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Volumn 33, Issue 11, 2011, Pages 851-859

The two faces of FBW7 in cancer drug resistance

Author keywords

Cancer; Drug resistance; FBW7; Mcl 1; P53; Tumor suppressor

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; GAMMA SECRETASE INHIBITOR; PACLITAXEL; SORAFENIB; VINCRISTINE;

EID: 80054679813     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201100101     Document Type: Article
Times cited : (43)

References (100)
  • 1
    • 79958189858 scopus 로고    scopus 로고
    • Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance
    • Shapira A, Livney YD, Broxterman HJ, Assaraf YG. 2011. Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance. Drug Resist Updat 14: 150-63.
    • (2011) Drug Resist Updat , vol.14 , pp. 150-163
    • Shapira, A.1    Livney, Y.D.2    Broxterman, H.J.3    Assaraf, Y.G.4
  • 2
    • 78651108985 scopus 로고    scopus 로고
    • Pancreatic cancer: understanding and overcoming chemoresistance
    • Wang Z, Li Y, Ahmad A, Banerjee S, et al. 2011. Pancreatic cancer: understanding and overcoming chemoresistance. Nat Rev Gastroenterol Hepatol 8: 27-33.
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 27-33
    • Wang, Z.1    Li, Y.2    Ahmad, A.3    Banerjee, S.4
  • 4
    • 77957969261 scopus 로고    scopus 로고
    • Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance
    • Wang Z, Li Y, Ahmad A, Azmi AS, et al. 2010. Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance. Drug Resist Updat 13: 109-18.
    • (2010) Drug Resist Updat , vol.13 , pp. 109-118
    • Wang, Z.1    Li, Y.2    Ahmad, A.3    Azmi, A.S.4
  • 6
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: role of ATP-dependent transporters
    • Gottesman MM, Fojo T, Bates SE. 2002. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2: 48-58.
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 7
    • 79951952653 scopus 로고    scopus 로고
    • Drug transporters of platinum-based anticancer agents and their clinical significance
    • Burger H, Loos WJ, Eechoute K, Verweij J, et al. 2011. Drug transporters of platinum-based anticancer agents and their clinical significance. Drug Resist Updat 14: 22-34.
    • (2011) Drug Resist Updat , vol.14 , pp. 22-34
    • Burger, H.1    Loos, W.J.2    Eechoute, K.3    Verweij, J.4
  • 8
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
    • Singh A, Settleman J. 2010. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29: 4741-51.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 9
    • 77954732188 scopus 로고    scopus 로고
    • Strategies for overcoming chemotherapy resistance in enterohepatic tumours
    • Marin JJ, Castano B, Blazquez AG, Rosales R, et al. 2010. Strategies for overcoming chemotherapy resistance in enterohepatic tumours. Curr Mol Med 10: 467-85.
    • (2010) Curr Mol Med , vol.10 , pp. 467-485
    • Marin, J.J.1    Castano, B.2    Blazquez, A.G.3    Rosales, R.4
  • 10
    • 20444400599 scopus 로고    scopus 로고
    • Paclitaxel resistance in cells with reduced beta-tubulin
    • Wang Y, Cabral F. 2005. Paclitaxel resistance in cells with reduced beta-tubulin. Biochim Biophys Acta 1744: 245-55.
    • (2005) Biochim Biophys Acta , vol.1744 , pp. 245-255
    • Wang, Y.1    Cabral, F.2
  • 11
    • 77951643141 scopus 로고    scopus 로고
    • Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor
    • Ercan D, Zejnullahu K, Yonesaka K, Xiao Y, et al. 2010. Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor. Oncogene 29: 2346-56.
    • (2010) Oncogene , vol.29 , pp. 2346-2356
    • Ercan, D.1    Zejnullahu, K.2    Yonesaka, K.3    Xiao, Y.4
  • 12
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M, Fojo T, Bates S. 2005. Tumour stem cells and drug resistance. Nat Rev Cancer 5: 275-84.
    • (2005) Nat Rev Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 13
    • 77951224759 scopus 로고    scopus 로고
    • ABC G2: a potential marker of stem cells and novel target in stem cell and cancer therapy
    • Ding XW, Wu JH, Jiang CP. 2010. ABC G2: a potential marker of stem cells and novel target in stem cell and cancer therapy. Life Sci 86: 631-7.
