Cerebral hypoperfusion during hypoxic exercise following two different hypoxic exposures: Independence from changes in dynamic autoregulation and reactivity

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 5, 2008, Pages

  Ainslie, Philip N ^a   Hamlin, Michael ^b   Hellemans, John ^c   Rasmussen, Peter ^d   Ogoh, Shigehiko ^e  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b LINCOLN UNIVERSITY   (New Zealand)

^c Auckland University of Technology High Performance Sport New Zealand   (New Zealand)

^d University of Copenhagen   (Denmark)

^e UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Cerebral blood flow; Exercise; Hypoxia; Intermittent and continuous hypoxia

Indexed keywords

CARBON DIOXIDE;

ADULT; ARTICLE; AUTOREGULATION; BLOOD PRESSURE; BRAIN BLOOD FLOW; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; EXERCISE; FEMALE; HUMAN; HYPERCAPNIA; HYPOXIA; MALE; MIDDLE CEREBRAL ARTERY; NEAR INFRARED SPECTROSCOPY; NORMAL HUMAN; OXYGENATION; PERFUSION; PRIORITY JOURNAL; RESPIRATORY FUNCTION;

ADULT; ALTITUDE; ANOXIA; BLOOD PRESSURE; CARBON DIOXIDE; CEREBROVASCULAR CIRCULATION; EXERCISE; FEMALE; HOMEOSTASIS; HUMANS; HYPERCAPNIA; MALE; MUSCLE, SKELETAL; OXYGEN; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE; YOUNG ADULT;

EID: 57349148171     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90420.2008     Document Type: Article

References (48)

