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Volumn , Issue 36, 2007, Pages 3765-3767

N-Methyl substituted 2′,4′-BNANC: A highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization

Author keywords

[No Author keywords available]

Indexed keywords

BRIDGED COMPOUND; NUCLEASE; NUCLEIC ACID; OLIGONUCLEOTIDE;

EID: 34548603852     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b707352f     Document Type: Article
Times cited : (42)

References (33)
  • 23
    • 3342961686 scopus 로고    scopus 로고
    • In addition to that, very recently, it is reported that antisense oligonucleotides containing 2′,4′-BNA (LNA) are hepatotoxic which demands discovery of new candidates with similar or better potency; see:
    • J. S. Jespen M. D. Sørensen J. Wengel Oligonucleotides 2004 14 130
    • (2004) Oligonucleotides , vol.14 , pp. 130
    • Jespen, J.S.1    Sørensen, M.D.2    Wengel, J.3
  • 26
    • 33645723021 scopus 로고    scopus 로고
    • NC[N-H] analogue. The triplex-forming ability was higher than that of 2′,4′-BNA (LNA) and ENA;15 see:
    • M. Koizumi Curr. Opin. Mol. Ther. 2006 8 144
    • (2006) Curr. Opin. Mol. Ther. , vol.8 , pp. 144
    • Koizumi, M.1
  • 29
    • 34548616727 scopus 로고    scopus 로고
    • m values against DNA increased by 3°C per modification; see:
    • Direct cyclization of the aminoxy derivative employing various bases resulted in failure
  • 31
    • 0043237532 scopus 로고    scopus 로고
    • The Sp-isomer of phosphorthioate was used in this study which is known to be more resistant to degradation by SVPDE than an Rp-isomer; see:
    • M. D. Sørensen M. Petersen J. Wengel Chem. Commun. 2003 2130
    • (2003) Chem. Commun. , pp. 2130
    • Sørensen, M.D.1    Petersen, M.2    Wengel, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.