    • (2010) Life Sci , vol.86 , pp. 631-637
    • Ding, X.W.1    Wu, J.H.2    Jiang, C.P.3
  • 14
    • 79959508436 scopus 로고    scopus 로고
    • Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer
    • Baselga J. 2011. Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer. Oncologist 16: 12-9.
    • (2011) Oncologist , vol.16 , pp. 12-19
    • Baselga, J.1
  • 15
    • 77953496226 scopus 로고    scopus 로고
    • Chemosensitization of prostate cancer by modulating Bcl-2 family proteins
    • Karnak D, Xu L. 2010. Chemosensitization of prostate cancer by modulating Bcl-2 family proteins. Curr Drug Targets 11: 699-707.
    • (2010) Curr Drug Targets , vol.11 , pp. 699-707
    • Karnak, D.1    Xu, L.2
  • 16
    • 79952746216 scopus 로고    scopus 로고
    • Secondary mutations of BRCA1/2 and drug resistance
    • Dhillon KK, Swisher EM, Taniguchi T. 2011. Secondary mutations of BRCA1/2 and drug resistance. Cancer Sci 102: 663-9.
    • (2011) Cancer Sci , vol.102 , pp. 663-669
    • Dhillon, K.K.1    Swisher, E.M.2    Taniguchi, T.3
  • 17
    • 77953935053 scopus 로고    scopus 로고
    • Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers
    • Ku JL, Shin YK, Kim DW, Kim KH, et al. 2010. Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers. Carcinogenesis 31: 1003-9.
    • (2010) Carcinogenesis , vol.31 , pp. 1003-1009
    • Ku, J.L.1    Shin, Y.K.2    Kim, D.W.3    Kim, K.H.4
  • 18
    • 69449095853 scopus 로고    scopus 로고
    • Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1
    • Zwart W, Rondaij M, Jalink K, Sharp ZD, et al. 2009. Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1. Mol Endocrinol 23: 1335-45.
    • (2009) Mol Endocrinol , vol.23 , pp. 1335-1345
    • Zwart, W.1    Rondaij, M.2    Jalink, K.3    Sharp, Z.D.4
  • 19
    • 42449146501 scopus 로고    scopus 로고
    • Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy
    • McCubrey JA, Steelman LS, Abrams SL, Bertrand FE, et al. 2008. Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy. Leukemia 22: 708-22.
    • (2008) Leukemia , vol.22 , pp. 708-722
    • McCubrey, J.A.1    Steelman, L.S.2    Abrams, S.L.3    Bertrand, F.E.4
  • 20
    • 77953744612 scopus 로고    scopus 로고
    • FoxM1 mediates resistance to herceptin and paclitaxel
    • Carr JR, Park HJ, Wang Z, Kiefer MM, et al. 2010. FoxM1 mediates resistance to herceptin and paclitaxel. Cancer Res 70: 5054-63.
    • (2010) Cancer Res , vol.70 , pp. 5054-5063
    • Carr, J.R.1    Park, H.J.2    Wang, Z.3    Kiefer, M.M.4
  • 21
    • 77950614776 scopus 로고    scopus 로고
    • Forkhead box M1 transcription factor: a novel target for cancer therapy
    • Wang Z, Ahmad A, Li Y, Banerjee S, et al. 2010. Forkhead box M1 transcription factor: a novel target for cancer therapy. Cancer Treat Rev 36: 151-6.
    • (2010) Cancer Treat Rev , vol.36 , pp. 151-156
    • Wang, Z.1    Ahmad, A.2    Li, Y.3    Banerjee, S.4
  • 22
    • 78649988884 scopus 로고    scopus 로고
    • Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer
    • Di Fiore F, Sesboue R, Michel P, Sabourin JC, et al. 2010. Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer. Br J Cancer 103: 1765-72.
    • (2010) Br J Cancer , vol.103 , pp. 1765-1772
    • Di Fiore, F.1    Sesboue, R.2    Michel, P.3    Sabourin, J.C.4
  • 23
    • 70349739221 scopus 로고    scopus 로고
    • The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer
    • Kono SA, Marshall ME, Ware KE, Heasley LE. 2009. The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer. Drug Resist Updat 12: 95-102.
    • (2009) Drug Resist Updat , vol.12 , pp. 95-102
    • Kono, S.A.1    Marshall, M.E.2    Ware, K.E.3    Heasley, L.E.4
  • 25
    • 77954235111 scopus 로고    scopus 로고
    • Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response
    • Pratilas CA, Solit DB. 2010. Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response. Clin Cancer Res 16: 3329-34.
