2′-O-[2-[2-(N, N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: Symbiosis of charge interaction factors and stereoelectronic effects

Organic Letters

Volumn 5, Issue 12, 2003, Pages 2017-2020

  Prhavc, Marija ^a,b   Prakash, Thazha P ^a,b   Minasov, George ^a,b   Cook, P Dan ^a,b   Egli, Martin ^a,b,c   Manoharan, Muthiah ^a,b  

^a ISIS PHARMACEUTICALS   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; METHYL GROUP; NUCLEASE; OLIGONUCLEOTIDE; RNA; 2' O (2 (2 (N,N DIMETHYLAMINO)ETHOXY)ETHYL); 2'-O-(2-(2-(N,N-DIMETHYLAMINO)ETHOXY)ETHYL); ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY RNA; DRUG DERIVATIVE; ETHANE; ETHER DERIVATIVE; HETERODUPLEX; ORGANOPHOSPHORUS COMPOUND; PHOSPHODIESTERASE; SNAKE VENOM;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; ENZYME DEGRADATION; MOLECULAR INTERACTION; STRUCTURE ANALYSIS; SYNTHESIS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; CONFORMATION; DRUG STABILITY; ELECTRICITY; ELECTROSPRAY MASS SPECTROMETRY; ENZYMOLOGY; METABOLISM; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDE SEQUENCE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ANIMALS; BASE SEQUENCE; DRUG STABILITY; ELECTROSTATICS; ETHANE; ETHERS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDES, ANTISENSE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORIC DIESTER HYDROLASES; RNA, COMPLEMENTARY; SNAKE VENOMS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0141742594     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0340991     Document Type: Article

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