Toxic influence of organophosphate, carbamate, and organochlorine pesticides on cellular metabolism of lipids, proteins, and carbohydrates: A systematic review

Human and Experimental Toxicology

Volumn 30, Issue 9, 2011, Pages 1119-1140

  Karami Mohajeri, Somayyeh ^a,b,c   Abdollahi, Mohammad ^a,b,c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

carbamate; hyperglycemia; organochlorines; organophosphates; oxidative stress; pesticide; review

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ACEPHATE; ACETYLCHOLINESTERASE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; ASCORBIC ACID; BETA HEXACHLOROCYCLOHEXANE; BUTHIONINE SULFOXIMINE; CARBAMATE PESTICIDE; CARBOFURAN; CARBOHYDRATE; DIMETHOATE; DIMPYLATE; FENITROTHION; HEXACHLOROBIPHENYL; INTERLEUKIN 10; LIPID; MELATONIN; NONACHLOR; ORGANOCHLORINE PESTICIDE; ORGANOPHOSPHATE PESTICIDE; PENTOXIFYLLINE; PIPERONYL BUTOXIDE; POLYCHLORINATED BIPHENYL; PROTEIN; ROLIPRAM; SELENIUM; UNINDEXED DRUG; ZINC;

ACUTE PANCREATITIS; ADIPOSE TISSUE; ANTIOXIDANT ACTIVITY; BLOOD; BRAIN; CANCER MORTALITY; CARBOHYDRATE METABOLISM; CELL METABOLISM; CELL PROTECTION; CELL STRESS; CENTRAL NERVOUS SYSTEM; CYTOPLASM; DIABETES MELLITUS; DIET SUPPLEMENTATION; DIET THERAPY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME INHIBITION; FIRST TRIMESTER PREGNANCY; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE UTILIZATION; GLUCOSURIA; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; INSULIN RESISTANCE; INTRACELLULAR SIGNALING; LACTATE BLOOD LEVEL; LETHAL DOSE; LIPID METABOLISM; LIVER; LIVER INJURY; LIVER MICROSOME; METABOLIC DISORDER; METABOLIC SYNDROME X; MITOCHONDRION; MUSCLE; NEUROTOXICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS; PANCREAS CANCER; PANCREAS DISEASE; PANCREAS INJURY; PERIPHERAL NERVE; PEROXISOME; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN METABOLISM; REVIEW;

ANIMALS; CARBAMATES; CARBOHYDRATE METABOLISM; DATABASES, BIBLIOGRAPHIC; HUMANS; HYDROCARBONS, CHLORINATED; LIPID METABOLISM; METABOLIC DISEASES; OXIDATIVE STRESS; PESTICIDES; PHOSPHORIC ACID ESTERS; PROTEINS;

EID: 80052525189     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110388959     Document Type: Review

References (222)

1. Peter K. Mechanism of organophosphates (nerve gases and pesticides) and antidotes: electron transfer and oxidative stress. Curr Med Chem. 2003 ; 10: 2705-2709
2. Fukuto TR. Mechanism of action of organophosphorus and carbamate insecticides. Environ Health Perspect. 1990 ; 87: 245-254 (Pubitemid 20316924)
3. Kwong TC. Organophosphate pesticides: biochemistry and clinical toxicology. Ther Drug Monit. 2002 ; 24: 144-149 (Pubitemid 34106743)
4. Davis PW, Wedemeyer GA. Na+, K+-activated-ATPase inhibition in rainbow trout: a site for organochlorine pesticide toxicity?. Comp Biochem Physiol B Comp Biochem. 1971 ; 40: 823-827
5. Coats JR. Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides. Environ Health Perspect. 1990 ; 87: 255-262 (Pubitemid 20316925)
6. Abdollahi M, Jalali N, Sabzevari O, Hoseini R, Ghanea T. A retrospective study of poisoning in Tehran. J Toxicol Clin Toxicol. 1997 ; 35: 387-393 (Pubitemid 27285828)
7. Dekin MS, Guy HR, Edwards C. Effects of organophosphate insecticides on the cholinergic receptors of frog skeletal muscle. J Pharmacol Exp Ther. 1978 ; 205: 319-325 (Pubitemid 8357778)
8. Morgan DP, Lin LI, Saikaly HH. Morbidity and mortality in workers occupationally exposed to pesticides. Arch Environ Contam Toxicol. 1980 ; 9: 349-382 (Pubitemid 10156533)
9. Soltaninejad K, Shadnia S, Afkhami-Taghipour M, Saljooghi R, Mohammadirad A, Abdollahi M. Blood β-glucuronidase as a suitable biomarker at acute exposure of severe organophosphorus poisoning in human. Hum Exp Toxicol. 2007 ; 26: 963-966 (Pubitemid 351650814)
10. Soltaninejad K, Abdollahi M. Current opinion on the science of organophosphate pesticides and toxic stress: a systematic review. Med Sci Monit. 2009 ; 15: RA75 - RA90
11. Datta C, Gupta J, Sarkar A, Sengupta D. Effects of organophosphorus insecticide phosphomidon on antioxidant defence components of human erythrocyte and plasma. Indian J Exp Biol. 1992 ; 30: 65-67
12. Abdollahi M, Mostafalou S, Pournourmohammadi S, Shadnia S. Oxidative stress and cholinesterase inhibition in saliva and plasma of rats following subchronic exposure to malathion. Comp Biochem Physiol C Toxicol Pharmacol. 2004 ; 137: 29-34 (Pubitemid 38230919)
13. Matschinsky FM, Ellerman JE, Landgraf krzanowski J, Kotler-Brajtburg J, Fertel R. Quantitative histochemistry of glucose metabolism in the islets of Langerhans. Curr Probl Clin Biochem. 1971 ; 3: 143-182
14. Koundinya PR, Ramamurthi R. Effect of organophosphate pesticide Sumithion (Fenitrothion) on some aspects of carbohydrate metabolism in a freshwater fish, Sarotherodon (Tilapia) mossambicus (Peters). Experientia. 1979 ; 35: 1632-1633 (Pubitemid 10099141)
15. Clement JG, Lee MJ. Soman-induced convulsions: significance of changes in levels of blood electrolytes, gases, glucose, and insulin. Toxicol Appl Pharmacol. 1980 ; 55: 203-204 (Pubitemid 10036708)
16. Deotare ST, Chakrabarti CH. Effect of acephate (orthene) on tissue levels of thiamine, pyruvic acid, lactic acid, glycogen and blood sugar. Indian J Physiol Pharmacol. 1981 ; 25: 259-264 (Pubitemid 12195091)
17. Garg UK, Pal AK, Jha GJ, Jadhao SB. Haemato-biochemical and immuno-pathophysiological effects of chronic toxicity with synthetic pyrethroid, organophosphate and chlorinated pesticides in broiler chicks. Int Immunopharmacol. 2004 ; 4: 1709-1722 (Pubitemid 39348867)
18. Rahimi R, Abdollahi M. A review on the mechanisms involved in hyperglycemia induced by organophosphorus pesticides. Pestic Biochem Physiol. 2007 ; 88: 115-121 (Pubitemid 46463976)
19. Amanvermez R, Baydin A, Yardan T, Basol N, Gunay M. Emergency laboratory abnormalities in suicidal patients with acute organophosphate poisoning. Turkish J Biochem. 2010 ; 35: 29-34