    • (2010) Clin Cancer Res , vol.16 , pp. 3329-3334
    • Pratilas, C.A.1    Solit, D.B.2
  • 26
    • 77349114891 scopus 로고    scopus 로고
    • The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment
    • Haagenson KK, Wu GS. 2010. The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment. Cancer Metastasis Rev 29: 143-9.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 143-149
    • Haagenson, K.K.1    Wu, G.S.2
  • 27
    • 46149092748 scopus 로고    scopus 로고
    • Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment
    • Jiang BH, Liu LZ. 2008. Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Updat 11: 63-76.
    • (2008) Drug Resist Updat , vol.11 , pp. 63-76
    • Jiang, B.H.1    Liu, L.Z.2
  • 28
    • 77649341172 scopus 로고    scopus 로고
    • Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy
    • Li F, Sethi G. 2010. Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy. Biochim Biophys Acta 1805: 167-80.
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 167-180
    • Li, F.1    Sethi, G.2
  • 29
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
    • Baud V, Karin M. 2009. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 8: 33-40.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 30
    • 78649466892 scopus 로고    scopus 로고
    • Targeting Notch signaling pathway to overcome drug resistance for cancer therapy
    • Wang Z, Li Y, Ahmad A, Azmi AS, et al. 2010. Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta 1806: 258-67.
    • (2010) Biochim Biophys Acta , vol.1806 , pp. 258-267
    • Wang, Z.1    Li, Y.2    Ahmad, A.3    Azmi, A.S.4
  • 31
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    • Wang Z, Li Y, Kong D, Banerjee S, et al. 2009. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res 69: 2400-7.
    • (2009) Cancer Res , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4
  • 32
    • 77953725367 scopus 로고    scopus 로고
    • Emerging roles of PDGF-D signaling pathway in tumor development and progression
    • Wang Z, Ahmad A, Li Y, Kong D, et al. 2010. Emerging roles of PDGF-D signaling pathway in tumor development and progression. Biochim Biophys Acta 1806: 122-30.
    • (2010) Biochim Biophys Acta , vol.1806 , pp. 122-130
    • Wang, Z.1    Ahmad, A.2    Li, Y.3    Kong, D.4
  • 33
    • 77956236877 scopus 로고    scopus 로고
    • PI(3)king apart PTEN's role in cancer
    • Zhang S, Yu D. 2010. PI(3)king apart PTEN's role in cancer. Clin Cancer Res 16: 4325-30.
    • (2010) Clin Cancer Res , vol.16 , pp. 4325-4330
    • Zhang, S.1    Yu, D.2
  • 34
    • 79955025768 scopus 로고    scopus 로고
    • Investigations of survivin: the past, present and future
    • Cheung CH, Cheng L, Chang KY, Chen HH, et al. 2011. Investigations of survivin: the past, present and future. Front Biosci 16: 952-61.
    • (2011) Front Biosci , vol.16 , pp. 952-961
    • Cheung, C.H.1    Cheng, L.2    Chang, K.Y.3    Chen, H.H.4
  • 36
    • 79952261405 scopus 로고    scopus 로고
    • SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
    • Inuzuka H, Shaik S, Onoyama I, Gao D, et al. 2011. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 471: 104-9.
    • (2011) Nature , vol.471 , pp. 104-109
    • Inuzuka, H.1    Shaik, S.2    Onoyama, I.3    Gao, D.4
  • 37
    • 79952271269 scopus 로고    scopus 로고
    • Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
    • Wertz IE, Kusam S, Lam C, Okamoto T, et al. 2011. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 471: 110-4.
    • (2011) Nature , vol.471 , pp. 110-114
    • Wertz, I.E.1    Kusam, S.2    Lam, C.3    Okamoto, T.4
  • 38
    • 77956342583 scopus 로고    scopus 로고
    • The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation
    • Crusio KM, King B, Reavie LB, Aifantis I. 2010. The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation. Oncogene 29: 4865-73.
    • (2010) Oncogene , vol.29 , pp. 4865-4873
    • Crusio, K.M.1    King, B.2    Reavie, L.B.3    Aifantis, I.4
  • 39
    • 38549086019 scopus 로고    scopus 로고
    • FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
    • Welcker M, Clurman BE. 2008. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 8: 83-93.
