Synthesis and properties of 2′-O,4′-C-methyleneoxymethylene bridged nucleic acid

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 4, 2006, Pages 1029-1038

  Hari, Yoshiyuki ^a,d   Obika, Satoshi ^a,b   Ohnishi, Ryo ^a   Eguchi, Ken ^a   Osaki, Tomohisa ^a   Ohishi, Hirofumi ^c   Imanishi, Takeshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c OSAKA MEDICAL COLLEGE   (Japan)

^d NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Bridged nucleic acids; Conformation; Nucleosides; Oligonucleotides

Indexed keywords

2' O,4' METHYLENEOXYMETHYLENE; 3' O [2 CYANOETHOXY(DIISOPROPYLAMINO)PHOSPHINO] 5' O (4,4' DIMETHOXYTRITYL) 5 METHYL 2' O,4' C (METHYLENOXYMETHYLENE)URIDINE; 3' O BENZYL 5' O TERT BUTYLDIPHENYLSILY 5 METHYL 2' O,4' C (METHYLENOXYMETHYLENE)CYTIDINE; 4 N BENZOYL 3' O [2 CYANOETHOXY(DIISOPROPYLAMINO)PHOSPHINO] 5' O (4,4' DIMETHOXYTRITYL) 2' O,4' C (METHYLENOXYMETHYLENE)CYTIDINE; 4 N BENZOYL 3' O [2 CYANOETHOXY(DIISOPROPYLAMINO)PHOSPHINO] 5' O (4,4' DIMETHOXYTRITYL) 5 METHYL 2' O,4' C (METHYLENOXYMETHYLENE)CYTIDINE; 4 N BENZOYL 3' O BENZYL 5 METHYL 2' O,4' C (METHYLENOXYMETHYLENE)CYTIDINE; 4 N BENZOYL 5 METHYL 2' O,4' C (METHYLENOXYMETHYLENE)CYTIDINE; 4 N BENZOYL 5' O (4,4' DIMETHOXYTRITYL) 5 METHYL 2' O,4' C (METHYLENOXYMETHYLENE)CYTIDINE; 4 N BENZOYL 5' O TERT BUTYLDIPHENYLSILY 5 METHYL 2' O,4' C (METHYLENOXYMETHYLENE)CYTIDINE; CARBENE; PHOSPHODIESTERASE; SNAKE VENOM; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONFORMATION; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME STABILITY; THERMOSTABILITY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; HETEROCYCLIC COMPOUNDS; MOLECULAR STRUCTURE; NUCLEIC ACID DENATURATION; NUCLEIC ACIDS; PHOSPHODIESTERASE I; SNAKES; TEMPERATURE;

EID: 30344476699     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.09.020     Document Type: Article

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