Arthritis in space and time - To boldly go!

FEBS Letters

Volumn 585, Issue 23, 2011, Pages 3640-3648

  Benson, R A ^a   Patakas, A ^a   McQueenie, R ^a   Ross, K ^a   McInnes, I B ^a   Brewer, J M ^a   Garside, P ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Animal model; Arthritis; Imaging; Spatiotemporal; Therapeutic; Tolerance

Indexed keywords

ABATACEPT; CD28 ANTIGEN; CD40 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GRANZYME B; HLA DR ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2 RECEPTOR; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; ORAL CONTRACEPTIVE AGENT; OSTEOCLAST DIFFERENTIATION FACTOR; RITUXIMAB; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ALCOHOL CONSUMPTION; AUTOIMMUNITY; B LYMPHOCYTE; BIRTH WEIGHT; BREAST FEEDING; CD28 GENE; CD40 GENE; CELL INTERACTION; CIGARETTE SMOKING; CTLA4 GENE; DENDRITIC CELL; DISEASE COURSE; DISEASE MODEL; DRUG RESEARCH; DRUG TARGETING; ENVIRONMENTAL FACTOR; FIBROBLAST; GENE; GENETIC ASSOCIATION; GEOGRAPHY; HUMAN; IMMUNOLOGICAL TOLERANCE; INNATE IMMUNITY; INTESTINE FLORA; MACROPHAGE; MONOCYTE; NONHUMAN; OSTEOCLAST; PATHOGENESIS; PERSONALIZED MEDICINE; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PTPN22 GENE; REMISSION; REVIEW; RHEUMATOID ARTHRITIS; SOCIAL STATUS; T LYMPHOCYTE;

ANIMALS; ARTHRITIS; AUTOIMMUNITY; HUMANS; IMMUNE TOLERANCE; JOINTS; MODELS, BIOLOGICAL; TIME FACTORS;

ANIMALIA;

EID: 81755172037     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.04.069     Document Type: Review

References (162)

1. G.S. Firestein Evolving concepts of rheumatoid arthritis Nature 423 2003 356 361 (Pubitemid 40852711)
2. J.L. Jorizzo, and J.C. Daniels Dermatologic conditions reported in patients with rheumatoid arthritis J. Am. Acad. Dermatol. 8 1983 439 457
3. F. Wolfe, and K. Michaud Heart failure in rheumatoid arthritis: rates, predictors, and the effect of anti-tumor necrosis factor therapy Am. J. Med. 116 2004 305 311 (Pubitemid 38230289)
4. D.M. Geddes, M. Webley, and P.A. Emerson Airways obstruction in rheumatoid arthritis Ann. Rheum. Dis. 38 1979 222 225 (Pubitemid 9236368)
5. G.J. Herbison, J.F. Ditunno, and M.M. Jaweed Muscle atrophy in rheumatoid arthritis J. Rheumatol. Suppl. 14 Suppl. 15 1987 78 81 (Pubitemid 17128388)
6. H.E. Seymour, A. Worsley, J.M. Smith, and S.H. Thomas Anti-TNF agents for rheumatoid arthritis Br. J. Clin. Pharmacol. 51 2001 201 208 (Pubitemid 32391495)
7. D. Symmons The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century Rheumatology (Oxford) 41 2002 793 800 (Pubitemid 34822963)
8. K. Michaud, and F. Wolfe Comorbidities in rheumatoid arthritis Best Pract. Res. Clin. Rheumatol. 21 2007 885 906 (Pubitemid 47377810)
9. A.J. Hueber Mast cells express IL-17A in rheumatoid arthritis synovium J. Immunol. 184 2010 3336 3340
10. H.P. Lemos Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production Proc. Natl. Acad. Sci. USA 106 2009 5954 5959
11. I.B. McInnes The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis Nat. Med. 2 1996 175 182
12. I.B. McInnes, B.P. Leung, R.D. Sturrock, M. Field, and F.Y. Liew Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis Nat. Med. 3 1997 189 195 (Pubitemid 27064704)
13. M. Feldmann Development of anti-TNF therapy for rheumatoid arthritis Nat. Rev. Immunol. 2 2002 364 371 (Pubitemid 37328759)
14. F.C. Breedveld, and J.R. Kalden Appropriate and effective management of rheumatoid arthritis Ann. Rheum. Dis. 63 2004 627 633 (Pubitemid 38658389)
15. A. Barton, W. Thomson, and X. Ke Wellcome Trust Case Control Consortium; YEAR Consortium; BIRAC Consortium. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13 Nat. Genet. 40 2008 1156 1159
16. J.A. Bluestone Mechanisms of tolerance Immunol. Rev. 241 2011 5 19 10.1111/j.1600-065X.2011.01019.x
17. A.M. Gallegos, and M.J. BeVan Central tolerance: good but imperfect Immunol. Rev. 209 2006 290 296
18. K.A. Hogquist, T.A. Baldwin, and S.C. Jameson Central tolerance: learning self-control in the thymus Nat. Rev. Immunol. 5 2005 772 782 (Pubitemid 41400851)
