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Volumn 26, Issue , 2008, Pages 651-675

Immunity to citrullinated proteins in rheumatoid arthritis

Author keywords

Autoimmunity; Environment; Genes; HLA DR; Smoking

Indexed keywords

ANTIBODY; ANTIGEN; ARGININE; ARGININE DEIMINASE; AUTOANTIBODY; BIOLOGICAL MARKER; CITRULLINE; CITRULLINE ANTIBODY; COLLAGEN TYPE 2; DISEASE MODIFYING ANTIRHEUMATIC DRUG; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN ARGININE DEIMINASE;

EID: 42649092503     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.26.021607.090244     Document Type: Review
Times cited : (397)

References (137)
  • 1
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Block DA, McShane DJ, Fries JF, et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315-24
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Block, D.A.3    McShane, D.J.4    Fries, J.F.5
  • 2
    • 84979107869 scopus 로고
    • On the occurrence of a factor in human serum activating the specific agglutination of sheep blood corpuscles
    • Waaler E. 1940. On the occurrence of a factor in human serum activating the specific agglutination of sheep blood corpuscles. Acta Pathol. Microbiol. Scand. 17:172
    • (1940) Acta Pathol. Microbiol. Scand , vol.17 , pp. 172
    • Waaler, E.1
  • 3
    • 0022005534 scopus 로고
    • Immune complexes can trigger specific T-cell dependent autoanti-IgG antibody production in mice
    • Nemazee D. 1985. Immune complexes can trigger specific T-cell dependent autoanti-IgG antibody production in mice. J. Exp. Med. 161:242
    • (1985) J. Exp. Med , vol.161 , pp. 242
    • Nemazee, D.1
  • 4
    • 0021830703 scopus 로고
    • Simultaneous induction of rheumatoid factor- and antigen-specific antibody-secreting cells during the secondary immune response in man
    • Tarkowski A, Czerkinsky C, Nilsson LA. 1985. Simultaneous induction of rheumatoid factor- and antigen-specific antibody-secreting cells during the secondary immune response in man. Clin. Exp. Immunol. 61:379-87
    • (1985) Clin. Exp. Immunol , vol.61 , pp. 379-387
    • Tarkowski, A.1    Czerkinsky, C.2    Nilsson, L.A.3
  • 5
    • 0017878054 scopus 로고
    • Association of the B-cell alloantigen DRw4 with rheumatoid arthritis
    • Stastny P. 1978. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N. Engl. J. Med. 298:869-71
    • (1978) N. Engl. J. Med , vol.298 , pp. 869-871
    • Stastny, P.1
  • 6
    • 0023500817 scopus 로고
    • The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
    • Gregersen PK, Silver J, Winchester RJ. 1987. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30:1205-13
    • (1987) Arthritis Rheum , vol.30 , pp. 1205-1213
    • Gregersen, P.K.1    Silver, J.2    Winchester, R.J.3
  • 7
    • 0000785070 scopus 로고
    • Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis
    • Klareskog L, Forsum U, Scheynius A, Kabelitz D, Wigzell H. 1982. Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 79:3632-36
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 3632-3636
    • Klareskog, L.1    Forsum, U.2    Scheynius, A.3    Kabelitz, D.4    Wigzell, H.5
  • 9
    • 0035093233 scopus 로고    scopus 로고
    • Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes
    • Edwards JC, Cambridge G. 2001. Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology 40:205-11
    • (2001) Rheumatology , vol.40 , pp. 205-211
    • Edwards, J.C.1    Cambridge, G.2
  • 11
    • 1542376173 scopus 로고    scopus 로고
    • The transfer of a laboratory based hypothesis to a clinically useful therapy: The development of anti-TNF therapy of rheumatoid arthritis
    • Feldmann M, Brennan FM, Williams RO, Woody JN, Maini RN. 2004. The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis. Best Pract. Res. Clin. Rheumatol. 18:59-80
    • (2004) Best Pract. Res. Clin. Rheumatol , vol.18 , pp. 59-80
    • Feldmann, M.1    Brennan, F.M.2    Williams, R.O.3    Woody, J.N.4    Maini, R.N.5
  • 12
    • 33748997948 scopus 로고    scopus 로고
    • Cytokine networks - toward new therapies for rheumatoid arthritis
    • McInnes IB, Liew FY. 2005. Cytokine networks - toward new therapies for rheumatoid arthritis. Nat. Clin. Pract. Rheumatol. 1:31-39
    • (2005) Nat. Clin. Pract. Rheumatol , vol.1 , pp. 31-39
    • McInnes, I.B.1    Liew, F.Y.2
  • 13
    • 20844442966 scopus 로고    scopus 로고
    • Immunologic mechanisms in the pathogenesis of rheumatoid arthritis
    • Firestein GS. 2005. Immunologic mechanisms in the pathogenesis of rheumatoid arthritis. J. Clin. Rheumatol. 11:S39-44
    • (2005) J. Clin. Rheumatol , vol.11
    • Firestein, G.S.1
  • 14
    • 33748488886 scopus 로고    scopus 로고
    • Chemokine inhibition in inflammatory arthritis
    • Tak PP. 2006. Chemokine inhibition in inflammatory arthritis. Best Pract. Res. Clin. Rheumatol. 20:929-39
    • (2006) Best Pract. Res. Clin. Rheumatol , vol.20 , pp. 929-939
    • Tak, P.P.1
  • 15
    • 0034091322 scopus 로고    scopus 로고
    • The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide
    • Schellekens GA, Visser H, de Jong BA, van den Hoogen FH, Hazes JM, et al. 2000. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 43:155-63
    • (2000) Arthritis Rheum , vol.43 , pp. 155-163
    • Schellekens, G.A.1    Visser, H.2    de Jong, B.A.3    van den Hoogen, F.H.4    Hazes, J.M.5
  • 16
    • 0036676806 scopus 로고    scopus 로고
    • Detection of antibodies to deiminated recombinant rat filaggrin by enzyme-linked immunosorbent assay: A highly effective test for the diagnosis of rheumatoid arthritis
    • Vincent C, Nogueira L, Sebbag M, Chapuy-Regaud S, Arnaud M, et al. 2002. Detection of antibodies to deiminated recombinant rat filaggrin by enzyme-linked immunosorbent assay: a highly effective test for the diagnosis of rheumatoid arthritis. Arthritis Rheum. 46:2051-58
    • (2002) Arthritis Rheum , vol.46 , pp. 2051-2058
    • Vincent, C.1    Nogueira, L.2    Sebbag, M.3    Chapuy-Regaud, S.4    Arnaud, M.5
  • 17
    • 1542283760 scopus 로고    scopus 로고
    • Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: A prospective cohort study
    • van Gaalen FA, Linn-Rasker SP, van Venrooij WJ, de Jong BA, Breedveld FC, et al. 2004. Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study. Arthritis Rheum. 50:709-15
    • (2004) Arthritis Rheum , vol.50 , pp. 709-715
    • van Gaalen, F.A.1    Linn-Rasker, S.P.2    van Venrooij, W.J.3    de Jong, B.A.4    Breedveld, F.C.5
  • 18
    • 33745725970 scopus 로고    scopus 로고