    • (2008) Nat Rev Cancer , vol.8 , pp. 83-93
    • Welcker, M.1    Clurman, B.E.2
  • 40
    • 78650824534 scopus 로고    scopus 로고
    • Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets
    • Bedford L, Lowe J, Dick LR, Mayer RJ, et al. 2011. Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets. Nat Rev Drug Discov 10: 29-46.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 29-46
    • Bedford, L.1    Lowe, J.2    Dick, L.R.3    Mayer, R.J.4
  • 41
    • 63649086487 scopus 로고    scopus 로고
    • Targeting the ubiquitin system in cancer therapy
    • Hoeller D, Dikic I. 2009. Targeting the ubiquitin system in cancer therapy. Nature 458: 438-44.
    • (2009) Nature , vol.458 , pp. 438-444
    • Hoeller, D.1    Dikic, I.2
  • 42
    • 7544234937 scopus 로고    scopus 로고
    • Systematic analysis and nomenclature of mammalian F-box proteins
    • Jin J, Cardozo T, Lovering RC, Elledge SJ, et al. 2004. Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev 18: 2573-80.
    • (2004) Genes Dev , vol.18 , pp. 2573-2580
    • Jin, J.1    Cardozo, T.2    Lovering, R.C.3    Elledge, S.J.4
  • 43
    • 0035812709 scopus 로고    scopus 로고
    • Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
    • Koepp DM, Schaefer LK, Ye X, Keyomarsi K, et al. 2001. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294: 173-7.
    • (2001) Science , vol.294 , pp. 173-177
    • Koepp, D.M.1    Schaefer, L.K.2    Ye, X.3    Keyomarsi, K.4
  • 44
    • 22144457934 scopus 로고    scopus 로고
    • Ras activity regulates cyclin E degradation by the Fbw7 pathway
    • Minella AC, Welcker M, Clurman BE. 2005. Ras activity regulates cyclin E degradation by the Fbw7 pathway. Proc Natl Acad Sci USA 102: 9649-54.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9649-9654
    • Minella, A.C.1    Welcker, M.2    Clurman, B.E.3
  • 45
    • 2942614705 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
    • Yada M, Hatakeyama S, Kamura T, Nishiyama M, et al. 2004. Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 23: 2116-25.
    • (2004) EMBO J , vol.23 , pp. 2116-2125
    • Yada, M.1    Hatakeyama, S.2    Kamura, T.3    Nishiyama, M.4
  • 46
    • 2942650133 scopus 로고    scopus 로고
    • The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
    • Welcker M, Orian A, Jin J, Grim JE, et al. 2004. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci USA 101: 9085-90.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9085-9090
    • Welcker, M.1    Orian, A.2    Jin, J.3    Grim, J.E.4
  • 47
    • 22244476115 scopus 로고    scopus 로고
    • The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
    • Wei W, Jin J, Schlisio S, Harper JW, et al. 2005. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell 8: 25-33.
    • (2005) Cancer Cell , vol.8 , pp. 25-33
    • Wei, W.1    Jin, J.2    Schlisio, S.3    Harper, J.W.4
  • 48
    • 78049231370 scopus 로고    scopus 로고
    • Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun
    • Hoeck JD, Jandke A, Blake SM, Nye E, et al. 2010. Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nat Neurosci 13: 1365-72.
    • (2010) Nat Neurosci , vol.13 , pp. 1365-1372
    • Hoeck, J.D.1    Jandke, A.2    Blake, S.M.3    Nye, E.4
  • 49
    • 79951698621 scopus 로고    scopus 로고
    • FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation
    • Babaei-Jadidi R, Li N, Saadeddin A, Spencer-Dene B, et al. 2011. FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J Exp Med 208: 295-312.
    • (2011) J Exp Med , vol.208 , pp. 295-312
    • Babaei-Jadidi, R.1    Li, N.2    Saadeddin, A.3    Spencer-Dene, B.4
  • 50
    • 1542409037 scopus 로고    scopus 로고
    • Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
    • Tetzlaff MT, Yu W, Li M, Zhang P, et al. 2004. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci USA 101: 3338-45.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3338-3345
    • Tetzlaff, M.T.1    Yu, W.2    Li, M.3    Zhang, P.4
  • 51
    • 77952673813 scopus 로고    scopus 로고
    • Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7
    • Rocher-Ros V, Marco S, Mao JH, Gines S, et al. 2010. Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 29: 2950-61.
    • (2010) Oncogene , vol.29 , pp. 2950-2961
    • Rocher-Ros, V.1    Marco, S.2    Mao, J.H.3    Gines, S.4
  • 52
    • 23844530704 scopus 로고    scopus 로고
    • Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)
    • Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, et al. 2005. Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab 1: 379-91.
