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Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 1, 2002, Pages 73-76

2′-O,4′-C-ethylene-bridged nucleic acids (ENA): Highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

(8) Morita, Koji a Hasegawa, Chikako a Kaneko, Masakatsu a Tsutsumi, Shinya a Sone, Junko a Ishikawa, Tomio a Imanishi, Takeshi b Koizumi, Makoto a

a DAIICHI SANKYO CO (Japan)

b OSAKA UNIVERSITY (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BRIDGED COMPOUND; COMPLEMENTARY RNA; DNA; HYDROGEN; NUCLEASE; NUCLEIC ACID; OLIGONUCLEOTIDE; SUGAR; COMPLEMENTARY DNA; NUCLEASE S1; THYMIDINE;

ARTICLE; BINDING AFFINITY; CHEMICAL BINDING; CHEMICAL REACTION; CONFORMATION; DRUG STABILITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RNA BINDING; CHEMISTRY; DRUG DESIGN; KINETICS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TEMPERATURE;

ENA;

ASPERGILLUS NUCLEASE S1; BRIDGED COMPOUNDS; DNA, COMPLEMENTARY; DRUG DESIGN; DRUG STABILITY; KINETICS; OLIGONUCLEOTIDES, ANTISENSE; RNA, COMPLEMENTARY; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; THYMIDINE;

EID: 0037033135 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(01)00683-7 Document Type: Article

Times cited : (163)

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