TIMES-SS-A promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity

Regulatory Toxicology and Pharmacology

Volumn 48, Issue 2, 2007, Pages 225-239

  Patlewicz, Grace ^a   Dimitrov, Sabcho D ^b   Low, Lawrence K ^c   Kern, Petra S ^d   Dimitrova, Gergana D ^b   Comber, Mike I H ^c   Aptula, Aynur O ^e   Phillips, Richard D ^c   Niemelä, Jay ^f   Madsen, Charlotte ^f   Wedebye, Eva B ^f   Roberts, David W ^g   Bailey, Paul T ^h   Mekenyan, Ovanes G ^b  

^a JOINT RESEARCH CENTRE   (Italy)

^b ASSEN ZLATAROV UNIVERSITY   (Bulgaria)

^c EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

^d PROCTER AND GAMBLE COMPANY   (United States)

^e UNILEVER RESEARCH   (United Kingdom)

^f TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^g LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^h Bailey and Associates   (United States)

Author keywords

(Q)SARs; OECD principles for (Q)SAR Validation; REACH; Skin sensitization; TIMES SS

Indexed keywords

ARTICLE; LYMPH NODE; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RISK ASSESSMENT; SIMULATION; SKIN SENSITIZATION; TIMES METABOLISM SIMULATOR; TOXICITY TESTING; VALIDATION PROCESS;

ANIMAL TESTING ALTERNATIVES; ANIMALS; COMPUTER SIMULATION; EUROPEAN UNION; IRRITANTS; LOCAL LYMPH NODE ASSAY; MICE; MODELS, CHEMICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RISK ASSESSMENT; SKIN; SKIN IRRITANCY TESTS;

ANIMALIA; MURINAE;

EID: 34249709530     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2007.03.003     Document Type: Article

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