20. Everett CJ, Matheson EM. Biomarkers of pesticide exposure and diabetes in the 1999-2004 National Health and Nutrition Examination Survey. Environ Int. 2010 ; 36: 398-401
21. Lee DH, Lee IK, Porta M, Steffes M, Jacobs DR. Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002. Diabetologia. 2007 ; 50: 1841-1851 (Pubitemid 47222867)
22. Lee DH, Jacobs DR, Steffes M. Association of organochlorine pesticides with peripheral neuropathy in patients with diabetes or impaired fasting glucose. Diabetes. 2008 ; 57: 3108-3111
23. Ukropec J, Radikova Z, Huckova M, Koska J, Kocan A, Sebokova E, et al. High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail. Diabetologia. 2010 ; 53: 899-906
24. Cox S, Niskar AS, Narayan KM, Marcus M. Prevalence of self-reported diabetes and exposure to organochlorine pesticides among Mexican Americans: Hispanic health and nutrition examination survey, 1982-1984. Environ Health Perspect. 2007 ; 115: 1747-1752
25. Avsarogullari L, Ikizceli I, Sungur M, Sozuer E, Akdur O, Yucei M. Acute amitraz poisoning in adults: clinical features, laboratory findings, and management. Clin Toxicol (Phila). 2006 ; 44: 19-23 (Pubitemid 44112960)
26. Saldana TM, Basso O, Hoppin JA, Baird DD, Knott C, Blair A, et al. Pesticide exposure and self-reported gestational diabetes mellitus in the agricultural health study. Diabetes Care. 2007 ; 30: 529-534 (Pubitemid 46354329)
27. Longnecker MP, Klebanoff MA, Brock JW, Zhou H. Polychlorinated biphenyl serum levels in pregnant subjects with diabetes. Diabetes Care. 2001 ; 24: 1099-1101 (Pubitemid 33716383)
28. Chen JW, Wang SL, Liao PC, Chen HY, Ko YC, Lee CC. Relationship between insulin sensitivity and exposure to dioxins and polychlorinated biphenyls in pregnant women. Environ Res. 2008 ; 107: 245-253
29. Shobha TR, Prakash O. Glycosuria in organophosphate and carbamate poisoning. J Assoc Physicians India. 2000 ; 48: 1197-1199
30. Rylander L, Rignell-Hydbom A, Hagmar L. A cross-sectional study of the association between persistent organochlorine pollutants and diabetes. Environ Health. 2005 ; 4: 28
31. Michalek J, Ketchum N, Tripathi R. Diabetes mellitus and 2,3,7,8-tetrachlorodibenzo- p -dioxin elimination in veterans of operation ranch hand. J Toxicol Environ Health A. 2003 ; 66: 211-221 (Pubitemid 36184568)
32. Vasiliu O, Cameron L, Gardiner J, DeGuire P, Karmaus W. Polybrominated biphenyls, polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus. Epidemiology. 2006 ; 17: 352-359 (Pubitemid 44305507)
33. Everett CJ, Frithsen IL, Diaz VA, Koopman RJ, Simpson WM, Mainous AG. Association of a polychlorinated dibenzo-p-dioxin, a polychlorinated biphenyl, and DDT with diabetes in the 1999-2002 national health and nutrition examination survey. Environ Research. 2007 ; 103: 413-8 (Pubitemid 46217208)
34. Rignell-Hydbom A, Rylander L, Hagmar L. Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus. Hum Exp Toxicol. 2007 ; 26: 447-452 (Pubitemid 47057004)
35. Jorgensen ME, Borch-Johnsen K, Bjerregaard P. A cross-sectional study of the association between persistent organic pollutants and glucose intolerance among Greenland Inuit. Diabetologia. 2008 ; 51: 1416-1422
36. Joshi AK, Rajini PS. Reversible hyperglycemia in rats following acute exposure to acephate, an organophosphorus insecticide: role of gluconeogenesis. Toxicology. 2009 ; 257: 40-45
37. Kamath V, Rajini PS. Altered glucose homeostasis and oxidative impairment in pancreas of rats subjected to dimethoate intoxication. Toxicology. 2007 ; 231: 137-146 (Pubitemid 46283158)
38. Reena K, Ajay K, Sharma CB. Haematological changes induced by dimethoate in rat. Arh Hig Rada Toksikol. 1989 ; 40: 23-27 (Pubitemid 19194461)
39. Sancho E, Ferrando MD, Andreu E. Sublethal effects of an organophosphate insecticide on the European eel, Anguilla anguilla. Ecotoxicol Environ Saf. 1997 ; 36: 57-65 (Pubitemid 27093505)
40. Jyothi B, Narayan G. Certain pesticide-induced carbohydrate metabolic disorders in the serum of freshwater fish Clarias batrachus (Linn.). Food Chem Toxicol. 1999 ; 37: 417-421 (Pubitemid 29335766)
41. Ueyama J, Kamijima M, Asai K, Mochizuki A, Wang D, Kondo T, et al. Effect of the organophosphorus pesticide diazinon on glucose tolerance in type 2 diabetic rats. Toxicol Lett. 2008 ; 182: 42-47
42. Pourkhalili N, Pournourmohammadi S, Rahimi F, Vosough-Ghanbari S, Baeeri M, Ostad SN, et al. Comparative effects of calcium channel blockers, autonomic nervous system blockers, and free radical scavengers on diazinon-induced hyposecretion of insulin from isolated islets of Langerhans in rats. Arh Hig Rada Toksikol. 2009 ; 60: 157-164
43. Rezg R, Mornagui B, Kamoun A, El-Fazaa S, Gharbi N. Effect of subchronic exposure to malathion on metabolic parameters in the rat. C R Biol. 2007 ; 330: 143-147 (Pubitemid 46223885)
44. Rattner BA, Franson JC. Methyl parathion and fenvalerate toxicity in American kestrels: acute physiological responses and effects of cold. Can J Physiol Pharmacol. 1984 ; 62: 787-792
45. Ramu A, Drexler H. Hyperglycemia in acute malathion intoxication in rats. Isr J Med Sci. 1973 ; 9: 635-639
46. Chilcott RP, Dalton CH, Hill I, Davidson CM, Blohm KL, Hamilton MG. Clinical manifestations of VX poisoning following percutaneous exposure in the domestic white pig. Hum Exp Toxicol. 2003 ; 22: 255-261 (Pubitemid 36626423)
47. Sadeghi-Hashjin G, Moslemi M, Javadi S. The effect of organophosphate pesticides on the blood glucose levels in the mouse. Pak J Biol Sci. 2008 ; 11: 1290-1292
48. Alahyary P, Poor MI, Azarbaijani FF, Nejati V. The potential toxicity of diazinon on physiological factors in male rat. Pak J Biol Sci. 2008 ; 11: 127-130
49. Arsenault AL, Gibson MA, Mader ME. Hypoglycemia in malathion-treated chick embryos. Can J Zool. 1975 ; 53: 1055-1057
