Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 37, 2008, Pages 14082-14087

  Suárez, Yajaira ^a   Fernández Hernando, Carlos ^a   Yu, Jun ^a   Gerber, Scott A ^a   Harrison, Kenneth D ^a   Pober, Jordan S ^a   Iruela Arispe, M Luisa ^b   Merkenschlager, Matthias ^c   Sessa, William C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Endothelium; VEGF

Indexed keywords

DICER; MICRORNA; THROMBOSPONDIN 1; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; ENDOTHELIUM CELL; GENE CLUSTER; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIMB ISCHEMIA; MALE; MORPHOGENESIS; MOUSE; NONHUMAN; ONCOGENE C MYC; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROCESSING; REDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL; UPREGULATION; WOUND HEALING;

EID: 52949090784     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804597105     Document Type: Article

References (40)

1. He L, Hannon GJ (2004) MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet 5:522-531.
2. Vasudevan S, Tong Y, Steitz JA (2007) Switching from repression to activation: microRNAs can up-regulate translation. Science 318:1931-1934.
3. Bernstein E, et al. (2003) Dicer is essential for mouse development. Nat Genet 35:215-217.
4. Yang WJ, et al. (2005) Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem 280:9330-9335.
5. Harfe BD, McManus MT, Mansfield JH, Hornstein E, Tabin CJ (2005) The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci USA 102:10898-10903.
6. Harris KS, Zhang Z, McManus MT, Harfe BD, Sun X (2006) Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci USA 103:2208-2213.
7. Yi R, et al. (2006) Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet 38:356-362.
8. Andl T, et al. (2006) The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol 16:1041-1049.
9. Cobb BS, et al. (2005) T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med 201:1367-1373.
10. Cobb BS, et al. (2006) A role for Dicer in immune regulation. J Exp Med 203:2519-2527.
11. Kim J, et al. (2007) A microRNA feedback circuit in midbrain dopamine neurons. Science 317:1220-1224.
12. Pober JS, Sessa WC (2007) Evolving functions of endothelial cells in inflammation. Nat Rev Immunol 7:803-815.
13. Carmeliet P (2005) Angiogenesis in life, disease, and medicine. Nature 438:932-936.
14. Yancopoulos GD, et al. (2000) Vascular-specific growth factors and blood vessel formation. Nature 407:242-248.
15. Ferrara N (2002) Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications. Semin Oncol 29:10-14.
16. Suarez Y, Fernandez-Hernando C, Pober JS, Sessa WC (2007) Dicer-dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res 100:1164-1173.
17. Kuehbacher A, Urbich C, Zeiher AM, Dimmeler S (2007) Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res 101:59-68.
18. Otsuka M, et al. (2008) Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. J Clin Invest 118:1944-1954.
19. Kisanuki YY, et al. (2001) Tie2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo. Dev Biol 230:230-242.
20. Monvoisin A, et al. (2006) VE-cadherin-CreERT2 transgenic mouse: A model for inducible recombination in the endothelium. Dev Dyn 235:3413-3422.
21. Ackah E, et al. (2005) Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis. J Clin Invest 115:2119-2127.
22. Yu J, et al. (2005) Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Proc Natl Acad Sci USA 102:10999-11004.
23. Poliseno L, et al. (2006) MicroRNAs modulate the angiogenic properties of HUVECs. Blood 108:3068-3071.
24. Pedersen IM, et al. (2007) Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 449:919-922.
25. Davis BN, Hilyard AC, Lagna G, Hata A (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454:56-61.
26. van Rooij E, et al. (2007) Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316:575-579.
27. Volinia S, et al. (2006) AmicroRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103:2257-2261.
28. Cheng AM, Byrom MW, Shelton J, Ford LP (2005) Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res 33:1290-1297.
29. Chan JA, Krichevsky AM, Kosik KS (2005) MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65:6029-6033.
30. Dews M, et al. (2006) Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet 38:1060-1065.
31. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT (2005) c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435:839-843.
32. Woods K, Thomson JM, Hammond SM (2007) Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem 282:2130-2134.
33. Murchison EP, Partridge JF, Tam OH, Cheloufi S, Hannon GJ (2005) Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci USA 102:12135-12140.
34. Xiao C, et al. (2008) Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol 9:405-414.
35. Ventura A, et al. (2008) Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 132:875-886.
36. Fernandez-Hernando C, et al. (2007) Loss of akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab 6:446-457.
37. Gerber SA, et al. (2003) Mechanism of IL-12 mediated alterations in tumor blood vessel morphology: Analysis using whole-tissue mounts. Br J Cancer 88:1453-1461.
38. Lin MI, Yu J, Murata T, Sessa WC (2007) Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Cancer Res 67:2849-2856.
39. Zhou Z, et al. (2004) Impaired angiogenesis, delayed wound healing, and retarded tumor growth in perlecan heparan sulfate-deficient mice. Cancer Res 64:4699-4702.
40. Suarez Y, Shepherd BR, Rao DA, Pober JS (2007) Alloimmunity to human endothelial cells derived from cord blood progenitors. J Immunol 179:7488-7496.