LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1

Nucleic Acids Research

Volumn 32, Issue 10, 2004, Pages 3101-3107

  Darfeuille, Fabien ^a,b,d   Hansen, Jens Bo ^c   Orum, Henrik ^c   Di Primo, Carmelo ^a,b   Toulmé, Jean Jacques ^a,b  

^a INSERM   (France)

^b INSTITUT EUROPÉEN DE CHIMIE ET BIOLOGIE   (France)

^c Santaris Pharma AS   (Denmark)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ANTISENSE OLIGONUCLEOTIDE; APTAMER; DNA; GUANINE; LIGAND; NUCLEASE; NUCLEIC ACID; OLIGOMER; PROTEIN TAR; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA; LOCKED NUCLEIC ACID; OLIGORIBONUCLEOTIDE; RNA;

ARTICLE; CHIMERA; COMPLEX FORMATION; CONFORMATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA BINDING; DNA DENATURATION; DNA MODIFICATION; DRUG DESIGN; DRUG IDENTIFICATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYMATIC DEGRADATION; GEL MOBILITY SHIFT ASSAY; GENE TARGETING; HEATING; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MOLECULAR INTERACTION; MOLECULAR MIMICRY; MONITORING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; RNA ANALYSIS; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; ULTRAVIOLET SPECTROSCOPY; CHEMISTRY; CULTURE MEDIUM; DRUG EFFECT; ENZYME SPECIFICITY; GENETICS; KINETICS; LONG TERMINAL REPEAT; METABOLISM; NUCLEOTIDE SEQUENCE; TEMPERATURE; THERMODYNAMICS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

BASE SEQUENCE; CULTURE MEDIA; HIV LONG TERMINAL REPEAT; HIV-1; KINETICS; NUCLEIC ACID DENATURATION; OLIGONUCLEOTIDES, ANTISENSE; OLIGORIBONUCLEOTIDES; RNA; RNA, VIRAL; SUBSTRATE SPECIFICITY; SURFACE PLASMON RESONANCE; TEMPERATURE; THERMODYNAMICS;

EID: 2942631142     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh636     Document Type: Article

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