19. A. Basten, and P.A. Silveira B-cell tolerance: mechanisms and implications Curr. Opin. Immunol. 22 2010 566 574
20. D.L. Mueller Mechanisms maintaining peripheral tolerance Nat. Immunol. 11 2010 21 27
21. N. Sakaguchi Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice Nature 426 2003 454 460 (Pubitemid 37490133)
22. L. Michou Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene Proc. Natl. Acad. Sci. 104 2007 1649 1654 (Pubitemid 46214645)
23. S.A. Chung, and L.A. Criswell PTPN22: its role in SLE and autoimmunity Autoimmunity 40 2007 582 590
24. J. Bowes, and A. Barton Recent advances in the genetics of RA susceptibility Rheumatology 47 2008 399 402
25. The Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls Nature 447 2007 661 678
26. M.E. Brunkow Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorDer of the scurfy mouse Nat. Genet. 27 2001 68 73 (Pubitemid 32044521)
27. C.L. Bennett The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 Nat. Genet. 27 2001 20 21 (Pubitemid 32044513)
28. M.M. Nielen Antibodies to citrullinated human fibrinogen (ACF) have diagnostic and prognostic value in early arthritis Ann. Rheum. Dis. 64 2005 1199 1204
29. D.S. Majka Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with olDer age at time of disease diagnosis Ann. Rheum. Dis. 67 2008 801 807 (Pubitemid 351829380)
30. S. Rantapaa-Dahlqvist Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis Arthritis Rheum. 48 2003 2741 2749 (Pubitemid 37280601)
31. D.D. Brand, K.A. Latham, and E.F. Rosloniec Collagen-induced arthritis Nat. Protoc. 2 2007 1269 1275 (Pubitemid 46901304)
32. D.D. Anthony, and T.M. Haqqi Collagen-induced arthritis in mice: an animal model to study the pathogenesis of rheumatoid arthritis Clin. Exp. Rheumatol. 17 1999 240 244 (Pubitemid 29195833)
33. R.H. Swanborg Animal models of human disease. Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease Clin. Immunol. Immunopathol. 77 1995 4 13
34. V. Kouskoff Organ-specific disease provoked by systemic autoimmunity Cell 87 1996 811 822 (Pubitemid 26404281)
35. P. Monach The K/BxN mouse model of inflammatory arthritis: theory and practice Methods Mol. Med. 136 2007 269 282
36. S. Raychaudhuri Common variants at CD40 and other loci confer risk of rheumatoid arthritis Nat. Genet. 40 2008 1216 1223
37. C. Seidl CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis Tissue Antigens 51 1998 62 66 (Pubitemid 28014545)
38. S. Raychaudhuri Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk Nat. Genet. 41 2009 1313 1318
39. S. De Vita Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: evidence for a pathogenetic role of B cells Arthritis Rheum. 46 2002 2029 2033
40. J.M. Kremer Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig N. Engl. J. Med. 349 2003 1907 1915 (Pubitemid 37409707)
41. P.K. Gregersen Genetics of rheumatoid arthritis: confronting complexity Arthritis Res. 1 1999 37 44 (Pubitemid 32223665)
42. I. Auger, C. Roudier, S. Guis, N. Balandraud, and J. Roudier HLA-DRB10404 is strongly associated with anti-calpastatin antibodies in rheumatoid arthritis Ann. Rheum. Dis. 66 2007 1588 1593 (Pubitemid 350205445)
43. J.S. Alan, N. Jason, and J.M. AlexanDer Cigarette smoking increases the risk of rheumatoid arthritis: results from a nationwide study of disease-discordant twins Arthritis Rheum. 39 1996 732 735
44. L. Klareskog, L. Padyukov, J. Rnnelid, and L. Alfredsson Genes, environment and immunity in the development of rheumatoid arthritis Curr. Opin. Immunol. 18 2006 650 655 (Pubitemid 44635174)
45. K.G. Saag Cigarette smoking and rheumatoid arthritis severity Ann. Rheum. Dis. 56 1997 463 469 (Pubitemid 27396032)
46. K.H. Costenbader, D. Feskanich, L.A. Mandl, and E.W. Karlson Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women Am. J. Med. 119 2006 503
47. P. Stolt Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases Ann. Rheum. Dis. 62 2003 835 841 (Pubitemid 37026493)
48. L. Padyukov A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis Arthritis Rheum. 50 2004 3085 3092 (Pubitemid 39371983)
