Effective destruction of Fas-deficient insulin-producing β cells in type 1 diabetes

Journal of Experimental Medicine

Volumn 198, Issue 7, 2003, Pages 1103-1106

  Apostolou, Irina ^a   Hao, Zhenyue ^b   Rajewsky, Klaus ^c   Von Boehmer, Harald ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b Advanced Medical Discovery Institute   (Canada)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

cell death; Autoimmunity; Conditional knockout; Diabetes; Fas receptor

Indexed keywords

FAS ANTIGEN; INFLUENZA VIRUS HEMAGGLUTININ; INSULIN; PERFORIN; T LYMPHOCYTE RECEPTOR;

ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL DEATH; CELL DESTRUCTION; FAS GENE; GENE; GENE EXPRESSION; INSULIN DEPENDENT DIABETES MELLITUS; KNOCKOUT GENE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; DIABETES MELLITUS, TYPE 1; INSULIN; INTEGRASES; ISLETS OF LANGERHANS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED NOD; PROTEINS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; VIRAL PROTEINS;

EID: 0141993915     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030698     Document Type: Article

References (17)

1. Bach, J.F., and D. Mathis. 1997. The NOD mouse. Res. Immunol. 148:285-286.
2. Tisch, R., and H. McDevitt. 1996. Insulin-dependent diabetes mellitus. Cell. 85:291-297.
3. Degermann, S., C. Reilly, B. Scott, L. Ogata, H. von Boehmer, and D. Lo. 1994. On the various manifestations of spontaneous autoimmune diabetes in rodent models. Eur. J. Immunol. 24:3155-3160.
4. Scott, B., R. Liblau, S. Degermann, L.A. Marconi, L. Ogata, A.J. Caton, H.O. McDevitt, and D. Lo. 1994. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity. 1:73-83.
5. Sarukhan, A., A. Lanoue, A. Franzke, N. Brousse, J. Buer, and H. von Boehmer. 1998. Changes in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model. EMBO J. 17:71-80.
6. Katz, J.D., C. Benoist, and D. Mathis. 1995. T helper cell subsets in insulin-dependent diabetes. Science. 268:1185-1188.
7. Kagi, D., B. Odermatt, P. Seiler, R.M. Zinkernagel, T.W. Mak, and H. Hengartner. 1997. Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice. J. Exp. Med. 186:989-997.
8. Amrani, A., J. Verdaguer, B. Anderson, T. Utsugi, S. Bou, and P. Santamaria. 1999. Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice. J. Clin. Invest. 103:1201-1209.
9. Chervonsky, A.V., Y. Wang, F.S. Wong, I. Visintin, R.A. Flavell, C.A. Janeway, Jr., and L.A. Matis. 1997. The role of Fas in autoimmune diabetes. Cell. 89:17-24.
10. Itoh, N., A. Imagawa, T. Hanafusa, M. Waguri, K. Yamamoto, H. Iwahashi, M. Moriwaki, H. Nakajima, J. Miyagawa, M. Namba, et al. 1997. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J. Exp. Med. 186:613-618.
11. Savinov, A.Y., A. Tcherepanov, E.A. Green, R.A. Flavell, and A.V. Chervonsky. 2003. Contribution of Fas to diabetes development. Proc. Natl. Acad. Sci. USA. 100:628-632.
12. Nakayama, M., M. Nagata, H. Yasuda, K. Arisawa, R. Kotani, K. Yamada, S.A. Chowdhury, S. Chakrabarty, Z.Z. Jin, H. Yagita, et al. 2002. Fas/Fas ligand interactions play an essential role in the initiation of murine autoimmune diabetes. Diabetes. 51:1391-1397.
13. Kulkarni, R.N., J.C. Bruning, J.N. Winnay, C. Postic, M.A. Magnuson, and C.R. Kahn. 1999. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 96:329-339.
14. Allison, J., and A. Strasser. 1998. Mechanisms of beta cell death in diabetes: a minor role for CD95. Proc. Natl. Acad. Sci. USA. 95:13818-13822.
15. Kim, Y.H., S. Kim, K.A. Kim, H. Yagita, N. Kayagaki, K.W. Kim, and M.S. Lee. 1999. Apoptosis of pancreatic beta-cells detected in accelerated diabetes of NOD mice: no role of Fas-Fas ligand interaction in autoimmune diabetes. Eur. J. Immunol. 29:455-465.
16. Pakala, S.V., M. Chivetta, C.B. Kelly, and J.D. Katz. 1999. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha. J. Exp. Med. 189:1053-1062.
17. Sarukhan, A., O. Lechner, and H. von Boehmer. 1999. Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet beta-cells. Eur. J. Immunol. 29:3410-3416.