Insulin-like growth factor-I (IGF-I) serum concentrations in healthy children and adolescents: Relationship to level of contamination by DDT-derivative pesticides

Growth Hormone and IGF Research

Volumn 20, Issue 1, 2010, Pages 63-67

  Zumbado, Manuel ^a   Luzardo, Octavio P ^a   Lara, Pedro C ^a   Álvarez León, Eva E ^b   Losada, Antonio ^c   Apolinario, Rosa ^a   Serra Majem, Lluis ^a   Boada, Luis D ^a  

^a UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^b HOSPITAL UNIVERSITARIO INSULAR DE GRAN CANARIA   (Spain)

^c HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

Author keywords

Adolescents; Canary Islands; Children; DDT derivative pesticides; IGF I; IGFBP 3; Serum

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHANE; 1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ORGANOCHLORINE PESTICIDE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADOLESCENT; ADULT; AGE; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; BODY BURDEN; BODY HEIGHT; BODY WEIGHT; CHILD; CHILD GROWTH; CONTAMINATION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; GENDER; HUMAN; MALE; NORMAL HUMAN; PREPUBERTY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SPAIN;

ADOLESCENT; AGE FACTORS; BODY HEIGHT; BODY WEIGHT; CHILD; CROSS-SECTIONAL STUDIES; DDT; DICHLORODIPHENYL DICHLOROETHYLENE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; PESTICIDE RESIDUES; PUBERTY; SPAIN;

EID: 74649085192     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2009.07.003     Document Type: Article

References (46)

