Crystal structure and improved antisense properties of 2'-O-(2- methoxyethyl)-RNA

Nature Structural Biology

Volumn 6, Issue 6, 1999, Pages 535-539

  Teplova, M ^a   Minasov, G ^a   Tereshko, V ^a   Inamati, G B ^a   Cook, P D ^a   Manoharan, M ^a   Egli, M ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; COMPLEMENTARY RNA; ETHYLENE; NUCLEASE; NUCLEIC ACID; OXYGEN; PHOSPHATE; PHOSPHOROTHIOIC ACID DERIVATIVE;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME DEGRADATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION;

BASE PAIRING; BASE SEQUENCE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ETHYLENES; HYDROGEN BONDING; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; OXYGEN; PHOSPHATES; RNA, ANTISENSE; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 0033053332     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/9304     Document Type: Article

References (37)