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Volumn 11, Issue 6, 2010, Pages 398-408

Notch signaling proteins: Legitimate targets for cancer therapy

Author keywords

And gamma; secretase inhibitors; Cancer; Cancer therapy; Natural agents; Notch; Oncogene; Review; Signal pathway

Indexed keywords

FLUOROURACIL; GAMMA SECRETASE INHIBITOR; GLUCOCORTICOID; NOTCH RECEPTOR; OXALIPLATIN;

EID: 78549290515     PISSN: 13892037     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920310791824039     Document Type: Article
Times cited : (69)

References (107)
  • 1
    • 0032695278 scopus 로고    scopus 로고
    • Arbiter of differentiation and death: Notchsignaling meets apoptosis
    • Miele, L.; Osborne, B. Arbiter of differentiation and death: Notchsignaling meets apoptosis. J. Cell, Physiol., 1999, 181, 393-409.
    • (1999) J. Cell, Physiol. , vol.181 , pp. 393-409
    • Miele, L.1    Osborne, B.2
  • 2
    • 33644752839 scopus 로고    scopus 로고
    • Notch signaling
    • Miele, L. Notch signaling. Clin. Cancer Res., 2006, 12, 1074-1079.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1074-1079
    • Miele, L.1
  • 3
    • 0030748716 scopus 로고    scopus 로고
    • The ins and outs of notch signaling
    • Weinmaster, G. The ins and outs of notch signaling. Mol. Cell, Neurosci., 1997, 9, 91-102.
    • (1997) Mol. Cell, Neurosci. , vol.9 , pp. 91-102
    • Weinmaster, G.1
  • 4
    • 64249172203 scopus 로고    scopus 로고
    • The canonical Notch signaling pathway:Unfolding the activation mechanism
    • Kopan, R.; Ilagan, M. X. The canonical Notch signaling pathway:unfolding the activation mechanism. Cell, 2009, 137, 216-233.
    • (2009) Cell , vol.137 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.2
  • 5
    • 65549121943 scopus 로고    scopus 로고
    • Notch signaling: The core pathway and its posttranslationalregulation
    • Fortini, M. E. Notch signaling: the core pathway and its posttranslationalregulation. Dev. Cell, 2009, 16, 633-647.
    • (2009) Dev. Cell , vol.16 , pp. 633-647
    • Fortini, M.E.1
  • 6
  • 8
    • 58149174376 scopus 로고    scopus 로고
    • Exploitation of theNotch signaling pathway as a novel target for cancer therapy
    • Wang, Z.; Li, Y.; Banerjee, S.; Sarkar, F. H. Exploitation of theNotch signaling pathway as a novel target for cancer therapy. Anti-Cancer Res., 2008, 28, 3621-3630.
    • (2008) Anti-Cancer Res. , vol.28 , pp. 3621-3630
    • Wang, Z.1    Li, Y.2    Banerjee, S.3    Sarkar, F.H.4
  • 9
    • 50849104230 scopus 로고    scopus 로고
    • Notch tumor suppressor function
    • Dotto, G. P. Notch tumor suppressor function. Oncogene, 2008, 27, 5115-5123.
    • (2008) Oncogene , vol.27 , pp. 5115-5123
    • Dotto, G.P.1
  • 14
    • 67649313759 scopus 로고    scopus 로고
    • Notch and Kras in pancreatic cancer:At the crossroads of mutation, differentiation and signaling
    • De La, O. J.; Murtaugh, L. C. Notch and Kras in pancreatic cancer:at the crossroads of mutation, differentiation and signaling. Cell Cycle, 2009, 8, 1860-1864.
    • (2009) Cell Cycle , vol.8 , pp. 1860-1864
    • De La, O.J.1    Murtaugh, L.C.2
  • 15
    • 33845611029 scopus 로고    scopus 로고
    • Activation of Notch signalingin tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracenein mice
    • Kimura, K.; Satoh, K.; Kanno, A.; Hamada, S.; Hirota, M.; Endoh, M.; Masamune, A.; Shimosegawa, T. Activation of Notch signalingin tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracenein mice. Cancer Sci., 2007, 98, 155-162.
    • (2007) Cancer Sci. , vol.98 , pp. 155-162
    • Kimura, K.1    Satoh, K.2    Kanno, A.3    Hamada, S.4    Hirota, M.5    Endoh, M.6    Masamune, A.7    Shimosegawa, T.8
  • 17
    • 37649023286 scopus 로고    scopus 로고
    • Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway
    • Sawey, E. T.; Johnson, J. A.; Crawford, H. C. Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway. Proc. Natl. Acad. Sci. USA, 2007, 104, 19327-19332.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 19327-19332
    • Sawey, E.T.1    Johnson, J.A.2    Crawford, H.C.3
  • 18
    • 33645049305 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 inhibits invasion by inactivationof nuclear factor-{kappa}B, vascular endothelial growth factor, andmatrix metalloproteinase-9 in pancreatic cancer cells
    • Wang, Z.; Banerjee, S.; Li, Y.; Rahman, K. M.; Zhang, Y.; Sarkar, F. H. Down-regulation of Notch-1 inhibits invasion by inactivationof nuclear factor-{kappa}B, vascular endothelial growth factor, andmatrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res., 2006, 66, 2778-2784.
    • (2006) Cancer Res. , vol.66 , pp. 2778-2784
    • Wang, Z.1    Banerjee, S.2    Li, Y.3    Rahman, K.M.4    Zhang, Y.5    Sarkar, F.H.6
  • 19
    • 33645473185 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 contributes to cell growth inhibitionand apoptosis in pancreatic cancer cells
    • Wang, Z.; Zhang, Y.; Li, Y.; Banerjee, S.; Liao, J.; Sarkar, F. H. Down-regulation of Notch-1 contributes to cell growth inhibitionand apoptosis in pancreatic cancer cells. Mol. Cancer Ther., 2006,5, 483-493.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 483-493
    • Wang, Z.1    Zhang, Y.2    Li, Y.3    Banerjee, S.4    Liao, J.5    Sarkar, F.H.6
  • 20
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition ofepithelial-mesenchymal transition phenotype of gemcitabineresistantpancreatic cancer cells is linked with activation of thenotch signaling pathway
    • Wang, Z.; Li, Y.; Kong, D.; Banerjee, S.; Ahmad, A.; Azmi, A. S. Ali, S.; Abbruzzese, J. L.; Gallick, G. E.; Sarkar, F. H. Acquisition ofepithelial-mesenchymal transition phenotype of gemcitabineresistantpancreatic cancer cells is linked with activation of thenotch signaling pathway. Cancer Res., 2009, 69, 2400-2407.
    • (2009) Cancer Res. , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4    Ahmad, A.5    Azmi, A.S.6    Ali, S.7    Abbruzzese, J.L.8    Gallick, G.E.9    Sarkar, F.H.10
  • 22
    • 0035476048 scopus 로고    scopus 로고
    • Dynamics of notch expression during murine prostate developmentand tumorigenesis
    • Shou, J.; Ross, S.; Koeppen, H.; de, Sauvage, F. J.; Gao, W. Q. Dynamics of notch expression during murine prostate developmentand tumorigenesis. Cancer Res., 2001, 61, 7291-7297.
    • (2001) Cancer Res. , vol.61 , pp. 7291-7297
    • Shou, J.1    Ross, S.2    Koeppen, H.3    de Sauvage, F.J.4    Gao, W.Q.5
  • 23
    • 59449107891 scopus 로고    scopus 로고
    • Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator
    • Bin, H. B.; Adhami, V. M.; Asim, M.; Siddiqui, I. A.; Bhat, K. M.; Zhong, W.; Saleem, M.; Din, M.; Setaluri, V.; Mukhtar, H. Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator. Clin. Cancer Res., 2009, 15, 452-459.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 452-459
    • Bin, H.B.1    Adhami, V.M.2    Asim, M.3    Siddiqui, I.A.4    Bhat, K.M.5    Zhong, W.6    Saleem, M.7    Din, M.8    Setaluri, V.9    Mukhtar, H.10
  • 24
    • 55449084812 scopus 로고    scopus 로고
    • Notch signaling: Apotential therapeutic target in prostate cancer
    • Villaronga, M. A.; Bevan, C. L.; Belandia, B. Notch signaling: apotential therapeutic target in prostate cancer. Curr. Cancer Drug Targets, 2008, 8, 566-580.
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 566-580
    • Villaronga, M.A.1    Bevan, C.L.2    Belandia, B.3
  • 25
    • 47849127390 scopus 로고    scopus 로고
    • The Notch pathway in prostate developmentand cancer
    • Leong, K. G.; Gao, W. Q. The Notch pathway in prostate developmentand cancer. Differentiation, 2008, 76, 699-716.
    • (2008) Differentiation , vol.76 , pp. 699-716
    • Leong, K.G.1    Gao, W.Q.2
  • 26
    • 0942276369 scopus 로고    scopus 로고
    • Notch signalingand ERK activation are important for the osteomimetic propertiesof prostate cancer bone metastatic cell lines
    • Zayzafoon, M.; Abdulkadir, S. A.; McDonald, J. M. Notch signalingand ERK activation are important for the osteomimetic propertiesof prostate cancer bone metastatic cell lines. J. Biol. Chem., 2004,279, 3662-3670.
    • (2004) J. Biol. Chem. , vol.279 , pp. 3662-3670
    • Zayzafoon, M.1    Abdulkadir, S.A.2    McDonald, J.M.3
  • 28
    • 33748872289 scopus 로고    scopus 로고
    • Down-regulation of Jagged-1 induces cell growth inhibition and Sphase arrest in prostate cancer cells
    • Zhang, Y.; Wang, Z.; Ahmed, F.; Banerjee, S.; Li, Y.; Sarkar, F. H. Down-regulation of Jagged-1 induces cell growth inhibition and Sphase arrest in prostate cancer cells. Int. J. Cancer, 2006, 119(9), 2071-2077.
    • (2006) Int. J. Cancer , vol.119 , Issue.9 , pp. 2071-2077
    • Zhang, Y.1    Wang, Z.2    Ahmed, F.3    Banerjee, S.4    Li, Y.5    Sarkar, F.H.6
  • 29
    • 34249058671 scopus 로고    scopus 로고
    • Restoration of p53 expression in human cancer cell lines upregulatesthe expression of Notch1: Implications for cancer cell fate determinationafter genotoxic stress
    • Alimirah, F.; Panchanathan, R.; Davis F. J.; Chen, J.; Choubey, D. Restoration of p53 expression in human cancer cell lines upregulatesthe expression of Notch1: implications for cancer cell fate determinationafter genotoxic stress. Neoplasia, 2007, 9, 427-434.