49. L. Klareskog A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination Arthritis Rheum. 54 2006 38 46 (Pubitemid 43122184)
50. P.G. Woodruff A distinctive alveolar macrophage activation state induced by cigarette smoking Am. J. Respir. Crit. Care Med. 172 2005 1383 1392 (Pubitemid 43069811)
51. J.A. Hill Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC Class II molecule J. Immunol. 171 2003 538 541 (Pubitemid 36871358)
52. K.M. Maslowski, and C.R. Mackay Diet, gut microbiota and immune responses Nat. Immunol. 12 2011 5 9
53. L. Wen Innate immunity and intestinal microbiota in the development of Type 1 diabetes Nature 455 2008 1109 1113
54. E. Eerola Intestinal flora in early rheumatoid arthritis Rheumatology 33 1994 1030 1038
55. K.M. Maslowski Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 Nature 461 2009 1282 1286
56. S.K. Mazmanian, J.L. Round, and D.L. Kasper A microbial symbiosis factor prevents intestinal inflammatory disease Nature 453 2008 620 625 (Pubitemid 351769307)
57. H.J. Wu Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells Immunity 32 2010 815 827
58. H. Yoshitomi A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice J. Exp. Med. 201 2005 949 960 (Pubitemid 40524464)
59. K. Lundberg Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase Arthritis Rheum. 58 2008 3009 3019
60. L. Klareskog, J. Ronnelid, K. Lundberg, L. Padyukov, and L. Alfredsson Immunity to citrullinated proteins in rheumatoid arthritis Annu. Rev. Immunol. 26 2008 651 675 (Pubitemid 351600388)
61. N. Wegner Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritis Arthritis Rheum. 62 2010 2662 2672
62. T.R. Mikuls Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis Int. Immunopharmacol. 9 2009 38 42
63. H. Ogura Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction Immunity 29 2008 628 636
64. S.L. Teitelbaum Bone resorption by osteoclasts Science 289 2000 1504 1508
65. G. Schett Cells of the synovium in rheumatoid arthritis. Osteoclasts Arthritis Res. Ther. 9 2007 203
66. E.M. Gravallese Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis Am. J. Pathol. 152 1998 943 951 (Pubitemid 28173356)
67. M.G. Ellen Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor Arthritis Rheum. 43 2000 250 258
68. K. Sato Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction J. Exp. Med. 203 2006 2673 2682 (Pubitemid 44833343)
69. S. Georg Analysis of the kinetics of osteoclastogenesis in arthritic rats Arthritis Rheum. 52 2005 3192 3201
70. U. Muller-Ladner, C. Ospelt, S. Gay, O. Distler, and T. Pap Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts Arthritis Res. Ther. 9 2009 223 233
71. M.L. Cho Toll-like receptor 2 ligand mediates the upregulation of angiogenic factor, vascular endothelial growth factor and interleukin-8/CXCL8 in human rheumatoid synovial fibroblasts Immunol. Lett. 108 2007 121 128
72. Y.O. Jung Toll-like receptor 2 and 4 combination engagement upregulate IL-15 synergistically in human rheumatoid synovial fibroblasts Immunol. Lett. 109 2007 21 27 (Pubitemid 46365963)
73. M. Pierer Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by toll-like receptor 2 ligands J. Immunol. 172 2004 1256 1265 (Pubitemid 38113789)
74. B. Fabia, S. Olivier, E.G. Renate, G. Steffen, and K. Diego RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via toll-like receptor 3 Arthritis Rheum. 52 2005 2656 2665
75. M.K. Gernot Comparative analysis of cathepsin l, cathepsin d, and collagenase messenger rna expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization Arthritis Rheum. 38 1995 976 984
76. S. Honda Expression of membrane-type 1 matrix metalloproteinase in rheumatoid synovial cells Clin. Exp. Immunol. 126 2001 131 136 (Pubitemid 32989502)
77. P. Thomas Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis Arthritis Rheum. 43 2000 1226 1232
78. S. Lefevre Synovial fibroblasts spread rheumatoid arthritis to unaffected joints Nat. Med. 15 2009 1414 1420
79. S.Y. Hwang IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways Arthritis Res. Ther. 6 2004 R120 R128