    • Diagnostic and predictive value of anticyclic citrullinated protein antibodies in rheumatoid arthritis: A systematic literature review
    • Avouac J, Gossec L, Dougados M. 2006. Diagnostic and predictive value of anticyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. Ann. Rheum. Dis. 65:845-51
    • (2006) Ann. Rheum. Dis , vol.65 , pp. 845-851
    • Avouac, J.1    Gossec, L.2    Dougados, M.3
  • 19
    • 34250626806 scopus 로고    scopus 로고
    • Meta-analysis: Diagnostic accuracy of anticyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis
    • Nishimura K, Sugiyama D, Kogata Y, Tsuji G, Nakazawa T, et al. 2007. Meta-analysis: diagnostic accuracy of anticyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann. Intern. Med. 146:797-808
    • (2007) Ann. Intern. Med , vol.146 , pp. 797-808
    • Nishimura, K.1    Sugiyama, D.2    Kogata, Y.3    Tsuji, G.4    Nakazawa, T.5
  • 20
    • 0026681481 scopus 로고
    • Immunopathology of rheumatoid arthritis. Antikeratin antibodies precede the clinical disease
    • Kurki P, Aho K, Palosuo T, Heliovaara M. 1992. Immunopathology of rheumatoid arthritis. Antikeratin antibodies precede the clinical disease. Arthritis Rheum. 35:914-17
    • (1992) Arthritis Rheum , vol.35 , pp. 914-917
    • Kurki, P.1    Aho, K.2    Palosuo, T.3    Heliovaara, M.4
  • 21
    • 0033668801 scopus 로고    scopus 로고
    • Antifilaggrin antibodies within "normal" range predict rheumatoid arthritis in a linear fashion
    • Aho K, Palosuo T, Heliovaara M, Knekt P, Alha P, von Essen R. 2000. Antifilaggrin antibodies within "normal" range predict rheumatoid arthritis in a linear fashion. J. Rheumatol. 27:2743-46
    • (2000) J. Rheumatol , vol.27 , pp. 2743-2746
    • Aho, K.1    Palosuo, T.2    Heliovaara, M.3    Knekt, P.4    Alha, P.5    von Essen, R.6
  • 22
    • 18744430797 scopus 로고    scopus 로고
    • Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
    • Rantapää-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, et al. 2003. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 48:2741-49
    • (2003) Arthritis Rheum , vol.48 , pp. 2741-2749
    • Rantapää-Dahlqvist, S.1    de Jong, B.A.2    Berglin, E.3    Hallmans, G.4    Wadell, G.5
  • 24
    • 4344679600 scopus 로고    scopus 로고
    • Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project)
    • Kastbom A, Strandberg G, Lindroos A, Skogh T. 2004. Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project). Ann. Rheum. Dis. 63:1085-89
    • (2004) Ann. Rheum. Dis , vol.63 , pp. 1085-1089
    • Kastbom, A.1    Strandberg, G.2    Lindroos, A.3    Skogh, T.4
  • 25
    • 27844610761 scopus 로고    scopus 로고
    • Longitudinal analysis of anticitrullinated protein/peptide antibodies (anti-CP) during 5 year follow-up in early rheumatoid arthritis: Anti-CP status is a stable phenotype that predicts worse disease activity and greater radiological progression
    • Rönnelid J, Wick MC, Lampa J, Lindblad S, Nordmark B, et al. 2005. Longitudinal analysis of anticitrullinated protein/peptide antibodies (anti-CP) during 5 year follow-up in early rheumatoid arthritis: anti-CP status is a stable phenotype that predicts worse disease activity and greater radiological progression. Ann. Rheum. Dis. 64:1744-49
    • (2005) Ann. Rheum. Dis , vol.64 , pp. 1744-1749
    • Rönnelid, J.1    Wick, M.C.2    Lampa, J.3    Lindblad, S.4    Nordmark, B.5
  • 26
    • 31044445025 scopus 로고    scopus 로고
    • A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination
    • Klareskog L, Stolt P, Lundberg K, Källberg H, Bengtsson C, et al. 2006. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 54:38-46
    • (2006) Arthritis Rheum , vol.54 , pp. 38-46
    • Klareskog, L.1    Stolt, P.2    Lundberg, K.3    Källberg, H.4    Bengtsson, C.5
  • 27
    • 33847023027 scopus 로고    scopus 로고
    • The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide
    • van der Helm-van Mil AH, Verpoort KN, le Cessie S, Huizinga TW, de Vries RR, Toes RE. 2007. The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide. Arthritis Rheum. 56:425-32
    • (2007) Arthritis Rheum , vol.56 , pp. 425-432
    • van der Helm-van Mil, A.H.1    Verpoort, K.N.2    le Cessie, S.3    Huizinga, T.W.4    de Vries, R.R.5    Toes, R.E.6
  • 28
    • 33645511657 scopus 로고    scopus 로고
    • Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
    • Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, et al. 2006. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J. Clin. Invest. 116:961-73
    • (2006) J. Clin. Invest , vol.116 , pp. 961-973
    • Kuhn, K.A.1    Kulik, L.2    Tomooka, B.3    Braschler, K.J.4    Arend, W.P.5
  • 29
    • 27744515706 scopus 로고    scopus 로고
    • Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity
    • Lundberg K, Nijenhuis S, Vossenaar ER, Palmblad K, van Venrooij WJ, et al. 2005. Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity. Arthritis Res. Ther. 7:R458-67
    • (2005) Arthritis Res. Ther , vol.7
    • Lundberg, K.1    Nijenhuis, S.2    Vossenaar, E.R.3    Palmblad, K.4    van Venrooij, W.J.5
  • 30
    • 0242720407 scopus 로고    scopus 로고
    • PAD, a growing family of citrullinating enzymes: Genes, features and involvement in disease
    • Vossenaar ER, Zendman AJ, van Venrooij WJ, Pruijn GJ. 2003. PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. BioEssays 25:1106-18
    • (2003) BioEssays , vol.25 , pp. 1106-1118
    • Vossenaar, E.R.1    Zendman, A.J.2    van Venrooij, W.J.3    Pruijn, G.J.4
  • 31
    • 1842829046 scopus 로고    scopus 로고
    • Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved noncoding segments and a new human gene, PADI6
    • Chavanas S, Mechin MC, Takahara H, Kawada A, Nachat R, et al. 2004. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved noncoding segments and a new human gene, PADI6. Gene 330:19-27
    • (2004) Gene , vol.330 , pp. 19-27
    • Chavanas, S.1    Mechin, M.C.2    Takahara, H.3    Kawada, A.4    Nachat, R.5
  • 32
    • 0034757676 scopus 로고    scopus 로고
    • Baeten D, Peene I, Union A, Meheus L, Sebbag M, et al. 2001. Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies. Arthritis Rheum. 44:2255-62
    • Baeten D, Peene I, Union A, Meheus L, Sebbag M, et al. 2001. Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies. Arthritis Rheum. 44:2255-62
  • 35
  • 36
    • 33846914679 scopus 로고    scopus 로고
    • The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis
    • Moscarello MA, Mastronardi FG, Wood DD. 2007. The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis. Neurochem. Res. 32:251-56
