-
1
-
-
79958189858
-
Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance
-
Shapira A, Livney YD, Broxterman HJ, Assaraf YG. 2011. Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance. Drug Resist Updat 14: 150-63.
-
(2011)
Drug Resist Updat
, vol.14
, pp. 150-163
-
-
Shapira, A.1
Livney, Y.D.2
Broxterman, H.J.3
Assaraf, Y.G.4
-
2
-
-
78651108985
-
Pancreatic cancer: understanding and overcoming chemoresistance
-
Wang Z, Li Y, Ahmad A, Banerjee S, et al. 2011. Pancreatic cancer: understanding and overcoming chemoresistance. Nat Rev Gastroenterol Hepatol 8: 27-33.
-
(2011)
Nat Rev Gastroenterol Hepatol
, vol.8
, pp. 27-33
-
-
Wang, Z.1
Li, Y.2
Ahmad, A.3
Banerjee, S.4
-
3
-
-
33644775686
-
Targeting multidrug resistance in cancer
-
Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C, et al. 2006. Targeting multidrug resistance in cancer. Nat Rev Drug Discov 5: 219-34.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 219-234
-
-
Szakacs, G.1
Paterson, J.K.2
Ludwig, J.A.3
Booth-Genthe, C.4
-
4
-
-
77957969261
-
Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance
-
Wang Z, Li Y, Ahmad A, Azmi AS, et al. 2010. Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance. Drug Resist Updat 13: 109-18.
-
(2010)
Drug Resist Updat
, vol.13
, pp. 109-118
-
-
Wang, Z.1
Li, Y.2
Ahmad, A.3
Azmi, A.S.4
-
6
-
-
0036364467
-
Multidrug resistance in cancer: role of ATP-dependent transporters
-
Gottesman MM, Fojo T, Bates SE. 2002. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2: 48-58.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 48-58
-
-
Gottesman, M.M.1
Fojo, T.2
Bates, S.E.3
-
7
-
-
79951952653
-
Drug transporters of platinum-based anticancer agents and their clinical significance
-
Burger H, Loos WJ, Eechoute K, Verweij J, et al. 2011. Drug transporters of platinum-based anticancer agents and their clinical significance. Drug Resist Updat 14: 22-34.
-
(2011)
Drug Resist Updat
, vol.14
, pp. 22-34
-
-
Burger, H.1
Loos, W.J.2
Eechoute, K.3
Verweij, J.4
-
8
-
-
77956178360
-
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
-
Singh A, Settleman J. 2010. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29: 4741-51.
-
(2010)
Oncogene
, vol.29
, pp. 4741-4751
-
-
Singh, A.1
Settleman, J.2
-
9
-
-
77954732188
-
Strategies for overcoming chemotherapy resistance in enterohepatic tumours
-
Marin JJ, Castano B, Blazquez AG, Rosales R, et al. 2010. Strategies for overcoming chemotherapy resistance in enterohepatic tumours. Curr Mol Med 10: 467-85.
-
(2010)
Curr Mol Med
, vol.10
, pp. 467-485
-
-
Marin, J.J.1
Castano, B.2
Blazquez, A.G.3
Rosales, R.4
-
10
-
-
20444400599
-
Paclitaxel resistance in cells with reduced beta-tubulin
-
Wang Y, Cabral F. 2005. Paclitaxel resistance in cells with reduced beta-tubulin. Biochim Biophys Acta 1744: 245-55.
-
(2005)
Biochim Biophys Acta
, vol.1744
, pp. 245-255
-
-
Wang, Y.1
Cabral, F.2
-
11
-
-
77951643141
-
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor
-
Ercan D, Zejnullahu K, Yonesaka K, Xiao Y, et al. 2010. Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor. Oncogene 29: 2346-56.
-
(2010)
Oncogene
, vol.29
, pp. 2346-2356
-
-
Ercan, D.1
Zejnullahu, K.2
Yonesaka, K.3
Xiao, Y.4
-
12
-
-
16844368698
-
Tumour stem cells and drug resistance
-
Dean M, Fojo T, Bates S. 2005. Tumour stem cells and drug resistance. Nat Rev Cancer 5: 275-84.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 275-284
-
-
Dean, M.1
Fojo, T.2
Bates, S.3
-
13
-
-
77951224759
-
ABC G2: a potential marker of stem cells and novel target in stem cell and cancer therapy
-
Ding XW, Wu JH, Jiang CP. 2010. ABC G2: a potential marker of stem cells and novel target in stem cell and cancer therapy. Life Sci 86: 631-7.
