Stimulation of insulin and glucagon synthesis in rat Langerhans islets by malathion in vitro: Evidence for mitochondrial interaction and involvement of subcellular non-cholinergic mechanisms

Pesticide Biochemistry and Physiology

Volumn 89, Issue 2, 2007, Pages 130-136

  Vosough Ghanbari, Sanaz ^a   Sayyar, Parisa ^a   Pournourmohammadi, Shirin ^b   Aliahmadi, Atousa ^a   Ostad, Seyed Nasser ^a   Abdollahi, Mohammad ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

C peptide; Glucagon; Glucose; Insulin; Malathion; Non cholinergic; Organophosphorus; Pancreatic isolated islets; Toxicity

Indexed keywords

RATTUS;

EID: 34548280480     PISSN: 00483575     EISSN: 10959939     Source Type: Journal    
DOI: 10.1016/j.pestbp.2007.05.001     Document Type: Article

References (53)

1. John S., Kale M., Rathore N., and Bhatnagar D. Protective effect of Vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes. J. Nutr. Biochem. 12 (2001) 500-504
2. Thompson C.W., Frick J.A., Natke B.C., and Hansen L.K. Preparation, analysis, and anticholinesterase properties of O,O-dimethyl phosphorothioate isomerides. Chem. Res. Toxicol. 2 (1989) 386-391
3. Seifert J. Toxicologic significance of the hyperglycemia caused by organophosphorus insecticides. Bull. Environ. Contam. Toxicol. 67 (2001) 463-469
4. Hayes M.M.M., Van der Westhuizen N.G., and Gelfand M.S.A. Organophosphate poisoning in Rhodesia. S. Afr. Med. J. 54 (1978) 230-234
5. Meller D., Fraser I., and Kryger M. Hyperglycemia in anticholinesterase poisoning. Can. Med. Assoc. J. 124 (1981) 745-748
6. Namba T., Nolte C.T., Jackrel J., and Grob D. Poisoning due to organophosphate insecticides. Am. J. Med. 50 (1971) 475-492
7. Teichert-Kuliszenwska K., Lawecki J., and Szymczyk T. Glycemia and insulinemia resulting from dichlorvos intoxication. Acta Medica Polona 22 (1981) 303-308
8. Panahi P., Vosough-Ghanbari S., Pournourmohammadi S., Ostad S.N., Nikfar Sh., Minaie B., and Abdollahi M. Stimulatory effects of malathion on the key enzymes activities of insulin secretion in Langerhans islets, glutamate dehydrogenase and glucokinase. Toxicol. Mech. Methods 16 (2006) 161-167
9. Abdollahi M., Donyavi M., Pournourmohammadi S., and Saadat M. Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase activities in rats following subchronic exposure to malathion. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 137 (2004) 343-347
10. Pournourmohammadi S., Farzami B., Ostad S.N., Azizi E., and Abdollahi M. Effects of malathion subchronic exposure on rat skeletal muscle glucose metabolism. Environ. Toxicol. Pharmacol. 19 (2005) 191-196
11. Pournourmohammadi S., Ostad S.N., Azizi E., Hossein Ghahremani M., Farzami B., Minaie B., Larijani B., and Abdollahi M. Induction of insulin resistance by malathion; evidence for disturbed islets cells metabolism and mitochondrial dysfunction. Pestic. Biochem. Physiol. 88 (2007) 346-352
12. Tan G.D. The pancreas. Anesth. Intens. Care Med. 6 10 (2005) 329-332
13. Steiner D.F. On the role of the proinsulin C-peptide. Diabetes 27 (1978) 145-148
14. Weiss M.A., Frank B.H., Khait I., Pekar A., Heiney R., Shoelson S.E., and Neuringer L.J. NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition. Biochemistry 29 (1990) 8389-8401
15. Ido Y., Vindigni A., Chang K., Stramm L., Chance R., Heath W.F., DiMarchi R.D., Di Cera E., and Williamson J.R. Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science 277 (1997) 563-566
16. Wahren J., Ekberg K., Johansson J., Henriksson M., Pramanik A., Johansson B.L., Rigler R., and Jörnvall H. