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Volumn 27, Issue 8, 2011, Pages 790-796

Intracellular pathways of pancreatic β-cell apoptosis in type 1 diabetes

Author keywords

cells; Apoptosis; Bcl 2; Fas; Glucotoxicity; Granzymes

Indexed keywords

BIM PROTEIN; CASPASE 8; CYTOKINE; DEATH RECEPTOR; FAS ANTIGEN; GLUCOSE; GRANZYME B; PERFORIN; PROCASPASE 8; PROTEIN BCL 2; PROTEIN BID; PUMA PROTEIN; REACTIVE OXYGEN METABOLITE; RIBOSE;

EID: 80855124182     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1253     Document Type: Article
Times cited : (19)

References (72)
  • 2
    • 0030937468 scopus 로고    scopus 로고
    • Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse
    • O'Brien BA, Harmon BV, Cameron DP, Allan DJ. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 1997; 46(5): 750-757.
    • (1997) Diabetes , vol.46 , Issue.5 , pp. 750-757
    • O'Brien, B.A.1    Harmon, B.V.2    Cameron, D.P.3    Allan, D.J.4
  • 3
    • 0031739726 scopus 로고    scopus 로고
    • Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes
    • Augstein P, Elefanty AG, Allison J, Harrison LC. Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes. Diabetologia 1998; 41(11): 1381-1388.
    • (1998) Diabetologia , vol.41 , Issue.11 , pp. 1381-1388
    • Augstein, P.1    Elefanty, A.G.2    Allison, J.3    Harrison, L.C.4
  • 4
    • 0031684177 scopus 로고    scopus 로고
    • Beta-cell apoptosis in an accelerated model of autoimmune diabetes
    • Augstein P, Stephens LA, Allison J, et al. Beta-cell apoptosis in an accelerated model of autoimmune diabetes. Mol Med 1998; 4(8): 495-501.
    • (1998) Mol Med , vol.4 , Issue.8 , pp. 495-501
    • Augstein, P.1    Stephens, L.A.2    Allison, J.3
  • 6
    • 54549087863 scopus 로고    scopus 로고
    • Apoptosis: stabbed in the BAX
    • Green DR, Chipuk JE. Apoptosis: stabbed in the BAX. Nature 2008; 455(7216): 1047-1049.
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1047-1049
    • Green, D.R.1    Chipuk, J.E.2
  • 7
    • 80855157351 scopus 로고    scopus 로고
    • Expression of pro- and anti-apoptotic molecules of the Bcl-2 family in human islets post-isolation
    • In press, Epub ahead of print] PMID: 21535910.
    • Campbell PD, Weinberg A, Chee J, et al. Expression of pro- and anti-apoptotic molecules of the Bcl-2 family in human islets post-isolation. Cell Transplant 2011; In press, [Epub ahead of print] PMID: 21535910.
    • (2011) Cell Transplant
    • Campbell, P.D.1    Weinberg, A.2    Chee, J.3
  • 8
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998; 94(4): 491-501.
    • (1998) Cell , vol.94 , Issue.4 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 9
    • 0033607006 scopus 로고    scopus 로고
    • Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
    • Yin XM, Wang K, Gross A, et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 1999; 400(6747): 886-891.
    • (1999) Nature , vol.400 , Issue.6747 , pp. 886-891
    • Yin, X.M.1    Wang, K.2    Gross, A.3
  • 10
    • 20044381271 scopus 로고    scopus 로고
    • A central role for Bid in granzyme B-induced apoptosis
    • Waterhouse NJ, Sedelies KA, Browne KA, et al. A central role for Bid in granzyme B-induced apoptosis. J Biol Chem 2005; 280(6): 4476-4482.
    • (2005) J Biol Chem , vol.280 , Issue.6 , pp. 4476-4482
    • Waterhouse, N.J.1    Sedelies, K.A.2    Browne, K.A.3
  • 11
    • 34147141585 scopus 로고    scopus 로고
    • The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest
    • Kaufmann T, Tai L, Ekert PG, et al. The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell 2007; 129(2): 423-433.
    • (2007) Cell , vol.129 , Issue.2 , pp. 423-433
    • Kaufmann, T.1    Tai, L.2    Ekert, P.G.3
  • 12
    • 0032536771 scopus 로고    scopus 로고
    • Two CD95 (APO-1/Fas) signaling pathways
    • Scaffidi C, Fulda S, Srinivasan A, et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J 1998; 17(6): 1675-1687.