-
(2010)
Life Sci
, vol.86
, pp. 631-637
-
-
Ding, X.W.1
Wu, J.H.2
Jiang, C.P.3
-
14
-
-
79959508436
-
Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer
-
Baselga J. 2011. Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer. Oncologist 16: 12-9.
-
(2011)
Oncologist
, vol.16
, pp. 12-19
-
-
Baselga, J.1
-
15
-
-
77953496226
-
Chemosensitization of prostate cancer by modulating Bcl-2 family proteins
-
Karnak D, Xu L. 2010. Chemosensitization of prostate cancer by modulating Bcl-2 family proteins. Curr Drug Targets 11: 699-707.
-
(2010)
Curr Drug Targets
, vol.11
, pp. 699-707
-
-
Karnak, D.1
Xu, L.2
-
16
-
-
79952746216
-
Secondary mutations of BRCA1/2 and drug resistance
-
Dhillon KK, Swisher EM, Taniguchi T. 2011. Secondary mutations of BRCA1/2 and drug resistance. Cancer Sci 102: 663-9.
-
(2011)
Cancer Sci
, vol.102
, pp. 663-669
-
-
Dhillon, K.K.1
Swisher, E.M.2
Taniguchi, T.3
-
17
-
-
77953935053
-
Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers
-
Ku JL, Shin YK, Kim DW, Kim KH, et al. 2010. Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers. Carcinogenesis 31: 1003-9.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1003-1009
-
-
Ku, J.L.1
Shin, Y.K.2
Kim, D.W.3
Kim, K.H.4
-
18
-
-
69449095853
-
Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1
-
Zwart W, Rondaij M, Jalink K, Sharp ZD, et al. 2009. Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1. Mol Endocrinol 23: 1335-45.
-
(2009)
Mol Endocrinol
, vol.23
, pp. 1335-1345
-
-
Zwart, W.1
Rondaij, M.2
Jalink, K.3
Sharp, Z.D.4
-
19
-
-
42449146501
-
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy
-
McCubrey JA, Steelman LS, Abrams SL, Bertrand FE, et al. 2008. Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy. Leukemia 22: 708-22.
-
(2008)
Leukemia
, vol.22
, pp. 708-722
-
-
McCubrey, J.A.1
Steelman, L.S.2
Abrams, S.L.3
Bertrand, F.E.4
-
20
-
-
77953744612
-
FoxM1 mediates resistance to herceptin and paclitaxel
-
Carr JR, Park HJ, Wang Z, Kiefer MM, et al. 2010. FoxM1 mediates resistance to herceptin and paclitaxel. Cancer Res 70: 5054-63.
-
(2010)
Cancer Res
, vol.70
, pp. 5054-5063
-
-
Carr, J.R.1
Park, H.J.2
Wang, Z.3
Kiefer, M.M.4
-
21
-
-
77950614776
-
Forkhead box M1 transcription factor: a novel target for cancer therapy
-
Wang Z, Ahmad A, Li Y, Banerjee S, et al. 2010. Forkhead box M1 transcription factor: a novel target for cancer therapy. Cancer Treat Rev 36: 151-6.
-
(2010)
Cancer Treat Rev
, vol.36
, pp. 151-156
-
-
Wang, Z.1
Ahmad, A.2
Li, Y.3
Banerjee, S.4
-
22
-
-
78649988884
-
Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer
-
Di Fiore F, Sesboue R, Michel P, Sabourin JC, et al. 2010. Molecular determinants of anti-EGFR sensitivity and resistance in metastatic colorectal cancer. Br J Cancer 103: 1765-72.
-
(2010)
Br J Cancer
, vol.103
, pp. 1765-1772
-
-
Di Fiore, F.1
Sesboue, R.2
Michel, P.3
Sabourin, J.C.4
-
23
-
-
70349739221
-
The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer
-
Kono SA, Marshall ME, Ware KE, Heasley LE. 2009. The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer. Drug Resist Updat 12: 95-102.
-
(2009)
Drug Resist Updat
, vol.12
, pp. 95-102
-
-
Kono, S.A.1
Marshall, M.E.2
Ware, K.E.3
Heasley, L.E.4
-
24
-
-
78650001661
-
Development of inhibitors of the IGF-IR/PI3K/Akt/mTOR pathway
-
Hixon ML, Paccagnella L, Millham R, Perez-Olle R, et al. 2010. Development of inhibitors of the IGF-IR/PI3K/Akt/mTOR pathway. Rev Recent Clin Trials 5: 189-208.
