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Volumn 208, Issue 2, 2010, Pages 390-395

Paraoxonase 2 (PON2) decreases high glucose-induced macrophage triglycerides (TG) accumulation, via inhibition of NADPH-oxidase and DGAT1 activity: Studies in PON2-deficient mice

Author keywords

Diabetes mellitus; Macrophages; NADPH oxidase; Oxidative stress; Paraoxonase 2 (PON2); Triglycerides

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; APOCYNIN; ARYLDIALKYLPHOSPHATASE 2; DIACYLGLYCEROL ACYLTRANSFERASE 1; GLUCOSE; LOW DENSITY LIPOPROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRIACYLGLYCEROL;

EID: 75049083347     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.07.057     Document Type: Article
Times cited : (32)

References (30)
  • 1
    • 26244444682 scopus 로고    scopus 로고
    • Macrophage foam-cell formation in streptozotocin-induced diabetic mice: stimulatory effect of glucose
    • Hayek T., Hussein K., Aviram M., et al. Macrophage foam-cell formation in streptozotocin-induced diabetic mice: stimulatory effect of glucose. Atherosclerosis 183 (2005) 25-33
    • (2005) Atherosclerosis , vol.183 , pp. 25-33
    • Hayek, T.1    Hussein, K.2    Aviram, M.3
  • 2
    • 36049008500 scopus 로고    scopus 로고
    • Macrophage NADPH oxidase activation, impaired cholesterol fluxes and increased cholesterol biosynthesis in diabetic mice: a stimulating role for D glucose
    • Hayek T., Kaplan M., Kerry R., and Aviram M. Macrophage NADPH oxidase activation, impaired cholesterol fluxes and increased cholesterol biosynthesis in diabetic mice: a stimulating role for D glucose. Atherosclerosis 195 (2007) 277-286
    • (2007) Atherosclerosis , vol.195 , pp. 277-286
    • Hayek, T.1    Kaplan, M.2    Kerry, R.3    Aviram, M.4
  • 3
    • 43049162677 scopus 로고    scopus 로고
    • Paraoxonase 1 attenuates diabetes development in mice through its antioxidative properties
    • Rosenberg O., Shiner M., Aviram M., and Hayek T. Paraoxonase 1 attenuates diabetes development in mice through its antioxidative properties. Free Radic Biol Med 44 (2008) 1951-1959
    • (2008) Free Radic Biol Med , vol.44 , pp. 1951-1959
    • Rosenberg, O.1    Shiner, M.2    Aviram, M.3    Hayek, T.4
  • 4
    • 38149078193 scopus 로고    scopus 로고
    • Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE mice
    • Harja E., Bu D.X., Hudson B.I., et al. Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE mice. J Clin Invest 118 (2008) 183-194
    • (2008) J Clin Invest , vol.118 , pp. 183-194
    • Harja, E.1    Bu, D.X.2    Hudson, B.I.3
  • 5
    • 2942750058 scopus 로고    scopus 로고
    • Atherogenic lipoprotein particles in atherosclerosis
    • Carmena R., Duriez P., and Fruchart J.C. Atherogenic lipoprotein particles in atherosclerosis. Circulation 109 (2004) III2-III7
    • (2004) Circulation , vol.109
    • Carmena, R.1    Duriez, P.2    Fruchart, J.C.3
  • 6
    • 19944366619 scopus 로고    scopus 로고
    • Regulation of plasma triglycerides in insulin resistance and diabetes
    • Ginsberg N.G., Zhang Y.L., and Hernandez-Ono A. Regulation of plasma triglycerides in insulin resistance and diabetes. Arch Med Res 36 (2005) 232-240
    • (2005) Arch Med Res , vol.36 , pp. 232-240
    • Ginsberg, N.G.1    Zhang, Y.L.2    Hernandez-Ono, A.3
  • 7
    • 44149084832 scopus 로고    scopus 로고
    • Macrophages: an elusive yet emerging therapeutic target of atherosclerosis
    • Tiwari R.L., Singh Y., and Barthwal M.K. Macrophages: an elusive yet emerging therapeutic target of atherosclerosis. Med Res Rev 28 (2008) 483-544
    • (2008) Med Res Rev , vol.28 , pp. 483-544
    • Tiwari, R.L.1    Singh, Y.2    Barthwal, M.K.3