    • (1998) EMBO J , vol.17 , Issue.6 , pp. 1675-1687
    • Scaffidi, C.1    Fulda, S.2    Srinivasan, A.3
  • 13
    • 0033883377 scopus 로고    scopus 로고
    • The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells
    • O'Reilly LA, Cullen L, Visvader J, et al. The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells. Am J Pathol 2000; 157(2): 449-461.
    • (2000) Am J Pathol , vol.157 , Issue.2 , pp. 449-461
    • O'Reilly, L.A.1    Cullen, L.2    Visvader, J.3
  • 14
    • 0031769792 scopus 로고    scopus 로고
    • Rapid hybridoma screening method for the identification of monoclonal antibodies to low-abundance cytoplasmic proteins
    • O'Reilly LA, Cullen L, Moriishi K, O'Connor L, Huang DC, Strasser A. Rapid hybridoma screening method for the identification of monoclonal antibodies to low-abundance cytoplasmic proteins. Biotechniques 1998; 25(5): 824-830.
    • (1998) Biotechniques , vol.25 , Issue.5 , pp. 824-830
    • O'Reilly, L.A.1    Cullen, L.2    Moriishi, K.3    O'Connor, L.4    Huang, D.C.5    Strasser, A.6
  • 15
    • 34250758642 scopus 로고    scopus 로고
    • ER stress triggers apoptosis by activating BH3-only protein Bim
    • Puthalakath H, O'Reilly LA, Gunn P, et al. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 2007; 129(7): 1337-1349.
    • (2007) Cell , vol.129 , Issue.7 , pp. 1337-1349
    • Puthalakath, H.1    O'Reilly, L.A.2    Gunn, P.3
  • 16
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet P, Metcalf D, Huang DC, et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999; 286(5445): 1735-1738.
    • (1999) Science , vol.286 , Issue.5445 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.C.3
  • 17
    • 0037148840 scopus 로고    scopus 로고
    • BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    • Bouillet P, Purton JF, Godfrey DI, et al. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 2002; 415(6874): 922-926.
    • (2002) Nature , vol.415 , Issue.6874 , pp. 922-926
    • Bouillet, P.1    Purton, J.F.2    Godfrey, D.I.3
  • 18
    • 0037037543 scopus 로고    scopus 로고
    • Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim
    • Davey GM, Kurts C, Miller JF, et al. Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J Exp Med 2002; 196(7): 947-955.
    • (2002) J Exp Med , vol.196 , Issue.7 , pp. 947-955
    • Davey, G.M.1    Kurts, C.2    Miller, J.F.3
  • 19
    • 0141959215 scopus 로고    scopus 로고
    • Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells
    • Enders A, Bouillet P, Puthalakath H, Xu Y, Tarlinton DM, Strasser A. Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J Exp Med 2003; 198(7): 1119-1126.
    • (2003) J Exp Med , vol.198 , Issue.7 , pp. 1119-1126
    • Enders, A.1    Bouillet, P.2    Puthalakath, H.3    Xu, Y.4    Tarlinton, D.M.5    Strasser, A.6
  • 20
    • 0036069819 scopus 로고    scopus 로고
    • Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim
    • Hildeman DA, Zhu Y, Mitchell TC, et al. Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity 2002; 16(6): 759-767.
    • (2002) Immunity , vol.16 , Issue.6 , pp. 759-767
    • Hildeman, D.A.1    Zhu, Y.2    Mitchell, T.C.3
  • 21
    • 38949119408 scopus 로고    scopus 로고
    • Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
    • Hughes PD, Belz GT, Fortner KA, Budd RC, Strasser A, Bouillet P. Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity 2008; 28(2): 197-205.
    • (2008) Immunity , vol.28 , Issue.2 , pp. 197-205
    • Hughes, P.D.1    Belz, G.T.2    Fortner, K.A.3    Budd, R.C.4    Strasser, A.5    Bouillet, P.6
  • 22
    • 0344198588 scopus 로고    scopus 로고
    • Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
    • Pellegrini M, Belz G, Bouillet P, Strasser A. Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci U S A 2003; 100(24): 14175-14180.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.24 , pp. 14175-14180
    • Pellegrini, M.1    Belz, G.2    Bouillet, P.3    Strasser, A.4
  • 23
    • 0242410719 scopus 로고    scopus 로고
    • p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
    • Villunger A, Michalak EM, Coultas L, et al. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 2003; 302(5647): 1036-1038.