1. Kaklamani V.G., Linos A., Kaklamani E., Markaki I., and Mantzoros C. Age, sex and smoking are predictors of circulating Insulin-like growth factor 1 and Insulin-like growth factor-binding protein 3. J. Clin. Oncol. 17 (1999) 813-817
2. Sandhu J., Smith G.D., Holly J., Cole T.J., and Ben-Shlomo Y. Timing of puberty determines serum Insulin-like growth factor-I in late adulthood. J. Clin. Endocrinol. Metab. 91 (2006) 3150-3157
3. Schneider H.J., Saller B., Klotsche J., Marz W., Erwa W., Wittchen H., and Stalla G. Opposite associations of age-dependent insulin-like growth factor-I standard deviation scores with nutritional state in normal weight and obese subjects. Eur. J. Endocrinol. 154 (2006) 699-706
4. Baibas N., Bamia C., Vassilopoulou E., Sdrolias J., Trichopoulou A.A., and Trichopoulos D. Dietary and lifestyle factors in relation to plasma insulin-like growth factor I in a general population sample. Eur. J. Cancer Prev. 12 (2003) 229-234
5. Hoppe C., Udam T.R., Lauritzen L., Molgaard C., Juul A., and Michaelsen K.F. Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old Danish children. Am. J. Clin. Nutr. 80 (2004) 447-452
6. Löfqvist C., Andersson E., Gelander L., Rosberg S., Hulthen L., Blum W.F., and Wikland K.A. Reference values for Insulin-like growth factor-binding protein-3 (IGFBP3) and the ratio of Insulin-like growth factor-I to IGFBP-3 throughout childhood and adolescence. Clin. Endocrinol. Metab. 90 (2005) 1420-1427
7. Rogers I.S., Gunnell D., Emmett P.M., Glynn L.R., Dunger D.B., Holly J.M., and ALSPAC Study Team. Cross-sectional associations of diet and Insulin-like growth factor levels in 7-to 8-year-old children. Cancer Epidemiol. Biomarkers Prev. 14 (2005) 204-212
8. Chellakooty M., Juul A., Boisen K.A., Damgaard I.N., Kai C.M., Schmidt I.M., Petersen J.H., Skakkebaek N.E., and Main K.M. A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding. J. Clin. Endocrinol. Metab. 91 (2006) 820-826
9. Lukanova A., Toniolo P., Akhmedkhanov A., Hunt K., Rinaldi S., Zeleniuch-Jacquotte A., Haley N.J., Riboli E., Sttatin P., Lundin E., and Kaaks R. A cross-sectional study of IGF-I determinants in women. Eur. J. Cancer Prev. 10 (2001) 443-452
10. Holmes M.D., Pollack M.N., and Hankinson S.E. Lifestyle correlations of plasma insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol. Biomarkers Prev. 11 (2002) 862-867
11. Landin-Wilhemsen K., Wilhemsen L., Lappas G., Rosén T., Lindstedt G., Lunberg P.-A., and Bengtsson B.-A. Serum Insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clin. Endocrinol. 41 (1994) 351-357
12. Vaessen N., Heutink P., Janssen J., Witteman J., Testers L., Hofman A., Lamberts S., Oostra B., Huibert A.P., and van Duijn C.M. A polymorphism in the gene for IGF-I. Functional properties and risk of type 2 diabetes and myocardial infarction. Diabetes 50 (2001) 637-642
13. Johansson H., Baglietto L., Guerrieri-Gonzaga A., Bonnani B., Mariette F., Macis D., Serrano D., Sandri M.T., and Decensi A. Factors associated with circulating levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in 740 women at risk for breast cancer. Breast Cancer Res. Treat. 88 (2004) 63-73
14. Renehan A.G., Frystyk J., and Flyvbjerg A. Obesity and cancer risk: the role of the insulin-IGF axis. Trends Endocrinol. Metab. 17 (2006) 328-336
15. Ceda G.P., Dall'Aglio E., Maggio M., Lauretani F., Bandinelli S., Falzoi C., Grimaldi W., Ceresini G., Corradi F., Ferrucci L., Valenti G., and Hoffman A.R. Clinical implications of the reduced activity of the GH-IGF-I axis in older men. J. Endocrinol. Invest. 28 Suppl. 11 (2005) 96-100
16. Kehinde E.O., Akanji A., Mojiminiyi O., Bashir A.A., Daar A.S., and Varghese R. Putative role of serum insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) levels in the development of prostate cancer in Arab men. Prostate Cancer Prostatic Dis. 8 (2005) 84-90
17. Cohen P. Overview of the IGF-I system. Horm. Res. 65 Suppl. 1 (2006) 3-8
18. Scarth J.P. Modulation of GH-IGF axis by pharmaceutical, nutraceutical and environmental xenobiotics: an emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression. Xenobiotica 36 (2006) 119-218
19. Tannheimer S.L., Ethier S.P., Caldwell K.K., and Burchiel S.W. Benzo-a-pyrene and TCDD-induced alterations in tyrosine phosphorilation and insulin-like growth factor signalling pathways in the MCF-10A human mammary epithelial cell line. Carcinogenesis 19 (1998) 1291-1297
20. Wang S.-L., Pen-Hua S., Shiang-Bin J., Guo Y.L., Chou W.-L., and Päpke O. In utero exposure to dioxins and polychlorinated biphenyls and its relations to thyroid function and Growth Hormone in newborns. Environ. Health Perspect. 113 (2005) 1645-1650
21. Randi S., Cocca C., Carbone V., Núñez M., Croci M., Gutiérrez A., Bergoc R., and Kleiman D.L. Hexachlorobenzene is a tumor co-carcinogen and induces alterations in Insulin-growth factors signalling pathway in the rat mammary gland. Toxicol. Sci. 89 (2005) 83-92
