Using chemical categories to fill data gaps in hazard assessment

SAR and QSAR in Environmental Research

Volumn 20, Issue 3-4, 2009, Pages 207-220

  van Leeuwen, K ^a   Schultz, T W ^b   Henry, T ^c   Diderich, B ^b   Veith, G D ^d  

^a TNO   (Netherlands)

^b OECD   (France)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d International QSAR Foundation   (United States)

Author keywords

Chemical categories; Data gaps; Hazard assessment; QSAR

Indexed keywords

ANIMALS; CHEMICAL HAZARDS; COMPUTATIONAL CHEMISTRY; INDICATORS (CHEMICAL); INTERNATIONAL COOPERATION; ORGANIC CHEMICALS;

ANIMAL TESTING; ANIMAL TESTS; CHEMICAL CATEGORY; DATA GAP; HAZARD ASSESSMENT; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP; REGULATORY AGENCIES; RELIABLE ESTIMATES; TEST DATA; TOXICOLOGICAL BEHAVIOR;

INDUSTRIAL CHEMICALS;

ANIMALIA;

DANGEROUS GOODS; METHODOLOGY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; SAFETY;

HAZARDOUS SUBSTANCES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SAFETY MANAGEMENT;

EID: 85047684589     PISSN: 1062936X     EISSN: 1029046X     Source Type: Journal    
DOI: 10.1080/10629360902949179     Document Type: Article

References (29)

1. US Environmental Protection Agency, Chemical hazard data availability study, US Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, DC, 1998. Available at http://www.epa.gov/hpv/pubs/general/hazchem.htm
2. R. Allanou, B.G. Hansen, and Y. Van Der Bilt, Public availability of data on EU high production volume chemicals, Report EUR 18996 EN, European Commission, Joint Research Centre, Ispra, Italy, 1999.
3. S. Bradbury, T. Feijtel, and K. Van Leeuwen, Meeting the scientific needs of ecological risk assessment in a regulatory context, Environ. Sci. Technol. 38 (2004), pp. 463-470.
4. C.J. Van Leeuwen, G.Y. Patlewicz, and A.P. Worth, Intelligent testing strategies, in Risk Assessment of Chemicals. An Introduction, 2nd ed., C.J. Van Leeuwen and T.G. Vermeire, eds., Springer, Dordrecht, 2007, pp. 467-509.
5. National Research Council, Toxicity Testing in the Twenty-first Century: A Vision and a Strategy, The National Academies Press, Washington DC, 2007.
6. R. Lipnick, Charles Ernest Overton: Narcosis Studies and a Contribution to General Pharmocology, Chapman and Hall, New York, 1991.
7. G.D. Veith, On the nature, evolution and future of quantitative structure-activity relationships (QSAR) in toxicology, SAR QSAR Environ. Res. 15 (2004), pp. 323-330.
8. J.S. Jaworska, M. Comber, C. Auer, and C.J. van Leeuwen, Summary of a workshop on regulatory acceptance of (Q)SARs for human health and environmental endpoints, Environ. Health Perspect. 111 (2003), pp. 1358-1360.
9. BioByte. CQSAR Packages. Available at http://www.biobyte.com/bb/prod/cqsar.html
10. Organisation for Economic Co-operation and Development, OECD Principles for the Validation, for Regulatory Purposes, of (Q)SAR Models, 2004. Available at http://www.oecd. org/env/existingchemicals/qsar
11. S.R. Johnson, The trouble with QSAR (or How I learned to stop worrying and embrace fallacy). J. Chem. Inf. Model. 48 (2008), pp. 25-26.
12. US Environmental Protection Agency, Development of chemical categories in the HPV Challenge Programme, US Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, DC, 1998. Available at http://www.epa.gov/hpv/pubs/general/categuid.htm
13. Commission of the European Communities, Corrigendum to regulation (EC) No. 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No. 793/93 and Commission Regulation (EC) No. 1488/94 as well as Council Directive 76/769/ EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC (OJ L 396, 30.12.2006). OJ L136, volume 50, 29 May 2007.
14. Organisation for Economic Co-operation and Development, OECD environment health and safety publications series on testing and assessment, No. 80: Guidance Document on Grouping of Chemicals ENV/JM/MONO(2007)28.
15. The European Chemicals Agency, Guidance on information requirements and chemical safety assessment, 2007. Available at http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm?time1/41230839505
16. US Environmental Protection Agency, New chemical program, Chemical Categories Report, Available at http://www.epa.gov/oppt/newchems/pubs/chemcat.htm
17. US Environmental Protection Agency, Status and future directions of the High Production Volume Challenge Program, US Environmental Protection Agency, Office of Pollution Prevention and Toxics, Washington, DC, 2007.
18. US Environmental Protection Agency, Development of Chemical Categories in the HPV Challenge Program, High Production Volume (HPV) Challenge. Available at http://www.epa. gov/oppt/chemrtk/pubs/general/categuid.htm
19. US Environmental Protection Agency, High Production Volume (HPV) Challenge Program, Available at http://www.epa.gov/chemrtk/
20. A.P. Worth and G. Patlewicz (eds), A Compendium of Case Studies that Helped to Shape the REACH Guidance on Chemical Categories and Read Across, European Commission report EUR 22481 EN. Office for Official Publications of the European Communities, Luxembourg, 2007. Available at: http://ecb.jrc.it/qsar/publications/
21. European Chemicals Agency (ECHA), Available at http://echa.europa.eu/
22. Optimised Strategies for Risk Assessment of Industrial Chemicals through Integration of Non-Test and Test Information (OSIRIS), Available at http://www.osiris-reach.eu/
23. K. Van der Jagt, S. Munn, J. Tørsløv, and J. De Bruijn, Alternative approaches can reduce the use of test animals under REACH. Addendum to Assessment of additional testing needs under REACH. Effects of (Q)SARs, risk based testing and voluntary industry initiatives, Report EUR 21405, European Commission, Joint Research Centre, Ispra, Italy, 2004.
24. Organisation for Economic Co-operation and Development, Manual for investigation of HPV chemicals. Section 3.2. Guidance on the Development and use of Chemical Categories in the HPV Chemicals Programme. OECD, Paris, FR, 2005.
25. Organisation for Economic Co-operation and Development, Personal communication from Bob Diderich, 11 March 2008.
26. OECD, HPV database, Available at http://cs3-hq.oecd.org/scripts/hpv/
27. OECD, QSAR Application Toolbox, Available at http://www.oecd.org/env/existingchemicals/qsar
28. Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers, Report for establishing the timetable for phasing out animal testing for the purpose of the cosmetics directive issued by ECVAM, Report SCCNFP/0834/04, Brussels, BE, 2004. Available at http:// ec.europa.eu/health/ph_risk/committees/sccp/documents/out285_en.pdf/
29. C.J. Van Leeuwen, REACH data requirements and exposure scenarios. Presentation at the REACH workshop Japan, 29 October 2007, Ministry of The Environment Japan and TNO Quality of Life, the Netherlands. Tokyo, Japan, 2007.