    • (2003) Science , vol.302 , Issue.5647 , pp. 1036-1038
    • Villunger, A.1    Michalak, E.M.2    Coultas, L.3
  • 24
    • 10744228800 scopus 로고    scopus 로고
    • Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
    • Jeffers JR, Parganas E, Lee Y, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 2003; 4(4): 321-328.
    • (2003) Cancer Cell , vol.4 , Issue.4 , pp. 321-328
    • Jeffers, J.R.1    Parganas, E.2    Lee, Y.3
  • 25
    • 36348989734 scopus 로고    scopus 로고
    • Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis
    • Steckley D, Karajgikar M, Dale LB, et al. Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci 2007; 27(47): 12989-12999.
    • (2007) J Neurosci , vol.27 , Issue.47 , pp. 12989-12999
    • Steckley, D.1    Karajgikar, M.2    Dale, L.B.3
  • 26
    • 38049097948 scopus 로고    scopus 로고
    • Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice
    • Kieran D, Woods I, Villunger A, Strasser A, Prehn JH. Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice. Proc Natl Acad Sci U S A 2007; 104(51): 20606-20611.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.51 , pp. 20606-20611
    • Kieran, D.1    Woods, I.2    Villunger, A.3    Strasser, A.4    Prehn, J.H.5
  • 27
    • 33845913794 scopus 로고    scopus 로고
    • Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
    • Erlacher M, Labi V, Manzl C, et al. Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med 2006; 203(13): 2939-2951.
    • (2006) J Exp Med , vol.203 , Issue.13 , pp. 2939-2951
    • Erlacher, M.1    Labi, V.2    Manzl, C.3
  • 28
    • 0027979956 scopus 로고
    • Major histocompatibility complex class I-deficient NOD-beta 2-m null mice are diabetes and insulitis resistant
    • Serreze DV, Leiter EH, Christianson GJ, Greiner D, Roopenian DC. Major histocompatibility complex class I-deficient NOD-beta 2-m null mice are diabetes and insulitis resistant. Diabetes 1994; 43(3): 505-509.
    • (1994) Diabetes , vol.43 , Issue.3 , pp. 505-509
    • Serreze, D.V.1    Leiter, E.H.2    Christianson, G.J.3    Greiner, D.4    Roopenian, D.C.5
  • 29
    • 0028006398 scopus 로고
    • Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes
    • Wicker LS, Leiter EH, Todd JA, et al. Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes 1994; 43(3): 500-504.
    • (1994) Diabetes , vol.43 , Issue.3 , pp. 500-504
    • Wicker, L.S.1    Leiter, E.H.2    Todd, J.A.3
  • 30
    • 0034176744 scopus 로고    scopus 로고
    • Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions
    • Graser RT, DiLorenzo TP, Wang F, et al. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 2000; 164(7): 3913-3918.
    • (2000) J Immunol , vol.164 , Issue.7 , pp. 3913-3918
    • Graser, R.T.1    DiLorenzo, T.P.2    Wang, F.3
  • 31
    • 0030724897 scopus 로고    scopus 로고
    • Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
    • Verdaguer J, Schmidt D, Amrani A, Anderson B, Averill N, Santamaria P. Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. J Exp Med 1997; 186(10): 1663-1676.
    • (1997) J Exp Med , vol.186 , Issue.10 , pp. 1663-1676
    • Verdaguer, J.1    Schmidt, D.2    Amrani, A.3    Anderson, B.4    Averill, N.5    Santamaria, P.6
  • 32
    • 13344294394 scopus 로고    scopus 로고
    • CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells
    • Wong FS, Visintin I, Wen L, Flavell RA, Janeway CA Jr. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J Exp Med 1996; 183(1): 67-76.
    • (1996) J Exp Med , vol.183 , Issue.1 , pp. 67-76
    • Wong, F.S.1    Visintin, I.2    Wen, L.3    Flavell, R.A.4    Janeway Jr., C.A.5
  • 33
    • 1842289172 scopus 로고    scopus 로고
    • Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice
    • Kagi D, Odermatt B, Seiler P, Zinkernagel RM, Mak TW, Hengartner H. Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice. J Exp Med 1997; 186(7): 989-997.
    • (1997) J Exp Med , vol.186 , Issue.7 , pp. 989-997
    • Kagi, D.1    Odermatt, B.2    Seiler, P.3    Zinkernagel, R.M.4    Mak, T.W.5    Hengartner, H.6
  • 34
    • 33745617424 scopus 로고    scopus 로고
    • Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL
    • McKenzie MD, Dudek NL, Mariana L, et al. Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL. Int Immunol 2006; 18(6): 837-846.
