Protection by pentoxifylline of malathion-induced toxic stress and mitochondrial damage in rat brain

Human and Experimental Toxicology

Volumn 29, Issue 10, 2010, Pages 851-864

  Ranjbar, Akram ^a   Ghahremani, Mohammad Hossein ^a   Sharifzadeh, Mohammad ^a   Golestani, Abolfazl ^b   Ghazi Khansari, Mahmood ^b   Baeeri, Maryam ^a   Abdollahi, Mohammad ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

brain; malathion; mitochondria; oxidative stress; pentoxifylline; rat

Indexed keywords

3 NITROTYROSINE; ALPHA TOCOPHEROL; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; MALATHION; MANGANESE SUPEROXIDE DISMUTASE; PENTOXIFYLLINE; TROLOX C;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BRAIN MITOCHONDRION; CELL ISOLATION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALPHA-TOCOPHEROL; ANIMALS; BIOLOGICAL MARKERS; BRAIN; CHEMOPREVENTION; DRUG THERAPY, COMBINATION; FREE RADICAL SCAVENGERS; INSECTICIDES; LIPID PEROXIDATION; MALATHION; MALE; MITOCHONDRIA; OXIDATIVE STRESS; OXIDOREDUCTASES; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, WISTAR; TYROSINE;

RATTUS;

EID: 78649944924     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110363836     Document Type: Article

References (67)

