Chlorpropham induces mitochondrial dysfunction in rat hepatocytes

Toxicology

Volumn 200, Issue 2-3, 2004, Pages 123-133

  Nakagawa, Yoshio ^a   Nakajima, Kazuo ^a   Suzuki, Toshinari ^a  

^a TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

3 chloroaniline; 3CA; 4OH CIPC; Chlorpropham; chlorpropham; CIPC; Cytotoxicity; dimethyl sulfoxide; DMSO; Hepatocytes; HEPES; Herbicide; isopropyl N (3 chloro 4 hydroxyphenyl) carbamate; Metabolism; Mitochondrial dysfunction

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE TRIPHOSPHATE; CHLORPROPHAM; CYTOCHROME C OXIDASE; FLAVINE ADENINE NUCLEOTIDE; GLUCURONIDE; MALIC ACID; PROADIFEN; PYRUVIC ACID; ROTENONE; SUCCINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CELL LOSS; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG METABOLISM; ENZYME INHIBITION; LIVER CELL; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TOXICITY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN CONTENT; RAT;

ADENINE NUCLEOTIDES; ANIMALS; BIOTRANSFORMATION; CELL DEATH; CELL SEPARATION; CHLORPROPHAM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; HEPATOCYTES; HERBICIDES; KINETICS; MALE; MASS SPECTROMETRY; MITOCHONDRIA, LIVER; MIXED FUNCTION OXYGENASES; OXYGEN CONSUMPTION; PROADIFEN; RATS; RATS, INBRED F344;

EID: 2942699895     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.03.012     Document Type: Article

References (29)

1. Bellomo G., Mirabelli F., Richelmi P., Malorni W., Iosi F., Orrenius S. The cytoskeleton as a target in quinone toxicity. Free Radic. Res. Commun. 8:1990;391-399
2. Boyd E.M., Carsky E. The acute oral toxicity of the herbicide chlorpropham in albino rats. Arch. Environ. Health. 19:1969;621-627
3. Cain, K., Skilleter, D.S., 1987. Preparation and use of mitochondria in toxicological research. In: Snell, K., Mullock, B. (Eds.), Biochemical Toxicology, A Practical Approach, IRL Press, Oxford, pp. 217-254.
4. Carrera G., Alary J., Melgar M.J., Lamboeuf Y., Pipy B. Metabolism and cytotoxicity of chlorpropham (CIPC) and its essential metabolites in isolated rat hepatocytes during a partial inhibition of sulphation and glucuronidation reactions: a comparative study. Arch. Environ. Contam. Toxicol. 35:1998;89-96
5. 14C -labelled propham and chlorpropham in the female rats Pest. Biochem. Physiol. 4:1974;1-11
6. Fujitani T., Tada Y., Noguchi A.T., Yoneyama M. Hemotoxicity of chlorpropham (CIPC) in F344 rats. Toxicology. 123:1997;111-124
7. Fujitani T., Tada Y., Fujii A., Kimura M. Subchronic toxicity of chlorpropham (CIPC) in ICR mice. Food Chem. Toxicol. 38:2000;617-625
8. Fusi F., Sgaragli G., Murphy M.P. Interaction of butylated hydroxyanisole with mitochondrial oxidative phosphorylation. Biochem. Pharmacol. 43:1992;1203-1208
9. Hinshaw D.B., Sklar L.A., Bohl B., Schraufstatter I.U., Rossi M.W., Spragg R.G., Cochrane C.G. Cytoskeletal and morphological impact of cellular oxidant injury. Am. J. Pathol. 123:1986;454-464
10. Jakoby, W.B., Sekura, R.D., Lyon, E.S., Marcus, C.J., Wang, J.-L., 1980. Sulfotransferases. In: Jakoby, W.B. (Ed.), Enzymatic Basis of Detoxification, Academic Press, New York, pp. 199-228.
11. Jones D.P. Determination of pyridine dinucleotides in cell extracts by high-performance liquid chromatography. J. Chromatog. 225:1981;446-449
12. Kasper, C.E., Henton, D., 1980. Glucuronidation. In: Jakoby, W.B. (Ed.), Enzymatic Basis of Detoxification, Academic Press, New York, pp. 3-36.
13. Kehrer J.P., Jones D.P., Lemasters J.J., Farber H. Contemporary issue in toxicology: mechanisms of hypoxic cell injury. Toxicol. Appl. Pharmacol. 106:1990;1907-1914
14. 2+ and mitochondrial membrane potential preceding cell death in hepatocytes. Nature. 325:1987;78-80
15. Larson P.S., Crawford E.M., Blackwell Smith R., Henninger G.R. Chronic toxicologic studies on isopropyl-N-(3-chlorophenyl)carbamate (CIPC). Toxicol. Appl. Pharmacol. 2:1960;659-673
16. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275
17. Moldéus P., Hogberg J., Orrenius S. Isolation and use of liver cells. Methods Enzymol. 52:1978;60-71
18. Nakagawa Y., Moldéus P. Cytotoxic effects of phenyl-hydroquinone and some hydroquinones on isolated rat hepatocytes. Biochem. Pharmacol. 45:1992;1959-1965
19. Nakagawa Y., Nakajima K., Tayama S., Moldéus P. Metabolism and cytotoxicity of propyl gallate in isolated rat hepatocytes: effects of a thiol reductant and an esterase inhibitor. Mol. Pharmacol. 47:1995;1021-1027
20. Nakagawa Y., Moldéus P. Mechansim of p-hydroxybenzoate ester-induced mitochondrial dysfunction and cytotoxicity in rat hepatocytes. Biochem. Pharamcol. 55:1998;1907-1914
21. Nakagawa Y., Tayama S. Metabolism and cytotoxicity of bisphenol A and other bisphenols in isolated rat hepatocytes. Arch. Toxicol. 74:2000;99-105
22. Nicotera P., Bellomo G., Orrenius S. Calcium-mediated mechanisms in chemically induced cell death. Annu. Rev. Pharmacol. Toxicol. 32:1992;447-470
23. Nieminen A.L., Gores G.J., Dawson T.L., Herman B., Lemaster J.J. J. Biol. Chem. 265:1990;2399-2408
24. Pritsos C.A., Pointon M., Pardini R.S. Interaction of chlorinated phenolics and quinones with the mitochondrial respiration: a comparison of the o- and p-chlorinated quinones and hydroquinones. Bull. Environ. Contam. Toxicol. 38:1987;847-855
25. Ravanel P., Taillandier G., Tissut M. Uncoupling properties of a chlorophenol series on Acer cell suspensions: a QSAR study. Ecotoxicol. Environ. Saf. 18:1989;337-345
26. Sandy M.S., Moldéus P., Ross D., Smith M. Role of redox cycling and lipid peroxidation in bipyridyl herbicide cytotoxicity. Studies with a compromised isolated hepatocyte model system. Biochem. Pharmacol. 35:1986;3095-3101
27. 2+. J. Biol. Chem. 259:1984;6612-6615
28. Van Engelen, J., 2001. Chlorpropham. In: Pesticide residues in food 2000, Joint FAO/WHO Meeting on Pesticide Residues, WHO, Geneva, pp. 3-59.
29. Van Esch G.J., Kroes R. Long-term toxicity studies of chlorpropham and propham in mice and hamsters. Food Cosmet. Toxicol. 10:1972;373-381