    • (2007) Neurochem. Res , vol.32 , pp. 251-256
    • Moscarello, M.A.1    Mastronardi, F.G.2    Wood, D.D.3
  • 37
    • 33746214870 scopus 로고    scopus 로고
    • Cutting edge: Unique T cells that recognize citrullinated peptides are a feature of protein immunization
    • Ireland J, Herzog J, Unanue ER. 2006. Cutting edge: unique T cells that recognize citrullinated peptides are a feature of protein immunization. J. Immunol. 177:1421-25
    • (2006) J. Immunol , vol.177 , pp. 1421-1425
    • Ireland, J.1    Herzog, J.2    Unanue, E.R.3
  • 39
    • 33845568288 scopus 로고    scopus 로고
    • Citrullination in extra-articular manifestations of rheumatoid arthritis
    • Bongartz T, Cantaert T, Atkins SR, Harle P, Myers JL, et al. 2007. Citrullination in extra-articular manifestations of rheumatoid arthritis. Rheumatology 46:70-75
    • (2007) Rheumatology , vol.46 , pp. 70-75
    • Bongartz, T.1    Cantaert, T.2    Atkins, S.R.3    Harle, P.4    Myers, J.L.5
  • 40
    • 0037085720 scopus 로고    scopus 로고
    • Preparation of a monoclonal antibody to citrullinated epitopes: Its characterization and some applications to immunohistochemistry in human brain
    • Nicholas AP, Whitaker JN. 2002. Preparation of a monoclonal antibody to citrullinated epitopes: its characterization and some applications to immunohistochemistry in human brain. Glia 37:328-36
    • (2002) Glia , vol.37 , pp. 328-336
    • Nicholas, A.P.1    Whitaker, J.N.2
  • 42
    • 0035869593 scopus 로고    scopus 로고
    • The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the α- and β-chains of fibrin
    • Masson-Bessiere C, Sebbag M, Girbal-Neuhauser E, Nogueira L, Vincent C, et al. 2001. The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the α- and β-chains of fibrin. J. Immunol. 166:4177-84
    • (2001) J. Immunol , vol.166 , pp. 4177-4184
    • Masson-Bessiere, C.1    Sebbag, M.2    Girbal-Neuhauser, E.3    Nogueira, L.4    Vincent, C.5
  • 44
    • 34547785469 scopus 로고    scopus 로고
    • Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis
    • Bang H, Egerer K, Gauliard A, Lüthke K, Rudulph PE, et al. 2007. Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis. Arthritis Rheum. 56:2503-11
    • (2007) Arthritis Rheum , vol.56 , pp. 2503-2511
    • Bang, H.1    Egerer, K.2    Gauliard, A.3    Lüthke, K.4    Rudulph, P.E.5
  • 46
    • 0000769352 scopus 로고
    • A new serum factor in patients with rheumatoid arthritis, the antiperiuclear factor
    • Nienhuis RL, Mandena E. 1964. A new serum factor in patients with rheumatoid arthritis, the antiperiuclear factor. Ann. Rheum. Dis. 23:202-5
    • (1964) Ann. Rheum. Dis , vol.23 , pp. 202-205
    • Nienhuis, R.L.1    Mandena, E.2
  • 47
    • 0027217907 scopus 로고
    • The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis
    • Simon M, Girbal E, Sebbag M, Gomes-Daudrix V, Vincent C, et al. 1993. The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis. J. Clin. Invest. 92:1387-93
    • (1993) J. Clin. Invest , vol.92 , pp. 1387-1393
    • Simon, M.1    Girbal, E.2    Sebbag, M.3    Gomes-Daudrix, V.4    Vincent, C.5
  • 48
    • 0029017016 scopus 로고
    • The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies
    • Sebbag M, Simon M, Vincent C, Masson-Bessiere C, Girbal E, et al. 1995. The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies. J. Clin. Invest. 95:2672-79
    • (1995) J. Clin. Invest , vol.95 , pp. 2672-2679
    • Sebbag, M.1    Simon, M.2    Vincent, C.3    Masson-Bessiere, C.4    Girbal, E.5
  • 49
    • 0031974911 scopus 로고    scopus 로고
    • Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies
    • Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ. 1998. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J. Clin. Invest. 101:273-81
    • (1998) J. Clin. Invest , vol.101 , pp. 273-281
    • Schellekens, G.A.1    de Jong, B.A.2    van den Hoogen, F.H.3    van de Putte, L.B.4    van Venrooij, W.J.5
  • 50
    • 7644238939 scopus 로고    scopus 로고
    • Autoantibodies to citrullinated proteins in rheumatoid arthritis: Clinical performance and biochemical aspects of an RA-specific marker
    • Nijenhuis S, Zendman AJ, Vossenaar ER, Pruijn GJ, van Venrooij WJ. 2004. Autoantibodies to citrullinated proteins in rheumatoid arthritis: clinical performance and biochemical aspects of an RA-specific marker. Clin. Chim. Acta. 350:17-34
    • (2004) Clin. Chim. Acta , vol.350 , pp. 17-34
    • Nijenhuis, S.1    Zendman, A.J.2    Vossenaar, E.R.3    Pruijn, G.J.4    van Venrooij, W.J.5
  • 51
    • 0032960781 scopus 로고    scopus 로고
    • The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues
    • Girbal-Neuhauser E, Durieux JJ, Arnaud M, Dalbon P, Sebbag M, et al. 1999. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J. Immunol. 162:585-94
    • (1999) J. Immunol , vol.162 , pp. 585-594
    • Girbal-Neuhauser, E.1    Durieux, J.J.2    Arnaud, M.3    Dalbon, P.4    Sebbag, M.5
  • 52
    • 70350554075 scopus 로고    scopus 로고
    • Diagnostic value of antihuman citrullinated fibrinogen ELISA and comparison with four other anticitrullinated protein assays
    • Vander Cruyssen B, Cantaert T, Nogueira L, Clavel C, De Rycke L, et al. 2006. Diagnostic value of antihuman citrullinated fibrinogen ELISA and comparison with four other anticitrullinated protein assays. Arthritis Res. Ther. 8:R122
    • (2006) Arthritis Res. Ther , vol.8
    • Vander Cruyssen, B.1    Cantaert, T.2    Nogueira, L.3    Clavel, C.4    De Rycke, L.5
  • 53
    • 0028275351 scopus 로고
    • The Sa system: A novel antigen-antibody system specific for rheumatoid arthritis
    • Despres N, Boire G, Lopez-Longo FJ, Menard HA. 1994. The Sa system: a novel antigen-antibody system specific for rheumatoid arthritis. J. Rheumatol. 21:1027-33
    • (1994) J. Rheumatol , vol.21 , pp. 1027-1033
    • Despres, N.1    Boire, G.2    Lopez-Longo, F.J.3    Menard, H.A.4
  • 54
    • 0032891502 scopus 로고    scopus 로고
    • Anti-Sa antibody is an accurate diagnostic and prognostic marker in adult rheumatoid arthritis
    • Hayem G, Chazerain P, Combe B, Elias A, Haim T, et al. 1999. Anti-Sa antibody is an accurate diagnostic and prognostic marker in adult rheumatoid arthritis. J. Rheumatol. 26:7-13
    • (1999) J. Rheumatol , vol.26 , pp. 7-13
    • Hayem, G.1    Chazerain, P.2    Combe, B.3    Elias, A.4    Haim, T.5
  • 55
    • 0032748368 scopus 로고    scopus 로고
    • Sensitivity and specificity of anti-Sa autoantibodies for rheumatoid arthritis
