Central nervous system effects of intranasally administered insulin during euglycemia in men

Diabetes

Volumn 48, Issue 3, 1999, Pages 557-563

  Kern, Werner ^a   Born, Jan ^a   Schreiber, Herbert ^b   Fehm, Horst L ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; EVOKED AUDITORY RESPONSE; GLUCOSE BLOOD LEVEL; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; INSULIN RELEASE; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0033014163     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.3.557     Document Type: Article

References (74)

1. Baskin DG, Figlewicz DP, Woods SC, Porte D Jr, Dorsa DM: Insulin in the brain. Annu Rev Psychol 49:334-347, 1987
2. Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte D Jr: Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev 13:387-413, 1992
3. Wallum BJ, Porte D Jr, Figlewicz DP, Jacobson L, Dorsa D: Cerebrospinal fluid insulin levels increase during intravenous insulin infusion in man. J Clin Endocrinol Metab 64:190-194, 1987
4. Schwartz MW, Sipols AJ, Kahn SE, Lattemann DP, Taborsky G Jr, Bergman RN, Woods SC, Porte D Jr Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid. Am J Physiol 259:E378-E383, 1990
5. Unger JW, Livingston JN, Moss AM: Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects. Prog Neurobiol 36:343-362, 1991
6. Palovcik RA, Philiphs MI, Kappy MS, Raizada MK: Insulin inhibits pyramidal neurons in hippocampal slices. Brain Res 309:187-191, 1984
7. Shibata S, Liou SY, Ueki S, Oomura Y: Inhibitory action of insulin on suprachiasmatic nucleus neurons in rat hypothalamic slice preparation. Physiol Behav 36:79-81, 1985
8. Johanson CE, Murphy VA: Acetazolamide and insulin alter choroid plexus epithelial cell (Na), pH and volume. Am J Physiol 258:F1538-F1546, 1990
9. Shapiro E, Brown SD, Saltiel AR, Schwartz JH: Short-term action of insulin on Aplysia neurons: generation of a possible novel modulator of ion channels. J Neurobiol 22:55-62, 1991
10. Masters BA, Shemer J, Judkins JH, Clarke DW, LeRoith D, Raizada MK: Insulin receptors and insulin action in dissociated brain cells. Brain Res 417:247-256, 1987
11. Oliver EH, Sartin JL, Dieberg G, Rahe CH, Marple DN, Kemppainen RJ: Effects of acute insulin deficiency on catecholamine and indolamine content and catecholamine turnover in microdissected hypothalamic nuclei in streptozotocin-diabetic rats. Acta Endocrinol (Copenhagen) 120:343-350, 1989
12. Peinado JM, Meyers RD: Norepinephrine release from PVN and lateral hypothalamus during perfusion with 2-DG or insulin in the sated and fasted rat. Pharmacol Biochem Behav 27:715-721, 1991
13. Figlewicz DP, Szot P: Insulin stimulates membrane phospholipid metabolism by enhancing endogenous alpha1-adrenergic activity in the rat hippocampus. Brain Res 550:101-107, 1991
14. Figlewicz DP, Brot MD, McCall AL, Szot P: Diabetes causes differential changes in CNS noradrenergic and dopaminergic neurons in the rat: a molecular study. Brain Res 736:54-60, 1996
15. McCall AL: The impact of diabetes on the CNS. Diabetes 41:557-570, 1992
16. Strachan MWJ, Deary IJ, Ewing FME, Frier BM: Is type II diabetes associated with an increased risk of cognitive dysfunction? Diabetes Care 20:438-145, 1997
17. Pozzessere G, Valle E, De Crignis S, Cordischi VM, Fattapposta F, Rizzo PA, Pietravalle P, Cristina G, Morano S, Di Mario U: Abnormalities of cognitive functions in IDDM revealed by F300 event-related potential analysis. Diabetes 40:952-958, 1991
18. Kurita A, Katayama K, Mochio S: Neurophysiological evidence for altered higher brain functions in NIDDM. Diabetes Care 19:361-364, 1996
19. The DCCT Research Group: Hypoglycemia in the diabetes control and complications trial. Diabetes 46:271-286, 1997
20. Kern W, Born J, Kerner W, Fehm HL: Changes in blood pressure and norepinephrine levels during a placebo-controlled euglycemic hyperinsulinemic clamp in healthy subjects (Abstract). Exp Clin Endocrinol Diabetes 105:37, 1997
21. Barnett EM, Perlman S: The olfactory nerve and not the trigeminal nerve is the major site of CNS entry for mouse hepatitis virus, strain JHM. Virology 194:185-191, 1993
22. Shankar V, Kao M, Hamir AN, Sheng H, Koprowski H, Dietzschold B: Kinetics of virus spread and changes in levels of several cytokine mRNAs in the brain after intranasal infection of rats with Borna disease virus. J Virol 66:992-998, 1992