    • (2005) Cell Metab , vol.1 , pp. 379-391
    • Sundqvist, A.1    Bengoechea-Alonso, M.T.2    Ye, X.3    Lukiyanchuk, V.4
  • 53
    • 33748751591 scopus 로고    scopus 로고
    • Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding
    • Punga T, Bengoechea-Alonso MT, Ericsson J. 2006. Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding. J Biol Chem 281: 25278-86.
    • (2006) J Biol Chem , vol.281 , pp. 25278-25286
    • Punga, T.1    Bengoechea-Alonso, M.T.2    Ericsson, J.3
  • 54
    • 71549161146 scopus 로고    scopus 로고
    • Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy
    • Fu L, Kim YA, Wang X, Wu X, et al. 2009. Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res 69: 8967-76.
    • (2009) Cancer Res , vol.69 , pp. 8967-8976
    • Fu, L.1    Kim, Y.A.2    Wang, X.3    Wu, X.4
  • 55
    • 77953310667 scopus 로고    scopus 로고
    • The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs
    • Liu N, Li H, Li S, Shen M, et al. 2010. The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem 285: 18858-67.
    • (2010) J Biol Chem , vol.285 , pp. 18858-18867
    • Liu, N.1    Li, H.2    Li, S.3    Shen, M.4
  • 56
    • 77953158826 scopus 로고    scopus 로고
    • The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation
    • Zhao D, Zheng HQ, Zhou Z, Chen C. 2010. The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation. Cancer Res 70: 4728-38.
    • (2010) Cancer Res , vol.70 , pp. 4728-4738
    • Zhao, D.1    Zheng, H.Q.2    Zhou, Z.3    Chen, C.4
  • 57
    • 45149123052 scopus 로고    scopus 로고
    • Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
    • Thompson BJ, Jankovic V, Gao J, Buonamici S, et al. 2008. Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med 205: 1395-408.
    • (2008) J Exp Med , vol.205 , pp. 1395-1408
    • Thompson, B.J.1    Jankovic, V.2    Gao, J.3    Buonamici, S.4
  • 58
    • 47949124748 scopus 로고    scopus 로고
    • Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy
    • Finkin S, Aylon Y, Anzi S, Oren M, et al. 2008. Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy. Oncogene 27: 4411-21.
    • (2008) Oncogene , vol.27 , pp. 4411-4421
    • Finkin, S.1    Aylon, Y.2    Anzi, S.3    Oren, M.4
  • 59
    • 1542364470 scopus 로고    scopus 로고
    • Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
    • Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, et al. 2004. Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem 279: 9417-23.
    • (2004) J Biol Chem , vol.279 , pp. 9417-9423
    • Tsunematsu, R.1    Nakayama, K.2    Oike, Y.3    Nishiyama, M.4
  • 60
    • 36549071481 scopus 로고    scopus 로고
    • Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis
    • Onoyama I, Tsunematsu R, Matsumoto A, Kimura T, et al. 2007. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med 204: 2875-88.
    • (2007) J Exp Med , vol.204 , pp. 2875-2888
    • Onoyama, I.1    Tsunematsu, R.2    Matsumoto, A.3    Kimura, T.4
  • 61
    • 42149132696 scopus 로고    scopus 로고
    • Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
    • Matsuoka S, Oike Y, Onoyama I, Iwama A, et al. 2008. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev 22: 986-91.
    • (2008) Genes Dev , vol.22 , pp. 986-991
    • Matsuoka, S.1    Oike, Y.2    Onoyama, I.3    Iwama, A.4
  • 62
    • 78649494384 scopus 로고    scopus 로고
    • Inactivation of FBXW7/hCDC4-beta expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer
    • Akhoondi S, Lindstrom L, Widschwendter M, Corcoran M, et al. 2010. Inactivation of FBXW7/hCDC4-beta expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer. Breast Cancer Res 12: R105.
    • (2010) Breast Cancer Res , vol.12
    • Akhoondi, S.1    Lindstrom, L.2    Widschwendter, M.3    Corcoran, M.4
  • 63
    • 77956165036 scopus 로고    scopus 로고
    • F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor
    • Sancho R, Jandke A, Davis H, Diefenbacher ME, et al. 2010. F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology 139: 929-41.
    • (2010) Gastroenterology , vol.139 , pp. 929-941
    • Sancho, R.1    Jandke, A.2    Davis, H.3    Diefenbacher, M.E.4
  • 64
    • 35348887715 scopus 로고    scopus 로고
    • Mechanisms of transcription factor deregulation in lymphoid cell transformation
    • O'Neil J, Look AT. 2007. Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene 26: 6838-49.