    • Hueber W, Hassfeld W, Smolen JS, Steiner G. 1999. Sensitivity and specificity of anti-Sa autoantibodies for rheumatoid arthritis. Rheumatology 38:155-59
    • (1999) Rheumatology , vol.38 , pp. 155-159
    • Hueber, W.1    Hassfeld, W.2    Smolen, J.S.3    Steiner, G.4
  • 57
    • 33644667809 scopus 로고    scopus 로고
    • Identification of citrullinated α-enolase as a candidate autoantigen in rheumatoid arthritis
    • Kinloch A, Tatzer V, Wait R, Peston D, Lundberg K, et al. 2005. Identification of citrullinated α-enolase as a candidate autoantigen in rheumatoid arthritis. Arthritis Res. Ther. 7:R1421-29
    • (2005) Arthritis Res. Ther , vol.7
    • Kinloch, A.1    Tatzer, V.2    Wait, R.3    Peston, D.4    Lundberg, K.5
  • 58
    • 0017657009 scopus 로고
    • Autoimmunity to type II collagen an experimental model of arthritis
    • Trentham DE, Townes AS, Kang AH. 1977. Autoimmunity to type II collagen an experimental model of arthritis. J. Exp. Med. 146:857-68
    • (1977) J. Exp. Med , vol.146 , pp. 857-868
    • Trentham, D.E.1    Townes, A.S.2    Kang, A.H.3
  • 59
    • 0036484325 scopus 로고    scopus 로고
    • The molecular pathogenesis of collagen-induced arthritis in mice - a model for rheumatoid arthritis
    • Holmdahl R, Bockermann R, Backlund J, Yamada H. 2002. The molecular pathogenesis of collagen-induced arthritis in mice - a model for rheumatoid arthritis. Ageing Res. Rev. 1:135-47
    • (2002) Ageing Res. Rev , vol.1 , pp. 135-147
    • Holmdahl, R.1    Bockermann, R.2    Backlund, J.3    Yamada, H.4
  • 61
    • 0024427196 scopus 로고
    • Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis
    • Tarkowski A, Klareskog L, Carlsten H, Herberts P, Koopman WJ. 1989. Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis. Arthritis Rheum. 32:1087-92
    • (1989) Arthritis Rheum , vol.32 , pp. 1087-1092
    • Tarkowski, A.1    Klareskog, L.2    Carlsten, H.3    Herberts, P.4    Koopman, W.J.5
  • 62
    • 0028227428 scopus 로고
    • Local anti-type II collagen antibody production in rheumatoid arthritis synovial fluid. Evidence for an HLA-DR4-restricted IgG response
    • Rönnelid J, Lysholm J, Engström-Laurent A, Klareskog L, Heyman B. 1994. Local anti-type II collagen antibody production in rheumatoid arthritis synovial fluid. Evidence for an HLA-DR4-restricted IgG response. Arthritis Rheum. 37:1023-29
    • (1994) Arthritis Rheum , vol.37 , pp. 1023-1029
    • Rönnelid, J.1    Lysholm, J.2    Engström-Laurent, A.3    Klareskog, L.4    Heyman, B.5
  • 63
    • 18844386764 scopus 로고    scopus 로고
    • Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis
    • Burkhardt H, Sehnert B, Bockermann R, Engstrom A, Kalden JR, Holmdahl R. 2005. Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis. Eur. J. Immunol. 35:1643-52
    • (2005) Eur. J. Immunol , vol.35 , pp. 1643-1652
    • Burkhardt, H.1    Sehnert, B.2    Bockermann, R.3    Engstrom, A.4    Kalden, J.R.5    Holmdahl, R.6
  • 64
    • 33845622856 scopus 로고    scopus 로고
    • Isotype distribution of anticyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response
    • Verpoort KN, Jol-van der Zijde CM, Papendrecht-van der Voort EA, Ioan-Facsinay A, Drijfhout JW, et al. 2006. Isotype distribution of anticyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response. Arthritis Rheum. 54:3799-808
    • (2006) Arthritis Rheum , vol.54 , pp. 3799-3808
    • Verpoort, K.N.1    Jol-van der Zijde, C.M.2    Papendrecht-van der Voort, E.A.3    Ioan-Facsinay, A.4    Drijfhout, J.W.5
  • 65
    • 24044553794 scopus 로고    scopus 로고
    • Antibodies against cyclic citrullinated peptides in patients affected by rheumatoid arthritis before and after infliximab treatment
    • Caramaschi P, Biasi D, Tonolli E, Pieropan S, Martinelli N, et al. 2005. Antibodies against cyclic citrullinated peptides in patients affected by rheumatoid arthritis before and after infliximab treatment. Rheumatol. Int. 26:58-62
    • (2005) Rheumatol. Int , vol.26 , pp. 58-62
    • Caramaschi, P.1    Biasi, D.2    Tonolli, E.3    Pieropan, S.4    Martinelli, N.5
  • 66
    • 13244261140 scopus 로고    scopus 로고
    • Rheumatoid factor, but not anticyclic citrullinated peptide antibodies, is modulated by infliximab treatment in rheumatoid arthritis
    • De Rycke L, Verhelst X, Kruithof E, Van den Bosch F, Hoffman IE, et al. 2005. Rheumatoid factor, but not anticyclic citrullinated peptide antibodies, is modulated by infliximab treatment in rheumatoid arthritis. Ann. Rheum. Dis. 64:299-302
    • (2005) Ann. Rheum. Dis , vol.64 , pp. 299-302
    • De Rycke, L.1    Verhelst, X.2    Kruithof, E.3    Van den Bosch, F.4    Hoffman, I.E.5
  • 68
    • 1942440157 scopus 로고    scopus 로고
    • Decrease of anticyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFα therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement
    • Alessandri C, Bombardieri M, Papa N, Cinquini M, Magrini L, et al. 2004. Decrease of anticyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFα therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement. Ann. Rheum. Dis. 63:1218-21
    • (2004) Ann. Rheum. Dis , vol.63 , pp. 1218-1221
    • Alessandri, C.1    Bombardieri, M.2    Papa, N.3    Cinquini, M.4    Magrini, L.5
  • 69
    • 29144519684 scopus 로고    scopus 로고
    • The effect of etanercept on anticyclic citrullinated peptide antibodies and rheumatoid factor in patients with rheumatoid arthritis
    • Chen HA, Lin KC, Chen CH, Liao HT, Wang HP, et al. 2006. The effect of etanercept on anticyclic citrullinated peptide antibodies and rheumatoid factor in patients with rheumatoid arthritis. Ann. Rheum. Dis. 65:35-39
    • (2006) Ann. Rheum. Dis , vol.65 , pp. 35-39
    • Chen, H.A.1    Lin, K.C.2    Chen, C.H.3    Liao, H.T.4    Wang, H.P.5
  • 71
    • 24944475721 scopus 로고    scopus 로고
    • The clinical and genetic associations of anticyclic citrullinated peptide antibodies in psoriatic arthritis
    • Korendowych E, Owen P, Ravindran J, Carmichael C, McHugh N. 2005. The clinical and genetic associations of anticyclic citrullinated peptide antibodies in psoriatic arthritis. Rheumatology 44:1056-60
    • (2005) Rheumatology , vol.44 , pp. 1056-1060
    • Korendowych, E.1    Owen, P.2    Ravindran, J.3    Carmichael, C.4    McHugh, N.5
  • 73
    • 33144465716 scopus 로고    scopus 로고
    • Antibodies against cyclic citrullinated peptide (CCP) in psoriatic patients with or without joint inflammation
