Thymoquinone inhibits the activation of NF-κB in the brain and spinal cord of experimental autoimmune encephalomyelitis

Biomedical Sciences Instrumentation

Volumn 41, Issue , 2005, Pages 388-393

  Mohamed, A ^a   Afridi, D M ^a   Garani, O ^a   Tucci, M ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Experimental autoimmune encephalomyelitis; Glutathione; Multiple sclerosis; Nuclear factor kappa b; Oxidative stress; Perivascular mononuclear cell infiltration; Thymoquinone

Indexed keywords

BIOLOGICAL ORGANS; BLOOD; BRAIN; CELLS; EMULSIONS; PHYSIOLOGICAL MODELS; PROTEINS; BIOMEDICAL ENGINEERING; PATIENT TREATMENT;

RED BLOOD CELLS; SCLEROSIS; SPINAL CORD; THYMOQUINONE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MULTIPLE SCLEROSIS; PERIVASCULAR MONONUCLEAR CELL INFILTRATION;

AROMATIC COMPOUNDS; PROTEINS;

ANTIGEN; FREUND ADJUVANT; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELIN BASIC PROTEIN; THYMOQUINONE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLOOD LEVEL; BLOOD SAMPLING; BRAIN; CELL INFILTRATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EMULSION; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; ERYTHROCYTE LEVEL; EXPERIMENTAL MODEL; FEMALE; MONONUCLEAR CELL; NONHUMAN; PHARMACOLOGICAL BLOCKING; RAT; SPINAL CORD;

ANIMALS; BENZOQUINONES; BRAIN; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; NF-KAPPA B; RATS; RATS, INBRED LEW; SPINAL CORD; TRANS-ACTIVATION (GENETICS); TREATMENT OUTCOME;

EID: 17044423457     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (12)

1. Badary OA, Taha RA, Gamel El-Din AM, Abdel-Wahab MH. 2003 Thymoquinone is a potent superoxide anion scavenger. Drug and Chem Toxicol 26(2):87-98.
2. Badary OA, Al-Shabanah OA, Nagi MN, Al-Bekairi AM, Almazar MMA. 1998 Acute and subchronic toxicity of thynoquinone in mice. Drug Develop Res 44:56-61.
3. Badary OA, Al-Shabanah OA, Nagi MN, Al-Bekairi AM, Almazar MMA. 1999 Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone, Eur J Cancer Prev 8:435-440.
4. Badary OA, Gamal AM. 2001 Inhibitory effects of thymoquinone against 20-methylchlorantherene-induced fibrosarcoma tumorigenesis. Cancer Detec Prev 25:362-368.
5. Al-Gharably NM, Badary OA, Nagi M. 1997 Protective effects of thymoquinone against carbon tetrachloride-induced hepatotoxicity in mice. Res Comm Pharmacol Toxicol 2:41-50.
6. Al-Shabanah OA, Badary OA, Nagi MN, Al-Gharably NM, Al-Rikabi AC, Al-Bikairi AM. 1998 Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity. J Exp Clin Cancer Res 17:193-198.
7. Badary OA, Nagi MN, Al-Shabanah OA, Al-Sawaf HA, AL-Rikabi AC, Al-Bikairi AM. 1997 Protective effect of thymoquinone against carbon tetrachloride- toxicity in mice. Res Commun Pharmacol Toxicol 2:41-50.
8. Mutabagani A, El-Mahdi SM. 1997 A study of the anti-inflammatory activity of Nigella sativa L and thymoquinone in rats. Saudi Pharmacol J 5:110-113.
9. Akhtar AH, Ahmad KD, Gilani SN, Nazir A. 1996 Antiulcer effects of aqueous extracts of Nigella sativa and Pongamia pinnata in rats. Fitoterapia 38:163-168.
10. Al-Hader A, Aqel M, Hasan Z. 1993 Hypoglycemic effects of the volatile oil of Nigella sativa seeds. Int J Pharmacol 31-96-100.
11. El-Tahir KE, Ashour MM, Al-Harbi MM. 1993 The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 24:1123-1131.
12. Penders MP, Sears TA. 1986. Involvement of the dorsal root ganglion in acute experimental allergic encephalomyelitis in the Lewis rat. A histological and electrophysiological study. J Neurol Sci 72(2-3):231-42.