A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity

Critical Reviews in Toxicology

Volumn 41, Issue 9, 2011, Pages 783-802

  Enoch, S J ^a   Ellison, C M ^a   Schultz, T W ^b   Cronin, M T D ^a  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

(Q)SAR Toolbox; Chemical categories; Covalent protein binding; Electrophilic reaction chemistry; Structural alerts

Indexed keywords

ALKENE; ALKYNE; CARBONYL DERIVATIVE; ISOCYANATE; NITROGEN; QUINONE DERIVATIVE; SCHIFF BASE;

ACYLATION; CHROMOSOME ABERRATION; CORROSION; ELECTROPHILICITY; MICHAEL ADDITION; PROTEIN BINDING; REVIEW; SKIN IRRITATION; SKIN SENSITIZATION;

ACYLATION; HUMANS; ISOCYANATES; NITROGEN COMPOUNDS; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINONES; RISK ASSESSMENT; SOFTWARE; SULFUR COMPOUNDS; TOXICITY TESTS;

ANIMALIA;

EID: 80052959270     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2011.598141     Document Type: Review

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