    • (2006) Int Immunol , vol.18 , Issue.6 , pp. 837-846
    • McKenzie, M.D.1    Dudek, N.L.2    Mariana, L.3
  • 35
    • 33750602224 scopus 로고    scopus 로고
    • Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways
    • Dudek NL, Thomas HE, Mariana L, et al. Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways. Diabetes 2006; 55(9): 2412-2418.
    • (2006) Diabetes , vol.55 , Issue.9 , pp. 2412-2418
    • Dudek, N.L.1    Thomas, H.E.2    Mariana, L.3
  • 36
    • 33644856006 scopus 로고    scopus 로고
    • A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death
    • Sutton VR, Estella E, Li C, et al. A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death. Transplantation 2006; 81(2): 146-154.
    • (2006) Transplantation , vol.81 , Issue.2 , pp. 146-154
    • Sutton, V.R.1    Estella, E.2    Li, C.3
  • 37
    • 33749370738 scopus 로고    scopus 로고
    • Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid
    • Estella E, McKenzie MD, Catterall T, et al. Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid. Diabetes 2006; 55(8): 2212-2219.
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2212-2219
    • Estella, E.1    McKenzie, M.D.2    Catterall, T.3
  • 38
    • 33947496416 scopus 로고    scopus 로고
    • Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway
    • Casciola-Rosen L, Garcia-Calvo M, Bull HG, et al. Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway. J Biol Chem 2007; 282(7): 4545-4552.
    • (2007) J Biol Chem , vol.282 , Issue.7 , pp. 4545-4552
    • Casciola-Rosen, L.1    Garcia-Calvo, M.2    Bull, H.G.3
  • 39
    • 33846946478 scopus 로고    scopus 로고
    • Human and murine granzyme B exhibit divergent substrate preferences
    • Cullen SP, Adrain C, Luthi AU, Duriez PJ, Martin SJ. Human and murine granzyme B exhibit divergent substrate preferences. J Cell Biol 2007; 176(4): 435-444.
    • (2007) J Cell Biol , vol.176 , Issue.4 , pp. 435-444
    • Cullen, S.P.1    Adrain, C.2    Luthi, A.U.3    Duriez, P.J.4    Martin, S.J.5
  • 40
    • 33751252804 scopus 로고    scopus 로고
    • The major human and mouse granzymes are structurally and functionally divergent
    • Kaiserman D, Bird CH, Sun J, et al. The major human and mouse granzymes are structurally and functionally divergent. J Cell Biol 2006; 175(4): 619-630.
    • (2006) J Cell Biol , vol.175 , Issue.4 , pp. 619-630
    • Kaiserman, D.1    Bird, C.H.2    Sun, J.3
  • 41
    • 0029841157 scopus 로고    scopus 로고
    • The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus
    • Wang B, Gonzalez A, Benoist C, Mathis D. The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus. Eur J Immunol 1996; 26(8): 1762-1769.
    • (1996) Eur J Immunol , vol.26 , Issue.8 , pp. 1762-1769
    • Wang, B.1    Gonzalez, A.2    Benoist, C.3    Mathis, D.4
  • 43
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • Katz JD, Wang B, Haskins K, Benoist C, Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993; 74(6): 1089-1100.
    • (1993) Cell , vol.74 , Issue.6 , pp. 1089-1100
    • Katz, J.D.1    Wang, B.2    Haskins, K.3    Benoist, C.4    Mathis, D.5
  • 45
    • 0033178741 scopus 로고    scopus 로고
    • Evidence that beta cell death in the nonobese diabetic mouse is Fas independent
    • Thomas HE, Darwiche R, Corbett JA, Kay TW. Evidence that beta cell death in the nonobese diabetic mouse is Fas independent. J Immunol 1999; 163(3): 1562-1569.
    • (1999) J Immunol , vol.163 , Issue.3 , pp. 1562-1569
    • Thomas, H.E.1    Darwiche, R.2    Corbett, J.A.3    Kay, T.W.4
  • 46
    • 0030890721 scopus 로고    scopus 로고
    • The role of Fas in autoimmune diabetes
    • Chervonsky AV, Wang Y, Wong FS, et al. The role of Fas in autoimmune diabetes. Cell 1997; 89(1): 17-24.
    • (1997) Cell , vol.89 , Issue.1 , pp. 17-24
    • Chervonsky, A.V.1    Wang, Y.2    Wong, F.S.3
  • 47
    • 0030800122 scopus 로고    scopus 로고
    • Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice
    • Itoh N, Imagawa A, Hanafusa T, et al. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J Exp Med 1997; 186(4): 613-618.