80. A.A. Mohammad Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways Arthritis Rheum. 56 2007 1787 1797
81. J.M. Dayer, B. de Rochemonteix, B. Burrus, S. Demczuk, and C.A. Dinarello Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells J. Clin. Invest. 77 1986 645 648 (Pubitemid 16037670)
82. J.M. Dayer, B. Beutler, and A. Cerami Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts J. Exp. Med. 162 1985 2163 2168 (Pubitemid 16149701)
83. H. Carol Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts Arthritis Rheum. 46 2002 2587 2597
84. J.P. Case, R. Lafyatis, E.F. Remmers, G.K. Kumkumian, and R.L. WilDer Transin/stromelysin expression in rheumatoid synovium. A transformation- associated metalloproteinase secreted by phenotypically invasive synoviocytes Am. J. Pathol. 135 1989 1055 1064 (Pubitemid 20026525)
85. G.S. Firestein Immunologic mechanisms in the pathogenesis of rheumatoid arthritis JCR 11 3 2005 S39 S44
86. P.T. Paul Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity Arthritis Rheum. 40 1997 217 225
87. M. Diarmuid, F. Oliver, and B. Barry Synovial tissue macrophage populations and articular damage in rheumatoid arthritis Arthritis Rheum. 39 1996 115 124
88. R. Kinne, B. Stuhlmuller, and G.R. Burmester Cells of the synovium in rheumatoid arthritis. Macrophages Arthritis Res. Ther. 9 2007 224
89. J. Banchereau, and R.M. Steinman Dendritic cells and the control of immunity Nature 392 1998 245 252 (Pubitemid 28155090)
90. K. Shortman, and S.H. Naik Steady-state and inflammatory dendritic-cell development Nat. Rev. Immunol. 7 2007 19 30 (Pubitemid 46020824)
91. R. Thomas Dendritic cells and the pathogenesis of rheumatoid arthritis J. Leukoc. Biol. 66 1999 286 292 (Pubitemid 29379170)
92. V. Lutzky, S. Hannawi, and R. Thomas Cells of the synovium in rheumatoid arthritis. Dendritic cells Arthritis Res. Ther. 9 2007
93. B.P. Leung A novel dendritic cell-induced model of erosive inflammatory arthritis: distinct roles for dendritic cells in T cell activation and induction of local inflammation J. Immunol. 169 2002 7071 7077 (Pubitemid 36899295)
94. R.A. Benson Identifying the cells breaching self-tolerance in autoimmunity J. Immunol. 184 2010 6378 6385
95. R. Thomas, L.S. Davis, and P.E. Lipsky Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells J. Immunol. 152 1994 2613 2623 (Pubitemid 24097956)
96. S.L. Jongbloed Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis J. Immunol. 182 2009 963 968
97. H. Hadeiba CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease Nat. Immunol. 9 2008 1253 1260
98. L.M. Van Duivenvoorde Immunomodulatory dendritic cells inhibit Th1 responses and arthritis via different mechanisms J. Immunol. 179 2007 1506 1515
99. M.v.-D. Leonie Antigen-specific immunomodulation of collagen-induced arthritis with tumor necrosis factor-stimulated dendritic cells Arthritis Rheum. 50 2004 3354 3364
100. J. Olivier Dendritic cells modulated by innate immunity improve collagen-induced arthritis and induce regulatory T cells in vivo Immunology 126 2009 35 44
101. R.A. Moura Alterations on peripheral blood B-cell subpopulations in very early arthritis patients Rheumatology (Oxford) 49 2010 1082 1092
102. R.A. Moura Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival Rheumatology (Oxford) 50 2011 278 282
103. S. Bugatti, V. Codullo, R. Caporali, and C. Montecucco B cells in rheumatoid arthritis Autoimmun. Rev. 6 2007 482 487 (Pubitemid 47069974)
104. K.N. Verpoort Isotype distribution of ANTI-CYCLIC citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response Arthritis Rheum. 54 2006 3799 3808 (Pubitemid 44955880)
105. A. Manzo Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis Eur. J. Immunol. 35 2005 1347 1359 (Pubitemid 40691416)
106. S. Takemura Lymphoid neogenesis in rheumatoid synovitis J. Immunol. 167 2001 1072 1080 (Pubitemid 32660867)
107. T.M. Seyler BLyS and APRIL in rheumatoid arthritis J. Clin. Invest. 115 2005 3083 3092 (Pubitemid 41567573)