    • (2007) Neoplasia , vol.9 , pp. 427-434
    • Alimirah, F.1    Panchanathan, R.2    Davis, F.J.3    Chen, J.4    Choubey, D.5
  • 32
    • 34347240929 scopus 로고    scopus 로고
    • Notch signaling and its role inbreast cancer
    • Wu, F.; Stutzman, A.; Mo, Y. Y. Notch signaling and its role inbreast cancer. Front Biosci., 2007, 12, 4370-4383.
    • (2007) Front Biosci. , vol.12 , pp. 4370-4383
    • Wu, F.1    Stutzman, A.2    Mo, Y.Y.3
  • 33
    • 32944470488 scopus 로고    scopus 로고
    • Aberrant activation ofnotch signaling in human breast cancer
    • Stylianou, S.; Clarke, R. B.; Brennan, K. Aberrant activation ofnotch signaling in human breast cancer. Cancer Res., 2006, 66, 1517-1525.
    • (2006) Cancer Res. , vol.66 , pp. 1517-1525
    • Stylianou, S.1    Clarke, R.B.2    Brennan, K.3
  • 34
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpressionof JAG1 and NOTCH1 is observed in human breast cancerand is associated with poor overall survival
    • Reedijk, M.; Odorcic, S.; Chang, L.; Zhang, H.; Miller, N.; McCready, D. R.; Lockwood, G.; Egan, S. E. High-level coexpressionof JAG1 and NOTCH1 is observed in human breast cancerand is associated with poor overall survival. Cancer Res., 2005, 65, 8530-8537.
    • (2005) Cancer Res. , vol.65 , pp. 8530-8537
    • Reedijk, M.1    Odorcic, S.2    Chang, L.3    Zhang, H.4    Miller, N.5    McCready, D.R.6    Lockwood, G.7    Egan, S.E.8
  • 35
    • 33646415906 scopus 로고    scopus 로고
    • Survivalsignaling by Notch1: Mammalian target of rapamycin(mTOR)-dependent inhibition of p53
    • Mungamuri, S. K.; Yang, X.; Thor, A. D.; Somasundaram, K. Survivalsignaling by Notch1: mammalian target of rapamycin(mTOR)-dependent inhibition of p53. Cancer Res., 2006, 66, 4715-4724.
    • (2006) Cancer Res. , vol.66 , pp. 4715-4724
    • Mungamuri, S.K.1    Yang, X.2    Thor, A.D.3    Somasundaram, K.4
  • 38
    • 36549010842 scopus 로고    scopus 로고
    • Jagged1-mediated Notch activation induces epithelialto-mesenchymal transition through Slug-induced repression of Ecadherin
    • Leong, K. G.; Niessen, K.; Kulic, I.; Raouf, A.; Eaves, C.; Pollet, I.; Karsan, A. Jagged1-mediated Notch activation induces epithelialto-mesenchymal transition through Slug-induced repression of Ecadherin. J. Exp. Med., 2007, 204, 2935-2948.
    • (2007) J. Exp. Med. , vol.204 , pp. 2935-2948
    • Leong, K.G.1    Niessen, K.2    Kulic, I.3    Raouf, A.4    Eaves, C.5    Pollet, I.6    Karsan, A.7
  • 41
    • 37149013962 scopus 로고    scopus 로고
    • Effects of recombinant erythropoietin on breast cancer-initiatingcells
    • Phillips, T. M.; Kim, K.; Vlashi, E.; McBride, W. H.; Pajonk, F. Effects of recombinant erythropoietin on breast cancer-initiatingcells. Neoplasia, 2007, 9, 1122-1129.
    • (2007) Neoplasia , vol.9 , pp. 1122-1129
    • Phillips, T.M.1    Kim, K.2    Vlashi, E.3    McBride, W.H.4    Pajonk, F.5
  • 42
    • 36248953716 scopus 로고    scopus 로고
    • Mammary stem cells and breast cancer-role of Notch signalling
    • Farnie, G.; Clarke, R. B. Mammary stem cells and breast cancer-role of Notch signalling. Stem Cell Rev., 2007, 3, 169-175.
    • (2007) Stem Cell Rev. , vol.3 , pp. 169-175
    • Farnie, G.1    Clarke, R.B.2
  • 45
    • 0030974127 scopus 로고    scopus 로고
    • Conservation of the Drosophila lateral inhibition pathway in human lung cancer: A hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression
    • Chen, H.; Thiagalingam, A.; Chopra, H.; Borges, M. W.; Feder, J. N.; Nelkin, B. D.; Baylin, S. B.; Ball, D. W. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc. Natl. Acad. Sci. USA, 1997, 94, 5355-5360.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5355-5360
    • Chen, H.1    Thiagalingam, A.2    Chopra, H.3    Borges, M.W.4    Feder, J.N.5    Nelkin, B.D.6    Baylin, S.B.7    Ball, D.W.8
  • 46
    • 34548599785 scopus 로고    scopus 로고
    • Oxygen concentration determines the biologicaleffects of NOTCH-1 signaling in adenocarcinoma of thelung
    • Chen, Y.; De, Marco M. A.; Graziani, I.; Gazdar, A. F.; Strack, P. R.; Miele, L.; Bocchetta, M. Oxygen concentration determines the biologicaleffects of NOTCH-1 signaling in adenocarcinoma of thelung. Cancer Res., 2007, 67, 7954-7959.
