Skin sensitization: Modeling based on skin metabolism simulation and formation of protein conjugates

International Journal of Toxicology

Volumn 24, Issue 4, 2005, Pages 189-204

  Dimitrov, Sabcho D ^a   Low, Lawrence K ^b   Patlewicz, Grace Y ^c   Kern, Petra S ^d   Dimitrova, Gergana D ^a   Comber, Mike H I ^b   Phillips, Richard D ^b   Niemela, Jay ^e   Bailey, Paul T ^b   Mekenyan, Ovanes G ^a  

^a ASSEN ZLATAROV UNIVERSITY   (Bulgaria)

^b EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

^c UNILEVER RESEARCH   (United Kingdom)

^d PROCTER AND GAMBLE COMPANY   (United States)

^e The Danish Environmental Protection Agency EPA   (Denmark)

Author keywords

Applicability Domain; Metabolic Activation; QSAR; Skin Metabolism; Skin Sensitization

Indexed keywords

2 METHYL 5 HYDROXYETHYLAMINOPHENOL; BUTANOL; CARBOWAX 600; DIISOSTEARYL MALATE; ETHYL PARABEN; ETHYLIDENE HEPTANOATE ACETATE; MACROGOL; MESYLIC ACID METHYL ESTER; MYRISTIC ACID ISOPROPYL ESTER; OCTADECYL METHYL ESTER; PERNONANOIC ACID; SALICYLAMIDE; SALICYLIC ACID AMYL ESTER; TRIMETHYLAMMONIUM ETHYLOXYCARBOXYBENZENESULFONATE; TRIMETHYLAMMONIUM HEXANOYLOXY 4 BENZENESULFONATE; TRIMETHYLAMMONIUM SALT DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; CONJUGATION; METABOLIC REGULATION; NONHUMAN; PATTERN RECOGNITION; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SIMULATION; SKIN SENSITIZATION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING; TISSUE METABOLISM;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; DRUG HYPERSENSITIVITY; EUGENOL; HUMANS; HYPERSENSITIVITY, IMMEDIATE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PREDICTIVE VALUE OF TESTS; PROTEINS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SKIN; SKIN IRRITANCY TESTS; SOFTWARE; XENOBIOTICS;

EID: 23744479852     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1080/10915810591000631     Document Type: Article

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