1. Abdollahi M., Mostafalou S., Pournourmohammadi S., Shadnia S. Oxidative stress and cholinesterase inhibition in saliva and plasma of rats following sub-chronic exposure to malathion. Comp Biochem Physiol C: Toxicol Pharmacol 2004 ; 137: 29-34.
2. Abdollahi M., Ranjbar A., Shadnia S., Nikfar S., Rezaie A. Pesticides and oxidative stress: a review. Med Sci Monit 2004 ; 10: 144-147.
3. Akhgari M., Abdollahi M., Kebryaeezadeh A., Hosseini R., Sabzevari O. Biochemical evidence for free radical-induced lipid peroxidation as a mechanism for subchronic toxicity of malathion in plasma and liver of rats. Hum Exp Toxicol 2003 ; 22: 205-211.
4. Hsiao CT, Yang CC, Deng JF, Bullard MJ, Liaw SJ Acute pancreatitis following organophosphate intoxication. J Toxicol Clin Toxicol 1996 ; 34: 343-347.
5. Jamshidi HR, Ghahremani MH, Ostad SN, Sharifzadeh M., Dehpour AR, Abdollahi M. Effects of diazinon on the activity and gene expression of mitochondrial glutamate dehydrogenase from rat pancreatic Langerhans islets. Pestic Biochem Physiol 2009 ; 93: 23-27.
6. Pournourmohammadi S., Farzami B., Ostad N., Azizi E., Abdollahi M. Effects of malathion subchronic exposure on rat skeletal. muscle glucose metabolism. Environ Toxicol Pharmacol 2005 ; 19: 191-196.
7. Fortunato JJ, Feier G., Vitali AM, Petronilho FC, Dal-Pizzol F., Quevedo J. Malathion-induced oxidative stress in rat brain regions. Neurochem Res 2006 a; 31: 671-678.
8. Fortunato JJ, Feier G., Vitali AM, Petronilho FC, Dal-Pizzol F., Quevedo J. Malathion-induced oxidative stress in rat brain regions. Neurochem Res 2006 ; 31: 671-678.
9. Delgado EH, Streck EL, Quevedo JL, Dal-Pizzol F. Mitochondrial respiratory dysfunction and oxidative stress after chronic malathion exposure. Neurochem Res 2006 ; 31: 1021-1025. (Pubitemid 44310311)
10. Gupta RC Toxicology of organophosphate and carbamate compounds. San Diego, CA: Elsevier Academic Press, 2006.
11. Piantadosi CA, Zhang J. Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. Stroke 1996 ; 27: 327-331.
12. Floyd RA Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 1999 ; 222: 236-245.
13. Floyd RA, Hensley K. Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 2002 ; 23: 795-807.
14. Shadnia S., Dasga M., Taghikhani S., Mohammadirad A., Abdollahi M. Protective effects of a-tocopherol and N-acetyl-cysteine on diazinon-induced oxidative stress and acetylcholinesterase inhibition in rats. Toxicol Mech Methods 2007 ; 17: 1-8.
15. Ghafour-Rashidi Z., Dermenaki-Farahani E., Aliahmadi A., Esmaily H., Mohammadirad A., Ostad SN, et al. Protection by cAMP and cGMP phosphodiesterase inhibitors of diazinon-induced hyperglycemia and oxidative/nitrosative stress in rat Langerhans islets cells: Molecular evidence for involvement of non-cholinergic mechanisms. Pestic Biochem Physiol 2007 ; 87: 261-270.
16. Amirkabirian N., Teimouri F., Esmaily H., Mohammadirad A., Aliahmadi A., Abdollahi M. Protection by pentoxifylline of diazinon-induced toxic stress in rat liver and muscle. Toxicol Mech Methods 2007 ; 17: 215-221.
17. Teimouri F., Amirkabirian N., Esmaily H., Mohammadirad A., Aliahmadi A., Abdollahi M. Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxication mechanism in counteracting diazinon-induced oxidative stress. Hum Exp Toxicol 2006 ; 25: 697-703.
18. Milatovic D., Gupta RC Aschner M. Anticholinesterase toxicity and oxidative stress. Scient World J 2006 ; 28: 295-310.
19. Yurumez Y., Durukan P., Yavuz Y., Ikizceli I., Avsarogullari L., Ozkan S., et al. Acute organophosphate poisoning in university hospital emergency room patients. Intern Med 2007 ; 46: 965-969.
20. Gokalp O., Gulle K., Sulak O., Cicek E., Altuntas I. The effects of methidathion on liver: role of vitamins E and C. Toxicol Ind Health 2003 ; 19: 63-67.
21. Basiri S., Esmaily H., Vosough-Ghanbari S., Mohammadirad A., Yasa N., Abdollahi M. Improvement by Satureja khuzestanica essential oil of malathion-induced red blood cells acetylcholinesterase inhibition and altered hepatic mitochondrial glycogen phosphorylase and phosphoenolpyruvate carboxykinase activities. Pestic Biochem Physiol 2007 ; 89: 124-129.