  • 8
    • 15944425804 scopus 로고    scopus 로고
    • Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774. 2 macrophages to triacylglycerols facilities mitochondrial reactive oxygen species production and cellular necrosis
    • Aronis A., Madar Z., and Tirosh O. Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774. 2 macrophages to triacylglycerols facilities mitochondrial reactive oxygen species production and cellular necrosis. Free Radic Biol Med 38 (2005) 1221-1230
    • (2005) Free Radic Biol Med , vol.38 , pp. 1221-1230
    • Aronis, A.1    Madar, Z.2    Tirosh, O.3
  • 9
    • 21244491480 scopus 로고    scopus 로고
    • Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities
    • Draganov D.I., Teiber J.F., Speelman A., Osawa Y., Sunahara R., and La Du B.N. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. J Lipid Res 46 (2005) 1239-1247
    • (2005) J Lipid Res , vol.46 , pp. 1239-1247
    • Draganov, D.I.1    Teiber, J.F.2    Speelman, A.3    Osawa, Y.4    Sunahara, R.5    La Du, B.N.6
  • 10
    • 44949214649 scopus 로고    scopus 로고
    • Immunohistochemical analysis of paraoxonases 1, 2 and 3 expression in normal mouse tissue
    • Marsillach J., Machness B., Machness M., et al. Immunohistochemical analysis of paraoxonases 1, 2 and 3 expression in normal mouse tissue. Free Radic Biol Med 45 (2008) 146-157
    • (2008) Free Radic Biol Med , vol.45 , pp. 146-157
    • Marsillach, J.1    Machness, B.2    Machness, M.3
  • 11
    • 0346095221 scopus 로고    scopus 로고
    • Paraoxonase gene polymorphisms, oxidative stress, and diseases
    • Hong-Liang L., De-Pei L., and Chih-Chuan L. Paraoxonase gene polymorphisms, oxidative stress, and diseases. J Mol Med 81 (2003) 766-779
    • (2003) J Mol Med , vol.81 , pp. 766-779
    • Hong-Liang, L.1    De-Pei, L.2    Chih-Chuan, L.3
  • 12
    • 25444464894 scopus 로고    scopus 로고
    • The paraoxonase 2-310 polymorphism is associated with the presence of microvascular complications in diabetes mellitus
    • Mackness B., Mcelduff P., and Mackness M.I. The paraoxonase 2-310 polymorphism is associated with the presence of microvascular complications in diabetes mellitus. J Intern Med 258 (2005) 363-368
    • (2005) J Intern Med , vol.258 , pp. 363-368
    • Mackness, B.1    Mcelduff, P.2    Mackness, M.I.3
  • 13
    • 67649690455 scopus 로고    scopus 로고
    • Paraoxonase 2 attenuates macrophage triglyceride accumulation via inhibition of diacylglycerol acyltransferase 1 (DGAT1), the rate limiting enzyme in triglyceride biosynthesis
    • Rosenblat M., Coleman R., Reddy S.T., and Aviram M. Paraoxonase 2 attenuates macrophage triglyceride accumulation via inhibition of diacylglycerol acyltransferase 1 (DGAT1), the rate limiting enzyme in triglyceride biosynthesis. J Lipid Res 50 (2009) 870-879
    • (2009) J Lipid Res , vol.50 , pp. 870-879
    • Rosenblat, M.1    Coleman, R.2    Reddy, S.T.3    Aviram, M.4
  • 14
    • 0035976903 scopus 로고    scopus 로고
    • PON2 is a ubiquitously expressed protein with anti oxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein
    • Ng C.J., Wadleigh D.J., Gangopadhyay A., et al. PON2 is a ubiquitously expressed protein with anti oxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein. J Biol Chem 76 (2001) 44444-44449
    • (2001) J Biol Chem , vol.76 , pp. 44444-44449
    • Ng, C.J.1    Wadleigh, D.J.2    Gangopadhyay, A.3
  • 15
    • 0344064100 scopus 로고    scopus 로고
    • Incorporation of lycopene into chylomicron remnant-like particles enhances their induction of lipid accumulation in macrophages