23. Lafay F, Coulon P, Astic L, Saucier D, Riche D, Holley A, Flamand A: Spread of the CVS strain of rabies virus and of the avirulent mutant AvO1 along the olfactory pathways of the mouse after intranasal inoculation. Virology 183:320-330, 1991
24. Perlman S, Evans G, Afifi A: Effect of olfactory bulb ablation on spread of a neurotropic coronavirus into the mouse brain. J Exp Med 172:1127-1132, 1990
25. Morales JA, Herzog S, Kompter C, Frese K, Rott R: Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats. Med Microbiol Immunol Berl 177:51-68, 1988
26. Barthold SW: Olfactory neural pathway in mouse hepatitis virus nasoencephalitis. Acta Neuropathol Bert 76:502-506, 1988
27. Carbone KM, Duchala CS, Griffin JW, Kincaid AL, Narayan O: Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation. J Virol 61:3431-3440, 1987
28. Evans J, Hastings L Accumulation of Cd(II) in the CNS depending on the route of administration: intraperitoneal, intratracheal, or intranasal. Fundam Appl Toxicol 19:275-278, 1992
29. Hastings L, Evans JE: Olfactory primary neurons as a route of entry for toxic agents into the CNS. Neurotoxicology 12:707-714, 1991
30. Perl DP, Good PF: Uptake of aluminium into central nervous system along nasal-olfactory pathways (Letter). Lancet i:1028, 1987
31. Stortebecker P: Mercury poisoning from dental amalgam through a direct nose-brain transport (Letter). Lancet 1:1207, 1989
32. Sakane T, Akizuki M, Yoshida M, Yamashita S, Nadai T, Hashida M, Sezaki H: Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity. J Pharm Pharmacol 43:449-451, 1991
33. Balin BJ, Broadwell RD, Salcman M, El-Kalliny M: Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J Comp Neurol 251:260-280, 1980
34. Baker H, Spencer RF: Transneuronal transport of peroxidase-conjugated wheat germ agglutinin (WGA-HRP) from the olfactory epithelium to the brain of the adult rat. Exp Brain Res 63:461-173, 1986
35. Pietrowsky R, Born J, Kern W, Fehm HL: Functional evidence for a transmission of peptides along the olfactory systems into the brain in healthy humans. In The Peptidergic Neuron. Krisch B, Mentlein R, Eds. Birkhäuser, Basel, 1996, p. 291-296
36. Pietrowsky R, Thiemann A, Kern W, Fehm HL, Born J: A nose-brain pathway for psychotropic peptides: evidence from a brain evoked potential study with cholecystokinin. Psychoneuroendocrinology 21:559-572, 1996
37. Kern W, Schiefer B, Schwarzenburg J, Stange EF, Born J, Fehm HL: Evidence for central nervous effects of corticotropin-releasing hormone on gastric acid secretion in humans. Neuroendocrinology 65:291-298, 1997
38. Watanabe Y, Matsumoto Y, Kawamoto K, Yazawa S, Matsumoto M: Enhancing effect of cyclodextrins on nasal absorption of insulin and its duration in rabbits. Chem Pharm Bull Tokyo 40:3100-3104, 1992
39. Ilium L, Davis SS: Intranasal insulin. Clinical pharmacokinetics. Clin Pharmacokinet 23:30-41, 1992
40. Aungst BJ, Rogers NJ, Shefter E: Comparison of nasal, rectal, buccal, sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption promoter. J Pharmacol Exp Ther 244:23-27, 1988
41. Moses AC, Gordon GS, Carey MC, Flier JS: Insulin administered intranasally as an insulin-bile salt aerosol. Diabetes 32:1040-1047, 1983
42. Kern W, Kerner W, Pietrowsky R, Fehm HL, Born J: Effects of insulin and hypoglycemia on the auditory brainstem response in humans. J Neurophysiol 72:678-683, 1994
43. Kern W, Lieb K, Kerner W, Born J, Fehm HL: Differential effects of human and pork insulin-induced hypoglycemia on neuronal functions in humans. Diabetes 39:1091-1098, 1990
44. Kern W, Schlosser C, Kerner W, Pietrowsky R, Born J, Fehm HL: Evidence for effects of insulin on sensory processing in man. Diabetes 43:351-356, 1994
45. Näätänen R, Picton TW: The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. Psychophysiology 24:375-425, 1987
46. Donchin E: Surprise ... surprise? Psychophysiology 18:493-513, 1981
47. Janke W, Debus G: Die Eigenschaftswörterliste EWL, Göttingen, Hogrefe, 1978
48. Kern W, Peters A, Frühwald B, Born J, Fehm HL: Effects of hyperinsulinemia on sensory processing during an euglycemic clamp in healthy subjects. Exp Clin Endocrinol Diabetes 106:A15-A16, 1998
49. Tallroth G, Lindgren M, Stenberg G, Rosen I, Agardh CD: Neurophysiological changes during insulin-induced hypoglycaemia and in the recovery period following glucose infusion in type I (insulin-dependent) diabetes mellitus and in normal man. Diabetologia 33:319-323, 1990
50. Smid HGOM, Trümper BG, Pottag G, Wagner K, Lobmann R, Scheich H, Lehnert H, Heinze H-J: Differentiation of hypoglycemia induced cognitive impairments. Brain 120:1041-1056, 1997