    • Alenius GM, Berglin E, Rantapaa Dahlqvist S. 2006. Antibodies against cyclic citrullinated peptide (CCP) in psoriatic patients with or without joint inflammation. Ann. Rheum. Dis. 65:398-400
    • (2006) Ann. Rheum. Dis , vol.65 , pp. 398-400
    • Alenius, G.M.1    Berglin, E.2    Rantapaa Dahlqvist, S.3
  • 74
    • 4444323762 scopus 로고    scopus 로고
    • Determination of anticyclic citrullinated peptide antibodies in the sera of patients with juvenile idiopathic arthritis
    • Low JM, Chauhan AK, Kietz DA, Daud U, Pepmueller PH, Moore TL. 2004. Determination of anticyclic citrullinated peptide antibodies in the sera of patients with juvenile idiopathic arthritis. J. Rheumatol. 31:1829-33
    • (2004) J. Rheumatol , vol.31 , pp. 1829-1833
    • Low, J.M.1    Chauhan, A.K.2    Kietz, D.A.3    Daud, U.4    Pepmueller, P.H.5    Moore, T.L.6
  • 75
    • 9644265393 scopus 로고    scopus 로고
    • Diagnostic accuracy of anticyclic citrullinated peptide antibodies in juvenile idiopathic arthritis
    • Kasapcopur O, Altun S, Aslan M, Karaarslan S, Kamburoglu-Goksel A, et al. 2004. Diagnostic accuracy of anticyclic citrullinated peptide antibodies in juvenile idiopathic arthritis. Ann. Rheum. Dis. 63:1687-89
    • (2004) Ann. Rheum. Dis , vol.63 , pp. 1687-1689
    • Kasapcopur, O.1    Altun, S.2    Aslan, M.3    Karaarslan, S.4    Kamburoglu-Goksel, A.5
  • 76
    • 19944432037 scopus 로고    scopus 로고
    • Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis
    • Ferucci ED, Majka DS, Parrish LA, Moroldo MB, Ryan M, et al. 2005. Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum. 52:239-46
    • (2005) Arthritis Rheum , vol.52 , pp. 239-246
    • Ferucci, E.D.1    Majka, D.S.2    Parrish, L.A.3    Moroldo, M.B.4    Ryan, M.5
  • 77
    • 27544512187 scopus 로고    scopus 로고
    • Anti-cyclic citrullinated peptide: Diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population
    • Kwok JS, Hui KH, Lee TL, Wong W, Lau YL, et al. 2005. Anti-cyclic citrullinated peptide: diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population. Scand. J. Rheumatol. 34:359-66
    • (2005) Scand. J. Rheumatol , vol.34 , pp. 359-366
    • Kwok, J.S.1    Hui, K.H.2    Lee, T.L.3    Wong, W.4    Lau, Y.L.5
  • 78
    • 33947573778 scopus 로고    scopus 로고
    • Erosive arthropathy: Clinical variance in lupus erythematosus and association with anti-CCP case series and review of the literature
    • Martinez JB, Valero JS, Bautista AJ, Restrepo JF, Matteson EL, et al. 2007. Erosive arthropathy: clinical variance in lupus erythematosus and association with anti-CCP case series and review of the literature. Clin. Exp. Rheumatol. 25:47-53
    • (2007) Clin. Exp. Rheumatol , vol.25 , pp. 47-53
    • Martinez, J.B.1    Valero, J.S.2    Bautista, A.J.3    Restrepo, J.F.4    Matteson, E.L.5
  • 79
    • 8444245157 scopus 로고    scopus 로고
    • Anticyclic citrullinated peptide antibodies in patients with mixed connective tissue disease
    • Takasaki Y, Yamanaka K, Takasaki C, Matsushita M, Yamada H, et al. 2004. Anticyclic citrullinated peptide antibodies in patients with mixed connective tissue disease. Mod. Rheumatol. 14:367-75
    • (2004) Mod. Rheumatol , vol.14 , pp. 367-375
    • Takasaki, Y.1    Yamanaka, K.2    Takasaki, C.3    Matsushita, M.4    Yamada, H.5
  • 80
    • 0033869054 scopus 로고    scopus 로고
    • The prognostic value of anticyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis
    • Kroot EJ, de Jong BA, van Leeuwen MA, Swinkels H, van den Hoogen FH, et al. 2000. The prognostic value of anticyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum. 43:1831-35
    • (2000) Arthritis Rheum , vol.43 , pp. 1831-1835
    • Kroot, E.J.1    de Jong, B.A.2    van Leeuwen, M.A.3    Swinkels, H.4    van den Hoogen, F.H.5
  • 81
    • 4344630375 scopus 로고    scopus 로고
    • Prediction of radiological outcome in early RA in clinical practice: Role of antibodies to citrullinated peptides (anti-CCP)
    • Forslind K, Ahlmen M, Eberhardt K, Hafström I, Svensson B. 2004. Prediction of radiological outcome in early RA in clinical practice: role of antibodies to citrullinated peptides (anti-CCP). Ann. Rheum. Dis. 63:1090-95
    • (2004) Ann. Rheum. Dis , vol.63 , pp. 1090-1095
    • Forslind, K.1    Ahlmen, M.2    Eberhardt, K.3    Hafström, I.4    Svensson, B.5
  • 82
    • 0037404894 scopus 로고    scopus 로고
    • Autoantibodies can be prognostic markers of an erosive disease in early rheumatoid arthritis
    • Vencovsky J, Machacek S, Sedova L, Kafkova J, Gatterova J, et al. 2003. Autoantibodies can be prognostic markers of an erosive disease in early rheumatoid arthritis. Ann. Rheum. Dis. 62:427-30
    • (2003) Ann. Rheum. Dis , vol.62 , pp. 427-430
    • Vencovsky, J.1    Machacek, S.2    Sedova, L.3    Kafkova, J.4    Gatterova, J.5
  • 83
    • 0037310556 scopus 로고    scopus 로고
    • Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage
    • Meyer O, Labarre C, Dougados M, Goupille P, Cantagrel A, et al. 2003. Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage. Ann. Rheum. Dis. 62:120-26
    • (2003) Ann. Rheum. Dis , vol.62 , pp. 120-126
    • Meyer, O.1    Labarre, C.2    Dougados, M.3    Goupille, P.4    Cantagrel, A.5
  • 84
    • 34248512220 scopus 로고    scopus 로고
    • Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: A double-blind, randomized, placebo-controlled trial
    • van Dongen H, van Aken J, Lard LR, Visser K, Ronday HK, et al. 2007. Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial. Arthritis Rheum. 56:1424-32
    • (2007) Arthritis Rheum , vol.56 , pp. 1424-1432
    • van Dongen, H.1    van Aken, J.2    Lard, L.R.3    Visser, K.4    Ronday, H.K.5
  • 85
    • 0024829522 scopus 로고
    • HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region
    • Wordsworth BP, Lanchbury JSS, Sakkas LI, Welsh KI, Panayi GS, Bell JI. 1989. HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region. Proc. Natl. Acad. Sci. USA 86:10049-53
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 10049-10053
    • Wordsworth, B.P.1    Lanchbury, J.S.S.2    Sakkas, L.I.3    Welsh, K.I.4    Panayi, G.S.5    Bell, J.I.6
  • 87
    • 27744550413 scopus 로고    scopus 로고
    • Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins
    • Huizinga TW, Amos CI, van der Helm-van Mil AH, Chen W, van Gaalen FA, et al. 2005. Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum. 52:3433-38
    • (2005) Arthritis Rheum , vol.52 , pp. 3433-3438
    • Huizinga, T.W.1    Amos, C.I.2    van der Helm-van Mil, A.H.3    Chen, W.4    van Gaalen, F.A.5
  • 88