    • Moore E.H., Napolitano M., Prosperi A., et al. Incorporation of lycopene into chylomicron remnant-like particles enhances their induction of lipid accumulation in macrophages. Biochem Biophys Res Commun 312 (2003) 1216-1219
    • (2003) Biochem Biophys Res Commun , vol.312 , pp. 1216-1219
    • Moore, E.H.1    Napolitano, M.2    Prosperi, A.3
  • 16
    • 33749544927 scopus 로고    scopus 로고
    • Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2
    • Ng C.J., Bourquard N., Grijalva V., et al. Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2. J Biol Chem 281 (2006) 29491-29500
    • (2006) J Biol Chem , vol.281 , pp. 29491-29500
    • Ng, C.J.1    Bourquard, N.2    Grijalva, V.3
  • 17
    • 0037426322 scopus 로고    scopus 로고
    • Chylomicrons remnant induction of lipid accumulation in J774 A. 1 macrophages is associated with up-regulation of triacylglycerol synthesis which is not dependent on oxidation of the particles
    • Napolitano M., Avella M., Botham K.M., and Bravo E. Chylomicrons remnant induction of lipid accumulation in J774 A. 1 macrophages is associated with up-regulation of triacylglycerol synthesis which is not dependent on oxidation of the particles. Biochim Biophys Acta 1631 (2003) 255-264
    • (2003) Biochim Biophys Acta , vol.1631 , pp. 255-264
    • Napolitano, M.1    Avella, M.2    Botham, K.M.3    Bravo, E.4
  • 18
    • 3042845638 scopus 로고    scopus 로고
    • Up-regulation of hepatic acylCoA: diacylglycerol acyltransferase-1 (DGAT1) expression in neophrotic syndrome
    • Vaziri N.D., Kim C.H., Phan D., Kim S., and Liang K. Up-regulation of hepatic acylCoA: diacylglycerol acyltransferase-1 (DGAT1) expression in neophrotic syndrome. Kidney Int 66 (2004) 262-267
    • (2004) Kidney Int , vol.66 , pp. 262-267
    • Vaziri, N.D.1    Kim, C.H.2    Phan, D.3    Kim, S.4    Liang, K.5
  • 19
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • Buege J.A., and Aust S.D. Microsomal lipid peroxidation. Methods Enzymol 52 (1978) 302-310
    • (1978) Methods Enzymol , vol.52 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 20
    • 58149354540 scopus 로고    scopus 로고
    • High glucose concentration increase macrophage cholesterol biosynthesis in diabetes through activation of the sterol regulatory element binding protein: inhibitory effect of insulin
    • Kaplan M., Kerry R., Aviram M., and Hayek T. High glucose concentration increase macrophage cholesterol biosynthesis in diabetes through activation of the sterol regulatory element binding protein: inhibitory effect of insulin. J Cardiovasc Pharmacol 52 4 (2008) 324-332
    • (2008) J Cardiovasc Pharmacol , vol.52 , Issue.4 , pp. 324-332
    • Kaplan, M.1    Kerry, R.2    Aviram, M.3    Hayek, T.4
  • 21
    • 0037339957 scopus 로고    scopus 로고
    • Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraxonase 3 activity is decreased under oxidative stress
    • Rosenblat M., Draganov D., Watson C.E., Bisgaier C.L., La Du B.N., and Aviram M. Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraxonase 3 activity is decreased under oxidative stress. Arterioscler Thromb Vasc Biol 23 (2003) 468-474
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 468-474
    • Rosenblat, M.1    Draganov, D.2    Watson, C.E.3    Bisgaier, C.L.4    La Du, B.N.5    Aviram, M.6
  • 22
    • 14544290505 scopus 로고    scopus 로고
    • Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cell
    • Vejrazka M., Micek R., and Stipek S. Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cell. Biochim Biophys Acta 1722 (2005) 143-147
    • (2005) Biochim Biophys Acta , vol.1722 , pp. 143-147
    • Vejrazka, M.1    Micek, R.2    Stipek, S.3
  • 23