    • (2007) Cancer Res. , vol.67 , pp. 7954-7959
    • Chen, Y.1    De Marco, M.A.2    Graziani, I.3    Gazdar, A.F.4    Strack, P.R.5    Miele, L.6    Bocchetta, M.7
  • 47
    • 0037417132 scopus 로고    scopus 로고
    • Constitutive activation of Notch3 inhibits terminal epithelialdifferentiation in lungs of transgenic mice
    • Dang, T. P.; Eichenberger, S.; Gonzalez, A.; Olson, S.; Carbone, D. P. Constitutive activation of Notch3 inhibits terminal epithelialdifferentiation in lungs of transgenic mice. Oncogene, 2003, 22, 1988-1997.
    • (2003) Oncogene , vol.22 , pp. 1988-1997
    • Dang, T.P.1    Eichenberger, S.2    Gonzalez, A.3    Olson, S.4    Carbone, D.P.5
  • 49
    • 34548572895 scopus 로고    scopus 로고
    • Gamma-secretase inhibitor preventsNotch3 activation and reduces proliferation in human lung cancers
    • Konishi, J.; Kawaguchi, K. S.; Vo, H.; Haruki, N.; Gonzalez, A.; Carbone, D. P.; Dang, T. P. Gamma-secretase inhibitor preventsNotch3 activation and reduces proliferation in human lung cancers. Cancer Res., 2007, 67, 8051-8057.
    • (2007) Cancer Res. , vol.67 , pp. 8051-8057
    • Konishi, J.1    Kawaguchi, K.S.2    Vo, H.3    Haruki, N.4    Gonzalez, A.5    Carbone, D.P.6    Dang, T.P.7
  • 50
    • 18144426777 scopus 로고    scopus 로고
    • Dominantnegative Notch3 receptor inhibits mitogen-activated protein kinasepathway and the growth of human lung cancers
    • Haruki, N.; Kawaguchi, K. S.; Eichenberger, S.; Massion, P. P.; Olson, S.; Gonzalez, A.; Carbone, D. P.; Dang, T. P. Dominantnegative Notch3 receptor inhibits mitogen-activated protein kinasepathway and the growth of human lung cancers. Cancer Res., 2005,65, 3555-3561.
    • (2005) Cancer Res. , vol.65 , pp. 3555-3561
    • Haruki, N.1    Kawaguchi, K.S.2    Eichenberger, S.3    Massion, P.P.4    Olson, S.5    Gonzalez, A.6    Carbone, D.P.7    Dang, T.P.8
  • 51
    • 15544381570 scopus 로고    scopus 로고
    • Self-renewal and cancer of the gut: Twosides of a coin
    • Radtke, F.; Clevers, H. Self-renewal and cancer of the gut: twosides of a coin. Science, 2005, 307, 1904-1909.
    • (2005) Science , vol.307 , pp. 1904-1909
    • Radtke, F.1    Clevers, H.2
  • 55
    • 58349091690 scopus 로고    scopus 로고
    • Gamma-Secretase inhibitors abrogateoxaliplatin-induced activation of the Notch-1 signaling pathway incolon cancer cells resulting in enhanced chemosensitivity
    • Meng, R. D.; Shelton, C. C.; Li, Y. M; Qin, L. X.; Notterman, D.; Paty, P. B.; Schwartz, G. K. Gamma-Secretase inhibitors abrogateoxaliplatin-induced activation of the Notch-1 signaling pathway incolon cancer cells resulting in enhanced chemosensitivity. Cancer Res., 2009, 69, 573-582.
    • (2009) Cancer Res. , vol.69 , pp. 573-582
    • Meng, R.D.1    Shelton, C.C.2    Li, Y.M.3    Qin, L.X.4    Notterman, D.5    Paty, P.B.6    Schwartz, G.K.7
  • 56
    • 57749110620 scopus 로고    scopus 로고
    • Notch inhibits expression of the Kruppel-like factor 4tumor suppressor in the intestinal epithelium
    • Ghaleb, A. M.; Aggarwal, G.; Bialkowska, A. B.; Nandan, M. O.; Yang, V. W. Notch inhibits expression of the Kruppel-like factor 4tumor suppressor in the intestinal epithelium. Mol. Cancer Res., 2008, 6, 1920-1927.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1920-1927
    • Ghaleb, A.M.1    Aggarwal, G.2    Bialkowska, A.B.3    Nandan, M.O.4    Yang, V.W.5
  • 58
    • 25444506836 scopus 로고    scopus 로고
    • Up-regulation of delta-like 4 ligand in human tumorvasculature and the role of basal expression in endothelial cellfunction
    • Patel, N. S.; Li, J. L.; Generali, D.; Poulsom, R.; Cranston, D. W.; Harris, A. L. Up-regulation of delta-like 4 ligand in human tumorvasculature and the role of basal expression in endothelial cellfunction. Cancer Res., 2005, 65, 8690-8697.
    • (2005) Cancer Res. , vol.65 , pp. 8690-8697
    • Patel, N.S.1    Li, J.L.2    Generali, D.3    Poulsom, R.4    Cranston, D.W.5    Harris, A.L.6
  • 59
    • 68849097965 scopus 로고    scopus 로고
    • Expression and clinical significance of Notch receptors in humanrenal cell carcinoma
    • Sun, S.; Du, R.; Gao, J.; Ning, X.; Xie, H.; Lin, X.; Liu, J.; Fan, D. Expression and clinical significance of Notch receptors in humanrenal cell carcinoma. Pathology, 2009, 41, 335-341.