22. Vosough-Ghanbari S., Rahimi R., Kharabaf S., Zeinali S., Mohammadirad A., Amini S., et al. Effects of Satureja khuzestanica on serum glucose, lipids and markers of oxidative stress in patients with Type 2 diabetes mellitus: a Double-Blind Randomized Controlled Trial. Evid Based Complement Alternat Med 2008 [Epub ahead of print].
23. Soltaninejad K., Abdollahi M. Current opinion on the science of organophosphate pesticides and toxic stress: a systematic review. Med Sci Monit 2009 ; 15: 75-90.
24. Mandell GL ARDS, neutrophils and pentoxifylline. Am Rev Respir Dis 1988 ; 138: 1103-1105.
25. Radfar M., Larijani B., Hadjibabaie M., Rajabipour B., Mojtahedi A., et al. Effects of pentoxifylline on oxidative stress and levels of EGF and NO in plasma of diabetic type-2 patients; a randomized, double-blind placebo-controlled clinical trial. Biomed Pharmacoth 2005 ; 59: 302-306.
26. Noyan T., Onem O., Ramazan Sekeroglu M., Koseoglu B., Dulger H., Bayram I., et al. Effects of erythropoietin and pentoxifylline on the oxidant and antioxidant systems in the experimental short bowel syndrome. Cell Biochem Funct 2003 ; 21: 49-54.
27. Wilson JE, Messer JL, Felgner PL Isolation of a hexokinase binding protein from the outer mitochondrial membrane. Meth Enzymol 1983 ; 97: 469-475.
28. Wendel A. Glutathione peroxidase. Methods Enzymol 1981 ; 77: 325-333.
29. Aebi, H. Catalase in vitro. Method Enzymol 1984 ; 105: 121-126.
30. Spitz DR, Oberlery LW An assay for superoxide dismutase activity in mamalian tissue homogenates. J Annul Biochem 1989 ; 179: 8-15.
31. Satho K. Serum lipid peroxidation in cerebrovascular disorders determined by a new colorimetric method. Cline Chem Act 1978 ; 90: 37-43.
32. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principal of protein-dye binding. Anal Biochem 1976 ; 72: 248-254.
33. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. Immonol Method 1983 ; 65: 55-63.
34. Charles S., Powell, Robert MJ. Mitochondrial complex I, aconitase, and succinate dehydrogenase during hypoxia-reoxygenation modulation of enzyme activities by MnSOD. Am J Physiol Lung Cell Mol Physiol 2003 ; 285: 189-198.
35. Vidyasagar J., Karunakar N., Reddy MS, Rajnarayana K., Surender T., Krishna DR Oxidative stress and antioxidant status in acute organophosphorous insecticide poisoning. Ind J Pharmacol 2004 ; 36: 76-79.
36. Wenzel U., Kuntz S., De Sousa UJ, Daniel H. Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. Int J Cancer 2003 ; 106: 666-675.
37. Torreilles F., Salman-Tabcheh S., Guérin M., Torreilles J. Neurodegenerative disorders: the role of peroxynitrite. Brain Res Rev 1999 ; 30: 153-163.
38. Halliwell B. Oxidative stress and neurodegeneration: where are we now? J Neurochem 2006 ; 97: 1634-1658.
39. Keller JN, Kindy MS, Holtsberg FW, St Clair DK, Yen HC, Germeyer A., et al. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci 1998 ; 18: 687-697.
40. Raha S., Robinson BH Mitochondria, oxygen free radical, disease and aging. Tren Biochem Sci 2000 ; 25: 502-508.
41. Raha S., McEachern GE, Myint AT, Robinson BH Superoxide from mitochondrial complex III: the role of manganese superoxide dismutase. Free Rad Biol Med 2000 ; 291: 70-180.
42. Possamai FP, Fortunato JJ, Feier G., Agostinho FR, Quevedo J., Wilhelm Filho D., et al. Oxidative stress after acute and sub-chronic malathion intoxication in Wistar rats. Environ Toxicol Pharmacol 2007 ; 23: 198-204.
43. Petrosillo G., Matera M., Casanova G., Ruggiero FM, Paradies G. Mitochondrial dysfunction in rat brain with aging.Involvement of complex I, reactive oxygen species and cardiolipin. Neurochem Intern 2008 ; 53: 126-131.
44. Jha N., Jurma O., Lalli G., Liu Y., Pettus EH, Greenamyre JT, et al. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. J Biol Chem 2000 ; 275: 26096-26101.
45. Kroemer G., Zamzami N., Susin SA Mitochondrial control of apoptosis. Immunol Today 1997 ; 18: 44-51.
