The proapoptotic BH3-only protein Bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

American Journal of Pathology

Volumn 157, Issue 2, 2000, Pages 449-461

  O’Reilly, Lorraine A ^a   Cullen, Leonie ^a   Visvader, Jane ^a   Lindeman, Geoffrey J ^a   Print, Cris ^a   Bath, Mary L ^a   Huang, David C S ^a   Strasser, Andreas ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; ISOPROTEIN; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOG; EPITHELIUM CELL; GERM CELL; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MONKEY; MOUSE; NERVE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; RAT;

EID: 0033883377     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64557-9     Document Type: Article

References (55)

1. An evolutionary perspective on apoptosis
2. Programmed cell death in animal development
3. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
4. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
5. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
6. Apoptosis and its role in human disease
7. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetic
8. The molecular biology of apoptosis
9. Caspases: Enemies within
10. Auto-activation of procaspase-9 by Apaf-1-mediated oligomerization
11. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis
12. The Bcl-2 protein family: Arbiters of cell survival
13. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
14. The C. elegans protein EGL-1 is required for programmed ceil death and interacts with the Bcl-2-like protein CED-9
15. Bim - A novel member of the Bcl-2 family that promotes apoptosis
16. The pro-apoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
17. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
18. Bcl-2, Bcl-X(L) and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death
19. Complexes of polyoma virus medium T antigen and cellular proteins
20. The structure of an antigenic determinant in a protein
21. Interaction cloning: Identification of a helix-loop-helix zipper protein that interacts with c-Fos
22. Antibodies to major histocompatibility antigens produced by hybrid cell lines
23. Rapid hybridoma screening method for the identification of monoclonal antibodies to low abundance cytoplasmic proteins
24. Alkaline phosphatase in hematopoietic tumor cell lines of the mouse: High activity in cells of the B lymphoid lineage
25. Bcr-abl-induced cell lines can switch from mast cell to erythroid or myeloid differentiation in vitro
26. Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages
27. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
28. Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system
29. Megakaryocytic differentiation induced in 416B myeloid cells by GATA-2 and GATA-3 transgenes or 5-azacytidine is tightly coupled to GATA-1 expression
30. Establishment of mouse cell lines, which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified eDNA expression vectors
31. The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry
32. Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant
33. Bcl-2 family members do not inhibit apoptosis by binding the caspase-activator Apaf-1
34. α-Cell neogenesis in an animal model of IDDM
35. Location of stem cells of human hair follicles by clonal analysis
36. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
37. Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
38. Apoptosis signaling
39. Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2
40. Immunohistochemical analysis of in vivo patterns of bak expression, a proapoptotic member of the Bcl-2 protein family
41. Bad can act as a key regulator of T cell apoptosis and T cell development
42. Immunohistochemical analysis of in vivo patterns of Bcl-X expression
43. Immunohistochemical analysis of Mcl-1 protein in human tissues
44. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
45. Hair anatomy for the clinician
46. Manipulation of outer root sheath cell survival perturbs the hair-growth cycle
47. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
48. Bcl-2 gene family in the nervous system
49. Cell death during development of the nervous system
50. The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid β protein
51. Bok is a proapoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
52. Bax-deficient mice with lymphoid hyperplasia and male germ cell death
53. Testicular degeneration in Bclw-deficient mice
54. Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival