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Volumn 153, Issue 2, 2009, Pages 347-358

The Role of Vascular Endothelial Growth Factor in Wound Healing

Author keywords

angiogenesis; epithelialization; fibroblast; keratinocyte; VEGF; wound healing

Indexed keywords

GELATINASE A; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; PLATELET DERIVED GROWTH FACTOR BB; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

EID: 64849116779     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.04.023     Document Type: Review
Times cited : (909)

References (150)
  • 1
    • 0035525431 scopus 로고    scopus 로고
    • The 1999 National Pressure Ulcer Prevalence Survey: A benchmarking approach
    • Amlung S.R., Miller W.L., and Bosley L.M. The 1999 National Pressure Ulcer Prevalence Survey: A benchmarking approach. Adv Skin Wound Care 14 (2001) 297
    • (2001) Adv Skin Wound Care , vol.14 , pp. 297
    • Amlung, S.R.1    Miller, W.L.2    Bosley, L.M.3
  • 2
    • 84988547569 scopus 로고    scopus 로고
    • Hospitalizations Related to Pressure Sores, 2003 Accessed: August 31, 2006
    • Hospitalizations Related to Pressure Sores, 2003. Agency for Healthcare Research and Quality, 2006. http://www.hcup-us.ahrq.gov/reports/statbriefs/sb3.pdf Accessed: August 31, 2006
    • Agency for Healthcare Research and Quality, 2006
  • 3
    • 0015909753 scopus 로고
    • Venous thromboembolism and other venous disease in the Tecumseh community health study
    • Coon W.W., Willis III P.W., and Keller J.B. Venous thromboembolism and other venous disease in the Tecumseh community health study. Circulation 48 (1973) 839
    • (1973) Circulation , vol.48 , pp. 839
    • Coon, W.W.1    Willis III, P.W.2    Keller, J.B.3
  • 4
    • 0032771893 scopus 로고    scopus 로고
    • American Diabetes Association
    • Consensus Development Conference on Diabetic Foot Wound Care: 7-8 April 1999, Boston, Massachusetts
    • Consensus Development Conference on Diabetic Foot Wound Care: 7-8 April 1999, Boston, Massachusetts. American Diabetes Association. Diabetes Care 22 (1999) 1354
    • (1999) Diabetes Care , vol.22 , pp. 1354
  • 5
    • 0038003181 scopus 로고    scopus 로고
    • Epidemiology of nontraumatic lower-extremity amputation in area 7. Madrid, between 1989 and 1999: A population-based study
    • Calle-Pascual A., Garcia-Torre N., Moraga I., et al. Epidemiology of nontraumatic lower-extremity amputation in area 7. Madrid, between 1989 and 1999: A population-based study. Diabetes Care 24 (2001) 1686
    • (2001) Diabetes Care , vol.24 , pp. 1686
    • Calle-Pascual, A.1    Garcia-Torre, N.2    Moraga, I.3
  • 6
    • 26244464272 scopus 로고    scopus 로고
    • Evaluation of diabetic wound classifications and a new wound score
    • Strauss M.B., and Aksenov I.V. Evaluation of diabetic wound classifications and a new wound score. Clin Orthopaed Relat Res 439 (2005) 79
    • (2005) Clin Orthopaed Relat Res , vol.439 , pp. 79
    • Strauss, M.B.1    Aksenov, I.V.2
  • 7
    • 0033986417 scopus 로고    scopus 로고
    • A pilot study of noninvasive methods to assess healed acute and chronic wounds
    • Ho D.Q., Bello Y.M., Grove G.L., et al. A pilot study of noninvasive methods to assess healed acute and chronic wounds. Dermatol Surg 26 (2000) 42
    • (2000) Dermatol Surg , vol.26 , pp. 42
    • Ho, D.Q.1    Bello, Y.M.2    Grove, G.L.3
  • 8
    • 33846627240 scopus 로고    scopus 로고
    • Pathophysiology of acute wound healing
    • Li J., Chen J., and Kirsner R. Pathophysiology of acute wound healing. Clin Dermatol 25 (2007) 9
    • (2007) Clin Dermatol , vol.25 , pp. 9
    • Li, J.1    Chen, J.2    Kirsner, R.3
  • 9
    • 0642346665 scopus 로고    scopus 로고
    • Growth factors: the wound healing therapy of the future
    • S8, S22
    • Carter K. Growth factors: the wound healing therapy of the future. Br J Commu Nurs 8 (2003) S15 S8, S22
    • (2003) Br J Commu Nurs , vol.8
    • Carter, K.1
  • 10
    • 0034074334 scopus 로고    scopus 로고
    • [The role of growth factors in wound healing]
    • Debus E.S., Schmidt K., Ziegler U.E., et al. [The role of growth factors in wound healing]. Zentralbl Chir 125 Suppl 1 (2000) 49
    • (2000) Zentralbl Chir , vol.125 , Issue.SUPPL. 1 , pp. 49
    • Debus, E.S.1    Schmidt, K.2    Ziegler, U.E.3
  • 12
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara N., and Henzel W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161 (1989) 851
    • (1989) Biochem Biophys Res Commun , vol.161 , pp. 851
    • Ferrara, N.1    Henzel, W.J.2
  • 13
    • 0024816246 scopus 로고
    • Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells
    • Plouet J., Schilling J., and Gospodarowicz D. Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells. EMBO J 8 (1989) 3801
    • (1989) EMBO J , vol.8 , pp. 3801
    • Plouet, J.1    Schilling, J.2    Gospodarowicz, D.3
  • 14
    • 0008885761 scopus 로고
    • Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells
    • Gospodarowicz D., Abraham J.A., and Schilling J. Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc Natl Acad Sci USA 86 (1989) 7311
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7311
    • Gospodarowicz, D.1    Abraham, J.A.2    Schilling, J.3
  • 15
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung D.W., Cachianes G., Kuang W.J., et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246 (1989) 1306
    • (1989) Science , vol.246 , pp. 1306
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3
  • 16
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Keck P.J., Hauser S.D., Krivi G., et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246 (1989) 1309
    • (1989) Science , vol.246 , pp. 1309
    • Keck, P.J.1    Hauser, S.D.2    Krivi, G.3
  • 17
    • 0024461206 scopus 로고
    • Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis
    • Connolly D.T., Heuvelman D.M., Nelson R., et al. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84 (1989) 1470
    • (1989) J Clin Invest , vol.84 , pp. 1470
    • Connolly, D.T.1    Heuvelman, D.M.2    Nelson, R.3
  • 18
    • 0029945524 scopus 로고    scopus 로고
    • Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factor
    • Yoshida A., Anand-Apte B., and Zetter B.R. Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factor. Growth Factors 13 (1996) 57
    • (1996) Growth Factors , vol.13 , pp. 57
    • Yoshida, A.1    Anand-Apte, B.2    Zetter, B.R.3
  • 19
    • 0031886882 scopus 로고    scopus 로고
    • Podokinesis in endothelial cell migration: role of nitric oxide
    • Noiri E., Lee E., Testa J., et al. Podokinesis in endothelial cell migration: role of nitric oxide. Am J Physiol 274 (1998) C236
    • (1998) Am J Physiol , vol.274
    • Noiri, E.1    Lee, E.2    Testa, J.3
  • 20
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger D.R., Galli S.J., Dvorak A.M., et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219 (1983) 983
