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1
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27544490377
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+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
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+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6:1123-1132.
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(2005)
Nat Immunol
, vol.6
, pp. 1123-1132
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Harrington, L.1
Hatton, R.2
Mangan, P.3
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2
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33646577466
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Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Lett Nat 2006; 441:235-238. This study demonstrates an important role of TGF-β in Th17 development and the simultaneous induction of regulatory T cells.
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Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Lett Nat 2006; 441:235-238. This study demonstrates an important role of TGF-β in Th17 development and the simultaneous induction of regulatory T cells.
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3
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33644964894
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Hoeve M, Savage N, de Boer T, et al. Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur J Immunol 2006; 36:661-670. An in-vitro human model supporting the mouse studies that IL-23 is implicated in Th17 development and not Th1, and IL-12 in Th1 development and not Th17. Here, IL-23 induces and IL-12 inhibits IL-17 expression in human T cells.
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Hoeve M, Savage N, de Boer T, et al. Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur J Immunol 2006; 36:661-670. An in-vitro human model supporting the mouse studies that IL-23 is implicated in Th17 development and not Th1, and IL-12 in Th1 development and not Th17. Here, IL-23 induces and IL-12 inhibits IL-17 expression in human T cells.
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4
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33644512418
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Tan S, Zhao J, Bi C, et al. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice. J Immunol 2006; 176:2872-2879. A study in protein kinase C theta deficient mice demonstrating the regulatory effects of protein kinase C theta on IL-17 production in experimental autoimmune encephalomyelitis.
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Tan S, Zhao J, Bi C, et al. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice. J Immunol 2006; 176:2872-2879. A study in protein kinase C theta deficient mice demonstrating the regulatory effects of protein kinase C theta on IL-17 production in experimental autoimmune encephalomyelitis.
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5
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33746210212
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PKC-theta-deficient mice are protected from Th1-dependent antigen-induced arthritis
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A study in protein kinase C theta deficient mice on the regulatory effects of protein kinase C theta in a mouse model of arthritis
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Healy A, Izmailova E, Fitzgerald M, et al. PKC-theta-deficient mice are protected from Th1-dependent antigen-induced arthritis. J Immunol 2006; 177:1886-1893. A study in protein kinase C theta deficient mice on the regulatory effects of protein kinase C theta in a mouse model of arthritis.
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(2006)
J Immunol
, vol.177
, pp. 1886-1893
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Healy, A.1
Izmailova, E.2
Fitzgerald, M.3
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6
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33745297345
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Toy D, Kugler D, Wolfson M, et al. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol 2006; 177:36-39. A key paper demonstrating that, in contrast to previous concepts, the functional IL-17R in the mouse is composed of two chains, IL-17RA and IL-17RC, which mediate IL-17A and IL-17F effects.
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Toy D, Kugler D, Wolfson M, et al. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol 2006; 177:36-39. A key paper demonstrating that, in contrast to previous concepts, the functional IL-17R in the mouse is composed of two chains, IL-17RA and IL-17RC, which mediate IL-17A and IL-17F effects.
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7
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23644450623
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RANK and RANKL expression as markers of dendritic cell-T cell interactions in paired samples of rheumatoid synovium and lymph nodes
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Page G, Miossec P. RANK and RANKL expression as markers of dendritic cell-T cell interactions in paired samples of rheumatoid synovium and lymph nodes. Arthritis Rheum 2005; 52:2307-2312.
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(2005)
Arthritis Rheum
, vol.52
, pp. 2307-2312
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Page, G.1
Miossec, P.2
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8
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33646490259
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Koenders M, Lubberts E, van de Loo F, et al. Interleukin-17 acts independently of TNF-alpha under arthritic conditions. J Immunol 2006; 176:6262-6269. An in-vivo mouse study demonstrating the dependence of IL-17 on TNF in early arthritis and the loss of this dependence in established disease.
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Koenders M, Lubberts E, van de Loo F, et al. Interleukin-17 acts independently of TNF-alpha under arthritic conditions. J Immunol 2006; 176:6262-6269. An in-vivo mouse study demonstrating the dependence of IL-17 on TNF in early arthritis and the loss of this dependence in established disease.
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10
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33745042388
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+ T cells. J Exp Med 2006; 203:1459-1470. This paper demonstrates the role of IL-7-dependent homeostatic expansion of T cells in joint inflammation. IL-6 receptor gp130 mutant mice show a destructive arthritis only in the presence STAT3/IL-7-induced homeostatic proliferation.