1. Aaslid R, Lindegaard KF, Sorteberg W, Nornes H. Cerebral autoregulation dynamics in humans. Stroke 20: 45-52, 1989.
2. Ainslie PN, Barach A, Cummings KJ, Murrell C, Hamlin M, Hellemans J. Cardiorespiratory and cerebrovascular responses to acute poikilocapnic hypoxia following intermittent and continuous exposure to hypoxia in humans. J Appl Physiol 102: 1953-1961, 2007.
3. Ainslie PN, Barach A, Murrell C, Hamlin M, Hellemans J, Ogoh S. Alterations in cerebral autoregulation and cerebral blood flow velocity during acute hypoxia: rest and exercise. Am J Physiol Heart Circ Physiol 292: H976-H983, 2007.
4. Al-Rawi PG, Kirkpatrick PJ. Tissue oxygen index: thresholds for cerebral ischemia using near-infrared spectroscopy. Stroke 37: 2720-2725, 2006.
5. Delpy MD, Armstrong RB, Godfrey DA, Laughlin MH, Ross CD, Wilkerson MK. Exercise increases blood flow to locomotor, vestibular, cardiorespiratory and visual regions of the brain in miniature swine. J Physiol (Lond) 533: 849-859, 2001.
6. Fletcher EC. Invited review: Physiological consequences of intermittent hypoxia: systemic blood pressure. J Appl Physiol 90: 1600-1605, 2001.
7. Forster HV, Dempsey JA, Birnbaum ML, Reddan WG, Thoden J, Grover RF, Rankin J. Effect of chronic exposure to hypoxia on ventilatory response to CO2 and hypoxia. J Appl Physiol 31: 586-592, 1971.
8. Foster GE, McKenzie DC, Milsom WK, Sheel AW. Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia. J Physiol 567: 689-699, 2005.
9. Foster GE, McKenzie DC, Sheel AW. Effects of enhanced human chemosensitivity on ventilatory responses to exercise. Exp Physiol 91: 221-228, 2006.
10. Fu Q, Townsend NE, Shiller SM, Martini ER, Okazaki K, Shibata S, Truijens MJ, Rodriguez FA, Gore CJ, Stray-Gundersen J, Levine BD. Intermittent hypobaric hypoxia exposure does not cause sustained alterations in autonomic control of blood pressure in young athletes. Am J Physiol Regul Integr Comp Physiol 292: R1977-R1984, 2007.
11. Garcia N, Hopkins S, FLP. Effects of intermittent hypoxia on the isocapnic hypoxic ventilatory response and erythropoiesis in humans. Respir Physiol 123: 39-49, 2000.
12. Hohimer AR, Hales JR, Rowell LB, Smith OA. Regional distribution of blood flow during mild dynamic leg exercise in the baboon. J Appl Physiol 55: 1173-1177, 1983.
13. 2 in the hypocapnic-hypercapnic range in humans. J Appl Physiol 95: 129-137, 2003.
14. Ide K, Pott F, Van Lieshout JJ, Secher NH. Middle cerebral artery blood velocity depends on cardiac output during exercise with a large muscle mass. Acta Physiol Scand 162: 13-20, 1998.
15. Imray CHE, Myers SD, Pattinson KTS, Bradwell AR, Chan CW, Harris S, Collins P, Wright AD. Effect of exercise on cerebral perfusion in humans at high altitude. J Appl Physiol 99: 699-706, 2005.
16. Jansen GF, Krins A, Basnyat B, Bosch A, Odoom JA. Cerebral autoregulation in subjects adapted and not adapted to high altitude. Stroke 31: 2314-2318, 2000.
17. Jobsis FF. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198: 1264-1267, 1977.
18. Jones NL, Robertson DG, Kane JW. Difference between end-tidal and arterial PCO2 in exercise. J Appl Physiol 47: 954-960, 1979.
19. Julian CG, Gore CJ, Wilber RL, Daniels JT, Fredericson M, Stray-Gundersen J, Hahn AG, Parisotto R, Levine BD. Intermittent normobaric hypoxia does not alter performance or erythropoietic markers in highly trained distance runners. J Appl Physiol 96: 1800-1807, 2004.
20. Katayama K, Sato Y, Ishida K, Mori S, Miyamura M. The effects of intermittent exposure to hypoxia during endurance exercise training on the ventilatory responses to hypoxia and hypercapnia in humans. Eur J Appl Physi Occup Physiol 78: 189-194, 1998.
21. Katayama K, Sato Y, Morotome Y, Shima N, Ishida K, Mori S, Miyamura M. Intermittent hypoxia increases ventilation and SaO2 during hypoxic exercise and hypoxic chemosensitivity. J Appl Physiol 90: 1431-1440, 2001.
22. Katayama K, Shima N, Sato Y, Qiu JC, Ishida K, Mori S, Miyamura M. Effect of intermittent hypoxia on cardiovascular adaptations and response to progressive hypoxia in humans. High Alt Med Biol 2: 501-508, 2001.
23. Kety SS, Schmidt CF. The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest 27: 476-483, 1948.
24. Kim MB, Ward DS, Cartwright CR, Kolano J, Chlebowski S, Henson LC. Estimation of jugular venous O2 saturation from cerebral oximetry or arterial O2 saturation during isocapnic hypoxia. J Clin Monit Comput 16: 191-199, 2000.