    • (1983) Science , vol.219 , pp. 983
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3
  • 21
    • 0025194878 scopus 로고
    • Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor
    • Senger D.R., Connolly D.T., Van de Water L., et al. Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res 50 (1990) 1774
    • (1990) Cancer Res , vol.50 , pp. 1774
    • Senger, D.R.1    Connolly, D.T.2    Van de Water, L.3
  • 22
    • 33846660840 scopus 로고    scopus 로고
    • Vascular permeability induced by VEGF family members in vivo: Role of endogenous PAF and NO synthesis
    • Brkovic A., and Sirois M.G. Vascular permeability induced by VEGF family members in vivo: Role of endogenous PAF and NO synthesis. J Cell Biochem 100 (2007) 727
    • (2007) J Cell Biochem , vol.100 , pp. 727
    • Brkovic, A.1    Sirois, M.G.2
  • 23
    • 0032852528 scopus 로고    scopus 로고
    • Molecular and biological properties of vascular endothelial growth factor
    • Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med 77 (1999) 527
    • (1999) J Mol Med , vol.77 , pp. 527
    • Ferrara, N.1
  • 24
    • 33750529948 scopus 로고    scopus 로고
    • VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin
    • Gavard J., and Gutkind J.S. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol 8 (2006) 1223
    • (2006) Nat Cell Biol , vol.8 , pp. 1223
    • Gavard, J.1    Gutkind, J.S.2
  • 25
    • 0034090097 scopus 로고    scopus 로고
    • Angiogenesis: Potentials for pharmacological interventionin the treatment of cancer, cardiovascular diseases, and chronic inflammation
    • Griffoen A.W., and Molema G. Angiogenesis: Potentials for pharmacological interventionin the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 52 (2000) 237
    • (2000) Pharmacol Rev , vol.52 , pp. 237
    • Griffoen, A.W.1    Molema, G.2
  • 26
    • 0032932547 scopus 로고    scopus 로고
    • Vascular endothelial growth factor acts as a pericyte mitogen under hypoxic conditions
    • Yamagishi S., Yonekura H., Yamamoto Y., et al. Vascular endothelial growth factor acts as a pericyte mitogen under hypoxic conditions. Lab Invest 79 (1999) 501
    • (1999) Lab Invest , vol.79 , pp. 501
    • Yamagishi, S.1    Yonekura, H.2    Yamamoto, Y.3
  • 27
    • 64849109856 scopus 로고    scopus 로고
    • A novel, non-angiogenic mechanism of VEGF: Stimulation of keratinocyte and fibroblast migration
    • Stojadinovic O.K.A., Golinko M., Tomic-Canic M., et al. A novel, non-angiogenic mechanism of VEGF: Stimulation of keratinocyte and fibroblast migration. Wound Repair Regen 15 (2007) A30
    • (2007) Wound Repair Regen , vol.15
    • Stojadinovic, O.K.A.1    Golinko, M.2    Tomic-Canic, M.3
  • 28
    • 0034056971 scopus 로고    scopus 로고
    • Becaplermin gel (PDGF-BB) as topical wound therapy. Plastic Surgery Educational Foundation DATA Committee
    • Ladin D. Becaplermin gel (PDGF-BB) as topical wound therapy. Plastic Surgery Educational Foundation DATA Committee. Plast Reconstr Surg 105 (2000) 1230
    • (2000) Plast Reconstr Surg , vol.105 , pp. 1230
    • Ladin, D.1
  • 29
    • 0032468016 scopus 로고    scopus 로고
    • Apligraf treatment of venous ulcers and other chronic wounds
    • Falanga V. Apligraf treatment of venous ulcers and other chronic wounds. J Dermatol 25 (1998) 812
    • (1998) J Dermatol , vol.25 , pp. 812
    • Falanga, V.1
  • 30
    • 0035191587 scopus 로고    scopus 로고
    • Healing of venous ulcers of long duration with a bilayered living skin substitute: results from a general surgery and dermatology department
    • Brem H., Balledux J., Sukkarieh T., et al. Healing of venous ulcers of long duration with a bilayered living skin substitute: results from a general surgery and dermatology department. Dermatol Surg 27 (2001) 915
    • (2001) Dermatol Surg , vol.27 , pp. 915
    • Brem, H.1    Balledux, J.2    Sukkarieh, T.3
  • 31
    • 0034089949 scopus 로고    scopus 로고
    • Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: A new paradigm in wound healing
    • Brem H., Balledux J., Bloom T., et al. Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: A new paradigm in wound healing. Arch Surg 135 (2000) 627
    • (2000) Arch Surg , vol.135 , pp. 627
    • Brem, H.1    Balledux, J.2    Bloom, T.3
  • 32
    • 0025999033 scopus 로고
    • The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
    • Tischer E., Mitchell R., Hartman T., et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266 (1991) 11947
    • (1991) J Biol Chem , vol.266 , pp. 11947
    • Tischer, E.1    Mitchell, R.2    Hartman, T.3
  • 33
    • 0026395163 scopus 로고
    • The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
    • Houck K.A., Ferrara N., Winer J., et al. The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5 (1991) 1806
    • (1991) Mol Endocrinol , vol.5 , pp. 1806
    • Houck, K.A.1    Ferrara, N.2    Winer, J.3
  • 34
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • Houck K.A., Leung D.W., Rowland A.M., et al. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 267 (1992) 26031
    • (1992) J Biol Chem , vol.267 , pp. 26031
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3
  • 35
    • 0030614869 scopus 로고    scopus 로고
    • VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix
    • Poltorak Z., Cohen T., Sivan R., et al. VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J Biol Chem 272 (1997) 7151
    • (1997) J Biol Chem , vol.272 , pp. 7151
    • Poltorak, Z.1    Cohen, T.2    Sivan, R.3
  • 36
    • 34247874642 scopus 로고    scopus 로고
    • Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    • Maruyama K., Asai J., Ii M., et al. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol 170 (2007) 1178
    • (2007) Am J Pathol , vol.170 , pp. 1178
    • Maruyama, K.1    Asai, J.2    Ii, M.3
  • 37
    • 0027957807 scopus 로고
    • Glomerular endothelial cells in culture express and secrete vascular endothelial growth factor
    • Uchida K., Uchida S., Nitta K., et al. Glomerular endothelial cells in culture express and secrete vascular endothelial growth factor. Am J Physiol 266 (1994) F81
    • (1994) Am J Physiol , vol.266
    • Uchida, K.1    Uchida, S.2    Nitta, K.3
  • 38
    • 0029598486 scopus 로고
    • Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells
    • Namiki A., Brogi E., Kearney M., et al. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J Biol Chem 270 (1995) 31189
    • (1995) J Biol Chem , vol.270 , pp. 31189
    • Namiki, A.1    Brogi, E.2    Kearney, M.3
  • 39
    • 0031779927 scopus 로고    scopus 로고
    • Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing
    • Nissen N.N., Polverini P.J., Koch A.E., et al. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am J Pathol 152 (1998) 1445
    • (1998) Am J Pathol , vol.152 , pp. 1445
    • Nissen, N.N.1    Polverini, P.J.2    Koch, A.E.3
  • 40
    • 0028100605 scopus 로고
    • Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only
    • Brogi E., Wu T., Namiki A., and Isner J.M. Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only. Circulation 90 (1994) 649
    • (1994) Circulation , vol.90 , pp. 649
    • Brogi, E.1    Wu, T.2    Namiki, A.3    Isner, J.M.4
  • 41
    • 0029072011 scopus 로고
    • Basic fibroblast growth factor upregulates the expression of vascular endothelial growth factor in vascular smooth muscle cells. Synergistic interaction with hypoxia
    • Stavri G.T., Zachary I.C., Baskerville P.A., et al. Basic fibroblast growth factor upregulates the expression of vascular endothelial growth factor in vascular smooth muscle cells. Synergistic interaction with hypoxia. Circulation 92 (1995) 11
    • (1995) Circulation , vol.92 , pp. 11
    • Stavri, G.T.1    Zachary, I.C.2    Baskerville, P.A.3
  • 42
    • 0031889548 scopus 로고    scopus 로고
    • Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: Significance for VEGF measurements and cancer biology
    • Banks R.E., Forbes M.A., Kinsey S.E., et al. Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: Significance for VEGF measurements and cancer biology. Br J Cancer 77 (1998) 956
    • (1998) Br J Cancer , vol.77 , pp. 956
    • Banks, R.E.1    Forbes, M.A.2    Kinsey, S.E.3
  • 43
    • 1842366022 scopus 로고    scopus 로고
    • Intracellular pool of vascular endothelial growth factor in human neutrophils
    • Gaudry M., Bregerie O., Andrieu V., et al. Intracellular pool of vascular endothelial growth factor in human neutrophils. Blood 90 (1997) 4153
    • (1997) Blood , vol.90 , pp. 4153
    • Gaudry, M.1    Bregerie, O.2    Andrieu, V.3
  • 44
    • 0027104066 scopus 로고
    • Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors
    • Berse B., Brown L.F., Van de Water L., et al. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol Biol Cell 3 (1992) 211
    • (1992) Mol Biol Cell , vol.3 , pp. 211
    • Berse, B.1    Brown, L.F.2    Van de Water, L.3
  • 45
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • de Vries C., Escobedo J.A., Ueno H., et al. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255 (1992) 989
    • (1992) Science , vol.255 , pp. 989
    • de Vries, C.1    Escobedo, J.A.2    Ueno, H.3
  • 46
    • 0030044984 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, a potent and selective angiogenic agent
    • Thomas K.A. Vascular endothelial growth factor, a potent and selective angiogenic agent. J Biol Chem 271 (1996) 603
    • (1996) J Biol Chem , vol.271 , pp. 603
    • Thomas, K.A.1
  • 47
    • 0026702970 scopus 로고
    • Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
    • Terman B.I., Dougher-Vermazen M., Carrion M.E., et al. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 187 (1992) 1579
    • (1992) Biochem Biophys Res Commun , vol.187 , pp. 1579
    • Terman, B.I.1    Dougher-Vermazen, M.2    Carrion, M.E.3
  • 48
    • 0029965081 scopus 로고    scopus 로고
    • Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain
    • Soker S., Fidder H., Neufeld G., et al. Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain. J Biol Chem 271 (1996) 5761
    • (1996) J Biol Chem , vol.271 , pp. 5761
    • Soker, S.1    Fidder, H.2    Neufeld, G.3
  • 49
  • 50
    • 0027424647 scopus 로고
    • Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth
    • Peters K.G., De Vries C., and Williams L.T. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci USA 90 (1993) 8915
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8915
    • Peters, K.G.1    De Vries, C.2    Williams, L.T.3
  • 51
    • 0030809478 scopus 로고    scopus 로고
    • Angiogenesis in embryos and ischemic diseases
    • Breier G., Damert A., Plate K.H., et al. Angiogenesis in embryos and ischemic diseases. Thromb Haemost 78 (1997) 678
    • (1997) Thromb Haemost , vol.78 , pp. 678
    • Breier, G.1    Damert, A.2    Plate, K.H.3
  • 52
    • 0028281244 scopus 로고
    • Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells
    • Barleon B., Hauser S., Schollmann C., et al. Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells. J Cell Biochem 54 (1994) 56
    • (1994) J Cell Biochem , vol.54 , pp. 56
    • Barleon, B.1    Hauser, S.2    Schollmann, C.3
  • 53
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    • Shalaby F., Rossant J., Yamaguchi T.P., et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376 (1995) 62
    • (1995) Nature , vol.376 , pp. 62
    • Shalaby, F.1    Rossant, J.2    Yamaguchi, T.P.3
  • 54
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong G.H., Rossant J., Gertsenstein M., et al. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376 (1995) 66
    • (1995) Nature , vol.376 , pp. 66
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3
  • 55
    • 0027997863 scopus 로고
    • Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
    • Waltenberger J., Claesson-Welsh L., Siegbahn A., et al. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 269 (1994) 26988
    • (1994) J Biol Chem , vol.269 , pp. 26988
    • Waltenberger, J.1    Claesson-Welsh, L.2    Siegbahn, A.3
  • 56
    • 0031282098 scopus 로고    scopus 로고
    • Activation of Flk-1/KDR mediates angiogenesis but not hypotension
    • Malavaud B., Tack I., Jonca F., et al. Activation of Flk-1/KDR mediates angiogenesis but not hypotension. Cardiovasc Res 36 (1997) 276
    • (1997) Cardiovasc Res , vol.36 , pp. 276
    • Malavaud, B.1    Tack, I.2    Jonca, F.3
  • 57
    • 0029867554 scopus 로고    scopus 로고
    • Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • Barleon B., Sozzani S., Zhou D., et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87 (1996) 3336
    • (1996) Blood , vol.87 , pp. 3336
    • Barleon, B.1    Sozzani, S.2    Zhou, D.3
  • 58
    • 0032547763 scopus 로고    scopus 로고
    • Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: Role of flt-1
    • Wang H., and Keiser J.A. Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: Role of flt-1. Circ Res 83 (1998) 832
    • (1998) Circ Res , vol.83 , pp. 832
    • Wang, H.1    Keiser, J.A.2
  • 59
    • 0028880305 scopus 로고
    • Expression of the vascular endothelial growth factor (VEGF) receptor gene. KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation
    • Katoh O., Tauchi H., Kawaishi K., et al. Expression of the vascular endothelial growth factor (VEGF) receptor gene. KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation. Cancer Res 55 (1995) 5687
    • (1995) Cancer Res , vol.55 , pp. 5687
    • Katoh, O.1    Tauchi, H.2    Kawaishi, K.3
  • 60
    • 0026699255 scopus 로고
    • FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines
    • Pajusola K., Aprelikova O., Korhonen J., et al. FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res 52 (1992) 5738