108. E.A. Leadbetter Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors Nature 416 2002 603 607 (Pubitemid 34406754)
109. M.E. Duddy, A. Alter, and A. Bar-Or Distinct profiles of human B cell effector cytokines: A role in immune regulation? J. Immunol. 172 2004 3422 3427 (Pubitemid 38337921)
110. J.C.W. Edwards, and G. Cambridge B-cell targeting in rheumatoid arthritis and other autoimmune diseases Nat. Rev. Immunol. 6 2006 394 403
111. D. Schubert, B. Maier, L. Morawietz, V. Krenn, and T. Kamradt Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice J. Immunol. 172 2004 4503 4509 (Pubitemid 38375267)
112. P. Maffia Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells J. Immunol. 173 2004 151 156 (Pubitemid 38797336)
113. J. Duarte, A. Agua-Doce, V.G. Oliveira, J.E. Fonseca, and L. Graca Modulation of IL-17 and Foxp3 expression in the prevention of autoimmune arthritis in mice PLoS ONE 5 2010 e10558
114. M.-L. Toh, and P. Miossec The role of T cells in rheumatoid arthritis: new subsets and new targets Curr. Opin. Rheumatol. 19 2007 284 288 (Pubitemid 46597468)
115. H. Shen, J.C. Goodall, and J.S. Hill Gaston Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis Arthritis Rheum. 60 2009 1647 1656
116. R. Cascao Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis Arthritis Res. Ther. 12 2010 R196
117. T. De Smedt Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo J. Exp. Med. 184 1996 1413 1424 (Pubitemid 26354697)
118. M. Cella, A. Engering, V. Pinet, J. Pieters, and A. Lanzavecchia Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells Nature 388 1997 782 787 (Pubitemid 27375158)
119. M.K. Jenkins In vivo activation of antigen-specific CD4 T cells Annu. Rev. Immunol. 19 2001 23 45 (Pubitemid 32368028)
120. T.R. Mempel, S.E. Henrickson, and U.H. von Andrian T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases Nature 427 2004 154 159 (Pubitemid 38094955)
121. E.R. Kearney, K.A. Pape, D.Y. Loh, and M.K. Jenkins Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo Immunity 1 1994 327 339
122. M.G. McHeyzer-Williams, and M.M. Davis Antigen-specific development of primary and memory T cells in vivo Science 268 1995 106 111
123. P. Garside Visualization of specific B and T lymphocyte interactions in the lymph node Science 281 1998 96 99 (Pubitemid 28354051)
124. C.M. Rush Characterization of CD4+ T-cell-dendritic cell interactions during secondary antigen exposure in tolerance and priming Immunology 128 2009 463 471
125. B.H. Zinselmeyer In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance J. Exp. Med. 201 2005 1815 1823 (Pubitemid 41002900)
126. K.M. Smith, J.M. Brewer, A.M. Mowat, Y. Ron, and P. Garside The influence of follicular migration on T-cell differentiation Immunology 111 2004 248 251 (Pubitemid 38365745)
127. C. King, S.G. Tangye, and C.R. Mackay T follicular helper (TFH) cells in normal and dysregulated immune responses Annu. Rev. Immunol. 26 2008 741 766 (Pubitemid 351600391)
128. C.G. Vinuesa A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity Nature 435 2005 452 458 (Pubitemid 40734237)
129. A.M. Platt Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells J. Immunol. 185 2010 1558 1567
130. T. Garrood, and C. Pitzalis Targeting the inflamed synovium: the quest for specificity Arthritis Rheum. 54 2006 1055 1060 (Pubitemid 43672917)
131. A.J. George, L. Lee, and C. Pitzalis Isolating ligands specific for human vasculature using in vivo phage selection Trends Biotechnol. 21 2003 199 203 (Pubitemid 36515072)
132. S.E. Sweeney, and G.S. Firestein Rheumatoid arthritis: regulation of synovial inflammation Int. J. Biochem. Cell Biol. 36 2004 372 378 (Pubitemid 37542434)
133. H.B. Sun Mechanical loading, cartilage degradation, and arthritis Ann. N.Y. Acad. Sci. 1211 2010 37 50
134. A.W. Al-Allaf, P.A. Sanders, S.A. Ogston, and J.S. Marks A case control study examining the role of physical trauma in the onset of rheumatoid arthritis Rheumatology 40 2001 262 266
135. M. Murakami Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells J. Exp. Med. 208 2011 103 114