-
(2010)
Rev Recent Clin Trials
, vol.5
, pp. 189-208
-
-
Hixon, M.L.1
Paccagnella, L.2
Millham, R.3
Perez-Olle, R.4
-
25
-
-
77954235111
-
Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response
-
Pratilas CA, Solit DB. 2010. Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response. Clin Cancer Res 16: 3329-34.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3329-3334
-
-
Pratilas, C.A.1
Solit, D.B.2
-
26
-
-
77349114891
-
The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment
-
Haagenson KK, Wu GS. 2010. The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment. Cancer Metastasis Rev 29: 143-9.
-
(2010)
Cancer Metastasis Rev
, vol.29
, pp. 143-149
-
-
Haagenson, K.K.1
Wu, G.S.2
-
27
-
-
46149092748
-
Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment
-
Jiang BH, Liu LZ. 2008. Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Updat 11: 63-76.
-
(2008)
Drug Resist Updat
, vol.11
, pp. 63-76
-
-
Jiang, B.H.1
Liu, L.Z.2
-
28
-
-
77649341172
-
Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy
-
Li F, Sethi G. 2010. Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy. Biochim Biophys Acta 1805: 167-80.
-
(2010)
Biochim Biophys Acta
, vol.1805
, pp. 167-180
-
-
Li, F.1
Sethi, G.2
-
29
-
-
58149202128
-
Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
-
Baud V, Karin M. 2009. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 8: 33-40.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 33-40
-
-
Baud, V.1
Karin, M.2
-
30
-
-
78649466892
-
Targeting Notch signaling pathway to overcome drug resistance for cancer therapy
-
Wang Z, Li Y, Ahmad A, Azmi AS, et al. 2010. Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta 1806: 258-67.
-
(2010)
Biochim Biophys Acta
, vol.1806
, pp. 258-267
-
-
Wang, Z.1
Li, Y.2
Ahmad, A.3
Azmi, A.S.4
-
31
-
-
65549141305
-
Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
-
Wang Z, Li Y, Kong D, Banerjee S, et al. 2009. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res 69: 2400-7.
-
(2009)
Cancer Res
, vol.69
, pp. 2400-2407
-
-
Wang, Z.1
Li, Y.2
Kong, D.3
Banerjee, S.4
-
32
-
-
77953725367
-
Emerging roles of PDGF-D signaling pathway in tumor development and progression
-
Wang Z, Ahmad A, Li Y, Kong D, et al. 2010. Emerging roles of PDGF-D signaling pathway in tumor development and progression. Biochim Biophys Acta 1806: 122-30.
-
(2010)
Biochim Biophys Acta
, vol.1806
, pp. 122-130
-
-
Wang, Z.1
Ahmad, A.2
Li, Y.3
Kong, D.4
-
33
-
-
77956236877
-
PI(3)king apart PTEN's role in cancer
-
Zhang S, Yu D. 2010. PI(3)king apart PTEN's role in cancer. Clin Cancer Res 16: 4325-30.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4325-4330
-
-
Zhang, S.1
Yu, D.2
-
34
-
-
79955025768
-
Investigations of survivin: the past, present and future
-
Cheung CH, Cheng L, Chang KY, Chen HH, et al. 2011. Investigations of survivin: the past, present and future. Front Biosci 16: 952-61.
-
(2011)
Front Biosci
, vol.16
, pp. 952-961
-
-
Cheung, C.H.1
Cheng, L.2
Chang, K.Y.3
Chen, H.H.4
-
35
-
-
80052056009
-
Mcl-1 ubiquitination and destruction
-
Inuzuka H, Fukushima H, Shaik S, Liu P, et al. 2011. Mcl-1 ubiquitination and destruction. Oncotarget 2: 239-44.
-
(2011)
Oncotarget
, vol.2
, pp. 239-244
-
-
Inuzuka, H.1
Fukushima, H.2
Shaik, S.3
Liu, P.4
-
36
-
-
79952261405
-
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
-
Inuzuka H, Shaik S, Onoyama I, Gao D, et al. 2011. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 471: 104-9.
-
(2011)
Nature
, vol.471
, pp. 104-109
-
-
Inuzuka, H.1
Shaik, S.2
Onoyama, I.3
Gao, D.4
-
37
-
-
79952271269
-
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
-
Wertz IE, Kusam S, Lam C, Okamoto T, et al. 2011. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 471: 110-4.