    • (1997) J Exp Med , vol.186 , Issue.4 , pp. 613-618
    • Itoh, N.1    Imagawa, A.2    Hanafusa, T.3
  • 48
    • 0032506224 scopus 로고    scopus 로고
    • Mechanisms of beta cell death in diabetes: a minor role for CD95
    • Allison J, Strasser A. Mechanisms of beta cell death in diabetes: a minor role for CD95. Proc Natl Acad Sci U S A 1998; 95(23): 13818-13822.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.23 , pp. 13818-13822
    • Allison, J.1    Strasser, A.2
  • 49
    • 0034653419 scopus 로고    scopus 로고
    • Inhibition of autoimmune diabetes by Fas Ligand: the paradox is solved
    • Kim S, Kim KA, Hwang DY, et al. Inhibition of autoimmune diabetes by Fas Ligand: the paradox is solved. J Immunol 2000; 164: 2931-2936.
    • (2000) J Immunol , vol.164 , pp. 2931-2936
    • Kim, S.1    Kim, K.A.2    Hwang, D.Y.3
  • 50
    • 0033560930 scopus 로고    scopus 로고
    • Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice
    • Amrani A, Verdaguer J, Anderson B, Utsugi T, Bou S, Santamaria P. Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice. J Clin Invest 1999; 103(8): 1201-1209.
    • (1999) J Clin Invest , vol.103 , Issue.8 , pp. 1201-1209
    • Amrani, A.1    Verdaguer, J.2    Anderson, B.3    Utsugi, T.4    Bou, S.5    Santamaria, P.6
  • 51
    • 0037942773 scopus 로고    scopus 로고
    • Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice
    • Darwiche R, Chong MM, Santamaria P, Thomas HE, Kay TW. Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice. J Immunol 2003; 170: 6292-6297.
    • (2003) J Immunol , vol.170 , pp. 6292-6297
    • Darwiche, R.1    Chong, M.M.2    Santamaria, P.3    Thomas, H.E.4    Kay, T.W.5
  • 52
    • 0034175965 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci
    • Kanagawa O, Xu G, Tevaarwerk A, Vaupel BA. Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci. J Immunol 2000; 164(7): 3919-3923.
    • (2000) J Immunol , vol.164 , Issue.7 , pp. 3919-3923
    • Kanagawa, O.1    Xu, G.2    Tevaarwerk, A.3    Vaupel, B.A.4
  • 53
    • 21244498127 scopus 로고    scopus 로고
    • Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice
    • Allison J, Thomas HE, Catterall T, Kay TW, Strasser A. Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice. J Immunol 2005; 175(1): 293-301.
    • (2005) J Immunol , vol.175 , Issue.1 , pp. 293-301
    • Allison, J.1    Thomas, H.E.2    Catterall, T.3    Kay, T.W.4    Strasser, A.5
  • 54
    • 0141993915 scopus 로고    scopus 로고
    • Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes
    • Apostolou I, Hao Z, Rajewsky K, von Boehmer H. Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes. J Exp Med 2003; 198(7): 1103-1106.
    • (2003) J Exp Med , vol.198 , Issue.7 , pp. 1103-1106
    • Apostolou, I.1    Hao, Z.2    Rajewsky, K.3    von Boehmer, H.4
  • 56
    • 48449089654 scopus 로고    scopus 로고
    • Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells
    • McKenzie MD, Carrington EM, Kaufmann T, et al. Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells. Diabetes 2008; 57(5): 1284-1292.
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1284-1292
    • McKenzie, M.D.1    Carrington, E.M.2    Kaufmann, T.3
  • 57
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52(1): 102-110.
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 58
    • 0024213009 scopus 로고
    • Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes
    • Clark A, Wells CA, Buley ID, et al. Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 1988; 9(4): 151-159.
    • (1988) Diabetes Res , vol.9 , Issue.4 , pp. 151-159
    • Clark, A.1    Wells, C.A.2    Buley, I.D.3
  • 59
    • 0036163156 scopus 로고    scopus 로고
    • Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients
    • Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia 2002; 45(1): 85-96.
    • (2002) Diabetologia , vol.45 , Issue.1 , pp. 85-96
    • Sakuraba, H.1    Mizukami, H.2    Yagihashi, N.3    Wada, R.4    Hanyu, C.5    Yagihashi, S.6
  • 60
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008; 29(1): 42-61.
