Structural origins of the exonuclease resistance of a zwitterionic RNA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 25, 1999, Pages 14240-14245

  Teplova, Marianna ^a   Wallace, Scot T ^b,d   Tereshko, Valentina ^a   Minasov, George ^a   Symons, Alice M ^c   Cook, P Dan ^c   Manoharan, Muthiah ^c   Egli, Martin ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF VIENNA   (Austria)

^c ISIS PHARMACEUTICALS   (United States)

^d Department of Immunology   (Austria)

Author keywords

Antisense; Cationic oligonucleotides; Exonuclease inhibitor; Hydration; X ray crystallography

Indexed keywords

AMPHOLYTE; COMPLEMENTARY RNA; DNA FRAGMENT; DOUBLE STRANDED DNA; EXONUCLEASE; METAL ION; OLIGODEOXYNUCLEOTIDE; PHOSPHODIESTERASE; PHOSPHOROTHIOIC ACID; RNA; SINGLE STRANDED DNA; SNAKE VENOM; THYMIDINE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DNA MODIFICATION; ESCHERICHIA COLI; PRIORITY JOURNAL; RNA BINDING; RNA DEGRADATION; RNA STRUCTURE;

BASE SEQUENCE; BINDING SITES; CRYSTALLIZATION; DNA; EXONUCLEASES; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PHOSPHORIC DIESTER HYDROLASES; RNA;

ESCHERICHIA COLI; SERPENTES;

EID: 0033435202     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.25.14240     Document Type: Article

References (37)

1. De Mesmaeker, A., Häner, R., Martin, P. & Moser, H. E. (1995) Acc. Chem. Res. 28, 366-374.
2. Crooke, S. T. (1998) in Handbook of Experimental Pharmacology: Antisense Research and Applications, ed. Crooke, S. T. (Springer, Heidelberg), Vol. 131, pp. 1-50.
3. Freier, S. M. & Altmann, K.-H. (1997) Nucleic Acids Res. 25, 4429-4443.
4. Cook, P. D. (1998) Annu. Med. Rep. Chem. 33, 313-325.
5. Egli, M. (1996) Angew. Chem. Intl. Ed. Engl. 35, 1894-1909.
6. Herdewijn, P. (1996) Liebigs Ann. Chem. 1337-1348.
7. Egli, M. (1998) Antisense Nucleic Acid Drug Dev. 8, 123-128.
8. Martin, P. (1995) Helv. Chim. Acta 78, 486-504.
9. Altmann, K.-H., Fabbro, D., Dean, N. M., Geiger, T., Monia, B. P., Müller, M. & Nicklin, P. (1996) Biochem. Soc. Trans. 24, 630-637.
10. Tereshko, V., Portmann, S., Tay, E. C., Martin, P., Natt, F., Altmann, K.-H. & Egli, M. (1998) Biochemistry 37, 10626-10634.
11. Teplova, M., Minasov, G., Tereshko, V., Inamati, G. B., Cook, P. D., Manoharan, M. & Egli, M. (1999) Nat. Struct. Biol. 6, 535-539.
12. Griffey, R. H., Monia, B. P., Cummins, L. L., Freier, S. M., Greig, M. J., Guinosso, C. J., Lesnik, E., Manalili, S. M., Mohan, V., Owens, S. R., et al. (1996) J. Med. Chem. 39, 5100-5109.
13. Lesnik, E. A., Guinosso, C. J., Kawasaki, A. M., Sasmor, H., Zounes, M., Cummins, L. L., Ecker, D. J., Cook, P. D. & Freier, S. M. (1993) Biochemistry 32, 7832-7838.
14. Cummins, L. L., Owens, S. R., Risen, L. M., Lesnik, E. A., Freier, S. M., McGee, D., Guinosso, C. J. & Cook, P. D. (1995) Nucleic Acids Res. 23, 2019-2024.
15. Akhtar S & Agrawal, S. (1997) Trends Pharmaceut. Sci. 18 12-18.
16. Berger, I., Kang, C. H., Sinha, N., Wolters, M. & Rich, A. (1996) Acta Crystallogr. D 52, 465-468.
17. Otwinowski, Z. & Minor, W. (1997) Methods Enzymol. 276, 307-326.
18. Navaza, J. (1994) Acta Crystrallogr. A 50, 157-163.
19. Brünger, A. T. (1992) X-PLOR: A System for X-Ray Crystallography and NMR (Yale Univ. Press, New Haven, CT), Version 3.1.
20. Parkinson, G., Vojtechovsky, J., Clowney, L., Brünger, A. T. & Berman, H. M. (1996) Acta Crystallogr. D 52, 57-64.
21. Brünger, A. T. (1992) Nature (London) 355, 472-475.
22. Joyce, C. M. & Grindley, N. D. F. (1983) Proc. Natl. Acad. Sci. USA 80, 1830-1834.
23. Brick, P., Ollis, D. & Steitz, T. A. (1983) J. Mol. Biol. 166, 453-456.
24. Freemont, P. S., Friedman, J. M., Beese, L. S., Sanderson, M. R. & Steitz, T. A. (1988) Proc. Natl. Acad. Sci. USA 85, 8924-8928.
25. Ollis, D. L., Brick, P., Hamlin, R., Xuong, N. G. & Steitz, T. A. (1985) Nature (London) 313, 762-766.
26. Brünger, A. T. (1998) CNS: Crystallography & NMR System (Yale Univ., New Haven, CT), Version 0.3.
27. Linn, S. M., Lloyd, R. S. & Roberts, R. J., eds. (1993) Nucleases (Cold Spring Harbor Lab. Press, Plainview, NY), 2nd Ed.
28. Joyce, C. M. & Steitz, T. A. (1995) J. Bacteriol. 177, 6321-6329.
29. Brautigam, C. A. & Steitz, T. A. (1998) Curr. Opin. Struct. Biol. 8, 54-63.
30. Brautigam, C. A. & Steitz, T. A. (1998) J. Mol. Biol. 277, 363-377.
31. Steitz, T. A. & Steitz, J. A. (1993) Proc. Natl. Acad. Sci. USA 90, 6498-6502.
32. Derbyshire, V., Freemont, P. S., Sanderson, M. R., Beese, L., Friedman, J. M., Joyce, C. M. & Steitz, T. A. (1988) Science 240, 199-201.
33. Derbyshire, V., Grindley, N. D. F. & Joyce, C. M. (1991) EMBO J. 10, 17-24.
34. Curley, J. F., Joyce, C. M. & Piccirilli, J. A. (1997) J. Am. Chem. Soc. 119, 12691-12692.
35. Couture, C. & Chow, T. Y. K. (1992) Nucleic Acids Res. 20, 4355-4361.
36. Manoharan, M., Guinosso, C. J. & Cook, P. D. (1991) Tetrahedron Lett. 32, 7171-7174.
37. Manoharan, M., Tivel, K. L., Anrade, L. K. & Cook, P. D. (1995) Tetrahedron Lett. 36, 3647-3650.