-
(2011)
Nature
, vol.471
, pp. 110-114
-
-
Wertz, I.E.1
Kusam, S.2
Lam, C.3
Okamoto, T.4
-
38
-
-
77956342583
-
The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation
-
Crusio KM, King B, Reavie LB, Aifantis I. 2010. The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation. Oncogene 29: 4865-73.
-
(2010)
Oncogene
, vol.29
, pp. 4865-4873
-
-
Crusio, K.M.1
King, B.2
Reavie, L.B.3
Aifantis, I.4
-
39
-
-
38549086019
-
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
-
Welcker M, Clurman BE. 2008. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 8: 83-93.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 83-93
-
-
Welcker, M.1
Clurman, B.E.2
-
40
-
-
78650824534
-
Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets
-
Bedford L, Lowe J, Dick LR, Mayer RJ, et al. 2011. Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets. Nat Rev Drug Discov 10: 29-46.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 29-46
-
-
Bedford, L.1
Lowe, J.2
Dick, L.R.3
Mayer, R.J.4
-
41
-
-
63649086487
-
Targeting the ubiquitin system in cancer therapy
-
Hoeller D, Dikic I. 2009. Targeting the ubiquitin system in cancer therapy. Nature 458: 438-44.
-
(2009)
Nature
, vol.458
, pp. 438-444
-
-
Hoeller, D.1
Dikic, I.2
-
42
-
-
7544234937
-
Systematic analysis and nomenclature of mammalian F-box proteins
-
Jin J, Cardozo T, Lovering RC, Elledge SJ, et al. 2004. Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev 18: 2573-80.
-
(2004)
Genes Dev
, vol.18
, pp. 2573-2580
-
-
Jin, J.1
Cardozo, T.2
Lovering, R.C.3
Elledge, S.J.4
-
43
-
-
0035812709
-
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
-
Koepp DM, Schaefer LK, Ye X, Keyomarsi K, et al. 2001. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294: 173-7.
-
(2001)
Science
, vol.294
, pp. 173-177
-
-
Koepp, D.M.1
Schaefer, L.K.2
Ye, X.3
Keyomarsi, K.4
-
44
-
-
22144457934
-
Ras activity regulates cyclin E degradation by the Fbw7 pathway
-
Minella AC, Welcker M, Clurman BE. 2005. Ras activity regulates cyclin E degradation by the Fbw7 pathway. Proc Natl Acad Sci USA 102: 9649-54.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9649-9654
-
-
Minella, A.C.1
Welcker, M.2
Clurman, B.E.3
-
45
-
-
2942614705
-
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
-
Yada M, Hatakeyama S, Kamura T, Nishiyama M, et al. 2004. Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 23: 2116-25.
-
(2004)
EMBO J
, vol.23
, pp. 2116-2125
-
-
Yada, M.1
Hatakeyama, S.2
Kamura, T.3
Nishiyama, M.4
-
46
-
-
2942650133
-
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
-
Welcker M, Orian A, Jin J, Grim JE, et al. 2004. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci USA 101: 9085-90.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 9085-9090
-
-
Welcker, M.1
Orian, A.2
Jin, J.3
Grim, J.E.4
-
47
-
-
22244476115
-
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
-
Wei W, Jin J, Schlisio S, Harper JW, et al. 2005. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell 8: 25-33.
-
(2005)
Cancer Cell
, vol.8
, pp. 25-33
-
-
Wei, W.1
Jin, J.2
Schlisio, S.3
Harper, J.W.4
-
48
-
-
78049231370
-
Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun
-
Hoeck JD, Jandke A, Blake SM, Nye E, et al. 2010. Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nat Neurosci 13: 1365-72.
-
(2010)
Nat Neurosci
, vol.13
, pp. 1365-1372
-
-
Hoeck, J.D.1
Jandke, A.2
Blake, S.M.3
Nye, E.4
-
49
-
-
79951698621
-
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation
-
Babaei-Jadidi R, Li N, Saadeddin A, Spencer-Dene B, et al. 2011. FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J Exp Med 208: 295-312.
-
(2011)
J Exp Med
, vol.208
, pp. 295-312
-
-
Babaei-Jadidi, R.1
Li, N.2
Saadeddin, A.3
Spencer-Dene, B.4
-
50
-
-
1542409037
-
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
-
Tetzlaff MT, Yu W, Li M, Zhang P, et al. 2004. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci USA 101: 3338-45.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3338-3345
-
-
Tetzlaff, M.T.1
Yu, W.2
Li, M.3
Zhang, P.4
-
51
-
-
77952673813
-
Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7
-
Rocher-Ros V, Marco S, Mao JH, Gines S, et al. 2010. Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 29: 2950-61.
