Perforin and Fas induced by IFNγ and TNFα mediate beta cell death by OT-I CTL

International Immunology

Volumn 18, Issue 6, 2006, Pages 837-846

  McKenzie, Mark D ^a   Dudek, Nadine L ^a   Mariana, Lina ^a   Chong, Mark M W ^a   Trapani, Joseph A ^b   Kay, Thomas W H ^a   Thomas, Helen E ^a  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

Apoptosis; Autoimmunity; Cytotoxic T cells; Diabetes; Ovalbumin

Indexed keywords

FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; OVALBUMIN; PERFORIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL DEATH; CELL MEDIATED CYTOTOXICITY; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; IN VITRO STUDY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE; UPREGULATION; WILD TYPE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; AUTOANTIBODIES; CARRIER PROTEINS; CELL DEATH; DIABETES MELLITUS, TYPE 1; FAS LIGAND PROTEIN; GENES, MHC CLASS I; INSULIN-SECRETING CELLS; INTERFERON TYPE II; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; PEPTIDES; PORE FORMING CYTOTOXIC PROTEINS; RECEPTORS, INTERFERON; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR NECROSIS FACTOR-ALPHA; TUMOR NECROSIS FACTORS; UP-REGULATION;

EID: 33745617424     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxl020     Document Type: Article

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