50. Kandalaft K, Liu S, Anivel C, Borner JW, Dressel TD, Sutherland DE, et al. Organophosphate increases the sensitivity of human exocrine pancreas to acetylcholine. Pancreas. 1991 ; 6: 398-403
51. Liu S, Oguchi Y, Borner JW, Runge W, Dressel TD, Goodale RL. Increased canine pancreatic acinar cell damage after organophosphate and acetylcholine or cholecystokinin. Pancreas. 1990 ; 5: 177-82 (Pubitemid 20074060)
52. Oguchi Y, Frick TW, Satterberg TL, Dressel TD, Borner JW, Goodale RL. Effect of the organophosphate iso-OMPA on amylase release by pancreatic lobules of dog, guinea pig, and cat. Pancreas. 1987 ; 2: 664-668
53. Goebell H. The effect of ethionine on the energy-producing metabolism in the rat pancreas. II. Alterations of tissue levels of adenine nucleotides, pyridine nucleotides, and glycolytic metabolites. Horm Metab Res. 1974 ; 6: 44-49
54. Duttaroy A, Zimliki CL, Gautam D, Cui Y, Mears D, Wess J. Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes. 2004 ; 53: 1714-1720 (Pubitemid 38857029)
55. Persaud SJ, Jones PM, Sugden D, Howell SL. The role of protein kinase C in cholinergic stimulation of insulin secretion from rat islets of Langerhans. Biochem J. 1989 ; 264: 753-758 (Pubitemid 20023445)
56. Panahi P, Vosough-Ghanbari S, Pournourmohammadi S, Ostad SN, Nikfar S, Minaie B, et al. Stimulatory effects of malathion on the key enzymes activities of insulin secretion in langerhans islets, glutamate dehydrogenase and glucokinase. Toxicol Mech Methods. 2006 ; 16: 161-167
57. Pournourmohammadi S, Ostad SN, Azizi E, Ghahremani MH, Farzami B, Minaie B, et al. Induction of insulin resistance by malathion: Evidence for disrupted islets cells metabolism and mitochondrial dysfunction. Pestic Biochem Physiol. 2007 ; 88: 346-352 (Pubitemid 46719373)
58. Vosough-Ghanbari S, Sayyar P, Pournourmohammadi S, Aliahmadi A, Ostad SN, Abdollahi M. Stimulation of insulin and glucagon synthesis in rat Langerhans islets by malathion in vitro: Evidence for mitochondrial interaction and involvement of subcellular non-cholinergic mechanisms. Pestic Biochem Physiol. 2007 ; 89: 130-136 (Pubitemid 47321798)
59. Jamshidi HR, Ghahremani MH, Ostad SN, Sharifzadeh M, Dehpour AR, Abdollahi M. Effects of diazinon on the activity and gene expression of mitochondrial glutamate dehydrogenase from rat pancreatic Langerhans islets. Pestic Biochem Physiol. 2009 ; 93: 23-27
60. Novelli M, Piaggi S, Tata VD. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin- induced impairment of glucose-stimulated insulin secretion in isolated rat pancreatic islets. Toxicol Lett. 2005 ; 156: 307-314 (Pubitemid 40292804)
61. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin. Mol Pharmacol. 2005 ; 67: 444
62. Yau DT, Mennear JH. The inhibitory effect of DDT on insulin secretion in mice. Toxicol Appl Pharmacol. 1977 ; 39: 81-88 (Pubitemid 8050558)
63. Berdanier CD, de Dennis SK. Effect of exercise on the responses of rats to DDT. J Toxicol Environ Health. 1977 ; 2: 651-656 (Pubitemid 8187176)
64. Singh M, Sandhir R, Kiran R. Erythrocyte antioxidant enzymes in toxicological evaluation of commonly used organophosphate pesticides. Indian J Exp Biol. 2006 ; 44: 580-583 (Pubitemid 44049412)
65. Romero-Navarro G, Lopez-Aceves T, Rojas-Ochoa A, Fernandez-Mejia C. Effect of dichlorvos on hepatic and pancreatic glucokinase activity and gene expression, and on insulin mRNA levels. Life Sci. 2006 ; 78: 1015-1020 (Pubitemid 43112541)
66. Lo AC, Soliman AS, El-Ghawalby N, Abdel-Wahab M, Fathy O, Khaled HM, et al. Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer risk. Pancreas. 2007 ; 35: 120-129 (Pubitemid 47075565)
67. Weizman Z, Sofer S. Acute pancreatitis in children with anticholinesterase insecticide intoxication. Pediatrics. 1992 ; 90: 204-206
68. Beard J, Sladden T, Morgan G, Berry G, Brooks L, McMichael A. Health impacts of pesticide exposure in a cohort of outdoor workers. Environ Health Perspect. 2003 ; 111: 724-730 (Pubitemid 36621603)
69. Harputluoglu MM, Demirel U, Alan H, Ates F, Aladag M, Karincaoglu M, et al. Pancreatic pseudocyst development due to organophosphate poisoning. Turk J Gastroenterol. 2007 ; 18: 122-125 (Pubitemid 351676969)
70. Hsiao CT, Yang CC, Deng JF, Bullard MJ, Liaw SJ. Acute pancreatitis following organophosphate intoxication. J Toxicol Clin Toxicol. 1996 ; 34: 343-347 (Pubitemid 26199211)
71. Zamir DL, Novis BN. Organophosphate poisoning and necrotizing pancreatitis. Isr J Med Sci. 1994 ; 30: 855-856
72. Goodale RL, Manivel JC, Borner JW, Liu S, Judge J, Li C, et al. Organophosphate sensitizes the human pancreas to acinar cell injury: an ultrastructural study. Pancreas. 1993 ; 8: 171-175 (Pubitemid 23062067)
73. Moore PG, James OF. Acute pancreatitis induced by acute organophosphate poisoning?. Postgrad Med J. 1981 ; 57: 660-662 (Pubitemid 11014809)
74. Hagar HH, Azza H, Fahmy . A biochemical, histochemical, and ultrastructural evaluation of the effect of dimethoate intoxication on rat pancreas. Toxicol Lett. 2002 ; 133: 161-170 (Pubitemid 34761973)
75. Andreotti G, Freeman LE, Hou L, Coble J, Rusiecki J, Hoppin JA, et al. Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort. Int J Cancer. 2009 ; 124: 2495-2500
76. Srivastava AK, Mishra J. Effects of fenthion on the blood and tissue chemistry of a teleost fish (Heteropneustes fossilis). J Comp Pathol. 1983 ; 93: 27-31 (Pubitemid 13131631)
77. Lal B, Singh A, Kumari A, Sinha N. Biochemical and haematological changes following malathion treatment in the freshwater catfish Heteropneustes fossilis (Bloch). Environ Poll A Ecol Biol. 1986 ; 42: 151-156 (Pubitemid 16044805)
78. Bretaud S, Saglio P, Saligaut C, Auperin B. Biochemical and behavioral effects of carbofuran in goldfish (Carassius auratus). Environ Toxicol Chem. 2002 ; 21: 175-181 (Pubitemid 34028586)
79. Abdollahi M, Donyavi M, Pournourmohammadi S, Saadat M. Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase in rats following subchronic exposure to malathion. Comp Biochem Physiol C Toxicol Pharmacol. 2004 ; 137: 343-347 (Pubitemid 38844670)
80. Teimouri F, Amirkabirian N, Esmaily H, Mohammadirad A, Aliahmadi A, Abdollahi M. Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxication mechanism in counteracting diazinon-induced oxidative stress. Hum Exp Toxicol. 2006 ; 25: 697-703 (Pubitemid 46101695)
81. Basiri S, Esmaily H, Vosough-Ghanbari S, Mohammadirad A, Yasa N, Abdollahi M. Improvement by Satureja khuzestanica essential oil of malathion-induced red blood cells acetylcholinesterase inhibition and altered hepatic mitochondrial glycogen phosphorylase and phosphoenolpyruvate carboxykinase activities. Pestic Biochem Physiol. 2007 ; 89: 124-129 (Pubitemid 47321797)
82. Rezg R, Mornagui B, El-Fazaa S, Gharbi N. Caffeic acid attenuates malathion induced metabolic disruption in rat liver, involvement of acetylcholinesterase activity. Toxicology. 2008 ; 250: 27-31
83. Rezg R, Mornagui B, El-Arbi M, Kamoun A, El-Fazaa S, Gharbi N. Effect of subchronic exposure to malathion on glycogen phosphorylase and hexokinase activities in rat liver using native PAGE. Toxicology. 2006 ; 223: 9-14 (Pubitemid 43728622)
84. Das BK, Mukherjee SC. Chronic toxic effects of quinalphos on some biochemical parameters in Labeo rohita (Ham.). Toxicol Lett. 2000 ; 114: 11-18 (Pubitemid 30125436)
85. Sastry KV, Siddiqui AA. Chronic toxic effects of the carbamate pesticide sevin on carbohydrate metabolism in a freshwater snakehead fish, Channa punctatus. Toxicol Lett. 1982 ; 14: 123-130 (Pubitemid 13255377)
86. Adigun AA, Wrench N, Seidler FJ, Slotkin TA. Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion. Environ Health Persp. 2010 ; 118: 211
87. Tuzmen N, Candan N, Kaya E, Demiryas N. Biochemical effects of chlorpyrifos and deltamethrin on altered antioxidative defense mechanisms and lipid peroxidation in rat liver. Cell Biochem Funct. 2008 ; 26: 119-24 (Pubitemid 351155278)
88. Sutcu R, Altuntas I, Yildirim B, Karahan N, Demirin H, Delibas N. The effects of subchronic methidathion toxicity on rat liver: role of antioxidant vitamins C and E. Cell Biol Toxicol. 2006 ; 22: 221-227
89. Gokalp O, Gulle K, Sulak O, Cicek E, Altuntas I. The effects of methidathion on liver: role of vitamins E and C. Toxicol Ind Health. 2003 ; 19: 63-67 (Pubitemid 40036695)
90. Undeger U, Institoris L, Siroki O, Nehez M, Desi I. Simultaneous geno- and immunotoxicological investigations for early detection of organophosphate toxicity in rats. Ecotoxicol Environ Saf. 2000 ; 45: 43-48 (Pubitemid 30075606)
91. Enan EE, El-Sebae AH, Enan OH, El-Fiki S. In-vivo interaction of some organophosphorus insecticides with different biochemical targets in white rats. J Environ Sci Health B. 1982 ; 17: 549-570 (Pubitemid 13174949)
92. Venkateswara Rao J. Sublethal effects of an organophosphorus insecticide (RPR-II) on biochemical parameters of tilapia, Oreochromis mossambicus. Comp Biochem Physiol C Toxicol Pharmacol. 2006 ; 143: 492-498 (Pubitemid 44137297)
93. Sharma Y, Bashir S, Irshad M, Gupta SD, Dogra TD. Effects of acute dimethoate administration on antioxidant status of liver and brain of experimental rats. Toxicology. 2005 ; 206: 49-57 (Pubitemid 39601044)
94. Gomes J, Dawodu AH, Lloyd O, Revitt DM, Anilal SV. Hepatic injury and disturbed amino acid metabolism in mice following prolonged exposure to organophosphorus pesticides. Hum Exp Toxicol. 1999 ; 18: 33-37 (Pubitemid 29054470)
95. Begum G. Carbofuran insecticide induced biochemical alterations in liver and muscle tissues of the fish Clarias batrachus (linn) and recovery response. Aquat Toxicol. 2004 ; 66: 83-92 (Pubitemid 37543780)
96. Boros LG, Williams RD. Isofenphos induced metabolic changes in K562 myeloid blast cells. Leuk Res. 2001 ; 25: 883-890 (Pubitemid 32776579)
97. Ceron JJ, Sancho E, Ferrando MD, Gutierrez C, Andreu E. Changes in carbohydrate metabolism in the eel anguilla anguilla, during short-term exposure to diazinon. Toxicol Environ Chem. 1997 ; 60: 201-210 (Pubitemid 27235775)
98. Koch RB. Inhibition of animal tissue atpase activities by chlorinated hydrocarbon pesticides. Chem Biol Interact. 1969 ; 1: 199-209
99. Murphy SD, Porter S. Effects of toxic chemicals on some adaptive liver enzymes, liver glycogen, and blood glucose in fasted rats. Biochem Pharmacol. 1966 ; 15: 1665-1676
100. Trankina ML, Beitz DC, Trenkle AH. Effects of in vitro ronnel on metabolic activity in subcutaneous adipose tissue and skeletal muscle from steers. J Anim Sci. 1985 ; 60: 652-658
101. Begum G, Vijayaraghavan S. Effect of acute exposure of the organophosphate insecticide Rogor on some biochemical aspects of Clarias batrachus (Linnaeus). Environ Res. 1999 ; 80: 80-83 (Pubitemid 29045208)
102. Pena-Llopis S, Ferrando MD, Pena JB. Impaired glutathione redox status is associated with decreased survival in two organophosphate-poisoned marine bivalves. Chemosphere. 2002 ; 47: 485-497 (Pubitemid 35177331)
103. Yang ZP, Dettbarn WD. Lipid peroxidation and changes in cytochrome c oxidase and xanthine oxidase activity in organophosphorus anticholinesterase induced myopathy. J Physiol Paris. 1998 ; 92: 157-161 (Pubitemid 29050926)
104. Yang D, Lu X, Zhang W, He F. Biochemical changes in primary culture of skeletal muscle cells following dimethoate exposure. Toxicology. 2002 ; 174: 79-85 (Pubitemid 34460692)
105. Calore EE, Sesso A, Puga FR, Cavaliere MJ, Calore NM, Weg R. Sarcoplasmic lipase and non-specific esterase inhibition in myofibers of rats intoxicated with the organophosphate isofenphos. Exp Toxicol Pathol. 1999 ; 51: 27-33 (Pubitemid 29046559)
106. Rambabu JP, Rao MB. Effect of an organochlorine and three organophosphate pesticides on glucose, glycogen, lipid, and protein contents in tissues of the freshwater snail Bellamya dissimilis (Muller). Bull Environ Contam Toxicol. 1994 ; 53: 142-148 (Pubitemid 24149639)