-
(2010)
Oncogene
, vol.29
, pp. 2950-2961
-
-
Rocher-Ros, V.1
Marco, S.2
Mao, J.H.3
Gines, S.4
-
52
-
-
23844530704
-
Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)
-
Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, et al. 2005. Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab 1: 379-91.
-
(2005)
Cell Metab
, vol.1
, pp. 379-391
-
-
Sundqvist, A.1
Bengoechea-Alonso, M.T.2
Ye, X.3
Lukiyanchuk, V.4
-
53
-
-
33748751591
-
Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding
-
Punga T, Bengoechea-Alonso MT, Ericsson J. 2006. Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding. J Biol Chem 281: 25278-86.
-
(2006)
J Biol Chem
, vol.281
, pp. 25278-25286
-
-
Punga, T.1
Bengoechea-Alonso, M.T.2
Ericsson, J.3
-
54
-
-
71549161146
-
Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy
-
Fu L, Kim YA, Wang X, Wu X, et al. 2009. Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res 69: 8967-76.
-
(2009)
Cancer Res
, vol.69
, pp. 8967-8976
-
-
Fu, L.1
Kim, Y.A.2
Wang, X.3
Wu, X.4
-
55
-
-
77953310667
-
The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs
-
Liu N, Li H, Li S, Shen M, et al. 2010. The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem 285: 18858-67.
-
(2010)
J Biol Chem
, vol.285
, pp. 18858-18867
-
-
Liu, N.1
Li, H.2
Li, S.3
Shen, M.4
-
56
-
-
77953158826
-
The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation
-
Zhao D, Zheng HQ, Zhou Z, Chen C. 2010. The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation. Cancer Res 70: 4728-38.
-
(2010)
Cancer Res
, vol.70
, pp. 4728-4738
-
-
Zhao, D.1
Zheng, H.Q.2
Zhou, Z.3
Chen, C.4
-
57
-
-
45149123052
-
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
-
Thompson BJ, Jankovic V, Gao J, Buonamici S, et al. 2008. Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med 205: 1395-408.
-
(2008)
J Exp Med
, vol.205
, pp. 1395-1408
-
-
Thompson, B.J.1
Jankovic, V.2
Gao, J.3
Buonamici, S.4
-
58
-
-
47949124748
-
Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy
-
Finkin S, Aylon Y, Anzi S, Oren M, et al. 2008. Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy. Oncogene 27: 4411-21.
-
(2008)
Oncogene
, vol.27
, pp. 4411-4421
-
-
Finkin, S.1
Aylon, Y.2
Anzi, S.3
Oren, M.4
-
59
-
-
1542364470
-
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
-
Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, et al. 2004. Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem 279: 9417-23.
-
(2004)
J Biol Chem
, vol.279
, pp. 9417-9423
-
-
Tsunematsu, R.1
Nakayama, K.2
Oike, Y.3
Nishiyama, M.4
-
60
-
-
36549071481
-
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis
-
Onoyama I, Tsunematsu R, Matsumoto A, Kimura T, et al. 2007. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med 204: 2875-88.
-
(2007)
J Exp Med
, vol.204
, pp. 2875-2888
-
-
Onoyama, I.1
Tsunematsu, R.2
Matsumoto, A.3
Kimura, T.4
-
61
-
-
42149132696
-
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
-
Matsuoka S, Oike Y, Onoyama I, Iwama A, et al. 2008. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev 22: 986-91.
-
(2008)
Genes Dev
, vol.22
, pp. 986-991
-
-
Matsuoka, S.1
Oike, Y.2
Onoyama, I.3
Iwama, A.4
-
62
-
-
78649494384
-
Inactivation of FBXW7/hCDC4-beta expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer
-
Akhoondi S, Lindstrom L, Widschwendter M, Corcoran M, et al. 2010. Inactivation of FBXW7/hCDC4-beta expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer. Breast Cancer Res 12: R105.
-
(2010)
Breast Cancer Res
, vol.12
-
-
Akhoondi, S.1
Lindstrom, L.2
Widschwendter, M.3
Corcoran, M.4
-
63
-
-
77956165036
-
F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor
-
Sancho R, Jandke A, Davis H, Diefenbacher ME, et al. 2010. F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology 139: 929-41.