    • (2009) Pathology , vol.41 , pp. 335-341
    • Sun, S.1    Du, R.2    Gao, J.3    Ning, X.4    Xie, H.5    Lin, X.6    Liu, J.7    Fan, D.8
  • 60
    • 0346365362 scopus 로고    scopus 로고
    • Notch1 signaling inhibits growth of human hepatocellularcarcinoma through induction of cell cycle arrest and apoptosis
    • Qi, R.; An, H.; Yu, Y.; Zhang, M.; Liu, S.; Xu, H.; Guo, Z.; Cheng, T.; Cao, X. Notch1 signaling inhibits growth of human hepatocellularcarcinoma through induction of cell cycle arrest and apoptosis. Cancer Res., 2003, 63, 8323-8329.
    • (2003) Cancer Res. , vol.63 , pp. 8323-8329
    • Qi, R.1    An, H.2    Yu, Y.3    Zhang, M.4    Liu, S.5    Xu, H.6    Guo, Z.7    Cheng, T.8    Cao, X.9
  • 61
    • 67650236862 scopus 로고    scopus 로고
    • Notch1 signaling sensitizes tumor necrosis factor-relatedapoptosis-inducing ligand-induced apoptosis in human hepatocellularcarcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradationand up-regulating p53-dependent DR5 expression
    • Wang, C.; Qi, R.; Li, N.; Wang, Z.; An, H.; Zhang, Q.; Yu, Y.; Cao, X. Notch1 signaling sensitizes tumor necrosis factor-relatedapoptosis-inducing ligand-induced apoptosis in human hepatocellularcarcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradationand up-regulating p53-dependent DR5 expression. J. Biol. Chem., 2009, 284, 16183-16190.
    • (2009) J. Biol. Chem. , vol.284 , pp. 16183-16190
    • Wang, C.1    Qi, R.2    Li, N.3    Wang, Z.4    An, H.5    Zhang, Q.6    Yu, Y.7    Cao, X.8
  • 62
    • 42349090918 scopus 로고    scopus 로고
    • Inhibition of gammasecretaseaffects proliferation of leukemia and hepatoma cell linesthrough Notch signaling
    • Suwanjunee, S.; Wongchana, W.; Palaga, T. Inhibition of gammasecretaseaffects proliferation of leukemia and hepatoma cell linesthrough Notch signaling. Anticancer Drugs, 2008, 19, 477-486.
    • (2008) Anticancer Drugs , vol.19 , pp. 477-486
    • Suwanjunee, S.1    Wongchana, W.2    Palaga, T.3
  • 64
    • 33749012860 scopus 로고    scopus 로고
    • The role of the vascular endothelial growthfactor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vesselremodeling and endothelial cell functions
    • Hainaud, P.; Contreres, J. O.; Villemain, A.; Liu, L. X.; Plouet, J.; Tobelem, G.; Dupuy, E. The role of the vascular endothelial growthfactor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vesselremodeling and endothelial cell functions. Cancer Res., 2006,66, 8501-8510.
    • (2006) Cancer Res. , vol.66 , pp. 8501-8510
    • Hainaud, P.1    Contreres, J.O.2    Villemain, A.3    Liu, L.X.4    Plouet, J.5    Tobelem, G.6    Dupuy, E.7
  • 65
    • 70449732855 scopus 로고    scopus 로고
    • Expression of Notch1, Jagged1 and beta-catenin and their clinicopathologicalsignificance in hepatocellular carcinoma
    • Wang, M.; Xue, L.; Cao, Q.; Lin, Y.; Ding, Y.; Yang, P.; Che, L. Expression of Notch1, Jagged1 and beta-catenin and their clinicopathologicalsignificance in hepatocellular carcinoma. Neoplasma, 2009, 56, 533-541.
    • (2009) Neoplasma , vol.56 , pp. 533-541
    • Wang, M.1    Xue, L.2    Cao, Q.3    Lin, Y.4    Ding, Y.5    Yang, P.6    Che, L.7
  • 69
    • 33747072601 scopus 로고    scopus 로고
    • Aspartyl-asparagyl beta hydroxylaseover-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms
    • Cantarini, M. C.; de la Monte, S. M.; Pang, M.; Tong, M.; D'Errico, A.; Trevisani, F.; Wands, J. R. Aspartyl-asparagyl beta hydroxylaseover-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms. Hepatology, 2006, 44, 446-457.
    • (2006) Hepatology , vol.44 , pp. 446-457
    • Cantarini, M.C.1    de la Monte, S.M.2    Pang, M.3    Tong, M.4    D'Errico, A.5    Trevisani, F.6    Wands, J.R.7
  • 70
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophilanotch gene, is broken by chromosomal translocations in Tlymphoblastic neoplasms
    • Ellisen, L. W.; Bird, J.; West, D. C.; Soreng, A. L.; Reynolds, T. C.; Smith, S. D.; Sklar, J. TAN-1, the human homolog of the Drosophilanotch gene, is broken by chromosomal translocations in Tlymphoblastic neoplasms. Cell, 1991, 66, 649-661.
    • (1991) Cell , vol.66 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3    Soreng, A.L.4    Reynolds, T.C.5    Smith, S.D.6    Sklar, J.7
  • 72
    • 68749088356 scopus 로고    scopus 로고
    • Notch inhibition and glucocorticoid therapyin T-cell acute lymphoblastic leukemia
    • Real, PJ.; Ferrando, A. A. Notch inhibition and glucocorticoid therapyin T-cell acute lymphoblastic leukemia. Leukemia, 2009, 23, 1374-1377.