136. T. Hamada Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis Arthritis Rheum. 58 2008 2675 2685
137. Y.G. Cho, M.L. Cho, S.Y. Min, and H.Y. Kim Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis Autoimmun. Rev. 7 2007 65 70
138. R. Holmdahl, L. Jansson, A. Larsson, and R. Jonsson Arthritis in DBA/1 mice induced with passively transferred type II collagen immune serum. Immunohistopathology and serum levels of anti-type II collagen auto-antibodies Scand. J. Immunol. 31 1990 147 157 (Pubitemid 20049601)
139. J.M. Stuart, and F.J. Dixon Serum transfer of collagen-induced arthritis in mice J. Exp. Med. 158 1983 378 392 (Pubitemid 13049395)
140. P. Zhu Oral administration of type-II collagen peptide 250-270 suppresses specific cellular and humoral immune response in collagen-induced arthritis Clin. Immunol. 122 2007 75 84 (Pubitemid 46026693)
141. E. Michaelsson, M. Andersson, A. Engstrom, and R. Holmdahl Identification of an immunodominant type-II collagen peptide recognized by T cells in H-2q mice: self tolerance at the level of determinant selection Eur. J. Immunol. 22 1992 1819 1825
142. D.D. Brand Characterization of the T cell determinants in the induction of autoimmune arthritis by bovine alpha 1(II)-CB11 in H-2q mice J. Immunol. 152 1994 3088 3097
143. E.F. Rosloniec, K.B. Whittington, D.M. Zaller, and A.H. Kang HLA-DR1 (DRB1*0101) and DR4 (DRB1*0401) use the same anchor residues for binding an immunodominant peptide derived from human type II collagen J. Immunol. 168 2002 253 259 (Pubitemid 34014125)
144. J. Huan MHC Class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis J. Immunol. 180 2008 1249 1257
145. J. Huan Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch J. Immunol. 172 2004 4556 4566 (Pubitemid 38375273)
146. A.A. Vandenbark Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice J. Immunol. 171 2003 127 133 (Pubitemid 36745280)
147. A.L. Rankin CD4+ T cells recognizing a single self-peptide expressed by APCs induce spontaneous autoimmune arthritis J. Immunol. 180 2008 833 841
148. H. Hata Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice J. Clin. Invest. 114 2004 582 588 (Pubitemid 39572108)
149. M.B. Nickdel Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis Ann. Rheum. Dis. 68 2009 1059 1066
150. H.J. McBride Nuclear imaging of autoimmunity: focus on IBD and RA Autoimmunity 43 2010 539 549 10.3109/08916931003674766
151. R. Kijowski Clinical cartilage imaging of the knee and hip joints AJR Am. J. Roentgenol. 195 2010 618 628
152. J. Caetano-Lopes Chronic arthritis leads to disturbances in the bone collagen network Arthritis Res. Ther. 12 2010 R9
153. X. Qian In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags Nat. Biotechnol. 26 2008 83 90
154. M.E. Llewellyn, R.P. Barretto, S.L. Delp, and M.J. Schnitzer Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans Nature 454 2008 784 788
155. R.P. Barretto Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy Nat. Med. 17 2011 223 228
156. M. Pedersen Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides Arthritis Res. Ther. 8 2006 R133
157. H. Kallberg Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies Ann. Rheum. Dis. 68 2009 222 227
158. L.A. Mandl, K.H. Costenbader, J.F. Simard, and E.W. Karlson Is birthweight associated with risk of rheumatoid arthritis? Data from a large cohort study Ann. Rheum. Dis. 68 2009 514 518
159. S.S. Bhatia Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis Ann. Rheum. Dis. 66 2007 267 269 (Pubitemid 46226068)
160. M. Pikwer Breast feeding, but not use of oral contraceptives, is associated with a reduced risk of rheumatoid arthritis Ann. Rheum. Dis. 68 2009 526 530
161. C. Bengtsson Socioeconomic status and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study Ann. Rheum. Dis. 64 2005 1588 1594 (Pubitemid 41532042)
162. S.C. Chang, F. Laden, R. Puett, and E.W. Karlson Geographic variation in rheumatoid arthritis incidence among women in the United States Arch. Intern. Med. 15 2008 1664 1670