-
(2010)
Gastroenterology
, vol.139
, pp. 929-941
-
-
Sancho, R.1
Jandke, A.2
Davis, H.3
Diefenbacher, M.E.4
-
64
-
-
35348887715
-
Mechanisms of transcription factor deregulation in lymphoid cell transformation
-
O'Neil J, Look AT. 2007. Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene 26: 6838-49.
-
(2007)
Oncogene
, vol.26
, pp. 6838-6849
-
-
O'Neil, J.1
Look, A.T.2
-
65
-
-
35148842479
-
FBXW7/hCDC4 is a general tumor suppressor in human cancer
-
Akhoondi S, Sun D, von der Lehr N, Apostolidou S, et al. 2007. FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res 67: 9006-12.
-
(2007)
Cancer Res
, vol.67
, pp. 9006-9012
-
-
Akhoondi, S.1
Sun, D.2
von der Lehr, N.3
Apostolidou, S.4
-
66
-
-
1542377277
-
Inactivation of hCDC4 can cause chromosomal instability
-
Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, et al. 2004. Inactivation of hCDC4 can cause chromosomal instability. Nature 428: 77-81.
-
(2004)
Nature
, vol.428
, pp. 77-81
-
-
Rajagopalan, H.1
Jallepalli, P.V.2
Rago, C.3
Velculescu, V.E.4
-
67
-
-
0037102310
-
hCDC4 gene mutations in endometrial cancer
-
Spruck CH, Strohmaier H, Sangfelt O, Muller HM, et al. 2002. hCDC4 gene mutations in endometrial cancer. Cancer Res 62: 4535-9.
-
(2002)
Cancer Res
, vol.62
, pp. 4535-4539
-
-
Spruck, C.H.1
Strohmaier, H.2
Sangfelt, O.3
Muller, H.M.4
-
68
-
-
67649933397
-
Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb
-
Kitagawa K, Hiramatsu Y, Uchida C, Isobe T, et al. 2009. Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb. Oncogene 28: 2393-405.
-
(2009)
Oncogene
, vol.28
, pp. 2393-2405
-
-
Kitagawa, K.1
Hiramatsu, Y.2
Uchida, C.3
Isobe, T.4
-
69
-
-
78449239639
-
GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms
-
Kitagawa K, Kotake Y, Hiramatsu Y, Liu N, et al. 2010. GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms. Cell Div 5: 27.
-
(2010)
Cell Div
, vol.5
, pp. 27
-
-
Kitagawa, K.1
Kotake, Y.2
Hiramatsu, Y.3
Liu, N.4
-
70
-
-
34547780475
-
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
-
O'Neil J, Grim J, Strack P, Rao S, et al. 2007. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med 204: 1813-24.
-
(2007)
J Exp Med
, vol.204
, pp. 1813-1824
-
-
O'Neil, J.1
Grim, J.2
Strack, P.3
Rao, S.4
-
71
-
-
34547820257
-
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
-
Thompson BJ, Buonamici S, Sulis ML, Palomero T, et al. 2007. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med 204: 1825-35.
-
(2007)
J Exp Med
, vol.204
, pp. 1825-1835
-
-
Thompson, B.J.1
Buonamici, S.2
Sulis, M.L.3
Palomero, T.4
-
72
-
-
77955817977
-
Molecular targeted therapy of advanced hepatocellular carcinoma beyond sorafenib
-
Yau T, Pang R, Chan P, Poon RT. 2010. Molecular targeted therapy of advanced hepatocellular carcinoma beyond sorafenib. Expert Opin Pharmacother 11: 2187-98.
-
(2010)
Expert Opin Pharmacother
, vol.11
, pp. 2187-2198
-
-
Yau, T.1
Pang, R.2
Chan, P.3
Poon, R.T.4
-
73
-
-
38149102519
-
GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines
-
Panka DJ, Cho DC, Atkins MB, Mier JW. 2008. GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines. J Biol Chem 283: 726-32.
-
(2008)
J Biol Chem
, vol.283
, pp. 726-732
-
-
Panka, D.J.1
Cho, D.C.2
Atkins, M.B.3
Mier, J.W.4
-
74
-
-
79955809893
-
Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1
-
Huber S, Oelsner M, Decker T, zum Buschenfelde, CM, et al. 2011. Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia 25: 838-47.
-
(2011)
Leukemia
, vol.25
, pp. 838-847
-
-
Huber, S.1
Oelsner, M.2
Decker, T.3
zum Buschenfelde, C.M.4
-
75
-
-
26444480631
-
Mechanisms of tumor suppression by the SCF(Fbw7)
-
Minella AC, Clurman BE. 2005. Mechanisms of tumor suppression by the SCF(Fbw7). Cell Cycle 4: 1356-9.