    • (2009) Leukemia , vol.23 , pp. 1374-1377
    • Real, P.J.1    Ferrando, A.A.2
  • 73
    • 33646366173 scopus 로고    scopus 로고
    • Notch 1 activation in the molecularpathogenesis of T-cell acute lymphoblastic leukaemia
    • Grabher, C.; von, B. H.; Look AT. Notch 1 activation in the molecularpathogenesis of T-cell acute lymphoblastic leukaemia. Nat. Rev. Cancer, 2006, 6, 347-359.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 347-359
    • Grabher, C.1    von, B.H.2    Look, A.T.3
  • 74
    • 42049103185 scopus 로고    scopus 로고
    • Notch signaling in leukemiasand lymphomas
    • Jundt, F.; Schwarzer, R.; Dorken, B. Notch signaling in leukemiasand lymphomas. Curr. Mol. Med., 2008, 8, 51-59.
    • (2008) Curr. Mol. Med. , vol.8 , pp. 51-59
    • Jundt, F.1    Schwarzer, R.2    Dorken, B.3
  • 75
    • 33845595633 scopus 로고    scopus 로고
    • Notch signaling enhances nestin expressionin gliomas
    • Shih, A. H.; Holland, E. C. Notch signaling enhances nestin expressionin gliomas. Neoplasia, 2006, 8, 1072-1082.
    • (2006) Neoplasia , vol.8 , pp. 1072-1082
    • Shih, A.H.1    Holland, E.C.2
  • 79
    • 34547095240 scopus 로고    scopus 로고
    • Spontaneous transformation of human adult nontumorigenicstem cells to cancer stem cells is driven by genomic instabilityin a human model of glioblastoma
    • Shiras, A.; Chettiar, S. T.; Shepal, V.; Rajendran, G.; Prasad, G. R.; Shastry, P. Spontaneous transformation of human adult nontumorigenicstem cells to cancer stem cells is driven by genomic instabilityin a human model of glioblastoma. Stem Cells, 2007, 25, 1478-1489.
    • (2007) Stem Cells , vol.25 , pp. 1478-1489
    • Shiras, A.1    Chettiar, S.T.2    Shepal, V.3    Rajendran, G.4    Prasad, G.R.5    Shastry, P.6
  • 82
    • 0030927183 scopus 로고    scopus 로고
    • The link between integration and expression of human papillomavirustype 16 genomes and cellular changes in the evolution ofcervical intraepithelial neoplastic lesions
    • Daniel, B.; Rangarajan, A.; Mukherjee, G.; Vallikad, E.; Krishna, S. The link between integration and expression of human papillomavirustype 16 genomes and cellular changes in the evolution ofcervical intraepithelial neoplastic lesions. J. Gen. Virol., 1997, 78(Pt 5), 1095-1101.
    • (1997) J. Gen. Virol. , vol.78 , Issue.PART 5 , pp. 1095-1101
    • Daniel, B.1    Rangarajan, A.2    Mukherjee, G.3    Vallikad, E.4    Krishna, S.5
  • 85
    • 78651338072 scopus 로고    scopus 로고
    • Expression ofNotch intracellular domain in cervical cancer and effect of DAPTon cervical cancer cell
    • Sun, X. M.; Wen, H. W.; Chen, C. L.; Liao, Q. P. Expression ofNotch intracellular domain in cervical cancer and effect of DAPTon cervical cancer cell. Zhonghua Fu Chan Ke Za Zhi, 2009, 44,369-373.
    • (2009) Zhonghua Fu Chan Ke Za Zhi , vol.44 , pp. 369-373
    • Sun, X.M.1    Wen, H.W.2    Chen, C.L.3    Liao, Q.P.4
  • 86
    • 0037362373 scopus 로고    scopus 로고
    • HPV16E6 and E7 oncoproteins regulate Notch-1 expression and cooperateto induce transformation
    • Weijzen, S.; Zlobin, A.; Braid, M.; Miele, L.; Kast, W. M. HPV16E6 and E7 oncoproteins regulate Notch-1 expression and cooperateto induce transformation. J. Cell Physiol., 2003, 194, 356-362.
    • (2003) J. Cell Physiol. , vol.194 , pp. 356-362
    • Weijzen, S.1    Zlobin, A.2    Braid, M.3    Miele, L.4    Kast, W.M.5
  • 88
    • 35948943021 scopus 로고    scopus 로고
    • Overexpressedactive Notch1 induces cell growth arrest of He La cervicalcarcinoma cells
    • Wang, L.; Qin, H.; Chen, B.; Xin, X.; Li, J.; Han, H. Overexpressedactive Notch1 induces cell growth arrest of He La cervicalcarcinoma cells. Int. J. Gynecol. Cancer, 2007, 17, 1283-1292.
    • (2007) Int. J. Gynecol. Cancer , vol.17 , pp. 1283-1292
    • Wang, L.1    Qin, H.2    Chen, B.3    Xin, X.4    Li, J.5    Han, H.6
  • 89
    • 16244418366 scopus 로고    scopus 로고
    • Constitutively active Notch1induces growth arrest of HPV-positive cervical cancer cells viaseparate signaling pathways
    • Talora, C.; Cialfi, S.; Segatto, O.; Morrone, S.; Kim, C. J.; Frati, L.; Paolo, D. G.; Gulino, A.; Screpanti, I. Constitutively active Notch1induces growth arrest of HPV-positive cervical cancer cells viaseparate signaling pathways. Exp. Cell Res., 2005, 305, 343-354.
