An age-dependent physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus insecticide chlorpyrifos in the preweanling rat

Toxicological Sciences

Volumn 98, Issue 2, 2007, Pages 348-365

  Timchalk, Charles ^a   Kousba, Ahmed A ^a,b   Poet, Torka S ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b TargeGen Inc   (United States)

Author keywords

Age dependent sensitivity; Chlorpyrifos; PBPK PD; Preweanling rat

Indexed keywords

ARYLESTERASE; CARBOXYLESTERASE; CHLORPYRIFOS; CHOLINESTERASE; CYTOCHROME P450; ORGANOPHOSPHATE INSECTICIDE;

ACUTE TOXICITY; ADIPOSE TISSUE; ADULT; AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN BLOOD FLOW; CONTROLLED STUDY; DISEASE SIMULATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BLOOD LEVEL; ENZYME INHIBITION; HUMAN; LIVER METABOLISM; LIVER TOXICITY; MATHEMATICAL MODEL; NEUROTOXICITY; NONHUMAN; PROTEIN DEPLETION; RAT; TISSUE DISTRIBUTION; TOXICOKINETICS; TOXIN ANALYSIS;

ACETYLCHOLINESTERASE; AGE FACTORS; ANIMALS; ANIMALS, SUCKLING; BRAIN; BUTYRYLCHOLINESTERASE; CARBOXYLESTERASE; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; DIAPHRAGM; INSECTICIDES; LIVER; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RATTUS;

EID: 34547839628     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm119     Document Type: Article

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