Impact of age, sex, and exercise on brachial artery flow-mediated dilatation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 3, 2009, Pages

  Black, Mark A ^a   Cable, N Timothy ^a   Thijssen, Dick H J ^a,b   Green, Daniel J ^a,c  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Exercise training; Fitness; Upper limb nitric oxide dilator function

Indexed keywords

GLYCERYL TRINITRATE; NITRIC OXIDE;

ADULT; AGE; ARTICLE; BRACHIAL ARTERY; CARDIOVASCULAR DISEASE; ENDOTHELIAL DYSFUNCTION; EXERCISE; FEMALE; FITNESS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 69249113063     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00226.2009     Document Type: Article

References (55)

1. Betik AC, Luckham VB, Hughson RL. Flow-mediated dilation in human brachial artery after different circulatory occlusion conditions. Am J Physiol Heart Circ Physiol 286: H442-H448, 2004.
2. Black MA, Cable NT, Thijssen DH, Green DJ. Importance of measuring the time course of flow-mediated dilatation in humans. Hypertension 51: 203-210, 2008.
3. Black MA, Green DJ, Cable NT. Exercise prevents age-related decline in nitric-oxide-mediated vasodilator function in cutaneous microvessels. J Physiol 586: 3511-3524, 2008.
4. Brevetti G, Silvestro A, Schiano V, Chiariello M. Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease. Circulation 108: 2093-2098, 2003.
5. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 24: 471-476, 1994.
6. Charkoudian N, Joyner MJ, Barnes SA, Johnson CP, Eisenach JH, Dietz NM, Wallin BG. Relationship between muscle sympathetic nerve activity and systemic hemodynamics during nitric oxide synthase inhibition in humans. Am J Physiol Heart Circ Physiol 291: H1378-H1383, 2006.
7. Clarkson P, Montgomery HE, Mullen MJ, Donald AE, Powe AJ, Bull T, Jubb M, World M, Deanfield JE. Exercise training enhances endothelial function in young men. J Am Coll Cardiol 33: 1379-1385, 1999.
8. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer DS, Charbonneau F, Creager MA, Deanfield J, Drexer H, Gerhard-Herman M, Herrington D, Vallance P, Vogel R. Guidelines for the ultrasound assessment of flow-mediated vasodilation of the brachial artery. J Am Coll Cardiol 39: 257-265, 2002.
9. Dawson EA, Whyte GP, Black MA, Jones H, Hopkins ND, Oxborough D, Gaze D, Shave RE, Wilson M, George KP, Green DJ. Changes in vascular and cardiac function after prolonged strenuous exercise in humans. J Appl Physiol 105: 1562-1568, 2008.
10. Deanfield J, Donald A, Ferri C, Giannattasio C, Halcox J, Halligan S, Lerman A, Mancia G, Oliver JJ, Pessina AC, Rizzoni D, Rossi GP, Salvetti A, Schiffrin EL, Taddei S, Webb DJ. Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens 23: 7-17, 2005.
11. DeSouza CA, Shapiro LF, Clevenger C, Dinenno FA, Monahan KD, Tanaka H, Seals DR. Regular aerobic exercise prevents and restores the age-related decile in endothelium-dependent vasodilation. Circulation 102: 1351-1357, 2000.
12. Doshi SN, Naka KK, Payne N, Jones CJ, Ashton M, Lewis MJ, Goodfellow J. Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide. Clin Sci (Lond) 101: 629-635, 2001.
13. Dyson KS, Shoemaker JK, Hughson RL. Effect of acute sympathetic nervous system activation on flow-mediated dilation of brachial artery. Am J Physiol Heart Circ Physiol 290: H1446-H1453, 2006.
14. Eskurza I, Kahn ZD, Seals DR. Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing. J Physiol 571: 661-668, 2006.