    • (2007) Oncogene , vol.26 , pp. 6838-6849
    • O'Neil, J.1    Look, A.T.2
  • 65
    • 35148842479 scopus 로고    scopus 로고
    • FBXW7/hCDC4 is a general tumor suppressor in human cancer
    • Akhoondi S, Sun D, von der Lehr N, Apostolidou S, et al. 2007. FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res 67: 9006-12.
    • (2007) Cancer Res , vol.67 , pp. 9006-9012
    • Akhoondi, S.1    Sun, D.2    von der Lehr, N.3    Apostolidou, S.4
  • 68
    • 67649933397 scopus 로고    scopus 로고
    • Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb
    • Kitagawa K, Hiramatsu Y, Uchida C, Isobe T, et al. 2009. Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb. Oncogene 28: 2393-405.
    • (2009) Oncogene , vol.28 , pp. 2393-2405
    • Kitagawa, K.1    Hiramatsu, Y.2    Uchida, C.3    Isobe, T.4
  • 69
    • 78449239639 scopus 로고    scopus 로고
    • GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms
    • Kitagawa K, Kotake Y, Hiramatsu Y, Liu N, et al. 2010. GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms. Cell Div 5: 27.
    • (2010) Cell Div , vol.5 , pp. 27
    • Kitagawa, K.1    Kotake, Y.2    Hiramatsu, Y.3    Liu, N.4
  • 70
    • 34547780475 scopus 로고    scopus 로고
    • FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
    • O'Neil J, Grim J, Strack P, Rao S, et al. 2007. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med 204: 1813-24.
    • (2007) J Exp Med , vol.204 , pp. 1813-1824
    • O'Neil, J.1    Grim, J.2    Strack, P.3    Rao, S.4
  • 71
    • 34547820257 scopus 로고    scopus 로고
    • The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
    • Thompson BJ, Buonamici S, Sulis ML, Palomero T, et al. 2007. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med 204: 1825-35.
    • (2007) J Exp Med , vol.204 , pp. 1825-1835
    • Thompson, B.J.1    Buonamici, S.2    Sulis, M.L.3    Palomero, T.4
  • 72
    • 77955817977 scopus 로고    scopus 로고
    • Molecular targeted therapy of advanced hepatocellular carcinoma beyond sorafenib
    • Yau T, Pang R, Chan P, Poon RT. 2010. Molecular targeted therapy of advanced hepatocellular carcinoma beyond sorafenib. Expert Opin Pharmacother 11: 2187-98.
    • (2010) Expert Opin Pharmacother , vol.11 , pp. 2187-2198
    • Yau, T.1    Pang, R.2    Chan, P.3    Poon, R.T.4
  • 73
    • 38149102519 scopus 로고    scopus 로고
    • GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines
    • Panka DJ, Cho DC, Atkins MB, Mier JW. 2008. GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines. J Biol Chem 283: 726-32.
    • (2008) J Biol Chem , vol.283 , pp. 726-732
    • Panka, D.J.1    Cho, D.C.2    Atkins, M.B.3    Mier, J.W.4
  • 74
    • 79955809893 scopus 로고    scopus 로고
    • Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1
    • Huber S, Oelsner M, Decker T, zum Buschenfelde, CM, et al. 2011. Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia 25: 838-47.
    • (2011) Leukemia , vol.25 , pp. 838-847
    • Huber, S.1    Oelsner, M.2    Decker, T.3    zum Buschenfelde, C.M.4
  • 75
    • 26444480631 scopus 로고    scopus 로고
    • Mechanisms of tumor suppression by the SCF(Fbw7)
    • Minella AC, Clurman BE. 2005. Mechanisms of tumor suppression by the SCF(Fbw7). Cell Cycle 4: 1356-9.
    • (2005) Cell Cycle , vol.4 , pp. 1356-1359
    • Minella, A.C.1    Clurman, B.E.2
  • 76
    • 37249003928 scopus 로고    scopus 로고
    • Oncogene addiction: setting the stage for molecularly targeted cancer therapy
    • Sharma SV, Settleman J. 2007. Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev 21: 3214-31.
    • (2007) Genes Dev , vol.21 , pp. 3214-3231
    • Sharma, S.V.1    Settleman, J.2
  • 77
    • 65849378710 scopus 로고    scopus 로고
    • Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
    • Cragg MS, Harris C, Strasser A, Scott CL. 2009. Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat Rev Cancer 9: 321-6.