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+ T cells. J Exp Med 2006; 203:1459-1470. This paper demonstrates the role of IL-7-dependent homeostatic expansion of T cells in joint inflammation. IL-6 receptor gp130 mutant mice show a destructive arthritis only in the presence STAT3/IL-7-induced homeostatic proliferation.
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12
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33646353397
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Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes
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A study demonstrating that T cells from RA patients will spontaneously induce osteoclastogenesis in monocytes
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Miranda-Carus M, Benito-Miguel M, Balsa A, et al. Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes. Arthritis Rheum 2006; 54:1151-1164. A study demonstrating that T cells from RA patients will spontaneously induce osteoclastogenesis in monocytes.
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(2006)
Arthritis Rheum
, vol.54
, pp. 1151-1164
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Miranda-Carus, M.1
Benito-Miguel, M.2
Balsa, A.3
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13
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33745024234
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CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL-mediated osteoclastogenesis evidence of NFκB-dependent, CD40-mediated bone destruction in rheumatoid arthritis
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Lee H, Jeon H, Song E, et al. CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL-mediated osteoclastogenesis evidence of NFκB-dependent, CD40-mediated bone destruction in rheumatoid arthritis. Arthritis Rheum 2006; 54:1747-1758.
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(2006)
Arthritis Rheum
, vol.54
, pp. 1747-1758
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Lee, H.1
Jeon, H.2
Song, E.3
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14
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18644371735
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T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis
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Sawai H, Park Y, Roberson J, et al. T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis. Arthritis Rheum 2005; 52:1392-1401.
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(2005)
Arthritis Rheum
, vol.52
, pp. 1392-1401
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Sawai, H.1
Park, Y.2
Roberson, J.3
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15
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20744439542
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+ T cells and macrophages. Arthritis Rheum 2005; 52:1700-1710. IL-7, previously known to be implicated in T-cell differentiation, proliferation and survival, is shown to activate synovial T cells and macrophages.
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+ T cells and macrophages. Arthritis Rheum 2005; 52:1700-1710. IL-7, previously known to be implicated in T-cell differentiation, proliferation and survival, is shown to activate synovial T cells and macrophages.
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16
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13444268243
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Interleukin-7 deficiency in rheumatoid arthritis: Consequences for therapy-induced lymphopenia
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Ponchel F, Verburg R, Bingham S, et al. Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia. Arthritis Res Ther 2005; 7:R80-R92.
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(2005)
Arthritis Res Ther
, vol.7
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Ponchel, F.1
Verburg, R.2
Bingham, S.3
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17
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22544438174
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Cytokine production by dendritic cells genetically engineered to express IL-4:induction of Th2 responses and differential regulation of IL-12 and IL-23 synthesis
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Morita Y, Gupta R, Seidl K, et al. Cytokine production by dendritic cells genetically engineered to express IL-4:induction of Th2 responses and differential regulation of IL-12 and IL-23 synthesis. J Gene Med 2005; 7:869-877.
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(2005)
J Gene Med
, vol.7
, pp. 869-877
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Morita, Y.1
Gupta, R.2
Seidl, K.3
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18
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17644384896
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+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
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+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol 2005; 140:360-367.
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(2005)
Clin Exp Immunol
, vol.140
, pp. 360-367
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Möttönen, M.1
Heikkinen, J.2
Mustonen, L.3
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19
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22344432319
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Coexpression of CD25 and CD27 identifies FoxP3 regulatory T cells in inflamed synovia
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Ruprecht C, Gattorno M, Ferlito F, et al. Coexpression of CD25 and CD27 identifies FoxP3 regulatory T cells in inflamed synovia. J Exp Med 2005; 201:1793-1803.
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(2005)
J Exp Med
, vol.201
, pp. 1793-1803
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Ruprecht, C.1
Gattorno, M.2
Ferlito, F.3
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20
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33745813929
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Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
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Seddiki N, Santner-Nanan B, Martinson J, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203:1693-1700.
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(2006)
J Exp Med
, vol.203
, pp. 1693-1700
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Seddiki, N.1
Santner-Nanan, B.2
Martinson, J.3
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21
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hi T-regulatory cells. Blood 2006; 108:253-261. This study suuports previous data that the efficacy of anti-TNF therapy in RA may be due to both direct anti-inflammatory effects and due to the restoration of normal regulatory T-cell function.
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hi T-regulatory cells. Blood 2006; 108:253-261. This study suuports previous data that the efficacy of anti-TNF therapy in RA may be due to both direct anti-inflammatory effects and due to the restoration of normal regulatory T-cell function.