-
(2005)
Cell Cycle
, vol.4
, pp. 1356-1359
-
-
Minella, A.C.1
Clurman, B.E.2
-
76
-
-
37249003928
-
Oncogene addiction: setting the stage for molecularly targeted cancer therapy
-
Sharma SV, Settleman J. 2007. Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev 21: 3214-31.
-
(2007)
Genes Dev
, vol.21
, pp. 3214-3231
-
-
Sharma, S.V.1
Settleman, J.2
-
77
-
-
65849378710
-
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
-
Cragg MS, Harris C, Strasser A, Scott CL. 2009. Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat Rev Cancer 9: 321-6.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 321-326
-
-
Cragg, M.S.1
Harris, C.2
Strasser, A.3
Scott, C.L.4
-
78
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
van Delft MF, Wei AH, Mason KD, Vandenberg CJ, et al. 2006. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 10: 389-99.
-
(2006)
Cancer Cell
, vol.10
, pp. 389-399
-
-
van Delft, M.F.1
Wei, A.H.2
Mason, K.D.3
Vandenberg, C.J.4
-
79
-
-
77957564567
-
Weekly paclitaxel in the treatment of recurrent ovarian cancer
-
Baird RD, Tan DS, Kaye SB. 2010. Weekly paclitaxel in the treatment of recurrent ovarian cancer. Nat Rev Clin Oncol 7: 575-82.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 575-582
-
-
Baird, R.D.1
Tan, D.S.2
Kaye, S.B.3
-
80
-
-
77649191871
-
Microtubules and resistance to tubulin-binding agents
-
Kavallaris M. 2010. Microtubules and resistance to tubulin-binding agents. Nat Rev Cancer 10: 194-204.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 194-204
-
-
Kavallaris, M.1
-
81
-
-
70449713823
-
Vincristine: can its therapeutic index be enhanced?
-
Moore A, Pinkerton R. 2009. Vincristine: can its therapeutic index be enhanced? Pediatr Blood Cancer 53: 1180-7.
-
(2009)
Pediatr Blood Cancer
, vol.53
, pp. 1180-1187
-
-
Moore, A.1
Pinkerton, R.2
-
82
-
-
50849111710
-
Rational targeting of Notch signaling in cancer
-
Rizzo P, Osipo C, Foreman K, Golde T, et al. 2008. Rational targeting of Notch signaling in cancer. Oncogene 27: 5124-31.
-
(2008)
Oncogene
, vol.27
, pp. 5124-5131
-
-
Rizzo, P.1
Osipo, C.2
Foreman, K.3
Golde, T.4
-
83
-
-
78549290515
-
Notch signaling proteins: legitimate targets for cancer therapy
-
Wang Z, Li Y, Sarkar FH. 2010. Notch signaling proteins: legitimate targets for cancer therapy. Curr Protein Pept Sci 11: 398-408.
-
(2010)
Curr Protein Pept Sci
, vol.11
, pp. 398-408
-
-
Wang, Z.1
Li, Y.2
Sarkar, F.H.3
-
84
-
-
79955460636
-
Notch signalling in solid tumours: a little bit of everything but not all the time
-
Ranganathan P, Weaver KL, Capobianco AJ. 2011. Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer 11: 338-51.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 338-351
-
-
Ranganathan, P.1
Weaver, K.L.2
Capobianco, A.J.3
-
86
-
-
68749088356
-
NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia
-
Real PJ, Ferrando AA. 2009. NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia. Leukemia 23: 1374-7.
-
(2009)
Leukemia
, vol.23
, pp. 1374-1377
-
-
Real, P.J.1
Ferrando, A.A.2
-
87
-
-
34250863886
-
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
-
Maser RS, Choudhury B, Campbell PJ, Feng B, et al. 2007. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447: 966-71.
-
(2007)
Nature
, vol.447
, pp. 966-971
-
-
Maser, R.S.1
Choudhury, B.2
Campbell, P.J.3
Feng, B.4
-
88
-
-
10644269326
-
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
-
Mao JH, Perez-Losada J, Wu D, Delrosario R, et al. 2004. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 432: 775-9.