107. Bomser JA, Quistad GB, Casida JE. Chlorpyrifos oxon potentiates diacylglycerol-induced extracellular signal-regulated kinase (ERK 44/42) activation, possibly by diacylglycerol lipase inhibition. Toxicol Appl Pharmacol. 2002 ; 178: 29-36 (Pubitemid 34084728)
108. Meggs WJ, Brewer KL. Weight gain associated with chronic exposure to chlorpyrifos in rats. J Med Toxicol. 2007 ; 3: 89-93
109. Lassiter TL, Ryde IT, Mackillop EA, Brown KK, Levin ED, Seidler FJ, et al. Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood. Environ Health Perspect. 2008 ; 116: 1456-1462
110. Lal B, Singh TP. The effect of malathion and [gamma]-BHC on the lipid metabolism in relation to reproduction in the tropical teleost, Clarias batrachus. Environ Poll. 1987 ; 48: 37-47 (Pubitemid 18044562)
111. Lam CKL, Chari M, Wang PYT, Lam TKT. Central lactate metabolism regulates food intake. Am J Physiol Endocrinol Metab. 2008 ; 295: E491 - E496
112. Chari M, Lam CKL, Wang PYT, Lam TKT. Activation of central lactate metabolism lowers glucose production in uncontrolled diabetes and diet-induced insulin resistance. Diabetes. 2008 ; 57: 836-840
113. Michael WS, Daniel Porte. Diabetes, Obesity, and the Brain. Science. 2005 ; 307: 375-379
114. Miller AL, Medina MA. Cerebral metabolic effects of organophosphorus anticholinesterase compounds. Metab Brain Dis. 1986 ; 1: 147-156 (Pubitemid 17127639)
115. Matin MA, Sattar S, Husain K. Modification of malathion induced neurochemical changes by adrenalectomy in rats. Mol Chem Neuropathol. 1990 ; 13: 119-128
116. Matsuda H, Seo Y, Kakizaki E, Takahama K. Changes in mRNA expression levels of synaptic- and target tissue-specific proteins after organophosphate exposure. Leg Med (Tokyo). 2000 ; 2: 55-63
117. Beatty PW, Reed DJ. Involvement of the cystathionine pathway in the biosynthesis of glutathione by isolated rat hepatocytes. Arch Biochem Biophys. 1980 ; 204: 80-87 (Pubitemid 11186356)
118. Junqueira VBC, Simizu K, Van-Halsema L, Koch OR, Barros SBM, Videla LA. Lindane-Induced Oxidative Stress. I. Time Course of changes in hepatic microsomal parameters, antioxidant enzymes, lipid peroxidative indices and morphological characteristics. Xenobiotica. 1988 ; 18: 1297-1304 (Pubitemid 19002033)
119. Łukaszewicz-Hussain A. Chlorfenvinphos, an organophosphate insecticide, affects liver mitochondria antioxidative enzymes, glutathione and hydrogen peroxide concentration. J Environ Stud. 2004 ; 13: 397-401 (Pubitemid 39026733)
120. Ehrich M, Larsen C, Arnold J. Organophosphate detoxification related to induced hepatic microsomal enzymes of chickens. Am J Vet Res. 1984 ; 45: 755-758 (Pubitemid 14142927)
121. Ranjbar A, Solhi H, Mashayekhi FJ, Susanabdi A, Rezaie A, Abdollahi M. Oxidative stress in acute human poisoning with organophosphorus insecticides; a case control study. Environ Toxicol Pharmacol. 2005 ; 20: 88-91 (Pubitemid 40615362)
122. Akhgari M, Abdollahi M, Kebryaeezadeh A, Hosseini R, Sabzevari O. Biochemical evidence for free radical-induced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats. Hum Exp Toxicol. 2003 ; 22: 205-211 (Pubitemid 36582596)
123. Ranjbar A, Pasalar P, Abdollahi M. Induction of oxidative stress and acetylcholinesterase inhibition in organophosphorous pesticide manufacturing workers. Hum Exp Toxicol. 2002 ; 21: 179-182 (Pubitemid 34662044)
124. Zaja-Milatovic S, Gupta RC, Aschner M, Milatovic D. Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist. Toxicol Appl Pharmacol. 2009 ; 240: 124-131
125. Abdollahi M, Ranjbar A, Shadnia S, Nikfar S, Rezaie A. Pesticides and oxidative stress: a review. Med Sci Monit. 2004 ; 10: RA141 - RA147
126. Soussi B, Idstrom JP, Schersten T, Bylund-Fellenius AC. Cytochrome c oxidase and cardiolipin alterations in response to skeletal muscle ischaemia and reperfusion. Acta Physiol Scand. 1990 ; 138: 107-114 (Pubitemid 20142481)
127. Moore PD, Yedjou CG, Tchounwou PB. Malathion-induced oxidative stress, cytotoxicity, and genotoxicity in human liver carcinoma (HepG(2)) cells. Environ Toxicol. 2010 ; 25: 221-226
128. Monteiro DA, Rantin FT, Kalinin AL. The effects of selenium on oxidative stress biomarkers in the freshwater characid fish matrinxa, Brycon cephalus (Gunther, 1869) exposed to organophosphate insecticide Folisuper 600 BR (methyl parathion). Comp Biochem Physiol C Toxicol Pharmacol. 2009 ; 149: 40-49
129. Uner N, Sevgiler Y, Piner P, Durmaz H. Modulation of fenthion-induced oxidative effects by BSO in the liver of Cyprinus carpio L. Drug Chem Toxicol. 2008 ; 31: 353-369 (Pubitemid 352009249)
130. Buyukokuroglu ME, Cemek M, Yurumez Y, Yavuz Y, Aslan A. Antioxidative role of melatonin in organophosphate toxicity in rats. Cell Biol Toxicol. 2008 ; 24: 151-158 (Pubitemid 351311390)
131. Uner N, Sevgiler Y, Durmaz H, Piner P. In vivo alterations in glutathione-related processes, lipid peroxidation, and cholinesterase enzyme activities in the liver of diazinon-exposed Oreochromis niloticus. Toxicol Mech Methods. 2007 ; 17: 317-324 (Pubitemid 47124024)
132. Shadnia S, Azizi E, Hosseini R, Khoei S, Fouladdel S, Pajoumand A, et al. Evaluation of oxidative stress and genotoxicity in organophosphorus insecticide formulators. Hum Exp Toxicol. 2005 ; 24: 439-445 (Pubitemid 41433667)
133. Woo S, Yum S, Kim DW, Park HS. Transcripts level responses in a marine medaka (Oryzias javanicus) exposed to organophosphorus pesticide. Comp Biochem Physiol C Toxicol Pharmacol. 2009 ; 149: 427-432
134. Lewis JA, Szilagyi M, Gehman E, Dennis WE, Jackson DA. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. BMC Genomics. 2009 ; 10: 202
135. Mehta A, Verma RS, Srivastava N. Chlorpyrifos-induced DNA damage in rat liver and brain. Environ Mol Mutagen. 2008 ; 49: 426-433
136. Brocardo PS, Pandolfo P, Takahashi RN, Rodrigues AL, Dafre AL. Antioxidant defenses and lipid peroxidation in the cerebral cortex and hippocampus following acute exposure to malathion and/or zinc chloride. Toxicology. 2005 ; 207: 283-291 (Pubitemid 39642843)
