B-cell tolerance: Mechanisms and implications

Current Opinion in Immunology

Volumn 22, Issue 5, 2010, Pages 566-574

  Basten, Antony ^a,b   Silveira, Pablo A ^a,b  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; B CELL ACTIVATING FACTOR; CD22 ANTIGEN; CD5 ANTIGEN; CD69 ANTIGEN; FC RECEPTOR IIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; INTERLEUKIN 10; INTERLEUKIN 4; MYELOID DIFFERENTIATION FACTOR 88; RECOMBINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR;

ALLERGIC ENCEPHALOMYELITIS; ANTIGEN PRESENTATION; ANTIGEN STRUCTURE; ANTIPHOSPHOLIPID SYNDROME; AUTOIMMUNITY; B LYMPHOCYTE; CD4 CD8 RATIO; CELL DIFFERENTIATION; CLONAL ANERGY; DEPLETION; GOODPASTURE SYNDROME; GRAVES DISEASE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MYASTHENIA GRAVIS; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW; RHEUMATOID ARTHRITIS; SIALYLATION; SYSTEMIC SCLEROSIS; ULCERATIVE COLITIS;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; B-LYMPHOCYTES; HUMANS; IMMUNE TOLERANCE;

EID: 78049290499     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2010.08.001     Document Type: Review

References (67)