    • 33646348123 scopus 로고    scopus 로고
    • The HLA-DRB1 shared epitope alleles are primarily a risk factor for anticyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis
    • van der Helm-van Mil AR, Verpoort KN, Breedveld FC, Huizinga TW, Toes RE, de Vries RR. 2006. The HLA-DRB1 shared epitope alleles are primarily a risk factor for anticyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. Arthritis Rheum. 54:1117-21
    • (2006) Arthritis Rheum , vol.54 , pp. 1117-1121
    • van der Helm-van Mil, A.R.1    Verpoort, K.N.2    Breedveld, F.C.3    Huizinga, T.W.4    Toes, R.E.5    de Vries, R.R.6
  • 89
    • 29144460980 scopus 로고    scopus 로고
    • Regulation of anticyclic citrullinated peptide antibodies in rheumatoid arthritis: Contrasting effects of HLA-DR3 and the shared epitope alleles
    • Irigoyen P, Lee AT, Wener MH, Li W, Kern M, et al. 2005. Regulation of anticyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles. Arthritis Rheum. 52:3813-18
    • (2005) Arthritis Rheum , vol.52 , pp. 3813-3818
    • Irigoyen, P.1    Lee, A.T.2    Wener, M.H.3    Li, W.4    Kern, M.5
  • 90
    • 28144441356 scopus 로고    scopus 로고
    • Replication of putative candidate-gene associations with rheumatoid arthritis in >4000 samples from North America and Sweden: Association of susceptibility with PTPN22, CTLA4, and PADI4
    • Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, et al. 2005. Replication of putative candidate-gene associations with rheumatoid arthritis in >4000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am. J. Hum. Genet. 77:1044-60
    • (2005) Am. J. Hum. Genet , vol.77 , pp. 1044-1060
    • Plenge, R.M.1    Padyukov, L.2    Remmers, E.F.3    Purcell, S.4    Lee, A.T.5
  • 91
    • 25444455578 scopus 로고    scopus 로고
    • Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort
    • Wesoly J, van der Helm-van Mil AH, Toes RE, Chokkalingam AP, Carlton VE, et al. 2005. Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort. Arthritis Rheum. 52:2948-50
    • (2005) Arthritis Rheum , vol.52 , pp. 2948-2950
    • Wesoly, J.1    van der Helm-van Mil, A.H.2    Toes, R.E.3    Chokkalingam, A.P.4    Carlton, V.E.5
  • 92
    • 34247626741 scopus 로고    scopus 로고
    • Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis
    • Källberg H, Padyukov L, Plenge RM, Rönnelid J, Gregersen PK, et al. 2007. Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Am. J. Hum. Genet. 80:867-75
    • (2007) Am. J. Hum. Genet , vol.80 , pp. 867-875
    • Källberg, H.1    Padyukov, L.2    Plenge, R.M.3    Rönnelid, J.4    Gregersen, P.K.5
  • 93
    • 34547492359 scopus 로고    scopus 로고
    • Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis
    • Sigurdsson S, Padyukov L, Kurreeman FA, Liljedahl U, Wiman AC, et al. 2007. Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. Arthritis Rheum. 56:2202-10
    • (2007) Arthritis Rheum , vol.56 , pp. 2202-2210
    • Sigurdsson, S.1    Padyukov, L.2    Kurreeman, F.A.3    Liljedahl, U.4    Wiman, A.C.5
  • 94
    • 34547762142 scopus 로고    scopus 로고
    • Association with arthritis of a gene complex encoding C-type lectin-like receptors
    • Lorentzen JC, Flomes L, Eklöw C, Bäckdahl L, Ribbhammar U, et al. 2007. Association with arthritis of a gene complex encoding C-type lectin-like receptors. Arthritis Rheum. 56:2620-32
    • (2007) Arthritis Rheum , vol.56 , pp. 2620-2632
    • Lorentzen, J.C.1    Flomes, L.2    Eklöw, C.3    Bäckdahl, L.4    Ribbhammar, U.5
  • 96
    • 33747457301 scopus 로고    scopus 로고
    • In the rat, citrullinated autologous fibrinogen is immunogenic but the induced autoimmune response is not arthritogenic
    • Duplan V, Foulquier C, Clavel C, Al Badine R, Serre G, et al. 2006. In the rat, citrullinated autologous fibrinogen is immunogenic but the induced autoimmune response is not arthritogenic. Clin. Exp. Immunol. 145:502-12
    • (2006) Clin. Exp. Immunol , vol.145 , pp. 502-512
    • Duplan, V.1    Foulquier, C.2    Clavel, C.3    Al Badine, R.4    Serre, G.5
  • 97
    • 3242713277 scopus 로고    scopus 로고
    • A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    • Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, et al. 2004. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am. J. Hum. Genet. 75:330-37
    • (2004) Am. J. Hum. Genet , vol.75 , pp. 330-337
    • Begovich, A.B.1    Carlton, V.E.2    Honigberg, L.A.3    Schrodi, S.J.4    Chokkalingam, A.P.5
  • 98
    • 16244411098 scopus 로고    scopus 로고
    • Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond
    • Gregersen PK. 2005. Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond. Immunol. Rev. 204:74-86
    • (2005) Immunol. Rev , vol.204 , pp. 74-86
    • Gregersen, P.K.1
  • 99
    • 65949107734 scopus 로고    scopus 로고
    • PTPN22 polymorphism and anticyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease
    • Johansson M, Arlestig L, Hallmans G, Rantapaa-Dahlqvist S. 2006. PTPN22 polymorphism and anticyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease. Arthritis Res. Ther. 8:R19
    • (2006) Arthritis Res. Ther , vol.8
    • Johansson, M.1    Arlestig, L.2    Hallmans, G.3    Rantapaa-Dahlqvist, S.4
  • 100
    • 34447273288 scopus 로고    scopus 로고
    • The PTPN22 1858C/T polymorphism is associated with anticyclic citrullinated peptide antibody positive early rheumatoid arthritis in northern Sweden
    • Kokkonen H, Johansson M, Innala L, Eriksson C, Jidell E, Rantapaa Dahlqvist S. 2007. The PTPN22 1858C/T polymorphism is associated with anticyclic citrullinated peptide antibody positive early rheumatoid arthritis in northern Sweden. Arthritis Res. Ther. 9:R56
    • (2007) Arthritis Res. Ther , vol.9
    • Kokkonen, H.1    Johansson, M.2    Innala, L.3    Eriksson, C.4    Jidell, E.5    Rantapaa Dahlqvist, S.6
  • 101
    • 70449491816 scopus 로고    scopus 로고
    • Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: Higher frequency of the risk allele in male compared to female patients
    • Pierer M, Kaltenhauser S, Arnold S, Wahle M, Baerwald C, et al. 2006. Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients. Arthritis Res. Ther. 8:R75
    • (2006) Arthritis Res. Ther , vol.8
    • Pierer, M.1    Kaltenhauser, S.2    Arnold, S.3    Wahle, M.4    Baerwald, C.5
  • 102
    • 34548849168 scopus 로고    scopus 로고
    • Genome-wide search identifies TRAF1-C5 as rheumatoid arthritis risk locus
    • Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, et al. 2007. Genome-wide search identifies TRAF1-C5 as rheumatoid arthritis risk locus. N. Engl. J. Med. 357:1199-209
