1Kgt7o%3D
    • S Breyer K Effenberger R Schobert 2009 Effects of thymoquinone-fatty acid conjugates on cancer cells Chem Med Chem 4 761 768 19322799 1:CAS:528:DC%2BD1MXls1Kgt7o%3D
    • (2009) Chem Med Chem , vol.4 , pp. 761-768
    • Breyer, S.1    Effenberger, K.2    Schobert, R.3
  • 11
    • 75449101581 scopus 로고    scopus 로고
    • Terpene conjugates of the nigella sativa seed oil constituent thymoquinone with enhanced efficacy in cancer cells
    • 10.1002/cbdv.200900328 1:CAS:528:DC%2BC3cXhtVKgsrw%3D
    • K Effenberger S Breyer R Schobert 2010 Terpene conjugates of the nigella sativa seed oil constituent thymoquinone with enhanced efficacy in cancer cells Chem Biodiv 7 129 139 10.1002/cbdv.200900328 1:CAS:528:DC%2BC3cXhtVKgsrw%3D
    • (2010) Chem Biodiv , vol.7 , pp. 129-139
    • Effenberger, K.1    Breyer, S.2    Schobert, R.3
  • 12
    • 77949485534 scopus 로고    scopus 로고
    • Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones
    • 20133021 10.1016/j.ejmech.2010.01.037 1:CAS:528:DC%2BC3cXjs12qsbk%3D
    • K Effenberger S Breyer R Schobert 2010 Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones Eur J Med Chem 45 1947 1954 20133021 10.1016/j.ejmech.2010.01.037 1:CAS:528: DC%2BC3cXjs12qsbk%3D
    • (2010) Eur J Med Chem , vol.45 , pp. 1947-1954
    • Effenberger, K.1    Breyer, S.2    Schobert, R.3
  • 14
    • 0033836675 scopus 로고    scopus 로고
    • Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: A possible mechanism of protection
    • DOI 10.1006/phrs.1999.0585
    • MN Nagi MA Mansour 2000 Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection Pharmacol Res 41 283 289 10675279 10.1006/phrs.1999.0585 1:CAS:528: DC%2BD3cXhtFWjs78%3D (Pubitemid 30663132)
    • (2000) Pharmacological Research , vol.41 , Issue.3 , pp. 283-289
    • Nagi, M.N.1    Mansour, M.A.2
  • 16
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • T Mosmann 1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Meth 65 55 63 10.1016/0022-1759(83)90303-4 1:STN:280:DyaL2c%2FovFSmtw%3D%3D (Pubitemid 14203433)
    • (1983) Journal of Immunological Methods , vol.65 , Issue.1-2 , pp. 55-63
    • Mosmann, T.1
  • 17
    • 0032885388 scopus 로고    scopus 로고
    • Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
    • DOI 10.1146/annurev.biochem.68.1.383
    • WC Earnshaw LM Martins SC Kaufmann 1999 Mammalian caspases: structure, activation, substrates, and functions during apoptosis Annu Rev Biochem 68 383 424 10872455 10.1146/annurev.biochem.68.1.383 1:CAS:528:DyaK1MXlvFajsb0%3D (Pubitemid 29449198)
    • (1999) Annual Review of Biochemistry , vol.68 , pp. 383-424
    • Earnshaw, W.C.1    Martins, L.M.2    Kaufmann, S.H.3
  • 18
    • 2942700135 scopus 로고    scopus 로고
    • Utility of the housekeeping genes 18S rRNA, β-actin and glyceraldehyde-3-phosphate-dehydrogenase for normalization in real-time quantitative reverse transcriptase-polymerase chain reaction analysis of gene expression in human T lymphocytes
    • DOI 10.1111/j.0300-9475.2004.01440.x
    • A Bas G Forsberg S Hammarström ML Hammarström 2004 Utility of the housekeeping genes 18S rRNA, beta-actin and glyceraldehyde-3-phosphate- dehydrogenase for normalization in real-time quantitative reverse transcriptase-polymerase chain reaction analysis of gene expression in human T-lymphocytes Scand J Immunol 59 560 573 10.1111/j.0300-9475.2004.01440.x (Pubitemid 38789226)
    • (2004) Scandinavian Journal of Immunology , vol.59 , Issue.6 , pp. 566-573
    • Bas, A.1    Forsberg, G.2    Hammarstrom, S.3    Hammarstrom, M.-L.4
  • 20
    • 0022359899 scopus 로고
    • A simple method for the solubilisation of reduced NBT, and its use as a colorimetric assay for activation of human macrophages by γ-interferon
    • DOI 10.1016/0022-1759(85)90235-2
    • GAW Rook J Steele S Umar HM Dockrell 1985 A simple method for the solubilisation of reduced NBT, and its use as a colorimetric assay for the activation of human macrophages by gamma interferon J Immunol Methods 82 161 167 3928762 10.1016/0022-1759(85)90235-2 1:CAS:528:DyaL2MXltl2rtLk%3D (Pubitemid 16247531)
    • (1985) Journal of Immunological Methods , vol.82 , Issue.1 , pp. 161-167
    • Rook, G.A.W.1    Steele, J.2    Umar, S.3    Dockrell, H.M.4
  • 21
    • 0019882480 scopus 로고
    • Generalized equations for the analysis of inhibitors of Michaelis-Menten and higher order kinetic systems with two or more mutually exclusive and non-exclusive inhibitors