    • (1992) Cancer Res , vol.52 , pp. 5738
    • Pajusola, K.1    Aprelikova, O.2    Korhonen, J.3
  • 61
    • 0026753981 scopus 로고
    • Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene
    • Galland F., Karamysheva A., Mattei M.G., et al. Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene. Genomics 13 (1992) 475
    • (1992) Genomics , vol.13 , pp. 475
    • Galland, F.1    Karamysheva, A.2    Mattei, M.G.3
  • 62
    • 17744396472 scopus 로고    scopus 로고
    • Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice
    • Veikkola T., Jussila L., Makinen T., et al. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J 20 (2001) 1223
    • (2001) EMBO J , vol.20 , pp. 1223
    • Veikkola, T.1    Jussila, L.2    Makinen, T.3
  • 63
    • 0035970622 scopus 로고    scopus 로고
    • Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin
    • Enholm B., Karpanen T., Jeltsch M., et al. Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin. Circ Res 88 (2001) 623
    • (2001) Circ Res , vol.88 , pp. 623
    • Enholm, B.1    Karpanen, T.2    Jeltsch, M.3
  • 64
    • 0002626182 scopus 로고
    • Angiogenesis and inflammation
    • Gallin J., Goldstein I., and Snyderman R. (Eds), Raven Press, New York
    • Folkman J., and Brem H. Angiogenesis and inflammation. In: Gallin J., Goldstein I., and Snyderman R. (Eds). Inflammation: Basic Principles and Clinical Correlates. 2nd ed. (1992), Raven Press, New York 821-839
    • (1992) Inflammation: Basic Principles and Clinical Correlates. 2nd ed. , pp. 821-839
    • Folkman, J.1    Brem, H.2
  • 65
    • 0031974158 scopus 로고    scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin
    • Murohara T., Horowitz J.R., Silver M., et al. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. Circulation 97 (1998) 99
    • (1998) Circulation , vol.97 , pp. 99
    • Murohara, T.1    Horowitz, J.R.2    Silver, M.3
  • 66
    • 0027217832 scopus 로고
    • Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries
    • Ku D.D., Zaleski J.K., Liu S., et al. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. Am J Physiol 265 (1993) H586
    • (1993) Am J Physiol , vol.265
    • Ku, D.D.1    Zaleski, J.K.2    Liu, S.3
  • 67
    • 0031041932 scopus 로고    scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium
    • van der Zee R., Murohara T., Luo Z., et al. Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 95 (1997) 1030
    • (1997) Circulation , vol.95 , pp. 1030
    • van der Zee, R.1    Murohara, T.2    Luo, Z.3
  • 68
    • 0030878259 scopus 로고    scopus 로고
    • Stretch-induced VEGF expression in the heart
    • Li J., Hampton T., Morgan J.P., et al. Stretch-induced VEGF expression in the heart. J Clin Invest 100 (1997) 18
    • (1997) J Clin Invest , vol.100 , pp. 18
    • Li, J.1    Hampton, T.2    Morgan, J.P.3
  • 69
    • 0026089929 scopus 로고
    • Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells
    • Brock T.A., Dvorak H.F., and Senger D.R. Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells. Am J Pathol 138 (1991) 213
    • (1991) Am J Pathol , vol.138 , pp. 213
    • Brock, T.A.1    Dvorak, H.F.2    Senger, D.R.3
  • 70
    • 0026446859 scopus 로고
    • Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells
    • Unemori E.N., Ferrara N., Bauer E.A., et al. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153 (1992) 557
    • (1992) J Cell Physiol , vol.153 , pp. 557
    • Unemori, E.N.1    Ferrara, N.2    Bauer, E.A.3
  • 71
    • 0026321129 scopus 로고
    • Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
    • Pepper M.S., Ferrara N., Orci L., et al. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 181 (1991) 902
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 902
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3
  • 72
    • 0029847191 scopus 로고    scopus 로고
    • Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration
    • Yebra M., Parry G.C., Stromblad S., et al. Requirement of receptor-bound urokinase-type plasminogen activator for integrin alphavbeta5-directed cell migration. J Biol Chem 271 (1996) 29393
    • (1996) J Biol Chem , vol.271 , pp. 29393
    • Yebra, M.1    Parry, G.C.2    Stromblad, S.3
  • 73
    • 0031976812 scopus 로고    scopus 로고
    • Hypoxia and vascular endothelial growth factor stimulate angiogenic integrin expression in bovine retinal microvascular endothelial cells
    • Suzuma K., Takagi H., Otani A., et al. Hypoxia and vascular endothelial growth factor stimulate angiogenic integrin expression in bovine retinal microvascular endothelial cells. Invest Ophthalmol Vis Sci 39 (1998) 1028
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 1028
    • Suzuma, K.1    Takagi, H.2    Otani, A.3
  • 74
    • 0029999603 scopus 로고    scopus 로고
    • Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin
    • Senger D.R., Ledbetter S.R., Claffey K.P., et al. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin. Am J Pathol 149 (1996) 293
    • (1996) Am J Pathol , vol.149 , pp. 293
    • Senger, D.R.1    Ledbetter, S.R.2    Claffey, K.P.3
  • 75
    • 0030042761 scopus 로고    scopus 로고
    • Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium
    • Morbidelli L., Chang C.H., Douglas J.G., et al. Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am J Physiol 270 (1996) H411
    • (1996) Am J Physiol , vol.270
    • Morbidelli, L.1    Chang, C.H.2    Douglas, J.G.3
  • 76
    • 0027053487 scopus 로고
    • Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro
    • Pepper M.S., Ferrara N., Orci L., et al. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun 189 (1992) 824
    • (1992) Biochem Biophys Res Commun , vol.189 , pp. 824
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3
  • 77
    • 0027133163 scopus 로고
    • Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels
    • Goto F., Goto K., Weindel K., et al. Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab Invest 69 (1993) 508
    • (1993) Lab Invest , vol.69 , pp. 508
    • Goto, F.1    Goto, K.2    Weindel, K.3
  • 78
    • 0030999445 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells
    • Watanabe Y., Lee S.W., Detmar M., et al. Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene 14 (1997) 2025
    • (1997) Oncogene , vol.14 , pp. 2025
    • Watanabe, Y.1    Lee, S.W.2    Detmar, M.3
  • 79
    • 0032515047 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
    • Gerber H.P., McMurtrey A., Kowalski J., et al. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem 273 (1998) 30336
    • (1998) J Biol Chem , vol.273 , pp. 30336
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3
  • 80
    • 0031149457 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: Balance between growth and death signals