137. Milagros Rocha M, Victor VM. Targeting antioxidants to mitochondria and cardiovascular diseases: the effects of mitoquinone. Med Sci Monit. 2007 ;: 13 RA132 - RA145
138. Kalender Y, Kalender S, Uzunhisarcikli M, Ogutcu A, Açikgoz F, Durak D. Effects of endosulfan on B cells of Langerhans islets in rat pancreas. Toxicology. 2004 ; 200: 205-211 (Pubitemid 38798430)
139. Lee HK, Cho YM, Kwak SH, Lim S, Park KS, Shim EB. Mitochondrial dysfunction and metabolic syndrome-looking for environmental factors. Biochim Biophys Acta. 2010 ; 1800: 282-289
140. Hasan M, Maitra SC, Ali SF. Organophosphate pesticide DDVP-induced alterations in the rat cerebellum and spinal cord-an electron microscopic study. Exp Pathol (Jena). 1979 ; 17: 88-94 (Pubitemid 9148149)
141. Abou-Donia MB. Organophosphorus ester-induced chronic neurotoxicity. Arch Environ Health. 2003 ; 58: 484-497 (Pubitemid 38828868)
142. Kaur P, Radotra B, Minz RW, Gill KD. Impaired mitochondrial energy metabolism and neuronal apoptotic cell death after chronic dichlorvos (OP) exposure in rat brain. Neurotoxicology. 2007 ; 28: 1208-1219 (Pubitemid 350026599)
143. Yen DHT, Chan JYH, Tseng HP, Huang CI, Lee CH, Chan SHH, et al. Depression of mitochondrial respiratory enzyme activity in rostral ventrolateral medulla during acute mevinphos intoxication in the rat. Shock. 2004 ; 21: 358-363
144. Venkatesh S, Ramachandran A, Zachariah A, Oommen A. Mitochondrial ATP synthase inhibition and nitric oxide are involved in muscle weakness that occurs in acute exposure of rats to monocrotophos. Toxicol Mech Methods. 2009 ; 19: 239-245
145. Nakagawa Y, Nakajima K, Suzuki T. Chlorpropham induces mitochondrial dysfunction in rat hepatocytes. Toxicology. 2004 ; 200: 123-133 (Pubitemid 38798423)
146. Xu WN, Liu WB, and Liu ZP. Trichlorfon-induced apoptosis in hepatocyte primary cultures of Carassius auratus gibelio. Chemosphere. 2009 ; 77: 895-901
147. Jones PM, Persaud SJ. Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic beta-cells. Endocr Rev. 1998 ; 19: 429-461 (Pubitemid 29116376)
148. Fernyhough ME, Okine E, Hausman G, Vierck JL, Dodson MV. PPARgamma and GLUT-4 expression as developmental regulators/markers for preadipocyte differentiation into an adipocyte. Domest Anim Endocrinol. 2007 ; 33: 367-378 (Pubitemid 47513814)
149. Doggrell S. Do peroxisome proliferation receptor-gamma antagonists have clinical potential as combined antiobesity and antidiabetic drugs?. Expert Opin
150. Rieusset J, Touri F, Michalik L, Escher P, Desvergne B, Niesor E, et al. A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity. Mol Endocrinol. 2002 ; 16: 2628-2644 (Pubitemid 35266080)
151. Ortiz-Zarragoitia M, Cajaraville MP. Effects of selected xenoestrogens on liver peroxisomes, vitellogenin levels and spermatogenic cell proliferation in male zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2005 ; 141: 133-144 (Pubitemid 41335482)
152. de Brito-Gitirana L, Miguel NC. Electron microscopical investigation on aldrin-induced hepatocyte pathology in Rana catesbeiana, with special emphasis on peroxisomes. Exp Toxicol Pathol. 2000 ; 52: 339-347 (Pubitemid 30665209)
153. Dantoine T, Debord J, Merle L, Charmes JP. From organophosphate compound toxicity to atherosclerosis: role of paraoxonase 1. Rev Med Interne. 2003 ; 24: 436-442 (Pubitemid 36781706)
154. Shih DM, Kast-Woelbern HR, Wong J, Xia YR, Edwards PA, Lusis AJ. A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. J Lipid Res. 2006 ; 47: 384-392 (Pubitemid 43276924)
155. Gouedard C, Barouki R, Morel Y. Induction of the paraoxonase-1 gene expression by resveratrol. Arterioscler Thromb Vasc Biol. 2004 ; 24: 2378-2383 (Pubitemid 39658045)
156. Mackness B, Durrington P, Povey A, Thomson S, Dippnall M, Mackness M, et al. Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping sheep. Pharmacogenetics. 2003 ; 13: 81-88 (Pubitemid 36259587)
157. Camps J, Marsillach J, Joven J. The paraoxonases: role in human diseases and methodological difficulties in measurement. Crit Rev Clin Lab Sci. 2009 ; 46 (2). 83-106
158. Cowan J, Sinton CM, Varley AW, Wians FH, Haley RW, Munford RS. Gene therapy to prevent organophosphate intoxication. Toxicol Appl Pharmacol. 2001 ; 173: 1-6 (Pubitemid 32480359)
159. Costa LG, Richter RJ, Li WF, Cole T, Guizzetti M, Furlon CE. Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers. 2003 ; 8: 1-12 (Pubitemid 36097533)
160. Sirivarasai J, Kaojarern S, Yoovathaworn K, Sura T. Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects. Chem Biol Interact. 2007 ; 168: 184-192 (Pubitemid 46992662)
161. Sozmen EY, Mackness B, Sozmen B, Durrington P, Girgin FK, Aslan L, et al. Effect of organophosphate intoxication on human serum paraoxonase. Hum Exp Toxicol. 2002 ; 21: 247-252 (Pubitemid 34785025)
162. Manthripragada AD, Costello S, Cockburn MG, Bronstein JM, Ritz B. Paraoxonase 1, agricultural organophosphate exposure, and parkinson disease. Epidemiology. 2010 ; 21: 87-94
163. Edna M, Michael A, Tony H. Paraoxonase 2 (PON2) decreases high glucose-induced macrophage triglycerides (TG) accumulation, via inhibition of NADPH-oxidase and DGAT1 activity: studies in PON2-deficient mice. Atherosclerosis. 2009 ; 208: 390-395
164. Timchalk C, Kousba AA, Poet TS. An age-dependent physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus insecticide chlorpyrifos in the preweanling rat. Toxicol Sci. 2007 ; 98: 348-365 (Pubitemid 47244808)
165. Pavkovic E, Simeon V, Reiner E, Sucic M, Lipovac V. Serum paraoxonase and cholineseterase activities in individuals with lipid and glucose metabolism disorders. Chem Biol Interact. 1993 ; 87: 179-182 (Pubitemid 23205377)