    • (2007) N. Engl. J. Med , vol.357 , pp. 1199-1209
    • Plenge, R.M.1    Seielstad, M.2    Padyukov, L.3    Lee, A.T.4    Remmers, E.F.5
  • 103
    • 42649084900 scopus 로고    scopus 로고
    • A genome-wide SNP association study identifies novel risk loci for rheumatoid arthritis in Swedish EIRA study
    • Seielstad M, Padyukov L, Ding B, Plenge RM, Alfredsson L, Klareskog L. 2007. A genome-wide SNP association study identifies novel risk loci for rheumatoid arthritis in Swedish EIRA study. Ann. Rheum. Dis. 66(Suppl. II):680
    • (2007) Ann. Rheum. Dis , vol.66 , Issue.SUPPL. II , pp. 680
    • Seielstad, M.1    Padyukov, L.2    Ding, B.3    Plenge, R.M.4    Alfredsson, L.5    Klareskog, L.6
  • 105
    • 0029877828 scopus 로고    scopus 로고
    • Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins
    • Silman AJ, Newman J, MacGregor AJ. 1996. Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins. Arthritis Rheum. 39:732-35
    • (1996) Arthritis Rheum , vol.39 , pp. 732-735
    • Silman, A.J.1    Newman, J.2    MacGregor, A.J.3
  • 106
    • 0032944413 scopus 로고    scopus 로고
    • Current tobacco smoking, formal education, and the risk of rheumatoid arthritis
    • Uhlig T, Hagen KB, Kvien TK. 1999. Current tobacco smoking, formal education, and the risk of rheumatoid arthritis. J. Rheumatol. 26:47-54
    • (1999) J. Rheumatol , vol.26 , pp. 47-54
    • Uhlig, T.1    Hagen, K.B.2    Kvien, T.K.3
  • 107
    • 0041885145 scopus 로고    scopus 로고
    • Quantification of the influence of cigarette smoking on rheumatoid arthritis: Results from a population based case-control study, using incident cases
    • Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, et al. 2003. Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Ann. Rheum. Dis. 62:835-41
    • (2003) Ann. Rheum. Dis , vol.62 , pp. 835-841
    • Stolt, P.1    Bengtsson, C.2    Nordmark, B.3    Lindblad, S.4    Lundberg, I.5
  • 109
    • 0034018518 scopus 로고    scopus 로고
    • The effect of smoking on clinical, laboratory, and radiographic status in rheumatoid arthritis
    • Wolfe F. 2000. The effect of smoking on clinical, laboratory, and radiographic status in rheumatoid arthritis. J. Rheumatol. 27:630-37
    • (2000) J. Rheumatol , vol.27 , pp. 630-637
    • Wolfe, F.1
  • 110
    • 5644239636 scopus 로고    scopus 로고
    • A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis
    • Padyukov L, Silva C, Stolt P, Alfredsson L, Klareskog L. 2004. A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum. 50:3085-92
    • (2004) Arthritis Rheum , vol.50 , pp. 3085-3092
    • Padyukov, L.1    Silva, C.2    Stolt, P.3    Alfredsson, L.4    Klareskog, L.5
  • 111
    • 34248587913 scopus 로고    scopus 로고
    • Strong combined gene-environment effects in anticyclic citrullinated peptide-positive rheumatoid arthritis: A nationwide case-control study in Denmark
    • Pedersen M, Jacobsen S, Garred P, Madsen HO, Klarlund M, et al. 2007. Strong combined gene-environment effects in anticyclic citrullinated peptide-positive rheumatoid arthritis: a nationwide case-control study in Denmark. Arthritis Rheum. 56:1446-53
    • (2007) Arthritis Rheum , vol.56 , pp. 1446-1453
    • Pedersen, M.1    Jacobsen, S.2    Garred, P.3    Madsen, H.O.4    Klarlund, M.5
  • 112
    • 42649115632 scopus 로고    scopus 로고
    • Smoking is associated with anti-CCP positive RA in a dose dependent manner, results from the Swedish EIRA study
    • Källberg H, Padyukov L, Bengtsson C, Rönnelid J, Klareskog L, Alfredsson L. 2007. Smoking is associated with anti-CCP positive RA in a dose dependent manner, results from the Swedish EIRA study. Ann. Rheum. Dis. 66(Suppl. II):291
    • (2007) Ann. Rheum. Dis , vol.66 , Issue.SUPPL. II , pp. 291
    • Källberg, H.1    Padyukov, L.2    Bengtsson, C.3    Rönnelid, J.4    Klareskog, L.5    Alfredsson, L.6
  • 113
    • 34447509669 scopus 로고    scopus 로고
    • Interaction between smoking, the shared epitope, and anticyclic citrullinated peptide: A mixed picture in three large North American rheumatoid arthritis cohorts
    • Lee HS, Irigoyen P, Kern M, Lee A, Batliwalla F, et al. 2007. Interaction between smoking, the shared epitope, and anticyclic citrullinated peptide: a mixed picture in three large North American rheumatoid arthritis cohorts. Arthritis Rheum. 56:1745-53
    • (2007) Arthritis Rheum , vol.56 , pp. 1745-1753
    • Lee, H.S.1    Irigoyen, P.2    Kern, M.3    Lee, A.4    Batliwalla, F.5
  • 114
    • 33644669227 scopus 로고    scopus 로고
    • Association between occupational exposure to mineral oil and rheumatoid arthritis: Results from the Swedish EIRA case-control study
    • Sverdrup B, Kallberg H, Bengtsson C, Lundberg I, Padyukov L, et al. 2005. Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case-control study. Arthritis Res. Ther. 7:R1296-303
    • (2005) Arthritis Res. Ther , vol.7
    • Sverdrup, B.1    Kallberg, H.2    Bengtsson, C.3    Lundberg, I.4    Padyukov, L.5
  • 115
    • 0038107566 scopus 로고    scopus 로고
    • The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule
    • Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E. 2003. The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J. Immunol. 171:538-41
    • (2003) J. Immunol , vol.171 , pp. 538-541
    • Hill, J.A.1    Southwood, S.2    Sette, A.3    Jevnikar, A.M.4    Bell, D.A.5    Cairns, E.6
  • 116
  • 117
    • 0028288510 scopus 로고
    • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
    • Casciola-Rosen LA, Anhalt G, Rosen A. 1994. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med. 179:1317-30
    • (1994) J. Exp. Med , vol.179 , pp. 1317-1330
    • Casciola-Rosen, L.A.1    Anhalt, G.2    Rosen, A.3
  • 118
    • 0042667153 scopus 로고    scopus 로고
    • Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis
    • Suzuki A, Yamada R, Chang X, Tokuhiro S, Sawada T, et al. 2003. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat. Genet. 34:395-402
    • (2003) Nat. Genet , vol.34 , pp. 395-402
    • Suzuki, A.1    Yamada, R.2    Chang, X.3    Tokuhiro, S.4    Sawada, T.5
  • 119
    • 31044440425 scopus 로고    scopus 로고
    • A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans
    • Kang CP, Lee HS, Ju H, Cho H, Kang C, Bae SC. 2006. A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans. Arthritis Rheum. 54:90-96
    • (2006) Arthritis Rheum , vol.54 , pp. 90-96
    • Kang, C.P.1    Lee, H.S.2    Ju, H.3    Cho, H.4    Kang, C.5    Bae, S.C.6