15. Eskurza I, Monahan KD, Robinson JA, Seals DR. Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing. J Physiol 556: 315-324, 2004.
16. Eskurza I, Myerburgh LA, Kahn ZD, Seals DR. Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J Physiol 568: 1057-1065, 2005.
17. Franzoni F, Ghiadoni L, Galetta F, Plantinga Y, Lubrano V, Huang Y, Salvetti G, Regoli F, Taddei S, Santoro G, Salvetti A. Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men. Am J Hypertens 18: 510-516, 2005.
18. Gates PE, Boucher ML, Silver AE, Monahan KD, Seals DR. Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression. J Appl Physiol 102: 63-71, 2007.
19. Green DJ. Point-Counterpoint: Flow-mediated dilation does reflect nitric oxide-mediated endothelial function. J Appl Physiol 99: 1233-1234, 2005.
20. Green DJ, Maiorana AJ, O'Driscoll G, Taylor R. Topical Review: Effects of exercise training on vascular endothelial nitric oxide function in humans. J Physiol (Lond) 561: 1-25, 2004.
21. Hagmar M, Eriksson MJ, Lindholm C, Schenck-Gustafsson K, Hirschberg AL. Endothelial function in post-menopausal former elite athletes. Clin J Sport Med 16: 247-252, 2006.
22. Hashimoto M, Akishita M, Eto M, Ishikawa M, Kozaki K, Toba K, Sagara Y, Taketani Y, Orimo H, Ouchi Y. Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle. Circulation 92: 3431-3435, 1995.
23. Heiss C, Keymel S, Niesler U, Ziemann J, Kelm M, Kalka C. Impaired progenitor cell activity in age-related endothelial dysfunction. J Am Coll Cardiol 45: 1441-1448, 2005.
24. Hijmering ML, Stroes ES, Olijhoek J, Hutten BA, Blankestijn PJ, Rabelink TJ. Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation. J Am Coll Cardiol 39: 683-688, 2002.
25. Holowatz LA, Thompson-Torgerson CS, Kenney WL. Altered mechanisms of vasodilation in aged human skin. Exerc Sport Sci Rev 35: 119-125, 2007.
26. Jensen-Urstad K, Johansson J. Gender difference in age-related changes in vascular function. J Intern Med 250: 29-36, 2001.
27. Jodoin I, Bussieres LM, Tardif JC, Juneau M. Effect of a short-term primary prevention program on endothelium-dependent vasodilation in adults at risk for atherosclerosis. Can J Cardiol 15: 83-88, 1999.
28. Kasprzak JD, Klosinska M, Drozdz J. Clinical aspects of assessment of endothelial function. Pharmacol Rep 58, Suppl: 33-40, 2006.
29. Keisler H. Elementary Calculus: An Infinitesimal Approach. Boston: Prindle, Weber & Schmidt, 1986.
30. Maiorana A, O'Driscoll G, Cheetham C, Dembo L, Stanton K, Goodman C, Taylor R, Green D. The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol 38: 860-866, 2001.
31. Mullen MJ, Kharbanda RK, Cross J, Donald AE, Taylor M, Vallance P, Deanfield JE, MacAllister RJ. Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo. Circ Res 88: 145-151, 2001.
32. Narkiewicz K, Phillips BG, Kato M, Hering D, Bieniaszewski L, Somers VK. Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity. Hypertension 45: 522-525, 2005.
33. Newcomer SC, Leuenberger UA, Hogeman CS, Proctor DN. Heterogeneous vasodilator responses of human limbs: influence of age and habitual endurance training. Am J Physiol Heart Circ Physiol 289: H308-H315, 2005.
34. Parker BA, Ridout SJ, Proctor DN. Age and flow-mediated dilation: a comparison of dilatory responsiveness in the brachial and popliteal arteries. Am J Physiol Heart Circ Physiol 291: H3043-H3049, 2006.