25. Kime R, Karlsen T, Nioka S, Lech G, Madsen O, Saeterdal R, Im J, Chance B, Stray-Gundersen J. Discrepancy between cardiorespiratory system and skeletal muscle in elite cyclists after hypoxic training (Abstract). Dyn Med 2: 4, 2003.
26. Koehle MS, Sheel AW, Milsom WK, McKenzie DC. Two patterns of daily hypoxic exposure and their effects on measures of chemosensitivity in humans. J Appl Physiol 103: 1973-1978, 2007.
27. Lusina SJC, Kennedy PM, Inglis JT, McKenzie DC, Ayas NT, Sheel AW. Long-term intermittent hypoxia increases sympathetic activity and chemosensitivity during acute hypoxia in humans. J Physiol (Lond) 575: 961-970, 2006.
28. Mahamed S, Duffin J. Repeated hypoxic exposures change respiratory chemoreflex control in humans. J Physiol (Lond) 534: 595-603, 2001.
29. Ogoh S, Dalsgaard MK, Yoshiga CC, Dawson EA, Keller DM, Raven PB, Secher NH. Dynamic cerebral autoregulation during exhaustive exercise in humans. Am J Physiol Heart Circ Physiol 288: H1461-H1467, 2005.
30. Panerai RB. Cerebral autoregulation: from models to clinical applications. Cardiovasc Eng 8: 42-59, 2008.
31. Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev 2: 161-192, 1990.
32. Peebles K, Celi L, McGrattan K, Murrell C, Thomas K, Ainslie PN. Human cerebrovascular and ventilatory CO2 reactivity to end-tidal, arterial and internal jugular vein PCO2. J Physiol 584: 347-357, 2007.
33. Prabhakar NR. Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J Appl Physiol 90: 1986-1994, 2001.
34. Rasmussen P, Dawson EA, Nybo L, van Lieshout JJ, Secher NH, Gjedde A. Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans. J Cereb Blood Flow Metab 27: 1082-1093, 2007.
35. 2 relates to ventilatory acclimatization at 4,300 m. J Appl Physiol 75: 1117-1122, 1993.
36. Roels B, Thomas C, Bentley DJ, Mercier J, Hayot M, Millet G. Effects of intermittent hypoxic training on amino and fatty acid oxidative combustion in human permeabilized muscle fibers. J Appl Physiol 102: 79-86, 2007.
37. Rostrup E, Law I, Pott F, Ide K, Knudsen GM. Cerebral hemodynamics measured with simultaneous PET and near-infrared spectroscopy in humans. Brain Res 954: 183-193, 2002.
38. Secher NH, Seifert T, Van Lieshout JJ. Cerebral blood flow and metabolism during exercise: implications for fatigue. J Appl Physiol 104: 306-314, 2008.
39. Skov L, Pryds O, Greisen G. Estimating cerebral blood flow in newborn infants: comparison of near infrared spectroscopy and 133Xe clearance. Pediatr Res 30: 570-573, 1991.
40. Strangman G, Culver JP, Thompson JH, Boas DA. A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation. Neuroimage 17: 719-731, 2002.
41. Sugawara J, Tanabe T, Miyachi M, Yamamoto K, Takahashi K, Iemitsu M, Otsuki T, Homma S, Maeda S, Ajisaka R, Matsuda M. Non-invasive assessment of cardiac output during exercise in healthy young humans: comparison between Modelflow method and Doppler echocardiography method. Acta Physiol Scand 179: 361-366, 2003.
42. Townsend NE, Gore CJ, Hahn AG, McKenna MJ, Aughey RJ, Clark SA, Kinsman T, Hawley JA, Chow CM. Living high-training low increases hypoxic ventilatory response of well-trained endurance athletes. J Appl Physiol 93: 1498-1505, 2002.
43. Van Osta A, Moraine JJ, Melot C, Mairbaurl H, Maggiorini M, Naeije R. Effects of high altitude exposure on cerebral hemodynamics in normal subjects. Stroke 36: 557-560, 2005.
44. Wang JS, Chen LY, Fu LL, Chen ML, Wong MK. Effects of moderate and severe intermittent hypoxia on vascular endothelial function and haemodynamic control in sedentary men. Eur J Appl Physiol 100: 127-135, 2007.
45. Whipp BJ. Peripheral chemoreceptor control of exercise hyperpnea in humans. Med Sci Sports Exerc 26: 337-347, 1994.
46. Wilber RL, Stray-Gundersen J, Levine BD. Effect of hypoxic "dose" on physiological responses and sea-level performance. Med Sci Sports Exerc 39: 1590-1599, 2007.
47. Williams IM, Vohra R, Farrell A, Picton AJ, Mortimer AJ, McCollum CN. Cerebral oxygen saturation, transcranial Doppler ultrasonography and stump pressure in carotid surgery. Br J Surg 81: 960-964, 1994.
48. Zhang R, Zuckerman JH, Giller CA, Levine BD. Transfer function analysis of dynamic cerebral autoregulation in humans. Am J Physiol Heart Circ Physiol 274: H233-H241, 1998.