    • (2009) Nat Rev Cancer , vol.9 , pp. 321-326
    • Cragg, M.S.1    Harris, C.2    Strasser, A.3    Scott, C.L.4
  • 78
    • 33750834023 scopus 로고    scopus 로고
    • The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
    • van Delft MF, Wei AH, Mason KD, Vandenberg CJ, et al. 2006. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 10: 389-99.
    • (2006) Cancer Cell , vol.10 , pp. 389-399
    • van Delft, M.F.1    Wei, A.H.2    Mason, K.D.3    Vandenberg, C.J.4
  • 79
    • 77957564567 scopus 로고    scopus 로고
    • Weekly paclitaxel in the treatment of recurrent ovarian cancer
    • Baird RD, Tan DS, Kaye SB. 2010. Weekly paclitaxel in the treatment of recurrent ovarian cancer. Nat Rev Clin Oncol 7: 575-82.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 575-582
    • Baird, R.D.1    Tan, D.S.2    Kaye, S.B.3
  • 80
    • 77649191871 scopus 로고    scopus 로고
    • Microtubules and resistance to tubulin-binding agents
    • Kavallaris M. 2010. Microtubules and resistance to tubulin-binding agents. Nat Rev Cancer 10: 194-204.
    • (2010) Nat Rev Cancer , vol.10 , pp. 194-204
    • Kavallaris, M.1
  • 81
    • 70449713823 scopus 로고    scopus 로고
    • Vincristine: can its therapeutic index be enhanced?
    • Moore A, Pinkerton R. 2009. Vincristine: can its therapeutic index be enhanced? Pediatr Blood Cancer 53: 1180-7.
    • (2009) Pediatr Blood Cancer , vol.53 , pp. 1180-1187
    • Moore, A.1    Pinkerton, R.2
  • 82
    • 50849111710 scopus 로고    scopus 로고
    • Rational targeting of Notch signaling in cancer
    • Rizzo P, Osipo C, Foreman K, Golde T, et al. 2008. Rational targeting of Notch signaling in cancer. Oncogene 27: 5124-31.
    • (2008) Oncogene , vol.27 , pp. 5124-5131
    • Rizzo, P.1    Osipo, C.2    Foreman, K.3    Golde, T.4
  • 83
    • 78549290515 scopus 로고    scopus 로고
    • Notch signaling proteins: legitimate targets for cancer therapy
    • Wang Z, Li Y, Sarkar FH. 2010. Notch signaling proteins: legitimate targets for cancer therapy. Curr Protein Pept Sci 11: 398-408.
    • (2010) Curr Protein Pept Sci , vol.11 , pp. 398-408
    • Wang, Z.1    Li, Y.2    Sarkar, F.H.3
  • 84
    • 79955460636 scopus 로고    scopus 로고
    • Notch signalling in solid tumours: a little bit of everything but not all the time
    • Ranganathan P, Weaver KL, Capobianco AJ. 2011. Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer 11: 338-51.
    • (2011) Nat Rev Cancer , vol.11 , pp. 338-351
    • Ranganathan, P.1    Weaver, K.L.2    Capobianco, A.J.3
  • 86
    • 68749088356 scopus 로고    scopus 로고
    • NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia
    • Real PJ, Ferrando AA. 2009. NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia. Leukemia 23: 1374-7.
    • (2009) Leukemia , vol.23 , pp. 1374-1377
    • Real, P.J.1    Ferrando, A.A.2
  • 87
    • 34250863886 scopus 로고    scopus 로고
    • Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
    • Maser RS, Choudhury B, Campbell PJ, Feng B, et al. 2007. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447: 966-71.
    • (2007) Nature , vol.447 , pp. 966-971
    • Maser, R.S.1    Choudhury, B.2    Campbell, P.J.3    Feng, B.4
  • 88
    • 10644269326 scopus 로고    scopus 로고
    • Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
    • Mao JH, Perez-Losada J, Wu D, Delrosario R, et al. 2004. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 432: 775-9.
    • (2004) Nature , vol.432 , pp. 775-779
    • Mao, J.H.1    Perez-Losada, J.2    Wu, D.3    Delrosario, R.4
  • 89
    • 65949107856 scopus 로고    scopus 로고
    • p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases
    • Yokobori T, Mimori K, Iwatsuki M, Ishii H, et al. 2009. p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases. Cancer Res 69: 3788-94.