    • (2008) Endocr Rev , vol.29 , Issue.1 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 61
    • 33847677975 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
    • Laybutt DR, Preston AM, Akerfeldt MC, et al. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 2007; 50(4): 752-763.
    • (2007) Diabetologia , vol.50 , Issue.4 , pp. 752-763
    • Laybutt, D.R.1    Preston, A.M.2    Akerfeldt, M.C.3
  • 62
    • 74949118002 scopus 로고    scopus 로고
    • Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice
    • Matsuda T, Kido Y, Asahara S, et al. Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest 2010; 120(1): 115-126.
    • (2010) J Clin Invest , vol.120 , Issue.1 , pp. 115-126
    • Matsuda, T.1    Kido, Y.2    Asahara, S.3
  • 63
    • 55849096988 scopus 로고    scopus 로고
    • Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes
    • Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest 2008; 118(10): 3378-3389.
    • (2008) J Clin Invest , vol.118 , Issue.10 , pp. 3378-3389
    • Song, B.1    Scheuner, D.2    Ron, D.3    Pennathur, S.4    Kaufman, R.J.5
  • 64
    • 0037125997 scopus 로고    scopus 로고
    • A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity
    • Tanaka Y, Tran PO, Harmon J, Robertson RP. A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity. Proc Natl Acad Sci U S A 2002; 99(19): 12363-12368.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.19 , pp. 12363-12368
    • Tanaka, Y.1    Tran, P.O.2    Harmon, J.3    Robertson, R.P.4
  • 65
    • 70350310991 scopus 로고    scopus 로고
    • Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes
    • SUPPL.
    • Jonas JC, Bensellam M, Duprez J, Elouil H, Guiot Y, Pascal SM. Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes. Diabetes Obes Metab 2009; 11:(Suppl): 465-481.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 465-481
    • Jonas, J.C.1    Bensellam, M.2    Duprez, J.3    Elouil, H.4    Guiot, Y.5    Pascal, S.M.6
  • 66
    • 0033499583 scopus 로고    scopus 로고
    • Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity
    • Kaneto H, Kajimoto Y, Miyagawa J, et al. Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes 1999; 48(12): 2398-2406.
    • (1999) Diabetes , vol.48 , Issue.12 , pp. 2398-2406
    • Kaneto, H.1    Kajimoto, Y.2    Miyagawa, J.3
  • 67
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    • Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 2010; 11(2): 136-140.
    • (2010) Nat Immunol , vol.11 , Issue.2 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 68
    • 42449110310 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis
    • Chen J, Saxena G, Mungrue IN, Lusis AJ, Shalev A. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes 2008; 57(4): 938-944.
    • (2008) Diabetes , vol.57 , Issue.4 , pp. 938-944
    • Chen, J.1    Saxena, G.2    Mungrue, I.N.3    Lusis, A.J.4    Shalev, A.5
  • 69
    • 77950352322 scopus 로고    scopus 로고
    • Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax
    • McKenzie MD, Jamieson E, Jansen ES, et al. Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes 2010; 59(3): 644-652.
    • (2010) Diabetes , vol.59 , Issue.3 , pp. 644-652
    • McKenzie, M.D.1    Jamieson, E.2    Jansen, E.S.3
  • 70
    • 59449084679 scopus 로고    scopus 로고
    • Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations
    • Bensellam M, Van Lommel L, Overbergh L, Schuit FC, Jonas JC. Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations. Diabetologia 2009; 52(3): 463-476.
    • (2009) Diabetologia , vol.52 , Issue.3 , pp. 463-476
    • Bensellam, M.1    Van Lommel, L.2    Overbergh, L.3    Schuit, F.C.4    Jonas, J.C.5
  • 71
    • 16844377896 scopus 로고    scopus 로고
    • High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB
    • Elouil H, Cardozo AK, Eizirik DL, Henquin JC, Jonas JC. High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB. Diabetologia 2005; 48(3): 496-505.
    • (2005) Diabetologia , vol.48 , Issue.3 , pp. 496-505
    • Elouil, H.1    Cardozo, A.K.2    Eizirik, D.L.3    Henquin, J.C.4    Jonas, J.C.5
  • 72
    • 33644669584 scopus 로고    scopus 로고
    • Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?
    • Welsh N, Cnop M, Kharroubi I, et al. Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets? Diabetes 2005; 54(11): 3238-3244.
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3238-3244
    • Welsh, N.1    Cnop, M.2    Kharroubi, I.3


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