-
(2004)
Nature
, vol.432
, pp. 775-779
-
-
Mao, J.H.1
Perez-Losada, J.2
Wu, D.3
Delrosario, R.4
-
89
-
-
65949107856
-
p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases
-
Yokobori T, Mimori K, Iwatsuki M, Ishii H, et al. 2009. p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases. Cancer Res 69: 3788-94.
-
(2009)
Cancer Res
, vol.69
, pp. 3788-3794
-
-
Yokobori, T.1
Mimori, K.2
Iwatsuki, M.3
Ishii, H.4
-
90
-
-
79952260898
-
Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3
-
Welcker M, Larimore EA, Frappier L, Clurman BE. 2011. Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3. Mol Cell Biol 31: 1214-24.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 1214-1224
-
-
Welcker, M.1
Larimore, E.A.2
Frappier, L.3
Clurman, B.E.4
-
91
-
-
78650294464
-
The tumour suppressor C/EBPdelta inhibits FBXW7 expression and promotes mammary tumour metastasis
-
Balamurugan K, Wang JM, Tsai HH, Sharan S, et al. 2010. The tumour suppressor C/EBPdelta inhibits FBXW7 expression and promotes mammary tumour metastasis. EMBO J 29: 4106-17.
-
(2010)
EMBO J
, vol.29
, pp. 4106-4117
-
-
Balamurugan, K.1
Wang, J.M.2
Tsai, H.H.3
Sharan, S.4
-
92
-
-
79959923295
-
miRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression
-
Lerner M, Lundgren J, Akhoondi S, Jahn A, et al. 2011. miRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression. Cell Cycle 10: 2172-83.
-
(2011)
Cell Cycle
, vol.10
, pp. 2172-2183
-
-
Lerner, M.1
Lundgren, J.2
Akhoondi, S.3
Jahn, A.4
-
94
-
-
77953022034
-
Implication of microRNAs in drug resistance for designing novel cancer therapy
-
Sarkar FH, Li Y, Wang Z, Kong D, et al. 2010. Implication of microRNAs in drug resistance for designing novel cancer therapy. Drug Resist Updat 13: 57-66.
-
(2010)
Drug Resist Updat
, vol.13
, pp. 57-66
-
-
Sarkar, F.H.1
Li, Y.2
Wang, Z.3
Kong, D.4
-
95
-
-
78751477191
-
Gene silencing by microRNAs: contributions of translational repression and mRNA decay
-
Huntzinger E, Izaurralde E. 2011. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 12: 99-110.
-
(2011)
Nat Rev Genet
, vol.12
, pp. 99-110
-
-
Huntzinger, E.1
Izaurralde, E.2
-
96
-
-
78049392503
-
MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7
-
Xu Y, Sengupta T, Kukreja L, Minella AC. 2010. MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7. J Biol Chem 285: 34439-46.
-
(2010)
J Biol Chem
, vol.285
, pp. 34439-34446
-
-
Xu, Y.1
Sengupta, T.2
Kukreja, L.3
Minella, A.C.4
-
97
-
-
79959714872
-
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)
-
Mavrakis KJ, Van Der Meulen J, Wolfe AL, Liu X, et al. 2011. A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL). Nat Genet 43: 673-8.
-
(2011)
Nat Genet
, vol.43
, pp. 673-678
-
-
Mavrakis, K.J.1
Van Der Meulen, J.2
Wolfe, A.L.3
Liu, X.4
-
98
-
-
79955847973
-
Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells
-
Zhao X, Yang L, Hu J. 2011. Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells. J Exp Clin Cancer Res 30: 55.
-
(2011)
J Exp Clin Cancer Res
, vol.30
, pp. 55
-
-
Zhao, X.1
Yang, L.2
Hu, J.3
-
99
-
-
80053257151
-
Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukemia
-
in press, DOI: 10.1111/j.1582-4934.2010.01213.x.
-
Feng DD, Zhang H, Zhang P, Zheng YS, et al. 2010. Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukemia. J Cell Mol Med in press, DOI: 10.1111/j.1582-4934.2010.01213.x.
-
(2010)
J Cell Mol Med
-
-
Feng, D.D.1
Zhang, H.2
Zhang, P.3
Zheng, Y.S.4
-
100
-
-
80053452602
-
Bortezomib: killing two birds with one stone in gastrointestinal stromal tumors
-
Duensing S, Duensing A. 2010. Bortezomib: killing two birds with one stone in gastrointestinal stromal tumors. Oncotarget 1: 6-8.
-
(2010)
Oncotarget
, vol.1
, pp. 6-8
-
-
Duensing, S.1
Duensing, A.2
|