    • (2009) Cancer Res , vol.69 , pp. 3788-3794
    • Yokobori, T.1    Mimori, K.2    Iwatsuki, M.3    Ishii, H.4
  • 90
    • 79952260898 scopus 로고    scopus 로고
    • Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3
    • Welcker M, Larimore EA, Frappier L, Clurman BE. 2011. Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3. Mol Cell Biol 31: 1214-24.
    • (2011) Mol Cell Biol , vol.31 , pp. 1214-1224
    • Welcker, M.1    Larimore, E.A.2    Frappier, L.3    Clurman, B.E.4
  • 91
    • 78650294464 scopus 로고    scopus 로고
    • The tumour suppressor C/EBPdelta inhibits FBXW7 expression and promotes mammary tumour metastasis
    • Balamurugan K, Wang JM, Tsai HH, Sharan S, et al. 2010. The tumour suppressor C/EBPdelta inhibits FBXW7 expression and promotes mammary tumour metastasis. EMBO J 29: 4106-17.
    • (2010) EMBO J , vol.29 , pp. 4106-4117
    • Balamurugan, K.1    Wang, J.M.2    Tsai, H.H.3    Sharan, S.4
  • 92
    • 79959923295 scopus 로고    scopus 로고
    • miRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression
    • Lerner M, Lundgren J, Akhoondi S, Jahn A, et al. 2011. miRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression. Cell Cycle 10: 2172-83.
    • (2011) Cell Cycle , vol.10 , pp. 2172-2183
    • Lerner, M.1    Lundgren, J.2    Akhoondi, S.3    Jahn, A.4
  • 94
    • 77953022034 scopus 로고    scopus 로고
    • Implication of microRNAs in drug resistance for designing novel cancer therapy
    • Sarkar FH, Li Y, Wang Z, Kong D, et al. 2010. Implication of microRNAs in drug resistance for designing novel cancer therapy. Drug Resist Updat 13: 57-66.
    • (2010) Drug Resist Updat , vol.13 , pp. 57-66
    • Sarkar, F.H.1    Li, Y.2    Wang, Z.3    Kong, D.4
  • 95
    • 78751477191 scopus 로고    scopus 로고
    • Gene silencing by microRNAs: contributions of translational repression and mRNA decay
    • Huntzinger E, Izaurralde E. 2011. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 12: 99-110.
    • (2011) Nat Rev Genet , vol.12 , pp. 99-110
    • Huntzinger, E.1    Izaurralde, E.2
  • 96
    • 78049392503 scopus 로고    scopus 로고
    • MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7
    • Xu Y, Sengupta T, Kukreja L, Minella AC. 2010. MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7. J Biol Chem 285: 34439-46.
    • (2010) J Biol Chem , vol.285 , pp. 34439-34446
    • Xu, Y.1    Sengupta, T.2    Kukreja, L.3    Minella, A.C.4
  • 97
    • 79959714872 scopus 로고    scopus 로고
    • A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)
    • Mavrakis KJ, Van Der Meulen J, Wolfe AL, Liu X, et al. 2011. A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL). Nat Genet 43: 673-8.
    • (2011) Nat Genet , vol.43 , pp. 673-678
    • Mavrakis, K.J.1    Van Der Meulen, J.2    Wolfe, A.L.3    Liu, X.4
  • 98
    • 79955847973 scopus 로고    scopus 로고
    • Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells
    • Zhao X, Yang L, Hu J. 2011. Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells. J Exp Clin Cancer Res 30: 55.
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 55
    • Zhao, X.1    Yang, L.2    Hu, J.3
  • 99
    • 80053257151 scopus 로고    scopus 로고
    • Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukemia
    • in press, DOI: 10.1111/j.1582-4934.2010.01213.x.
    • Feng DD, Zhang H, Zhang P, Zheng YS, et al. 2010. Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukemia. J Cell Mol Med in press, DOI: 10.1111/j.1582-4934.2010.01213.x.
    • (2010) J Cell Mol Med
    • Feng, D.D.1    Zhang, H.2    Zhang, P.3    Zheng, Y.S.4
  • 100
    • 80053452602 scopus 로고    scopus 로고
    • Bortezomib: killing two birds with one stone in gastrointestinal stromal tumors
    • Duensing S, Duensing A. 2010. Bortezomib: killing two birds with one stone in gastrointestinal stromal tumors. Oncotarget 1: 6-8.
    • (2010) Oncotarget , vol.1 , pp. 6-8
    • Duensing, S.1    Duensing, A.2


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