22. Tomei F., Ciarroca M., Rosati M.V., Baccolo T.P., Fiore P., Perrone P., and Tomao E. Occupational exposure to urban pollutants and plasma insulin-like growth factor 1 (IGF-1). Int. J. Environ. Health Res. 14 (2004) 135-142
23. Boada L.D., Lara P.C., Álvarez-León E.E., Losada A., Zumbado M., Limiñana-Cañal J.M., Apolinario R., Serra-Majem L., and Luzardo O.P. Serum levels of insulin-like growth factor-I in relation to organochlorine pesticides exposure. Growth Horm. IGF Res. 17 (2007) 506-511
24. Snedeker S. Pesticides and breast cancer risk: a review of DDT, DDE and dieldrin. Environ. Health Perspect. 109 suppl 1 (2001) 35-47
25. Jaga K., and Dharmani Ch. Global surveillance of DDT and DDE levels in human tissues. Int. Occup. Environ. Health 16 (2003) 7-20
26. Soto A.M., Sonneschein C., Chung K.L., Fernández M.F., Olea N., and Serrano F.O. The E-screen assays as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ. Health Perspect. 103 (1995) 113-122
27. López-Cervantes M., Torres-Sánchez L., Tobías A., and López-Carrillo L. Dichlorodiphenyldichloroethane burden and breast cancer risk: a meta-analysis of the epidemiologic evidence. Environ. Health Perspect. 112 (2004) 207-214
28. Sunyer J., Torrent M., Munoz-Ortiz L., Ribas-Fitó N., Carrizo D., Grimalt J., Anto J.M., and Cullinan P. Prenatal dichlorodiphenyldichloroethylene (DDE) and asthma in children. Environ. Health Perspect. 113 (2005) 1787-1790
29. Ribas-Fitó N., Gladen B.C., Brock J.W., Klebanoff M.A., and Longnecker M.P. Prenatal exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene in relation to child growth. Int. J. Epidemiol. 35 (2006) 853-858
30. Zumbado M., Goethals M., Álvarez-León E.E., Luzardo O.P., Cabrera F., Serra-Majem L., and Boada L.D. Inadvertent exposure to organochlorine pesticides DDT and derivatives in people from the Canary Islands (Spain). Sci. Total Environ. 339 (2005) 49-62
31. Álvarez-León E.E., Henríquez P., and Serra-Majem Ll. Mediterranean diet and metabolic syndrome: a cross-sectional study in the Canary Islands. Public Health. Nutr. 9 8A (2006) 1089-1098
32. Smith W.J., Underwood L.E., and Clemmons D.R. Effects of caloric or protein restriction to insulin-like growth factor-I (IGF-I) and IGF-binding proteins in children and adults. J. Clin. Endocrinol. Metab. 80 (1995) 443-449
33. Chistoforidis A., Maniadaki I., and Stanhope R. Growth hormone/insulin-like growth factor axis during puberty. Pediatr. Endocrinol. Rev. 3 (2005) 5-10
34. Juul A., Bang P., Hertel N.T., Main K., Dalgaard P., Jorgensen K., Müller J., Hall K., and Skakkebaek N.E. Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index. J. Clin. Endocrinol. Metab. 78 (1994) 744-752
35. Fontana L., Weiss E.P., Villareal D.T., Klein S., and Holloszy J.O. Long-term effects of calorie or protein restriction on serum IGF-I and IGFBP-3 concentration in humans. Aging Cell. 7 (2009) 681-687
36. Ceccatelli R., Faas O., Schlumpf M., and Lichtensteiger W. Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE 99 and PCB. Toxicology 220 (2006) 104-116
37. Davis L.K., Visitacion N., Riley L.G., Hiramatsu N., Sullivan C.V., Hirano T., and Grau E.G. Effects of o,p′-DDE, heptachlor, and 17β-estradiol on vitellogenin gene expression and the growth hormone/insulin-like growth factor-I in the tilapia Oreochromis mossambicus. Comp. Biochem. Phys. C 149 (2009) 507-514
38. Holloway A.C., Petrik J.J., and Younglai E.V. Influence of dichlorodiphenylchloroethylene on vascular endothelial growth factor and insulin-like growth factor in human and rat ovarian cells. Reprod. Toxicol. 24 (2007) 359-364
39. Veldhuis J.D., and Bowers C.Y. Determinants of GH-releasing hormone and GH-releasing peptide synergy in men. Am. J. Physiol. Endocrinol. Metab. 296 (2009) E1085-E1092
40. Sohoni P., and Sumpter J.P. Several environmental oestrogens are also anti-androgens. J. Endocrinol. 158 (1998) 327-339
41. Ho K.K., ÓSullivan A.J., Weissberger A.J., and Kelly J.J. Sex steroid regulation of growth hormone secretion and action. Horm. Res. 45 (1996) 67-73
42. Rooman R.P., De Beeck L.O., Martin M., Doorn J., Mohan S., and Du Caju M.V. Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature. Eur. J. Endocrinol. 152 (2005) 597-604
43. Casazza K., Higgins P.B., Fernández J.R., Goran M.I., and Gower B.A. Longitudinal analysis of the insulin-like growth factor system in African American and European American children and adolescents. J. Clin. Endocrinol. Metab. 93 (2008) 4917-4923
44. Lee D.H., Lee I.K., Song K., Steffes M., Toscano W., Baker B.A., and Jacobs D.R. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes. Diabetes Care 29 (2006) 1638-1644
45. Kortenkamp A. Breast cancer, oestrogens and environmental pollutants: a re-evaluation from a mixture perspective. Int. J. Androl. 29 (2006) 193-198
46. Weltje L., vom Saal F.S., and Oehlmenn J. Reproductive stimulation by low doses of xenoestrogens contrasts with the view of hormesis as an adaptive response. Hum. Exp. Toxicol. 24 (2005) 431-437