  • 120
    • 1842733194 scopus 로고    scopus 로고
    • A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population
    • Barton A, Bowes J, Eyre S, Spreckley K, Hinks A, et al. 2004. A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population. Arthritis Rheum. 50:1117-21
    • (2004) Arthritis Rheum , vol.50 , pp. 1117-1121
    • Barton, A.1    Bowes, J.2    Eyre, S.3    Spreckley, K.4    Hinks, A.5
  • 121
    • 20144388805 scopus 로고    scopus 로고
    • A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French population
    • Caponi L, Petit-Teixeira E, Sebbag M, Bongiorni F, Moscato S, et al. 2005. A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French population. Ann. Rheum. Dis. 64:587-93
    • (2005) Ann. Rheum. Dis , vol.64 , pp. 587-593
    • Caponi, L.1    Petit-Teixeira, E.2    Sebbag, M.3    Bongiorni, F.4    Moscato, S.5
  • 124
    • 0842287339 scopus 로고    scopus 로고
    • Peptidyl-arginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjogren syndrome
    • Nissinen R, Paimela L, Julkunen H, Tienari PJ, Leirisalo-Repo M, et al. 2003. Peptidyl-arginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjogren syndrome. Scand. J. Rheumatol. 32:337-42
    • (2003) Scand. J. Rheumatol , vol.32 , pp. 337-342
    • Nissinen, R.1    Paimela, L.2    Julkunen, H.3    Tienari, P.J.4    Leirisalo-Repo, M.5
  • 125
    • 33645088938 scopus 로고    scopus 로고
    • Antibodies against transglutaminases, peptidylarginine deiminase and citrulline in rheumatoid arthritis - new pathways to epitope spreading
    • Roth EB, Stenberg P, Book C, Sjoberg K. 2006. Antibodies against transglutaminases, peptidylarginine deiminase and citrulline in rheumatoid arthritis - new pathways to epitope spreading. Clin. Exp. Rheumatol. 24:12-18
    • (2006) Clin. Exp. Rheumatol , vol.24 , pp. 12-18
    • Roth, E.B.1    Stenberg, P.2    Book, C.3    Sjoberg, K.4
  • 126
    • 34548434509 scopus 로고
    • Contribution to discussion on rheumatoid pneumoconiosis
    • Caplan A. 1963. Contribution to discussion on rheumatoid pneumoconiosis. Grundfr. Silikoseforsch. 6:345-49
    • (1963) Grundfr. Silikoseforsch , vol.6 , pp. 345-349
    • Caplan, A.1
  • 127
    • 33644926954 scopus 로고    scopus 로고
    • Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anticitrullinated protein antibodies in rheumatoid arthritis
    • Pratesi F, Tommasi C, Anzilotti C, Chimenti D, Migliorini P. 2006. Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anticitrullinated protein antibodies in rheumatoid arthritis. Arthritis Rheum. 54:733-41
    • (2006) Arthritis Rheum , vol.54 , pp. 733-741
    • Pratesi, F.1    Tommasi, C.2    Anzilotti, C.3    Chimenti, D.4    Migliorini, P.5
  • 128
    • 0023413652 scopus 로고
    • Human leukocyte antigen (HLA) DR4. Positive association with rapidly progressing periodontitis
    • Katz J, Goultschin J, Benoliel R, Brautbar C. 1987. Human leukocyte antigen (HLA) DR4. Positive association with rapidly progressing periodontitis. J. Periodontol. 58:607-10
    • (1987) J. Periodontol , vol.58 , pp. 607-610
    • Katz, J.1    Goultschin, J.2    Benoliel, R.3    Brautbar, C.4
  • 129
    • 33745686201 scopus 로고    scopus 로고
    • The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction
    • Marotte H, Farge P, Gaudin P, Alexandre C, Mougin B, Miossec P. 2006. The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction. Ann. Rheum. Dis. 65:905-9
    • (2006) Ann. Rheum. Dis , vol.65 , pp. 905-909
    • Marotte, H.1    Farge, P.2    Gaudin, P.3    Alexandre, C.4    Mougin, B.5    Miossec, P.6
  • 130
    • 34547426477 scopus 로고    scopus 로고
    • Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms
    • Heinlen LD, McClain MT, Merrill J, Akbarali YW, Edgerton CC, et al. 2007. Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms. Arthritis Rheum. 56:2344-51
    • (2007) Arthritis Rheum , vol.56 , pp. 2344-2351
    • Heinlen, L.D.1    McClain, M.T.2    Merrill, J.3    Akbarali, Y.W.4    Edgerton, C.C.5
  • 131
    • 0036791894 scopus 로고    scopus 로고
    • Rheumatoid factor and antibodies to cyclic citrullinated peptide differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis
    • Jansen AL, van der Horst-Bruinsma I, van Schaardenburg D, van de Stadt RJ, de Koning MH, Dijkmans BA. 2002. Rheumatoid factor and antibodies to cyclic citrullinated peptide differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis. J. Rheumatol. 29:2074-76
    • (2002) J. Rheumatol , vol.29 , pp. 2074-2076
    • Jansen, A.L.1    van der Horst-Bruinsma, I.2    van Schaardenburg, D.3    van de Stadt, R.J.4    de Koning, M.H.5    Dijkmans, B.A.6
  • 132
    • 0033607499 scopus 로고    scopus 로고
    • Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme
    • Matsumoto I, Staub A, Benoist C, Mathis D. 1999. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science 286:1732-35
    • (1999) Science , vol.286 , pp. 1732-1735
    • Matsumoto, I.1    Staub, A.2    Benoist, C.3    Mathis, D.4
  • 133
    • 33645940600 scopus 로고    scopus 로고
    • Particularities of the vasculature can promote the organ specificity of autoimmune attack
    • Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, et al. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat. Immunol. 7:284-92
    • (2006) Nat. Immunol , vol.7 , pp. 284-292
    • Binstadt, B.A.1    Patel, P.R.2    Alencar, H.3    Nigrovic, P.A.4    Lee, D.M.5
  • 134
    • 0028915680 scopus 로고
    • Undifferentiated arthritis in an early synovitis outpatient clinic
    • Hulsemann JL, Zeidler H. 1995. Undifferentiated arthritis in an early synovitis outpatient clinic. Clin. Exp. Rheumatol. 13:37-43
    • (1995) Clin. Exp. Rheumatol , vol.13 , pp. 37-43
    • Hulsemann, J.L.1    Zeidler, H.2
  • 136
    • 84969213492 scopus 로고    scopus 로고
    • Wellcome Trust Case Control Consort. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls. Nature 447:661-78
    • Wellcome Trust Case Control Consort. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls. Nature 447:661-78
  • 137
    • 25444508917 scopus 로고    scopus 로고
    • Antigen microarray profiling of autoantibodies in rheumatoid arthritis
    • Hueber W, Kidd BA, Tomooka BH, Lee BJ, Bruce B, et al. 2005. Antigen microarray profiling of autoantibodies in rheumatoid arthritis. Arthritis Rheum. 52:2645-55
    • (2005) Arthritis Rheum , vol.52 , pp. 2645-2655
    • Hueber, W.1    Kidd, B.A.2    Tomooka, B.H.3    Lee, B.J.4    Bruce, B.5


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