    • Spyridopoulos I., Brogi E., Kearney M., et al. Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: Balance between growth and death signals. J Mol Cell Cardiol 29 (1997) 1321
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 1321
    • Spyridopoulos, I.1    Brogi, E.2    Kearney, M.3
  • 81
    • 0031570726 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor inhibits anchorage-disruption-induced apoptosis in microvessel endothelial cells by inducing scaffold formation
    • Watanabe Y., and Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor inhibits anchorage-disruption-induced apoptosis in microvessel endothelial cells by inducing scaffold formation. Exp Cell Res 233 (1997) 340
    • (1997) Exp Cell Res , vol.233 , pp. 340
    • Watanabe, Y.1    Dvorak, H.F.2
  • 82
    • 33846005165 scopus 로고    scopus 로고
    • A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression
    • Abid M.R., Shih S.C., Otu H.H., et al. A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression. J Biol Chem 281 (2006) 35544
    • (2006) J Biol Chem , vol.281 , pp. 35544
    • Abid, M.R.1    Shih, S.C.2    Otu, H.H.3
  • 83
    • 1642579540 scopus 로고    scopus 로고
    • Effect of vascular endothelial growth factor and epidermal growth factor on iatrogenic apoptosis in human endothelial cells
    • Vinci M.C., Visentin B., Cusinato F., et al. Effect of vascular endothelial growth factor and epidermal growth factor on iatrogenic apoptosis in human endothelial cells. Biochem Pharmacol 67 (2004) 277
    • (2004) Biochem Pharmacol , vol.67 , pp. 277
    • Vinci, M.C.1    Visentin, B.2    Cusinato, F.3
  • 84
    • 1042279522 scopus 로고    scopus 로고
    • Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells
    • Abid M.R., Guo S., Minami T., et al. Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol 24 (2004) 294
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 294
    • Abid, M.R.1    Guo, S.2    Minami, T.3
  • 85
    • 38149024921 scopus 로고    scopus 로고
    • Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation
    • Zheng J., Wen Y., Song Y., et al. Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation. Biol Reprod 78 (2008) 143
    • (2008) Biol Reprod , vol.78 , pp. 143
    • Zheng, J.1    Wen, Y.2    Song, Y.3
  • 86
    • 0035839556 scopus 로고    scopus 로고
    • Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells
    • Gratton J.P., Morales-Ruiz M., Kureishi Y., et al. Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J Biol Chem 276 (2001) 30359
    • (2001) J Biol Chem , vol.276 , pp. 30359
    • Gratton, J.P.1    Morales-Ruiz, M.2    Kureishi, Y.3
  • 87
    • 0001687330 scopus 로고
    • Angiogenesis and basic fibroblast growth factor during wound healing
    • Friedlander G.E., and Lane J.M. (Eds), American Academy of Orthopedic Surgeons, Rosemont, IL
    • Brem H., and Folkman J. Angiogenesis and basic fibroblast growth factor during wound healing. In: Friedlander G.E., and Lane J.M. (Eds). Bone Formation and Repair (1994), American Academy of Orthopedic Surgeons, Rosemont, IL 213-222
    • (1994) Bone Formation and Repair , pp. 213-222
    • Brem, H.1    Folkman, J.2
  • 88
    • 0000554843 scopus 로고    scopus 로고
    • Delay of wound healing by the angiogenesis inhibitor TNP-470
    • Brem H., Ehrlich H.P., Tsakayannis D., et al. Delay of wound healing by the angiogenesis inhibitor TNP-470. Surg Forum 48 (1997) 714
    • (1997) Surg Forum , vol.48 , pp. 714
    • Brem, H.1    Ehrlich, H.P.2    Tsakayannis, D.3
  • 89
    • 0021934716 scopus 로고
    • The effect of inhibition of angiogenesis in granulation tissue on wound healing and the fibroblast
    • McGrath M.H., and Emery III J.M. The effect of inhibition of angiogenesis in granulation tissue on wound healing and the fibroblast. Ann Plast Surg 15 (1985) 105
    • (1985) Ann Plast Surg , vol.15 , pp. 105
    • McGrath, M.H.1    Emery III, J.M.2
  • 90
    • 4243714115 scopus 로고
    • Time dependent suppression of wound healing with the angiogenesis inhibitor, AGM 1470
    • Brem H., Tsakayannis D., and Folkman J. Time dependent suppression of wound healing with the angiogenesis inhibitor, AGM 1470. J Cell Biol 115 (1991) 403a
    • (1991) J Cell Biol , vol.115
    • Brem, H.1    Tsakayannis, D.2    Folkman, J.3
  • 91
    • 0031029290 scopus 로고    scopus 로고
    • Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
    • Mohle R., Green D., and Moore M.A. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc Natl Acad Sci USA 94 (1997) 663
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 663
    • Mohle, R.1    Green, D.2    Moore, M.A.3
  • 92
    • 0023192006 scopus 로고
    • Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha
    • Leibovich S.J., Polverini P.J., Shepard H.M., et al. Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha. Nature 329 (1987) 630
    • (1987) Nature , vol.329 , pp. 630
    • Leibovich, S.J.1    Polverini, P.J.2    Shepard, H.M.3
  • 93
    • 0029045246 scopus 로고
    • Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing
    • Frank S., Hubner G., Breier G., et al. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem 270 (1995) 12607
    • (1995) J Biol Chem , vol.270 , pp. 12607
    • Frank, S.1    Hubner, G.2    Breier, G.3
  • 94
    • 0031578238 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: A new angiogenic factor for gastric ulcer healing
    • Takahashi M., Kawabe T., Ogura K., et al. Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: A new angiogenic factor for gastric ulcer healing. Biochem Biophys Res Commun 234 (1997) 493
    • (1997) Biochem Biophys Res Commun , vol.234 , pp. 493
    • Takahashi, M.1    Kawabe, T.2    Ogura, K.3
  • 95
    • 0015182552 scopus 로고
    • Oxygen and carbon dioxide tensions in experimental wounds
    • Niiinikoski J., Heughan C., and Hunt T. Oxygen and carbon dioxide tensions in experimental wounds. Surg Gynecol Obstet 133 (1971) 1003
    • (1971) Surg Gynecol Obstet , vol.133 , pp. 1003
    • Niiinikoski, J.1    Heughan, C.2    Hunt, T.3
  • 96
    • 0001483148 scopus 로고
    • The measurement of oxygen tension in healing tissue
    • Silver I.A. The measurement of oxygen tension in healing tissue. Progr Respir Res 3 (1969) 124
    • (1969) Progr Respir Res , vol.3 , pp. 124
    • Silver, I.A.1
  • 97
    • 0031057091 scopus 로고    scopus 로고
    • Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin
    • Detmar M., Brown L.F., Berse B., et al. Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin. J Invest Dermatol 108 (1997) 263
    • (1997) J Invest Dermatol , vol.108 , pp. 263
    • Detmar, M.1    Brown, L.F.2    Berse, B.3
  • 98
    • 0028901624 scopus 로고
    • Regulation of vascular endothelial growth factor in cardiac myocytes
    • Levy A.P., Levy N.S., Loscalzo J., et al. Regulation of vascular endothelial growth factor in cardiac myocytes. Circ Res 76 (1995) 758
