Mechanistic applicability domains for nonanimal-based prediction of toxicological end points: General principles and application to reactive toxicity

Chemical Research in Toxicology

Volumn 19, Issue 8, 2006, Pages 1097-1105

  Aptula, Aynur O ^a   Roberts, David W ^b  

^a UNILEVER RESEARCH   (United Kingdom)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; ALDEHYDE; ALKYL GROUP; CARBOXYLIC ACID; DIAZONIUM COMPOUND; ESTER; HALOGEN; ION; KETONE; METHYL GROUP; NARCOTIC AGENT; PROTEIN; QUINONE DERIVATIVE; SCHIFF BASE; THYMIDINE; URUSHIOL;

ARTICLE; CLASSIFICATION; DRUG MECHANISM; HYDROPHOBICITY; PREDICTION; PROTEIN BINDING; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RISK ASSESSMENT; SKIN SENSITIZATION; TOXICITY;

ANIMAL TESTING ALTERNATIVES; ENDPOINT DETERMINATION; MODELS, THEORETICAL; MOLECULAR STRUCTURE; ORGANIC CHEMICALS; PREDICTIVE VALUE OF TESTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SKIN; TOXICITY TESTS;

ANIMALIA;

EID: 33748640373     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0601004     Document Type: Article

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