    • 7227366 10.1111/j.1432-1033.1981.tb06218.x 1:CAS:528:DyaL3MXhtlCqsbk%3D
    • TC Chou P Talalay 1981 Generalized equations for the analysis of inhibitors of Michaelis-Menten and higher order kinetic systems with two or more mutually exclusive and non-exclusive inhibitors Eur J Biochem 115 207 216 7227366 10.1111/j.1432-1033.1981.tb06218.x 1:CAS:528:DyaL3MXhtlCqsbk%3D
    • (1981) Eur J Biochem , vol.115 , pp. 207-216
    • Chou, T.C.1    Talalay, P.2
  • 22
    • 0021118703 scopus 로고
    • Quantitative analysis of dose effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • 10.1016/0065-2571(84)90007-4 1:CAS:528:DyaL2cXktlaksLk%3D
    • TC Chou P Talalay 1984 Quantitative analysis of dose effect relationships: the combined effects of multiple drugs or enzyme inhibitors Adv Enzymol Regul 22 27 55 10.1016/0065-2571(84)90007-4 1:CAS:528:DyaL2cXktlaksLk%3D
    • (1984) Adv Enzymol Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 24
    • 12844275026 scopus 로고    scopus 로고
    • Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide
    • DOI 10.1016/j.lfs.2004.05.040, PII S0024320504009877
    • H Mizutani S Tada-Oikawa Y Hiraku M Kojima S Kawanishi 2005 Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide Life Sci 76 1439 1453 15680309 10.1016/j.lfs.2004.05.040 1:CAS:528: DC%2BD2MXntVSlsQ%3D%3D (Pubitemid 40164773)
    • (2005) Life Sciences , vol.76 , Issue.13 , pp. 1439-1453
    • Mizutani, H.1    Tada-Oikawa, S.2    Hiraku, Y.3    Kojima, M.4    Kawanishi, S.5
  • 25
    • 0033006172 scopus 로고    scopus 로고
    • A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
    • DOI 10.1016/S0006-2952(98)00307-4, PII S0006295298003074
    • DA Gewirtz 1999 A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin Biochem Pharmacol 55 727 741 10.1016/S0006-2952(98)00307-4 (Pubitemid 29094544)
    • (1999) Biochemical Pharmacology , vol.57 , Issue.7 , pp. 727-741
    • Gewirtz, D.A.1
  • 26
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: Molecular advances and pharmacologie developments in antitumor activity and cardiotoxicity
    • DOI 10.1124/pr.56.2.6
    • G Minotti P Menna E Salvatorelli G Cairo L Gianni 2004 Anthracyclines: molecular advances and pharmacologic developments in anti-tumour activity and cardiotoxicity Pharmacol Rev 56 185 229 15169927 10.1124/pr.56.2.6 1:CAS:528:DC%2BD2cXltlKgtb0%3D (Pubitemid 38720829)
    • (2004) Pharmacological Reviews , vol.56 , Issue.2 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorelli, E.3    Cairo, G.4    Gianni, L.5
  • 27
    • 77949263613 scopus 로고    scopus 로고
    • Reactive oxygen species mediated thymoquinone-induced apoptosis and activate ERK and JNK signalling
    • 19882352 10.1007/s10495-009-0421-z 1:CAS:528:DC%2BC3cXhtlSjsrg%3D
    • N El-Najjar M Chatila H Moukadem H Vuorela M Ocker M Gandesiri R Schneider-Stock H Gala-Muhtasib 2010 Reactive oxygen species mediated thymoquinone-induced apoptosis and activate ERK and JNK signalling Apoptosis 15 183 195 19882352 10.1007/s10495-009-0421-z 1:CAS:528:DC%2BC3cXhtlSjsrg%3D
    • (2010) Apoptosis , vol.15 , pp. 183-195
    • El-Najjar, N.1    Chatila, M.2    Moukadem, H.3    Vuorela, H.4    Ocker, M.5    Gandesiri, M.6    Schneider-Stock, R.7    Gala-Muhtasib, H.8
  • 28
  • 29
    • 11144220793 scopus 로고    scopus 로고
    • Relative Bcl-2 independence of drug-induced cytotoxicity and resistance in 518A2 melanoma cells
    • DOI 10.1158/1078-0432.CCR-04-1294
    • L Benimetskaya JC Lai A Khvorova S Wu E Hua P Miller LM Zhang CA Stein 2004 Relative bcl-2 independence of drug-induced cytotoxicity and resistance in 518A2 melanoma cells Clin Cancer Res 10 8371 8379 15623615 10.1158/1078-0432. CCR-04-1294 1:CAS:528:DC%2BD2cXhtFGjs7zN (Pubitemid 40053399)
    • (2004) Clinical Cancer Research , vol.10 , Issue.24 , pp. 8371-8379
    • Benimetskaya, L.1    Lai, J.C.2    Khvorova, A.3    Wu, S.4    Hua, E.5    Miller, P.6    Zhang, L.-M.7    Stein, C.A.8
  • 31
    • 0032472329 scopus 로고    scopus 로고
    • Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
    • DOI 10.1093/emboj/17.1.37
    • E Bossy-Wetzel DD Newmeyer DR Green 1998 Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independent of mitochondrial transmembrane depolarization EMBO J 17 37 49 9427739 10.1093/emboj/17.1.37 1:CAS:528:DyaK1cXnvVyjsg%3D%3D (Pubitemid 28041046)
    • (1998) EMBO Journal , vol.17 , Issue.1 , pp. 37-49
    • Bossy-Wetzel, E.1    Newmeyer, D.D.2    Green, D.R.3


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