    • (1995) Circ Res , vol.76 , pp. 758
    • Levy, A.P.1    Levy, N.S.2    Loscalzo, J.3
  • 99
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D., Itin A., Soffer D., et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359 (1992) 843
    • (1992) Nature , vol.359 , pp. 843
    • Shweiki, D.1    Itin, A.2    Soffer, D.3
  • 100
    • 0027999280 scopus 로고
    • Adenosine as an endogenous mediator of hypoxia for induction of vascular endothelial growth factor mRNA in U-937 cells
    • Hashimoto E., Kage K., Ogita T., et al. Adenosine as an endogenous mediator of hypoxia for induction of vascular endothelial growth factor mRNA in U-937 cells. Biochem Biophys Res Commun 204 (1994) 318
    • (1994) Biochem Biophys Res Commun , vol.204 , pp. 318
    • Hashimoto, E.1    Kage, K.2    Ogita, T.3
  • 101
    • 0029884640 scopus 로고    scopus 로고
    • Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells
    • Takagi H., King G.L., Ferrara N., et al. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Invest Ophthalmol Vis Sci 37 (1996) 1311
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 1311
    • Takagi, H.1    King, G.L.2    Ferrara, N.3
  • 102
    • 0030044039 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
    • Levy A.P., Levy N.S., and Goldberg M.A. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem 271 (1996) 2746
    • (1996) J Biol Chem , vol.271 , pp. 2746
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 103
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • Levy A.P., Levy N.S., Wegner S., et al. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 270 (1995) 13333
    • (1995) J Biol Chem , vol.270 , pp. 13333
    • Levy, A.P.1    Levy, N.S.2    Wegner, S.3
  • 104
    • 0029082384 scopus 로고
    • Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
    • Stein I., Neeman M., Shweiki D., et al. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol 15 (1995) 5363
    • (1995) Mol Cell Biol , vol.15 , pp. 5363
    • Stein, I.1    Neeman, M.2    Shweiki, D.3
  • 105
    • 0034326273 scopus 로고    scopus 로고
    • Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
    • Elson D.A., Ryan H.E., Snow J.W., et al. Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res 60 (2000) 6189
    • (2000) Cancer Res , vol.60 , pp. 6189
    • Elson, D.A.1    Ryan, H.E.2    Snow, J.W.3
  • 106
    • 34848879004 scopus 로고    scopus 로고
    • Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair
    • Mace K.A., Yu D.H., Paydar K.Z., et al. Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen 15 (2007) 636
    • (2007) Wound Repair Regen , vol.15 , pp. 636
    • Mace, K.A.1    Yu, D.H.2    Paydar, K.Z.3
  • 107
    • 0019446580 scopus 로고
    • Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration
    • Knighton D.R., Silver I.A., and Hunt T.K. Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration. Surgery 90 (1981) 262
    • (1981) Surgery , vol.90 , pp. 262
    • Knighton, D.R.1    Silver, I.A.2    Hunt, T.K.3
  • 108
    • 0026756163 scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing
    • Brown L.F., Yeo K.T., Berse B., et al. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 176 (1992) 1375
    • (1992) J Exp Med , vol.176 , pp. 1375
    • Brown, L.F.1    Yeo, K.T.2    Berse, B.3
  • 109
    • 0032539733 scopus 로고    scopus 로고
    • Differential expression of proteins during healing of cutaneous wounds in experimental normal and chronic models
    • Shukla A., Dubey M.P., Srivastava R., et al. Differential expression of proteins during healing of cutaneous wounds in experimental normal and chronic models. Biochem Biophys Res Commun 244 (1998) 434
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 434
    • Shukla, A.1    Dubey, M.P.2    Srivastava, R.3
  • 110
    • 84928953250 scopus 로고    scopus 로고
    • Differences in MMP and TIMP gene expression during wound repair
    • Howard E.W., Soo C., Hunter S., et al. Differences in MMP and TIMP gene expression during wound repair. Surg Forum 48 (1997) 688
    • (1997) Surg Forum , vol.48 , pp. 688
    • Howard, E.W.1    Soo, C.2    Hunter, S.3
  • 111
    • 0029867635 scopus 로고    scopus 로고
    • Basic fibroblast growth factor mediates angiogenic activity in early surgical wounds
    • Nissen N.N., Polverini P.J., Gamelli R.L., et al. Basic fibroblast growth factor mediates angiogenic activity in early surgical wounds. Surgery 119 (1996) 457
    • (1996) Surgery , vol.119 , pp. 457
    • Nissen, N.N.1    Polverini, P.J.2    Gamelli, R.L.3
  • 112
    • 0031053759 scopus 로고    scopus 로고
    • Biological roles of fibroblast growth factor-2
    • Bikfalvi A., Klein S., Pintucci G., et al. Biological roles of fibroblast growth factor-2. Endocr Rev 18 (1997) 26
    • (1997) Endocr Rev , vol.18 , pp. 26
    • Bikfalvi, A.1    Klein, S.2    Pintucci, G.3
  • 113
    • 0343605980 scopus 로고
    • Temporal expression of basic fibroblast growth factor during wound healing
    • Brem H., Shing Y., Watanabe Y., et al. Temporal expression of basic fibroblast growth factor during wound healing. Surg Forum 43 (1992) 664
    • (1992) Surg Forum , vol.43 , pp. 664
    • Brem, H.1    Shing, Y.2    Watanabe, Y.3
  • 114
    • 0041440927 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: An autocrine mechanism contributing to angiogenesis
    • Seghezzi G., Patel S., Ren C.J., et al. Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: An autocrine mechanism contributing to angiogenesis. J Cell Biol 141 (1998) 1659
    • (1998) J Cell Biol , vol.141 , pp. 1659
    • Seghezzi, G.1    Patel, S.2    Ren, C.J.3
  • 115
    • 0030848490 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor
    • Mandriota S.J., and Pepper M.S. Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor. J Cell Sci 110 Pt. 18 (1997) 2293
    • (1997) J Cell Sci , vol.110 , Issue.PART 18 , pp. 2293
    • Mandriota, S.J.1    Pepper, M.S.2
  • 116
    • 0029965462 scopus 로고    scopus 로고
    • Transient functional expression of alphaVbeta 3 on vascular cells during wound repair
    • Clark R.A., Tonnesen M.G., Gailit J., et al. Transient functional expression of alphaVbeta 3 on vascular cells during wound repair. Am J Pathol 148 (1996) 1407
    • (1996) Am J Pathol , vol.148 , pp. 1407
    • Clark, R.A.1    Tonnesen, M.G.2    Gailit, J.3
  • 117
    • 0030759955 scopus 로고    scopus 로고
    • Expression and function of endothelial cell alpha v integrin receptors in wound-induced human angiogenesis in human skin/SCID mice chimeras
    • Christofidou-Solomidou M., Bridges M., Murphy G.F., et al. Expression and function of endothelial cell alpha v integrin receptors in wound-induced human angiogenesis in human skin/SCID mice chimeras. Am J Pathol 151 (1997) 975
    • (1997) Am J Pathol , vol.151 , pp. 975
    • Christofidou-Solomidou, M.1    Bridges, M.2    Murphy, G.F.3