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22
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23844455192
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+ regulatory T cells from nonobese diabetic mice
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+ regulatory T cells from nonobese diabetic mice. J Immunol 2005; 175:3053-3059.
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(2005)
J Immunol
, vol.175
, pp. 3053-3059
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Masteller, E.1
Warner, M.2
Tang, Q.3
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24
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29744438008
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Activation of invariant NK T cells protects against experimental rheumatoid arthritis by an IL-10-dependent pathway
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Miellot A, Zhu R, Diem S, et al. Activation of invariant NK T cells protects against experimental rheumatoid arthritis by an IL-10-dependent pathway. Eur J Immunol 2005; 35:3704-3713.
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(2005)
Eur J Immunol
, vol.35
, pp. 3704-3713
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Miellot, A.1
Zhu, R.2
Diem, S.3
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25
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33748504567
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+ regulatory T cells
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The identification of a new immunoregulatory T-cell subset induced by dendritic cell vaccination
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+ regulatory T cells. J Immunol 2006; 177:3806-3813. The identification of a new immunoregulatory T-cell subset induced by dendritic cell vaccination.
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(2006)
J Immunol
, vol.177
, pp. 3806-3813
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Charbonnier, L.1
van Duivenvoorde, L.2
Apparailly, F.3
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27
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27744550642
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Outcome of intensive immunosuppression and autologous stem cell transplantation in patients with severe rheumatoid arthritis is associated with the composition of synovial T cell infiltration
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Verburg R, Flierman R, Sont J, et al. Outcome of intensive immunosuppression and autologous stem cell transplantation in patients with severe rheumatoid arthritis is associated with the composition of synovial T cell infiltration. Ann Rheum Dis 2005; 64:1397-1405.
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(2005)
Ann Rheum Dis
, vol.64
, pp. 1397-1405
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Verburg, R.1
Flierman, R.2
Sont, J.3
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28
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23644455857
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Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: Twelve-month results of a phase IIb, double-blind, randomized, placebo-controlled trial
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Kremer J, Dougados M, Emery P, et al. Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase IIb, double-blind, randomized, placebo-controlled trial. Arthritis Rheum 2005; 52:2263-2271.
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(2005)
Arthritis Rheum
, vol.52
, pp. 2263-2271
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Kremer, J.1
Dougados, M.2
Emery, P.3
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29
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Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition
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Genovese M, Becker J, Schiff M, et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition. N Engl J Med 2005; 353:1114-1123.
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(2005)
N Engl J Med
, vol.353
, pp. 1114-1123
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Genovese, M.1
Becker, J.2
Schiff, M.3
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30
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33749365296
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Safety of the selective costimulation modulator abatercept in rheumatoid arthritis patients recieving background biologic and nonbiologic disease-modifying antirheumatic drugs
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Weinblatt M, Combe B, Covucci A, et al. Safety of the selective costimulation modulator abatercept in rheumatoid arthritis patients recieving background biologic and nonbiologic disease-modifying antirheumatic drugs. Arthritis Rheum 2006; 54:2807-2816.
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(2006)
Arthritis Rheum
, vol.54
, pp. 2807-2816
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Weinblatt, M.1
Combe, B.2
Covucci, A.3
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31
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33846853779
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Selective co-stimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: A randomized clinical trial
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A RA clinical trial of combination treatment with abatercept and etanercept demonstrating lack of better efficacy and increased side effects
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Weinblatt M, Schiff M, Goldman A, et al. Selective co-stimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomized clinical trial. Ann Rheum Dis 2007; 66:228-234. A RA clinical trial of combination treatment with abatercept and etanercept demonstrating lack of better efficacy and increased side effects.
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(2007)
Ann Rheum Dis
, vol.66
, pp. 228-234
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Weinblatt, M.1
Schiff, M.2
Goldman, A.3
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32
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New therapeutics that treat rheumatoid arthritis by blocking T-cell activation
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Today, A good review on emerging T-cell-targeted therapies
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MacKenzie N. New therapeutics that treat rheumatoid arthritis by blocking T-cell activation. Drug Discov Today 2006; 11:952-956. A good review on emerging T-cell-targeted therapies.
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(2006)
Drug Discov
, vol.11
, pp. 952-956
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MacKenzie, N.1
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Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy results of a multicenter, randomized, double-blind, placebo-cntrolled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
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Cohen S, Emery P, Greenwald M, et al. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy results of a multicenter, randomized, double-blind, placebo-cntrolled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 2006; 54:2793-2806.
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(2006)
Arthritis Rheum
, vol.54
, pp. 2793-2806
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Cohen, S.1
Emery, P.2
Greenwald, M.3
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