51. Blackman JD, Towle VL, Lewis GF, Spire JP, Polonsky KS: Hypoglycemic thresholds for cognitive dysfunction in humans. Diabetes 39:828-835, 1990
52. Lingenfelser T, Overkamp D, Renn W, Buettner U, Kimmerle K, Schmalfuss A, Jakober B: Insulin-associated modulation of neuroendocrine counterregulation, hypoglycemia perception, and cerebral function in insulin-dependent diabetes mellitus: evidence for an intrinsic effect of insulin on the central nervous system. J Clin Endocrinol Metab 81:1197-1205, 1996
53. Donald MW, Erdahl DLW, Surridge DHC, Monga TN, Lawson JS, Bird CE, Letemendia FJJ: Functional correlates of reduced central conduction velocity in diabetic subjects. Diabetes 33:627-633, 1984
54. Fedele D, Martini A, Cardone C, Chomaccio F, Bellavere F, Molinari G, Negrin P, Crepaldi G: Impaired auditory brainstem evoked responses in insulin-dependent diabetic subjects. Diabetes 33:1085-1089, 1984
55. Seidl R, Birnbacher R, Hauser E, Bernert G, Freilinger M, Schober E: Brainstem auditory evoked potentials and visually evoked potentials in young patients with IDDM. Diabetes Care 19:1220-1224, 1996
56. Kurita A, Mochio S, Isogai Y: Changes in auditory P300 event-related potentials and brainstem evoked potentials in diabetes mellitus. Acta Neurol Scand 92:319-323, 1995
57. Uberall MA, Renner C, Edl S, Parzinger E, Wenzel D: VEP and ERP abnormalities in children and adolescents with prepubertal onset of insulin-dependent diabetes mellitus. Neuropediatrics 27:88-93, 1996
58. Boyd FT, Raizada MK: Effects of insulin and tunicamycin on neuronal insulin receptors in culture. Am J Physiol 245:C283-C287, 1983
59. Clarke DW, Boyd FT, Kappy MS, Raizada MK: Insulin stimulates macromolecular synthesis in cultured glial cells from brain. Am J Physiol 249:C484-C489, 1985
60. Lobmann R, Smid H, Pottag G, Wagner K, Heinze HJ, Lehnert H: Changes in information processing during a hypoglycemic clamp in type-II-diabetic patients (Abstract). Exp Clin Endocrinol Diabetes 106:S63, 1998
61. Ruchkin DS, Johnson R Jr, Mahaffey D, Sutton S: Towards a functional categorization of slow waves. Psychophysiology 25:339-353, 1988
62. Birbaumer N, Roberts LE, Lutzenberger W, Rockstroh B, Elbert T: Area-specific self-regulation of slow cortical potentials on the sagittal midline and its effects on behaviour. Electroenceph Clin Neurophysiol 84:353-361, 1992
63. Rockstroh B, Elbert T, Canavan AGMT, Lutzenberger W, Birbaumer N: Slow Cortical Potentials. 2nd ed. Munich, Germany, Urban and Schwarzenberg, 1989
64. Kalis D, Fabiani M, Donchin E: "P300" and memory: individual differences in the von Restorff effect. Cognitive Psychology 16:177-216, 1984
65. Mecklinger A, Kramer AF, Strayer DL: Event related potentials and EEG components in a semantic memory search task. Psychophysiology 29: 104-119, 1992
66. Tamburrano G, Lala A, Locuratolo N, Leonetti F, Sbraccia P, Giaccari A, Busco S, Porcu S: Electroencephalography and visually evoked potentials during moderate hypoglycemia. J Clin Endocrinol Metab 66:1301-1306, 1998
67. Gerbrandt LK, Lawrence JC, Erkardt MJ, Lloyd RL: Origin of the neocortically monitored theta rhythm in the curarized rat. Electroenceph Clin Neurophysiol 45:454-467, 1978
68. Shinba T, Andow Y, Shinozaki T, Ozawa N, Yamamoto K: Event-related potentials in the dorsal hippocampus of rats during an auditory discrimination task. Electroenceph Clin Neurophysiol 100:563-568, 1996
69. Halgren K, Squires NK, Wilson CL, Rohrbaugh JW, Babb TL, Crandall PH: Endogenous Potentials generated in the hippocampal formation and amygdala by infrequent events. Science 210:803-805, 1980
70. Okada YC, Kaufman L, Williamson SJ: The hippocampal formation as a source of the slow endogenous potentials. Electroenceph Clin Neurophysiol 55:417-426, 1983
71. Caudle RM: The demonstration of long latency potentials in the CA1 region of the rat hippocampal slice. Brain Res 613:247-250, 1993
72. Tarkka IM, Stokic DS, Basile LF, Papanicolaou AC: Electric source localization of the auditory P300 agrees with magnetic source localization. Electroenceph Clin Neurophysiol 96:538-545, 1995
73. Schwartz MW, Seeley RJ: Neuroendocrine responses to starvation and weight loss. N Engl J Med 336:1802-1811, 1997
74. Craft S, Peskind E, Schwartz MW, Schellenberg GD, Raskind M, Porte D Jr: Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease. Neurology 50:164-168, 1998