  • 118
    • 15844420661 scopus 로고    scopus 로고
    • Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb
    • Isner J.M., Pieczek A., Schainfeld R., et al. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet 348 (1996) 370
    • (1996) Lancet , vol.348 , pp. 370
    • Isner, J.M.1    Pieczek, A.2    Schainfeld, R.3
  • 119
    • 0032583951 scopus 로고    scopus 로고
    • Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia
    • Baumgartner I., Pieczek A., Manor O., et al. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 97 (1998) 1114
    • (1998) Circulation , vol.97 , pp. 1114
    • Baumgartner, I.1    Pieczek, A.2    Manor, O.3
  • 120
    • 0031797530 scopus 로고    scopus 로고
    • Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical results
    • discussion 73
    • Isner J.M., Baumgartner I., Rauh G., et al. Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical results. J Vasc Surg 28 (1998) 964 discussion 73
    • (1998) J Vasc Surg , vol.28 , pp. 964
    • Isner, J.M.1    Baumgartner, I.2    Rauh, G.3
  • 121
    • 0032578961 scopus 로고    scopus 로고
    • Gene therapy for myocardial angiogenesis: Initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia
    • Losordo D.W., Vale P.R., Symes J.F., et al. Gene therapy for myocardial angiogenesis: Initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. Circulation 98 (1998) 2800
    • (1998) Circulation , vol.98 , pp. 2800
    • Losordo, D.W.1    Vale, P.R.2    Symes, J.F.3
  • 122
    • 0034688216 scopus 로고    scopus 로고
    • Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty
    • Laitinen M., Hartikainen J., Hiltunen M.O., et al. Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty. Hum Gene Ther 11 (2000) 263
    • (2000) Hum Gene Ther , vol.11 , pp. 263
    • Laitinen, M.1    Hartikainen, J.2    Hiltunen, M.O.3
  • 123
    • 0033520056 scopus 로고    scopus 로고
    • Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease
    • Rosengart T.K., Lee L.Y., Patel S.R., et al. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. Circulation 100 (1999) 468
    • (1999) Circulation , vol.100 , pp. 468
    • Rosengart, T.K.1    Lee, L.Y.2    Patel, S.R.3
  • 124
    • 0033503798 scopus 로고    scopus 로고
    • Six-month assessment of a phase I trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA
    • discussion 70
    • Rosengart T.K., Lee L.Y., Patel S.R., et al. Six-month assessment of a phase I trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA. Ann Surg 230 (1999) 466 discussion 70
    • (1999) Ann Surg , vol.230 , pp. 466
    • Rosengart, T.K.1    Lee, L.Y.2    Patel, S.R.3
  • 125
    • 0029098881 scopus 로고
    • A model for the study of wounds in normal elderly adults and patients with peripheral vascular disease or diabetes mellitus
    • Olerud J.E., Odland G.F., Burgess E.M., et al. A model for the study of wounds in normal elderly adults and patients with peripheral vascular disease or diabetes mellitus. J Surg Res 59 (1995) 349
    • (1995) J Surg Res , vol.59 , pp. 349
    • Olerud, J.E.1    Odland, G.F.2    Burgess, E.M.3
  • 126
    • 0021399443 scopus 로고
    • Transcutaneous oxygen tension measurements on limbs of diabetic and nondiabetic patients with peripheral vascular disease
    • Wyss C.R., Matsen III F.A., Simmons C.W., et al. Transcutaneous oxygen tension measurements on limbs of diabetic and nondiabetic patients with peripheral vascular disease. Surgery 95 (1984) 339
    • (1984) Surgery , vol.95 , pp. 339
    • Wyss, C.R.1    Matsen III, F.A.2    Simmons, C.W.3
  • 127
    • 15644382445 scopus 로고    scopus 로고
    • Wound hypoxia and acidosis limit neutrophil bacterial killing mechanisms
    • Allen D.B., Maguire J.J., Mahdavian M., et al. Wound hypoxia and acidosis limit neutrophil bacterial killing mechanisms. Arch Surg 132 (1997) 991
    • (1997) Arch Surg , vol.132 , pp. 991
    • Allen, D.B.1    Maguire, J.J.2    Mahdavian, M.3
  • 128
    • 14444272042 scopus 로고    scopus 로고
    • Wound tissue oxygen tension predicts the risk of wound infection in surgical patients
    • discussion 995
    • Hopf H.W., Hunt T.K., West J.M., et al. Wound tissue oxygen tension predicts the risk of wound infection in surgical patients. Arch Surg 132 (1997) 997 discussion 995
    • (1997) Arch Surg , vol.132 , pp. 997
    • Hopf, H.W.1    Hunt, T.K.2    West, J.M.3
  • 129
    • 0025948350 scopus 로고
    • Chronology and determinants of tissue repair in diabetic lower-extremity ulcers
    • Pecoraro R.E., Ahroni J.H., Boyko E.J., et al. Chronology and determinants of tissue repair in diabetic lower-extremity ulcers. Diabetes 40 (1991) 1305
    • (1991) Diabetes , vol.40 , pp. 1305
    • Pecoraro, R.E.1    Ahroni, J.H.2    Boyko, E.J.3
  • 130
    • 0028353239 scopus 로고
    • Muscle fiber composition and capillary density in women and men with NIDDM
    • Marin P., Andersson B., Krotkiewski M., et al. Muscle fiber composition and capillary density in women and men with NIDDM. Diabetes Care 17 (1994) 382
    • (1994) Diabetes Care , vol.17 , pp. 382
    • Marin, P.1    Andersson, B.2    Krotkiewski, M.3
  • 131
    • 34248225758 scopus 로고    scopus 로고
    • Cellular and molecular basis of wound healing in diabetes
    • Brem H., and Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest 117 (2007) 1219
    • (2007) J Clin Invest , vol.117 , pp. 1219
    • Brem, H.1    Tomic-Canic, M.2
  • 132
    • 0030976646 scopus 로고    scopus 로고
    • Endothelial dysfunction and pathogenesis of diabetic angiopathy
    • Stehouwer C.D., Lambert J., Donker A.J., et al. Endothelial dysfunction and pathogenesis of diabetic angiopathy. Cardiovasc Res 34 (1997) 55
    • (1997) Cardiovasc Res , vol.34 , pp. 55
    • Stehouwer, C.D.1    Lambert, J.2    Donker, A.J.3
  • 133
    • 0032965317 scopus 로고    scopus 로고
    • Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF
    • Rivard A., Silver M., Chen D., et al. Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF. Am J Pathol 154 (1999) 355
    • (1999) Am J Pathol , vol.154 , pp. 355
    • Rivard, A.1    Silver, M.2    Chen, D.3
  • 134
    • 0029926439 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is induced by long-term high glucose concentration and up-regulated by acute glucose deprivation in cultured bovine retinal pigmented epithelial cells
    • Sone H., Kawakami Y., Okuda Y., et al. Vascular endothelial growth factor is induced by long-term high glucose concentration and up-regulated by acute glucose deprivation in cultured bovine retinal pigmented epithelial cells. Biochem Biophys Res Commun 221 (1996) 193
    • (1996) Biochem Biophys Res Commun , vol.221 , pp. 193
    • Sone, H.1    Kawakami, Y.2    Okuda, Y.3
  • 135
    • 0027301146 scopus 로고
    • PDGF and FGF reverse the healing impairment in protein-malnourished diabetic mice