46. Pani G., Colavitti R., Bedogni B., Fusco S., Ferraro D., Borrello S., et al. Mitochondrial superoxide dismutase: a promising target for new anticancer therapies. Cur Med Chem 2004 ; 11: 1299-1308.
47. Massicotte C., Knight K., Van der Schyf CJ, Jortner BS, Ehrich M. Effects of organophosphorus compounds on ATP production, mitochondrial integrity in cultured cells. Neurotox Res 2005 ; 7: 203-217.
48. Chauhan V., Chauhan A. Oxidative stress in Alzheimer's disease. Pathophysiol 2006 ; 13: 195-208.
49. Ranjbar A., Pasalar P., Abdollahi M. Induction of oxidative stress and acetylcholinesterase inhibition in organophosphorus pesticide manufacturing workers. Hum Exp Toxicol 2002 ; 21: 179-182.
50. Ranjbar A., Solhi H., Mashayekhi FJ, Susanabdi A., Rezaie A., Abdollahi M. Oxidative stress in acute human poisoning with organophosphorus insecticides; a case control study. Environ Toxicol Pharmacol 2005 ; 20: 88-91.
51. Hazarika A., Sarkar SN, Hajare S., Kataria M., Malik JK Influence of malathion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study. Toxicology 2003 ; 185: 1-8.
52. Susan PP, Dunn WA Jr. Starvation-induced lysosomal degradation of aldolase B requires glutamine 111 in a signal sequence for chaperone-mediated transport. J Cell Physiol 2001 ; 187: 48-58.
53. Bjerneboe A., Nestler MS, Hagen BF Effects of dietary deficiency and supplement with all rac-alpha-tocopherol on hepatic contents in rats. J Nutr 1991 ; 121: 1208-1213.
54. Punz A., Nanobashvili N., Feugel A., Huk I., Roth E. Effect of á-tocopherol pretreatment on high energy metabolites in rabbit skeletal muscle after ischemic reperfusion. Clin Nutr 1998 ; 17: 85-87.
55. Kotegawa M., Sugiyama M., Shoji T., Haramaki N., Oregura R. Effect of á-tocopherol on high energy phosphate metabolite levels in rat heart by P-NMR using a langendorff perfusion technique. J Mol Cell Cardiol 1993 ; 25: 1067-1074.
56. Khan JY, Black SM Developmental changes in murine brain antioxidant enzymes. Pediatric Res 2003 ; 54: 77-82.
57. Saliva RM, Lara DR, Ghisolfi ES, et al. Neuropsychiatric evaluation in subjects chronically exposed to organophosphate pesticides. Toxicol Sci 2003 ; 72: 267-271.
58. Karaoz E., Gultekin F., Akdogan M., Oncu M., Gokcimen A. Protective role of melatonin and a combination of vitamin C and vitamin E on lung toxicity induced by chlorpyrifosethyl in rats. Exp Toxicol Pathol 2002 ; 54: 97-108.
59. Oncu M., Gultekin F., Karaoz E., Altuntas I., Delibas N. Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidants. Hum Exp Toxicol 2002 ; 21: 223-230.
60. John S., Kale M., Rathore N., Bhatnagar D. Protective effect of AT in dimethoate and malathion induced oxidative stress in rat erythrocytes. J Nutr Biochem 2001 ; 12: 500-504.
61. Milani E., Nikfar S., Khorasani R., Zamani MJ, Abdollahi M. Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats. Comp Biochem Physiol Toxicol Pharmacol 2005 ; 140: 251-255.
62. Abdollahi M., Chan TS, Subrahmanyam V., O'Brien PJ Effects of phosphodiesterase 3, 4, 5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin. Mol Cell Biochem 2003 ; 252: 205-211.
63. Khoshakhlagh P., Bahrololoumi-Shapourabadi M., Mohammadirad A., Ashtaral-Nakhai L., Minaie B., Abdollahi M. Beneficial effect of phosphodiesterase-5 inhibitor in experimental inflammatory bowel disease; molecular evidence for involvement of oxidative stress. Toxicol Mech Methods 2007 ; 17: 281-288.
64. Aghababaeian R., Ghazi-Khansari M., Abdi K., Taghadosinejad F., Abdollahi M. Protective effects of sildenafil and dipyridamol from lead-induced lipid peroxidation in perfused rat liver. Int J Pharmacol 2005 ; 1: 157-160.
65. Hosseini-Tabatabaei A., Abdollahi M. Potassium channel openers and improvement of toxic stress: do they have role in the management of inflammatory bowel disease? Inflamm Allergy Drug Targets 2008 ; 7: 129-135.
66. Rahimi R., Nikfar S., Larijani B., Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother 2005 ; 59: 365-373.
67. Rahimi R., Abdollahi M. A review on the mechanisms involved in hyperglycemia induced by organophosphorus pesticides. Pestic Biochem Physiol 2007 ; 88: 115-121.