LC-MS-based characterization of the peptide reactivity of chemicals to improve the in vitro prediction of the skin sensitization potential

Toxicological Sciences

Volumn 106, Issue 2, 2008, Pages 464-478

  Natsch, Andreas ^a   Gfeller, Hans ^a  

^a GIVAUDAN SCHWEIZ AG   (Switzerland)

Author keywords

Adduct formation; Alternative test; LC MS; Peptide reactivity; Skin sensitization

Indexed keywords

1,4 BENZOQUINONE; 2 METHYL 4 ISOTHIAZOLIN 3 ONE; 2,3 BUTANEDIONE; ALDEHYDE; BENZALDEHYDE; BENZALKONIUM CHLORIDE; BENZYL ALCOHOL; BENZYL BENZOATE; BENZYL BROMIDE; BUTANOL; CINNAMALDEHYDE; CITRAL; DIPHENCYPRONE; EUGENOL; FORMALDEHYDE; FRAGRANCE; GALLIC ACID PROPYL ESTER; GLUTARALDEHYDE; GLYOXAL; ISOEUGENOL; LACTIC ACID; MALEIC ACID DIETHYL ESTER; OXAZOLONE; PEPTIDE; PERILLALDEHYDE; PHTHALIC ANHYDRIDE; THIOL DERIVATIVE; TRIMELLITIC ANHYDRIDE; UNINDEXED DRUG; VANILLIN;

ALLERGIC REACTION; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DIMERIZATION; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDE ANALYSIS; PROTEIN DEPLETION; PROTEIN METABOLISM; QUANTITATIVE ANALYSIS; SKIN SENSITIVITY; SKIN SENSITIZATION; TOXICOKINETICS;

ANIMAL TESTING ALTERNATIVES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LOCAL LYMPH NODE ASSAY; PEPTIDES; SKIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 56649085336     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn194     Document Type: Article

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