1. Yanaba K., Bouaziz J.D., Matsushita T., Magro C.M., St Clair E.W., Tedder T.F. B-lymphocyte contributions to human autoimmune disease. Immunol Rev 2008, 223:284-299.
2. Basten A., Brink R. Tolerance and autoimmunity: B cells. The Autoimmune Diseases 2006, 167-177. Academic Press. fourth edn. N.R. Rose, I.R. Mackay (Eds.).
3. von Boehmer H., Melchers F. Checkpoints in lymphocyte development and autoimmune disease. Nat Immunol 2010, 11:14-20.
4. Bretscher P., Cohn M. A theory of self-nonself discrimination. Science 1970, 169:1042-1049.
5. Duong B.H., Tian H., Ota T., Completo G., Han S., Vela J.L., Ota M., Kubitz M., Bovin N., Paulson J., et al. Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo. J Exp Med 2010, 207:173-187.
6. Chang W.W., Yu C.Y., Lin T.W., Wang P.H., Tsai Y.C. Soyasaponin I decreases the expression of alpha2,3-linked sialic acid on the cell surface and suppresses the metastatic potential of B16F10 melanoma cells. Biochem Biophys Res Commun 2006, 341:614-619.
7. Lyubchenko T., Dal Porto J.M., Holers V.M., Cambier J.C. Cutting edge: Complement (C3d)-linked antigens break B cell anergy. J Immunol 2007, 179:2695-2699.
8. Matzinger P. Friendly and dangerous signals: is the tissue in control?. Nat Immunol 2007, 8:11-13.
9. Hill N.J., Hultcrantz M., Sarvetnick N., Flodstrom-Tullberg M. The target tissue in autoimmunity-an influential niche. Eur J Immunol 2007, 37:589-597.
10. Kanta H., Mohan C. Three checkpoints in lupus development: central tolerance in adaptive immunity, peripheral amplification by innate immunity and end-organ inflammation. Genes Immun 2009, 10:390-396.
11. Ohata J., Zvaifler N.J., Nishio M., Boyle D.L., Kalled S.L., Carson D.A., Kipps T.J. Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol 2005, 174:864-870.
12. Zembala M., Asherson G.L., Noworolski J., Mayhew B. Contact sensitivity to picryl chloride: the occurrence of B suppressor cells in the lymph nodes and spleen of immunized mice. Cell Immunol 1976, 25:266-278.
13. Yanaba K., Bouaziz J.D., Haas K.M., Poe J.C., Fujimoto M., Tedder T.F. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 2008, 28:639-650.
14. Blair P.A., Norena L.Y., Flores-Borja F., Rawlings D.J., Isenberg D.A., Ehrenstein M.R., Mauri C. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity 2010, 32:129-140.
15. DiLillo D.J., Matsushita T., Tedder T.F. B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. Ann N Y Acad Sci 2010, 1183:38-57.
16. Tu W., Lau Y.L., Zheng J., Liu Y., Chan P.L., Mao H., Dionis K., Schneider P., Lewis D.B. Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells. Blood 2008, 112:2554-2562.
17. Frommer F., Heinen T.J., Wunderlich F.T., Yogev N., Buch T., Roers A., Bettelli E., Muller W., Anderton S.M., Waisman A. Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol 2008, 181:5748-5759.
18. Tretter T., Venigalla R.K., Eckstein V., Saffrich R., Sertel S., Ho A.D., Lorenz H.M. Induction of CD4+ T-cell anergy and apoptosis by activated human B cells. Blood 2008, 112:4555-4564.
19. Thaunat O., Morelon E., Defrance T. Am" B" valent: anti-CD20 antibodies unravel the dual role of B cells in immunopathogenesis. Blood 2010, 116:515-521.
20. Matsushita T., Yanaba K., Bouaziz J.D., Fujimoto M., Tedder T.F. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest 2008, 118:3420-3430.
21. Haas K.M., Watanabe R., Matsushita T., Nakashima H., Ishiura N., Okochi H., Fujimoto M., Tedder T.F. Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice. J Immunol 2010, 184:4789-4800.
22. Turka L.A., Lechler R.I. Towards the identification of biomarkers of transplantation tolerance. Nat Rev Immunol 2009, 9:521-526.
23. Zarkhin V., Kambham N., Li L., Kwok S., Hsieh S.C., Salvatierra O., Sarwal M.M. Characterization of intra-graft B cells during renal allograft rejection. Kidney Int 2008, 74:664-673.
24. Wardemann H., Nussenzweig M.C. B-cell self-tolerance in humans. Adv Immunol 2007, 95:83-110.
25. Goodnow C.C., Sprent J., Fazekas de St Groth B., Vinuesa C.G. Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 2005, 435:590-597.
26. Keenan R.A., De Riva A., Corleis B., Hepburn L., Licence S., Winkler T.H., Martensson I.L. Censoring of autoreactive B cell development by the pre-B cell receptor. Science 2008, 321:696-699.
27. Henderson R.B., Grys K., Vehlow A., de Bettignies C., Zachacz A., Henley T., Turner M., Batista F., Tybulewicz V.L. A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival. J Exp Med 2010, 207:837-853.
28. Vinuesa C.G., Sanz I., Cook M.C. Dysregulation of germinal centres in autoimmune disease. Nat Rev Immunol 2009, 9:845-857.
29. Shlomchik M.J. Sites and stages of autoreactive B cell activation and regulation. Immunity 2008, 28:18-28.
30. Fan X., Ang A., Pollock-Barziv S.M., Dipchand A.I., Ruiz P., Wilson G., Platt J.L., West L.J. Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation. Nat Med 2004, 10:1227-1233.
31. Urschel S., Campbell P.M., Meyer S.R., Larsen I.M., Nuebel J., Birnbaum J., Netz H., Tinckam K., Kauke T., Derkatz K., et al. Absence of donor-specific anti-HLA antibodies after ABO-incompatible heart transplantation in infancy: altered immunity or age?. Am J Transplant 2010, 10:149-156.
32. Hasler P., Zouali M. Subversion of B lymphocyte signaling by infectious agents. Genes Immun 2003, 4:95-103.
33. Rudnicka D., Schwartz O. Intrusive HIV-1-infected cells. Nat Immunol 2009, 10:933-934.
34. Baldari C.T., Lanzavecchia A., Telford J.L. Immune subversion by Helicobacter pylori. Trends Immunol 2005, 26:199-207.
