Ranibizumab for Macular Edema following Central Retinal Vein Occlusion. Six-Month Primary End Point Results of a Phase III Study

Ophthalmology

Volumn 117, Issue 6, 2010, Pages

  Brown, David M ^a   Campochiaro, Peter A ^b   Singh, Rishi P ^c   Li, Zhengrong ^d   Gray, Sarah ^d   Saroj, Namrata ^d   Rundle, Amy Chen ^d   Rubio, Roman G ^d   Murahashi, Wendy Yee ^d  

^a HOUSTON METHODIST HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RANIBIZUMAB;

ADULT; AGED; ARTICLE; CATARACT; CENTRAL RETINA VEIN OCCLUSION; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC RETINOPATHY; DRUG EFFICACY; DRUG SAFETY; ENDOPHTHALMITIS; EYE INFLAMMATION; FEMALE; HUMAN; IRIDOCYCLITIS; IRIS DISEASE; IRIS NEOVASCULARIZATION; IRITIS; LENS DISEASE; MAJOR CLINICAL STUDY; MALE; NEOVASCULAR GLAUCOMA; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINA DETACHMENT; RETINA MACULA EDEMA; RETINA TEAR; SCORING SYSTEM; TREATMENT DURATION; TREATMENT RESPONSE; VISUAL ACUITY; VISUAL SYSTEM FUNCTION; VITREOUS DISEASE; VITREOUS HEMORRHAGE; VITRITIS;

EID: 77952889477     PISSN: 01616420     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ophtha.2010.02.022     Document Type: Article

References (30)

1. Leibreich R. Ophthalmoskopische Notizen. 3. Apoplexia retinae. Arch Ophthalmologie 1 (1855) 346-351
2. Michel J. Die spontane Thrombose der Vena centralis des opticus. Albrecht Von Graefes Arch Ophthalmol 24 (1878) 37-70
3. Hayreh S.S. Classification of central retinal vein occlusion. Ophthalmology 90 (1983) 458-474
4. Central Vein Occlusion Study Group. Natural history and clinical management of central retinal vein occlusion. Arch Ophthalmol 115 (1997) 486-491
5. Mohamed Q., McIntosh R.L., Saw S.M., and Wong T.Y. Interventions for central retinal vein occlusion: an evidence-based systematic review. Ophthalmology 114 (2007) 507-519 524
6. Eye Disease Case-Control Study Group. Risk factors for central retinal vein occlusion. Arch Ophthalmol 114 (1996) 545-554
7. Branch Vein Occlusion Study Group. Argon laser photocoagulation for macular edema in branch vein occlusion. Am J Ophthalmol 98 (1984) 271-282
8. Early Treatment Diabetic Retinopathy Study Research Group. Photocoagulation for diabetic macular edema: Early Treatment Diabetic Retinopathy Study report number 1. Arch Ophthalmol 103 (1985) 1796-1806
9. Evaluation of grid pattern photocoagulation for macular edema in central vein occlusion. The Central Vein Occlusion Study Group M report. Ophthalmology 102 (1995) 1425-1433
10. Opremcak E.M., Bruce R.A., Lomeo M.D., et al. Radial optic neurotomy for central retinal vein occlusion: a retrospective pilot study of 11 consecutive cases. Retina 21 (2001) 408-415
11. McAllister I.L., and Constable I.J. Laser-induced chorioretinal venous anastomosis for treatment of nonischemic central retinal vein occlusion. Arch Ophthalmol 113 (1995) 456-462
12. Hayreh S.S. Venous occlusive disease: management 25 years ago. Retina 26 suppl (2006) S51-S62
13. Gregori N.Z., Rosenfeld P.J., Puliafito C.A., et al. One-year safety and efficacy of intravitreal triamcinolone acetonide for the management of macular edema secondary to central retinal vein occlusion. Retina 26 (2006) 889-895
14. Lee H.B., Pulido J.S., McCannel C.A., and Buettner H. Role of inflammation in retinal vein occlusion. Can J Ophthalmol 42 (2007) 131-133
15. SCORE Study Research Group. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to central retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 5. Arch Ophthalmol 127 (2009) 1101-1114
16. Ferrara N., and Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 18 (1997) 4-25
17. Aiello L.P., Avery R.L., Arrigg P.G., et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331 (1994) 1480-1487
18. Pe'er J., Folberg R., Itin A., et al. Vascular endothelial growth factor upregulation in human central retinal vein occlusion. Ophthalmology 105 (1998) 412-416
19. Brown D.M., Kaiser P.K., Michels M., et al., ANCHOR Study Group. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 355 (2006) 1432-1444
20. Rosenfeld P.J., Brown D.M., Heier J.S., et al., MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355 (2006) 1419-1431
21. Campochiaro P.A., Hafiz G., Shah S.M., et al. Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator. Mol Ther 16 (2008) 791-799
22. Pieramici D.J., Rabena M., Castellarin A.A., et al. Ranibizumab for the treatment of macular edema associated with perfused central retinal vein occlusions. [report online only]. Ophthalmology 115 (2008) e47-e54
23. Spaide R.F., Chang L.K., Klancnik J.M., et al. Prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion. Am J Ophthalmol 147 (2009) 298-306
24. Signorini D.F., Leung O., Simes R.J., et al. Dynamic balanced randomization for clinical trials. Stat Med 12 (1993) 2343-2350
25. Chan A., Duker J.S., Ko T.H., et al. Normal macular thickness measurements in healthy eyes using Stratus optical coherence tomography. Arch Ophthalmol 124 (2006) 193-198
26. Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy-I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 308 (1994) 81-106
27. Cugati S., Wang J.J., Rochtchina E., and Mitchell P. Ten-year incidence of retinal vein occlusion in an older population: the Blue Mountains Eye Study. Arch Ophthalmol 124 (2006) 726-732
28. Klein R., Moss S.E., Meuer S.M., and Klein B.E. The 15-year cumulative incidence of retinal vein occlusion: the Beaver Dam Eye Study. Arch Ophthalmol 126 (2008) 513-518
29. Servais G.E., Thompson H.S., and Hayreh S.S. Relative afferent pupillary defect in central retinal vein occlusion. Ophthalmology 93 (1986) 301-303
30. Green W.R., Chan C.C., Hutchins G.M., and Terry J.M. Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases. Retina 1 (1981) 27-55