    • 0034128280 scopus 로고    scopus 로고
    • Triglyceride synthesis: insights from the cloning of diacylglycerosl acyltransferase
    • Robert V., Farese Jr., Sylvaine C., and Smith S.J. Triglyceride synthesis: insights from the cloning of diacylglycerosl acyltransferase. Curr Opin Lipidol 11 (2000) 229-234
    • (2000) Curr Opin Lipidol , vol.11 , pp. 229-234
    • Robert, V.1    Farese, Jr.2    Sylvaine, C.3    Smith, S.J.4
  • 24
    • 13844264456 scopus 로고    scopus 로고
    • Increased diacylglycerol acyltransferase activity is associated with triglyceride accumulation in tissues of diet-induced insulin-resistant hyperlipidemic hamsters
    • Casaschi A., Maiyoh G.K., Adeli K., and Theriault A.G. Increased diacylglycerol acyltransferase activity is associated with triglyceride accumulation in tissues of diet-induced insulin-resistant hyperlipidemic hamsters. Metastasis Clin Exp 54 (2005) 403-409
    • (2005) Metastasis Clin Exp , vol.54 , pp. 403-409
    • Casaschi, A.1    Maiyoh, G.K.2    Adeli, K.3    Theriault, A.G.4
  • 25
    • 0036429189 scopus 로고    scopus 로고
    • Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin
    • Meegalla R.L., Billheimer J.T., and Cheng D. Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin. Biochem Biophys Res Commun 298 (2002) 317-323
    • (2002) Biochem Biophys Res Commun , vol.298 , pp. 317-323
    • Meegalla, R.L.1    Billheimer, J.T.2    Cheng, D.3
  • 26
    • 0037106461 scopus 로고    scopus 로고
    • Ednoplasmatic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide
    • van der Vlies D., Pap E.H., Post J.A., Celis J.E., and Wirtz K.W. Ednoplasmatic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide. Biochem J 366 (2002) 825-830
    • (2002) Biochem J , vol.366 , pp. 825-830
    • van der Vlies, D.1    Pap, E.H.2    Post, J.A.3    Celis, J.E.4    Wirtz, K.W.5
  • 27
    • 33750902737 scopus 로고    scopus 로고
    • The endoplasmatic reticulum: folding, calcium homeostasis, signaling, and redox control
    • Gorlach A., Klappa P., and Kietzmann T. The endoplasmatic reticulum: folding, calcium homeostasis, signaling, and redox control. Antioxid Redox Signal 8 (2006) 1391-1418
    • (2006) Antioxid Redox Signal , vol.8 , pp. 1391-1418
    • Gorlach, A.1    Klappa, P.2    Kietzmann, T.3
  • 28
    • 8444249207 scopus 로고    scopus 로고
    • Nifedipine inhibit gene expression of receptor for advanced glycation end products (RAGE) in endothelial cells by suppressing reactive oxygen species generation
    • Yamagishi S., and Takeuchi M. Nifedipine inhibit gene expression of receptor for advanced glycation end products (RAGE) in endothelial cells by suppressing reactive oxygen species generation. Drugs Exp Clin Res 30 (2004) 169-175
    • (2004) Drugs Exp Clin Res , vol.30 , pp. 169-175
    • Yamagishi, S.1    Takeuchi, M.2
  • 29
    • 46249131854 scopus 로고    scopus 로고
    • Urokinase plasminogen activator upregulates paraoxonase 2 expression in macrophages via an NADPH oxidase-dependent mechanism
    • Fuhrman B., Khateeb J., Shiner M., et al. Urokinase plasminogen activator upregulates paraoxonase 2 expression in macrophages via an NADPH oxidase-dependent mechanism. Arterioscler Thromb Vasc Biol 28 (2008) 1361-1367
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1361-1367
    • Fuhrman, B.1    Khateeb, J.2    Shiner, M.3
  • 30
    • 33745828640 scopus 로고    scopus 로고
    • Insulin resistance and atherosclerosis
    • Semenkovich C.F. Insulin resistance and atherosclerosis. J Clin Invest 116 (2006) 1813-1822
    • (2006) J Clin Invest , vol.116 , pp. 1813-1822
    • Semenkovich, C.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.