    • discussion 72
    • Albertson S., Hummel III R.P., Breeden M., et al. PDGF and FGF reverse the healing impairment in protein-malnourished diabetic mice. Surgery 114 (1993) 368 discussion 72
    • (1993) Surgery , vol.114 , pp. 368
    • Albertson, S.1    Hummel III, R.P.2    Breeden, M.3
  • 136
    • 64849103692 scopus 로고    scopus 로고
    • VEGF enhances angiogenic response in experimental wounds as measured by tensile properties of the wound, increased epithelialization, and decreased time to closure
    • Accessed: March 31, 2008
    • VEGF enhances angiogenic response in experimental wounds as measured by tensile properties of the wound, increased epithelialization, and decreased time to closure. Wounds (2007). http://www.woundsresearch.com/article/6976 Accessed: March 31, 2008
    • (2007) Wounds
  • 137
    • 0032720053 scopus 로고    scopus 로고
    • Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: a combined analysis of four randomized studies
    • Smiell J.M., Wieman T.J., Steed D.L., et al. Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: a combined analysis of four randomized studies. Wound Repair Regen 7 (1999) 335
    • (1999) Wound Repair Regen , vol.7 , pp. 335
    • Smiell, J.M.1    Wieman, T.J.2    Steed, D.L.3
  • 138
    • 0031299718 scopus 로고    scopus 로고
    • Pathophysiology of venous leg ulceration
    • Dormandy A. Pathophysiology of venous leg ulceration. Int J Microcirc Clin Exp 17 Suppl 1 (1997) 2
    • (1997) Int J Microcirc Clin Exp , vol.17 , Issue.SUPPL. 1 , pp. 2
    • Dormandy, A.1
  • 139
    • 0029550438 scopus 로고
    • Expression of elastase and fibrin in venous leg ulcer biopsies: A pilot study of pentoxifylline versus placebo
    • Mirshahi S., Soria J., Mirshahi M., et al. Expression of elastase and fibrin in venous leg ulcer biopsies: A pilot study of pentoxifylline versus placebo. J Cardiovasc Pharmacol 25 Suppl 2 (1995) S101
    • (1995) J Cardiovasc Pharmacol , vol.25 , Issue.SUPPL. 2
    • Mirshahi, S.1    Soria, J.2    Mirshahi, M.3
  • 140
    • 0029943232 scopus 로고    scopus 로고
    • Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds
    • Vaalamo M., Weckroth M., Puolakkainen P., et al. Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds. Br J Dermatol 135 (1996) 52
    • (1996) Br J Dermatol , vol.135 , pp. 52
    • Vaalamo, M.1    Weckroth, M.2    Puolakkainen, P.3
  • 141
    • 0032800451 scopus 로고    scopus 로고
    • Differential expression of tissue inhibitors of metalloproteinases (TIMP-1, -2, -3, and -4) in normal and aberrant wound healing
    • Vaalamo M., Leivo T., and Saarialho-Kere U. Differential expression of tissue inhibitors of metalloproteinases (TIMP-1, -2, -3, and -4) in normal and aberrant wound healing. Hum Pathol 30 (1999) 795
    • (1999) Hum Pathol , vol.30 , pp. 795
    • Vaalamo, M.1    Leivo, T.2    Saarialho-Kere, U.3
  • 142
    • 0032160609 scopus 로고    scopus 로고
    • Interleukin-1alpha and collagenase activity are elevated in chronic wounds
    • discussion 1028
    • Barone E.J., Yager D.R., Pozez A.L., et al. Interleukin-1alpha and collagenase activity are elevated in chronic wounds. Plast Reconstr Surg 102 (1998) 1023 discussion 1028
    • (1998) Plast Reconstr Surg , vol.102 , pp. 1023
    • Barone, E.J.1    Yager, D.R.2    Pozez, A.L.3
  • 143
    • 0031714785 scopus 로고    scopus 로고
    • Increased plasma vascular endothelial growth factor among patients with chronic venous disease
    • Shoab S.S., Scurr J.H., and Coleridge-Smith P.D. Increased plasma vascular endothelial growth factor among patients with chronic venous disease. J Vasc Surg 28 (1998) 535
    • (1998) J Vasc Surg , vol.28 , pp. 535
    • Shoab, S.S.1    Scurr, J.H.2    Coleridge-Smith, P.D.3
  • 144
    • 0031875678 scopus 로고    scopus 로고
    • Increased expression of platelet-derived growth factor receptor alpha and beta and vascular endothelial growth factor in the skin of patients with chronic venous insufficiency
    • Peschen M., Grenz H., Brand-Saberi B., et al. Increased expression of platelet-derived growth factor receptor alpha and beta and vascular endothelial growth factor in the skin of patients with chronic venous insufficiency. Arch Dermatol Res 290 (1998) 291
    • (1998) Arch Dermatol Res , vol.290 , pp. 291
    • Peschen, M.1    Grenz, H.2    Brand-Saberi, B.3
  • 145
    • 0025871251 scopus 로고
    • Hypotension as a risk factor for the development of pressure sores in elderly subjects
    • Schubert V. Hypotension as a risk factor for the development of pressure sores in elderly subjects. Age Ageing 20 (1991) 255
    • (1991) Age Ageing , vol.20 , pp. 255
    • Schubert, V.1
  • 146
    • 0024786821 scopus 로고
    • Local skin pressure and its effects on skin microcirculation as evaluated by laser-Doppler fluxmetry
    • Schubert V., and Fagrell B. Local skin pressure and its effects on skin microcirculation as evaluated by laser-Doppler fluxmetry. Clin Physiol 9 (1989) 535
    • (1989) Clin Physiol , vol.9 , pp. 535
    • Schubert, V.1    Fagrell, B.2
  • 147
    • 0029045920 scopus 로고
    • Analysis of arterial flowmotion in spinal cord injured and elderly subjects in an area at risk for the development of pressure sores
    • Schubert V., Schubert P.A., Breit G., et al. Analysis of arterial flowmotion in spinal cord injured and elderly subjects in an area at risk for the development of pressure sores. Paraplegia 33 (1995) 387
    • (1995) Paraplegia , vol.33 , pp. 387
    • Schubert, V.1    Schubert, P.A.2    Breit, G.3
  • 148
    • 0027160580 scopus 로고
    • Enhancing host resistance to pressure ulcers: A new approach to prevention
    • Mawson A.R., Siddiqui F.H., and Biundo Jr. J.J. Enhancing host resistance to pressure ulcers: A new approach to prevention. Prev Med 22 (1993) 433
    • (1993) Prev Med , vol.22 , pp. 433
    • Mawson, A.R.1    Siddiqui, F.H.2    Biundo Jr., J.J.3
  • 149
    • 0026786815 scopus 로고
    • The safety and effect of topically applied recombinant basic fibroblast growth factor on the healing of chronic pressure sores
    • discussion 406
    • Robson M.C., Phillips L.G., Lawrence W.T., et al. The safety and effect of topically applied recombinant basic fibroblast growth factor on the healing of chronic pressure sores. Ann Surg 216 (1992) 401 discussion 406
    • (1992) Ann Surg , vol.216 , pp. 401
    • Robson, M.C.1    Phillips, L.G.2    Lawrence, W.T.3
  • 150
    • 0034031419 scopus 로고    scopus 로고
    • Sequential cytokine therapy for pressure ulcers: Clinical and mechanistic response
    • Robson M.C., Hill D.P., Smith P.D., et al. Sequential cytokine therapy for pressure ulcers: Clinical and mechanistic response. Ann Surg 231 (2000) 600
    • (2000) Ann Surg , vol.231 , pp. 600
    • Robson, M.C.1    Hill, D.P.2    Smith, P.D.3


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