    • (2005) Exp. Cell Res. , vol.305 , pp. 343-354
    • Talora, C.1    Cialfi, S.2    Segatto, O.3    Morrone, S.4    Kim, C.J.5    Frati, L.6    Paolo, D.G.7    Gulino, A.8    Screpanti, I.9
  • 90
    • 0036713311 scopus 로고    scopus 로고
    • Specific downmodulationof Notch1 signaling in cervical cancer cells is requiredfor sustained HPV-E6/E7 expression and late steps of malignanttransformation
    • Talora, C.; Sgroi, D. C.; Crum, C. P.; Dotto, G. P. Specific downmodulationof Notch1 signaling in cervical cancer cells is requiredfor sustained HPV-E6/E7 expression and late steps of malignanttransformation. Genes. Dev., 2002, 16, 2252-2263.
    • (2002) Genes. Dev. , vol.16 , pp. 2252-2263
    • Talora, C.1    Sgroi, D.C.2    Crum, C.P.3    Dotto, G.P.4
  • 91
    • 33947230629 scopus 로고    scopus 로고
    • Notch1 induces cellcycle arrest and apoptosis in human cervical cancer cells: Involvementof nuclear factor kappa B inhibition
    • Yao, J.; Duan, L.; Fan, M.; Yuan, J.; Wu, X. Notch1 induces cellcycle arrest and apoptosis in human cervical cancer cells: involvementof nuclear factor kappa B inhibition. Int. J. Gynecol. Cancer, 2007, 17, 502-510.
    • (2007) Int. J. Gynecol. Cancer , vol.17 , pp. 502-510
    • Yao, J.1    Duan, L.2    Fan, M.3    Yuan, J.4    Wu, X.5
  • 92
    • 50849117455 scopus 로고    scopus 로고
    • The role of Notch signaling in human cervical cancer: Implicationsfor solid tumors
    • Maliekal, T. T.; Bajaj, J.; Giri, V.; Subramanyam, D.; Krishna, S. The role of Notch signaling in human cervical cancer: implicationsfor solid tumors. Oncogene, 2008, 27, 5110-5114.
    • (2008) Oncogene , vol.27 , pp. 5110-5114
    • Maliekal, T.T.1    Bajaj, J.2    Giri, V.3    Subramanyam, D.4    Krishna, S.5
  • 93
    • 67449088876 scopus 로고    scopus 로고
    • Expressionand Significance of Notch1 and PTEN in Gastric Cancer
    • Li, D. W.; Wu, Q.; Peng, Z. H.; Yang, Z. R.; Wang, Y. Expressionand Significance of Notch1 and PTEN in Gastric Cancer. Ai Zheng, 2007, 26, 1183-1187.
    • (2007) Ai Zheng , vol.26 , pp. 1183-1187
    • Li, D.W.1    Wu, Q.2    Peng, Z.H.3    Yang, Z.R.4    Wang, Y.5
  • 94
    • 67449168389 scopus 로고    scopus 로고
    • The activated Notch1 signalpathway is associated with gastric cancer progression through cyclooxygenase-2
    • Yeh, T. S.; Wu, C. W.; Hsu, K. W.; Liao, W. J.; Yang, M. C.; Li, A. F.; Wang, A. M.; Kuo, M. L.; Chi, C. W. The activated Notch1 signalpathway is associated with gastric cancer progression through cyclooxygenase-2. Cancer Res., 2009, 69, 5039-5048.
    • (2009) Cancer Res. , vol.69 , pp. 5039-5048
    • Yeh, T.S.1    Wu, C.W.2    Hsu, K.W.3    Liao, W.J.4    Yang, M.C.5    Li, A.F.6    Wang, A.M.7    Kuo, M.L.8    Chi, C.W.9
  • 95
    • 53949090314 scopus 로고    scopus 로고
    • Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
    • Ji, Q.; Hao, X.; Meng, Y.; Zhang, M.; Desano, J.; Fan, D.; Xu, L. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer, 2008, 8, 266.
    • (2008) BMC Cancer , vol.8 , pp. 266
    • Ji, Q.1    Hao, X.2    Meng, Y.3    Zhang, M.4    Desano, J.5    Fan, D.6    Xu, L.7
  • 96
    • 34548452775 scopus 로고    scopus 로고
    • Tumor suppressor role of Notch-1signaling in neuroendocrine tumors
    • Kunnimalaiyaan, M.; Chen, H. Tumor suppressor role of Notch-1signaling in neuroendocrine tumors. Oncologist, 2007, 12, 535-542.
    • (2007) Oncologist , vol.12 , pp. 535-542
    • Kunnimalaiyaan, M.1    Chen, H.2
  • 97
    • 50849100996 scopus 로고    scopus 로고
    • The many facets ofNotch ligands
    • D'Souza, B.; Miyamoto, A.; Weinmaster, G. The many facets ofNotch ligands. Oncogene, 2008, 27, 5148-5167.
    • (2008) Oncogene , vol.27 , pp. 5148-5167
    • D'Souza, B.1    Miyamoto, A.2    Weinmaster, G.3
  • 98
    • 50849103301 scopus 로고    scopus 로고
    • Notch signaling regulatestumor angiogenesis by diverse mechanisms
    • Dufraine, J.; Funahashi, Y.; Kitajewski, J. Notch signaling regulatestumor angiogenesis by diverse mechanisms. Oncogene, 2008,27, 5132-5137.