35. Halverson R., Torres R.M., Pelanda R. Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nat Immunol 2004, 5:645-650.
36. Liu S., Velez M.G., Humann J., Rowland S., Conrad F.J., Halverson R., Torres R.M., Pelanda R. Receptor editing can lead to allelic inclusion and development of B cells that retain antibodies reacting with high avidity autoantigens. J Immunol 2005, 175:5067-5076.
37. Isnardi I., Ng Y.S., Srdanovic I., Motaghedi R., Rudchenko S., von Bernuth H., Zhang S.Y., Puel A., Jouanguy E., Picard C., et al. IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Immunity 2008, 29:746-757.
38. Zhang Y., Su S.C., Hecox D.B., Brady G.F., Mackin K.M., Clark A.G., Foster M.H. Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. J Immunol 2008, 181:6092-6100.
39. Jellusova J., Wellmann U., Amann K., Winkler T.H., Nitschke L. CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity. J Immunol 2010, 184:3618-3627.
40. Fletcher C.A., Sutherland A.P., Groom J.R., Batten M.L., Ng L.G., Gommerman J., Mackay F. Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells. Eur J Immunol 2006, 36:2504-2514.
41. Sykes M. Immune tolerance: mechanisms and application in clinical transplantation. J Intern Med 2007, 262:288-310.
42. Enders A., Bouillet P., Puthalakath H., Xu Y., Tarlinton D.M., Strasser A. Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J Exp Med 2003, 198:1119-1126.
43. Nossal G.J., Pike B.L. Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen. Proc Natl Acad Sci U S A 1980, 77:1602-1606.
44. Cambier J.C., Gauld S.B., Merrell K.T., Vilen B.J. B-cell anergy: from transgenic models to naturally occurring anergic B cells?. Nat Rev Immunol 2007, 7:633-643.
45. Merrell K.T., Benschop R.J., Gauld S.B., Aviszus K., Decote-Ricardo D., Wysocki L.J., Cambier J.C. Identification of anergic B cells within a wild-type repertoire. Immunity 2006, 25:953-962.
46. Duty J.A., Szodoray P., Zheng N.Y., Koelsch K.A., Zhang Q., Swiatkowski M., Mathias M., Garman L., Helms C., Nakken B., et al. Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors. J Exp Med 2009, 206:139-151.
47. Browne C.D., Del Nagro C.J., Cato M.H., Dengler H.S., Rickert R.C. Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. Immunity 2009, 31:749-760.
48. Kitaura Y., Jang I.K., Wang Y., Han Y.C., Inazu T., Cadera E.J., Schlissel M., Hardy R.R., Gu H. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity 2007, 26:567-578.
49. O'Neill S.K., Veselits M.L., Zhang M., Labno C., Cao Y., Finnegan A., Uccellini M., Alegre M.L., Cambier J.C., Clark M.R. Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells. Proc Natl Acad Sci U S A 2009, 106:6262-6267.
50. Kranich J., Krautler N.J., Heinen E., Polymenidou M., Bridel C., Schildknecht A., Huber C., Kosco-Vilbois M.H., Zinkernagel R., Miele G., et al. Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8. J Exp Med 2008, 205:1293-1302.
51. Zhao D.M., Thornton A.M., DiPaolo R.J., Shevach E.M. Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 2006, 107:3925-3932.
52. Ludwig-Portugall I., Hamilton-Williams E.E., Gottschalk C., Kurts C. Cutting edge: CD25+ regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens. J Immunol 2008, 181:4447-4451.
53. Healy J.I., Goodnow C.C. Positive versus negative signaling by lymphocyte antigen receptors. Annu Rev Immunol 1998, 16:645-670.
54. Meffre E., Wardemann H. B-cell tolerance checkpoints in health and autoimmunity. Curr Opin Immunol 2008, 20:632-638.
55. Panigrahi A.K., Goodman N.G., Eisenberg R.A., Rickels M.R., Naji A., Luning Prak E.T. RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes. J Exp Med 2008, 205:2985-2994.
56. Zouali M. Receptor editing and receptor revision in rheumatic autoimmune diseases. Trends Immunol 2008, 29:103-109.
57. Kumar K.R., Li L., Yan M., Bhaskarabhatla M., Mobley A.B., Nguyen C., Mooney J.M., Schatzle J.D., Wakeland E.K., Mohan C. Regulation of B cell tolerance by the lupus susceptibility gene Ly108. Science 2006, 312:1665-1669.
58. Makdasi E., Fischel R., Kat I., Eilat D. Autoreactive anti-DNA transgenic B cells in lupus-prone New Zealand black/New Zealand white mice show near perfect L chain allelic exclusion. J Immunol 2009, 182:6143-6148.
59. Cox S.L., Silveira P.A. Emerging roles for B lymphocytes in Type 1 diabetes. Expert Rev Clin Immunol 2009, 5:311-324.
60. Roy V., Chang N.H., Cai Y., Bonventi G., Wither J. Aberrant IgM signaling promotes survival of transitional T1 B cells and prevents tolerance induction in lupus-prone New Zealand black mice. J Immunol 2005, 175:7363-7371.
61. Xu Z., Duan B., Morel L. Genetics of autoreactive B cells. Front Biosci 2007, 12:1707-1721.
62. Vuyyuru R., Mohan C., Manser T., Rahman Z.S. The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints. J Immunol 2009, 183:5716-5727.
63. William J., Euler C., Primarolo N., Shlomchik M.J. B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation. J Immunol 2006, 176:2142-2151.
64. Kono D.H., Theofilopoulos A.N. Genetics of SLE in mice. Springer Semin Immunopathol 2006, 28:83-96.
65. Gregersen P.K., Olsson L.M. Recent advances in the genetics of autoimmune disease. Annu Rev Immunol 2009, 27:363-391.
66. Moser K.L., Kelly J.A., Lessard C.J., Harley J.B. Recent insights into the genetic basis of systemic lupus erythematosus. Genes Immun 2009, 10:373-379.
67. Chistiakov D.A., Chistiakov A.P. Is FCRL3 a new general autoimmunity gene?. Hum Immunol 2007, 68:375-383.