35. Pyke KE, Tschakovsky ME. Peak vs. total reactive hyperemia: which determines the magnitude of flow-mediated dilation? J Appl Physiol 102: 1510-1519, 2007.
36. Rinder MR, Spina RJ, Ehsani AA. Enhanced endothelium-dependent vasodilation in older endurance-trained men. J Appl Physiol 88: 761-766, 2000.
37. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 340: 115-126, 1999.
38. Rywik TM, Blackman MR, Yataco AR, Vaitkevicius PV, Zink RC, Cottrell EH, Wright JG, Katzel LI, Fleg JL. Enhanced endothelial vasoreactivity in endurance-trained older men. J Appl Physiol 87: 2136-2142, 1999.
39. Seals DR, Moreau KL, Gates PE, Eskurza I. Modulatory influences on ageing of the vasculature in healthy humans. Exp Gerontol 41: 501-507, 2006.
40. Sen CK. Oxidants and antioxidants in exercise. J Appl Physiol 79: 675-686, 1995.
41. Taddei S, Galetta F, Virdis A, Ghiadoni L, Salvetti G, Franzoni F, Giusti C, Salvetti A. Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation 101: 2896-2901, 2000.
42. Taddei S, Virdis A, Mattei P, Ghiadoni L, Gennari A, Fasolo CB, Sudano I, Salvetti A. Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation 91: 1981-1987, 1995.
43. Taddei S, Virdis A, Mattei P, Salvetti A. Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension 21: 929-933, 1993.
44. Thijssen DH, Dawson EA, Black MA, Hopman MT, Cable NT, Green DJ. Brachial artery blood flow responses to different modalities of lower limb exercise. Med Sci Sport Exerc 41: 1072-1079, 2009.
45. Thijssen DH, Dawson EA, Tinken TM, Cable NT, Green DJ. Retrograde flow and shear rate acutely impair endothelial function in humans. Hypertension 53: 986-992, 2009.
46. Thijssen DH, de Groot P, Kooijman M, Smits P, Hopman MT. Sympathetic nervous system contributes to the age-related impairment of flow-mediated dilation of the superficial femoral artery. Am J Physiol Heart Circ Physiol 291: H3122-H3129, 2006.
47. Thijssen DH, de Groot PC, Smits P, Hopman MT. Vascular adaptations to 8-week cycling training in older men. Acta Physiol (Oxf) 190: 221-228, 2007.
48. Torgrimson BN, Meendering JR, Kaplan PF, Minson CT. Endothelial function across an oral contraceptive cycle in women using levonorgestrel and ethinyl estradiol. Am J Physiol Heart Circ Physiol 292: H2874-H2880, 2007.
49. Vita JA, Keaney JF. Endothelial function: a barometer for cardiovascular risk? Circulation 106: 640-642, 2002.
50. Watts K, Beye P, Siafarikas A, Davis EA, Jones TW, O'Driscoll G, Green DJ. Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents. J Am Coll Cardiol 43: 1823-1827, 2004.
51. Widlansky ME, Gokce N, Keaney JF Jr, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol 42: 1149-1160, 2003.
52. Woodman RJ, Playford DA, Watts GF, Cheetham C, Reed C, Taylor RR, Puddey IB, Beilin LJ, Burke V, Green D. Improved analysis of brachial artery ultrasound images using a novel edge-detection software system. J Appl Physiol 91: 929-937, 2001.
53. Wray DW, Uberoi A, Lawrenson L, Richardson RS. Evidence of preserved endothelial function and vascular plasticity with age. Am J Physiol Heart Circ Physiol 290: H1271-H1277, 2006.
54. Yataco AR, Corretti MC, Gardner AW, Womack CJ, Katzel LI. Endothelial reactivity and cardiac risk factors in older patients with peripheral arterial disease. Am J Cardiol 83: 754-758, 1999.
55. Zhang X, Zhao SP, Li XP, Gao M, Zhou QC. Endothelium-dependent and -independent functions are impaired in patients with coronary heart disease. Atherosclerosis 149: 19-24, 2000.