    • (2008) Oncogene , vol.27 , pp. 5132-5137
    • Dufraine, J.1    Funahashi, Y.2    Kitajewski, J.3
  • 99
    • 41349095228 scopus 로고    scopus 로고
    • Inhibition of Notch signaling induces apoptosis ofmyeloma cells and enhances sensitivity to chemotherapy
    • Nefedova, Y.; Sullivan, D. M.; Bolick, S. C.; Dalton, W. S.; Gabrilovich, D. I. Inhibition of Notch signaling induces apoptosis ofmyeloma cells and enhances sensitivity to chemotherapy. Blood, 2008, 111, 2220-2229.
    • (2008) Blood , vol.111 , pp. 2220-2229
    • Nefedova, Y.1    Sullivan, D.M.2    Bolick, S.C.3    Dalton, W.S.4    Gabrilovich, D.I.5
  • 100
    • 27144512725 scopus 로고    scopus 로고
    • Gamma secretase inhibitor blocks Notch activationand induces apoptosis in Kaposi's sarcoma tumor cells
    • Curry, C. L.; Reed, L. L.; Golde, T. E.; Miele, L.; Nickoloff, B. J.; Foreman, KE. Gamma secretase inhibitor blocks Notch activationand induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene, 2005, 24, 6333-6344.
    • (2005) Oncogene , vol.24 , pp. 6333-6344
    • Curry, C.L.1    Reed, L.L.2    Golde, T.E.3    Miele, L.4    Nickoloff, B.J.5    Foreman, K.E.6
  • 101
    • 50649125794 scopus 로고    scopus 로고
    • Erb B-2 inhibition activates Notch-1 and sensitizesbreast cancer cells to a gamma-secretase inhibitor
    • Osipo, C.; Patel, P.; Rizzo, P.; Clementz, A. G.; Hao, L.; Golde, T. E.; Miele, L. Erb B-2 inhibition activates Notch-1 and sensitizesbreast cancer cells to a gamma-secretase inhibitor. Oncogene, 2008, 27, 5019-5032.
    • (2008) Oncogene , vol.27 , pp. 5019-5032
    • Osipo, C.1    Patel, P.2    Rizzo, P.3    Clementz, A.G.4    Hao, L.5    Golde, T.E.6    Miele, L.7
  • 103
    • 33748872289 scopus 로고    scopus 로고
    • Down-regulation of Jagged-1 induces cell growth inhibition and Sphase arrest in prostate cancer cells
    • Zhang, Y.; Wang, Z.; Ahmed, F.; Banerjee, S.; Li, Y.; Sarkar, F. H. Down-regulation of Jagged-1 induces cell growth inhibition and Sphase arrest in prostate cancer cells. Int. J. Cancer, 2006, 119, 2071-2077.
    • (2006) Int. J. Cancer , vol.119 , pp. 2071-2077
    • Zhang, Y.1    Wang, Z.2    Ahmed, F.3    Banerjee, S.4    Li, Y.5    Sarkar, F.H.6
  • 104
    • 33646877856 scopus 로고    scopus 로고
    • Notch-1down-regulation by curcumin is associated with the inhibition ofcell growth and the induction of apoptosis in pancreatic cancercells
    • Wang, Z.; Zhang, Y.; Banerjee, S.; Li, Y.; Sarkar, F. H. Notch-1down-regulation by curcumin is associated with the inhibition ofcell growth and the induction of apoptosis in pancreatic cancercells. Cancer, 2006, 106, 2503-2513.
    • (2006) Cancer , vol.106 , pp. 2503-2513
    • Wang, Z.1    Zhang, Y.2    Banerjee, S.3    Li, Y.4    Sarkar, F.H.5
  • 105
    • 33645064160 scopus 로고    scopus 로고
    • Inhibitionof nuclear factor kappab activity by genistein is mediated viaNotch-1 signaling pathway in pancreatic cancer cells
    • Wang, Z.; Zhang, Y.; Banerjee, S.; Li, Y.; Sarkar, F. H. Inhibitionof nuclear factor kappab activity by genistein is mediated viaNotch-1 signaling pathway in pancreatic cancer cells. Int. J. Cancer, 2006, 118, 1930-1936.
    • (2006) Int. J. Cancer , vol.118 , pp. 1930-1936
    • Wang, Z.1    Zhang, Y.2    Banerjee, S.3    Li, Y.4    Sarkar, F.H.5
  • 107
    • 2342622022 scopus 로고    scopus 로고
    • Cancer chemopreventiveactivity of a mixture of Chinese herbs (antitumor B) in mouse lungtumor models
    • Zhang, Z.; Wang, Y.; Yao, R.; Li, J.; Yan, Y.; La, R. M.; Lemon, W. L.; Grubbs, C. J.; Lubet, R. A.; You, M. Cancer chemopreventiveactivity of a mixture of Chinese herbs (antitumor B) in mouse lungtumor models. Oncogene, 2004, 23, 3841-3850.
    • (2004) Oncogene , vol.23 , pp. 3841-3850
    • Zhang, Z.1    Wang, Y.2    Yao, R.3    Li, J.4    Yan, Y.5    La, R.M.6    Lemon, W.L.7    Grubbs, C.J.8    Lubet, R.A.9    You, M.10


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