166. Rosenblat M, Sapir O, Aviram M. Glucose inactivates paraoxonase 1 (PON1) and displaces it from high density lipoprotein (HDL) to a free PON1 form. The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism. 2008 ;: 35-49
167. Deakin S, Leviev I, Nicaud V, Brulhart Meynet MC, Tiret L, James RW. Paraoxonase-1 L55M polymorphism is associated with an abnormal oral glucose tolerance test and differentiates high risk coronary disease families. J Clin Endocrinol Metab. 2002 ; 87: 1268-1273 (Pubitemid 36121098)
168. Hegele RA. Paraoxonase genes and disease. Annal Med. 1999 ; 31: 217-224 (Pubitemid 29304460)
169. McEwen BS, Wingfield JC. The concept of allostasis in biology and biomedicine. Horm Behav. 2003 ; 43: 2-15 (Pubitemid 36293268)
170. Marik PE, Zaloga GP. Adrenal insufficiency in the critically ill: a new look at an old problem. Chest. 2002 ; 122: 1784-1796 (Pubitemid 35366095)
171. Hart BB, Stanford GG, Ziegler MG, Lake CR, Chernow B. Catecholamines: study of interspecies variation. Crit Care Med. 1989 ; 17: 1203-1222 (Pubitemid 19276548)
172. Siegel JH, Cerra FB, Coleman B, Giovannini I, Shetye M, Border JR, et al. Physiological and metabolic correlations in human sepsis. Invited commentary. Surgery. 1979 ; 86: 163-193
173. Chiasson JL, Shikama H, Chu DT, Exton JH. Inhibitory effect of epinephrine on insulin-stimulated glucose uptake by rat skeletal muscle. J Clin Invest. 1981 ; 68: 706-713 (Pubitemid 11005046)
174. Chiasson JL, Aylward JH, Shikama H, Exton JH. Hormonal regulation of glycogen synthase phosphorylation in perfused rat skeletal muscle. FEBS Lett. 1981 ; 127: 97-100 (Pubitemid 11084820)
175. Frayn KN, Little RA, Maycock PF, Stoner HB. The relationship of plasma catecholamines to acute metabolic and hormonal responses to injury in man. Circ Shock. 1985 ; 16: 229-240
176. Little RA, Frayn KN, Randall PE, Maycock PF, Stoner HB. Plasma catecholamine concentrations in acute states of stress and trauma. Arch Emerg Med. 1985 ; 2: 46-47
177. Hunt DG, Ivy JL. Epinephrine inhibits insulin-stimulated muscle glucose transport. J Appl Physiol. 2002 ; 93: 1638-1643 (Pubitemid 36082974)
178. Gustavson SM, Chu CA, Nishizawa M, Farmer B, Neal D, Yang Y, et al. Glucagon's actions are modified by the combination of epinephrine and gluconeogenic precursor infusion. Am J Physiol Endocrinol Metab. 2003 ; 285: E534 - E544 (Pubitemid 37010831)
179. Gustavson SM, Chu CA, Nishizawa M, Farmer B, Neal D, Yang Y, et al. Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog. Am J Physiol Endocrinol Metab. 2003 ; 284: E695 - E707 (Pubitemid 36323862)
180. Mizock BA. Alterations in fuel metabolism in critical illness: hyperglycaemia. Best Pract Res Clin Endocrinol Metab. 2001 ; 15: 533-551
181. Mechanick JI. Metabolic mechanisms of stress hyperglycemia. JPEN J Parenter Enteral Nutr. 2006 ; 30: 157-163 (Pubitemid 44314789)
182. Rezg R, Mornagui B, Benahmed M, Gharsalla-Chouchane S, Belhajhmida N, Abdeladhim M, et al. Malathion exposure modulates hypothalamic gene expression and induces dyslipedemia in Wistar rats. Food Chem Toxicol. 2010 ; 48: 1473-1477
183. Gore AC. Organochlorine pesticides directly regulate gonadotropin- releasing hormone gene expression and biosynthesis in the GT1-7 hypothalamic cell line. Mol Cell Endocrinol. 2002 ; 192: 157-170 (Pubitemid 34667234)
184. Gearhart MM, Parbhoo SK. Hyperglycemia in the critically ill patient. AACN Clin Issues. 2006 ; 17: 50-55
185. Spassova D, White T, Singh AK. Acute effects of acephate and methamidophos on acetylcholinesterase activity, endocrine system and amino acid concentrations in rats. Comp Biochem Physiol C Toxicol Pharmacol. 2000 ; 126: 79-89 (Pubitemid 30332428)
186. Tamura H, Maness SC, Reischmann K, Dorman DC, Gray LE, Gaido KW. Androgen receptor antagonism by the organophosphate insecticide fenitrothion. Toxicol Sci. 2001 ; 60: 56-62 (Pubitemid 32229827)
187. Turner KJ, Barlow NJ, Struve MF, Wallace DG, Gaido KW, Dorman DC, et al. Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD(SD)BR rat. Toxicol Sci. 2002 ; 68: 174-183 (Pubitemid 34785239)
188. Klieverik LP, Sauerwein HP, Ackermans MT, Boelen A, Kalsbeek A, Fliers E. Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. Am J Physiol Endocrinol Metab. 2008 ; 294: E513 - E520 (Pubitemid 351355221)
189. Rawlings NC, Cook SJ, Waldbillig D. Effects of the pesticides carbofuran, chlorpyrifos, dimethoate, lindane, triallate, trifluralin, 2,4-D, and pentachlorophenol on the metabolic endocrine and reproductive endocrine system in ewes. J Toxicol Environ Health A. 1998 ; 54: 21-36 (Pubitemid 28427194)
190. Boada LD, Lara PC, Alvarez-Leon EE, Losada A, Zumbado ML, Liminana-Canal JM, et al. Serum levels of insulin-like growth factor-I in relation to organochlorine pesticides exposure. Growth Horm IGF Res. 2007 ; 17: 506-511 (Pubitemid 350079969)
191. Zumbado M, Luzardo OP, Lara PC, Alvarez-León EE, Losada A, Apolinario R, et al. Insulin-like growth factor-I (IGF-I) serum concentrations in healthy children and adolescents: relationship to level of contamination by DDT-derivative pesticides. Growth Horm IGF Res. 2010 ; 20: 63-67
192. Blizard D, Sueyoshi T, Negishi M, Dehal SS, Kupfer D. Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system. Drug Metab Dispos. 2001 ; 29: 781-785 (Pubitemid 32488631)
193. Dehal SS, Kupfer D. Metabolism of the proestrogenic pesticide methoxychlor by hepatic P450 monooxygenases in rats and humans. Dual pathways involving novel ortho ring-hydroxylation by CYP2B. Drug Metab Dispos. 1994 ; 22: 937-946 (Pubitemid 24377371)
194. Shadnia S, Dasgar M, Taghikhani S, Mohammadirad A, Khorasani R, Abdollahi M. Protective Effects of alpha-tocopherol and N-acetyl-cysteine on diazinon-induced oxidative stress and acetylcholinesterase inhibition in rats. Toxicol Mech Methods. 2007 ; 17: 109-115
195. Saafi EB, Louedi M, Elfeki A, Zakhama A, Najjar MF, Hammami M, et al. Protective effect of date palm fruit extract (Phoenix dactylifera L.) on dimethoate induced-oxidative stress in rat liver. Exp Toxicol Pathol. 2010 ;:
196. Pond AL, Chambers HW, Chambers JE. Organophosphate detoxication potential of various rat tissues via A-esterase and aliesterase activities. Toxicol Lett. 1995 ; 78: 245-252
197. Amirkabirian N, Teimouri F, Esmaily H, Mohammadirad A, Aliahmadi A, Abdollahi M. Protection by pentoxifylline of diazinon-induced toxic stress in rat liver and muscle. Toxicol Mech Methods. 2007 ; 17: 215-221 (Pubitemid 46956936)
198. Ranjbar A, Ghahremani MH, Sharifzadeh M, Golestani A, Ghazi-Khansari M, Baeeri M, et al. Protection by pentoxifylline of malathion-induced toxic stress and mitochondrial damage in rat brain. Hum Exp Toxicol. 2010 ; 29: 851-864
199. Azadbar M, Ranjbar A, Hosseini-Tabatabaei A, Golestani A, Baeeri M, Sharifzadeh M, et al. Interaction of phosphodiesterase 5 inhibitor with malathion on rat brain mitochondrial-bound hexokinase activity. Pestic Biochem Physiol. 2009 ; 95: 121-125
200. Ghafour-Rashidi Z, Dermenaki-Farahani E, Aliahmadi A, Esmaily H, Mohammadirad A, Ostad SN, et al. Protection by cAMP and cGMP phosphodiesterase inhibitors of diazinon-induced hyperglycemia and oxidative/nitrosative stress in rat Langerhans islets cells: molecular evidence for involvement of non-cholinergic mechanisms. Pestic Biochem Physiol. 2007 ; 87: 261-270 (Pubitemid 46188336)
201. Rezvanfar MA, Ranjbar A, Baeeri M, Mohammadirad A, Abdollahi M. Biochemical evidence on positive effects of rolipram a phosphodiesterase-4 inhibitor in malathion-induced toxic stress in rat blood and brain mitochondria. Pestic Biochem Physiol. 2010 ; 98: 135-143
202. Rahimi R, Ghiasi S, Azimi H, Fakhari S, Abdollahi M. A review of the herbal phosphodiesterase inhibitors; future perspective of new drugs. Cytokine. 2010 ; 49: 123-129
203. Yurumez Y, Ikizceli I, Sozuer EM, Soyuer I, Yavuz Y, Avsarogullari L, et al. Effect of interleukin-10 on tissue damage caused by organophosphate poisoning. Basic Clin Pharmacol Toxicol. 2007 ; 100: 323-327 (Pubitemid 46633474)
204. Goel A, Dhawan DK. Zinc supplementation prevents liver injury in chlorpyrifos-treated rats. Biol Trace Elem Res. 2001 ; 82: 185-200 (Pubitemid 32989404)
205. Straus DL, Chambers JE. Effects of piperonyl butoxide on the metabolism of DEF S,S,S-Tributyl Phosphorotrithioate) in fingerling channel catfish. Toxicol Mech Methods. 2006 ; 16: 235-239
206. Shadnia S, Okazi A, Akhlaghi N, Sasanian G, Abdollahi M. Prognostic value of long QT interval in acute and severe organophosphate poisoning. J Med Toxicol. 2009 ; 5: 196-199
207. Sharaf AA, Mohaned AM, Abu El-Ghar MR, Mousa AH. Control of snail hosts of bilharziasis in Egypt. 3. Effect of the organophosphorous insecticide, dursban, on carbohydrate metabolism of the snails Biomphalaria alexandria and Bulinus truncatus. Egypt J Bilharz. 1975 ; 2: 49-61
208. Kuz'minskaia UA, Ivanitskii VA. [Functional state of the sympathetic-adrenal system under the effect of organochlorine insecticides]. Vrach Delo. 1978 ;: 127-30
209. Singh NN, Srivastava AK. Effect of a paired mixture of aldrin and formothion on carbohydrate metabolism in a fish, Heteropneustes fossilis. Pesticide Biochemistry and Physiology. 1981 ; 15: 257-61 (Pubitemid 11024907)
210. Verma SR, Rani S, Tonk IP, Dalela RC. Pesticide-induced dysfunction in carbohydrate metabolism in three freshwater fishes. Environmental Research. 1983 ; 32 (1). 127-33 (Pubitemid 14240604)
211. Rodrigues MA, Puga FR, Chenker E, Mazanti MT. Short-term effect of malathion on rats' blood glucose and on glucose utilization by mammalian cells in vitro. Ecotoxicol Environ Saf. 1986 ; 12: 110-3 (Pubitemid 17185138)
212. Nemcsok J, Asztalos B, Vig E, Orban L. The effect of an organophosphorus pesticide on the enzymes of carp (Cyprinus carpio L.). Acta Biol Hung. 1987 ; 38: 77-85 (Pubitemid 18049024)
213. Matin MA, Husain K. Cerebral glycogenolysis and glycolysis in malathion-treated hyperglycaemic animals. Biochem Pharmacol. 1987 ; 36: 1815-7 (Pubitemid 17084463)
214. Husain K, Ansari RA. Influence of cholinergic and adrenergic blocking drugs on hyperglycemia and brain glycogenolysis in diazinon-treated animals. Can J Physiol Pharmacol. 1988 ; 66: 1144-7 (Pubitemid 18259799)
215. Shih TM, Scremin OU. Cerebral blood flow and metabolism in soman-induced convulsions. Brain Res Bull. 1992 ; 28: 735-42
216. Anam KK, Maitra SK. Impact of quinalphos on blood glucose and acetylcholinesterase (AChE) activity in brain and pancreas in a roseringed parakeet (Psittacula krameri borealis: Newmann). Archives of Environmental Contamination and Toxicology. 1995 ; 29: 20-3
217. Sarin S, Gill KD. Dichlorvos induced alterations in glucose homeostasis: possible implications on the state of neuronal function in rats. Mol Cell Biochem. 1999 ; 199: 87-92 (Pubitemid 29476146)
218. Kalender S, Kalender Y, Ogutcu A, Uzunhisarcikli M, Durak D, Acikgoz F. Endosulfan-induced cardiotoxicity and free radical metabolism in rats: the protective effect of vitamin E. Toxicology. 2004 ; 202: 227-35 (Pubitemid 39165397)
219. de Aguiar LH, Moraes G, Avilez IM, Altran AE, Correa CF. Metabolical effects of Folidol 600 on the neotropical freshwater fish matrinxa, Brycon cephalus. Environ Res. 2004 ; 95: 224-30 (Pubitemid 38625899)
220. Effects of malathion subchronic exposure on rat skeletal muscle glucose metabolism. Environmental Toxicology and Pharmacology. 2005 ; 19: 191-6
221. Teimouri F, Amirkabirian N, Esmaily H, Mohammadirad A, Aliahmadi A, Abdollahi M. Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxication mechanism in counteracting diazinon-induced oxidative stress. Hum Exp Toxicol. 2006 ; 25: 697-703 (Pubitemid 46101695)
222. Thangavel P, Sumathiral K, Maheswari S, Rita S, Ramaswamy M. Hormone profile of an edible, freshwater teleost, Sarotherodon mossambicus (Peters) under endosulfan toxicity. Pesticide Biochemistry and Physiology. 2010 ; 97: 229-234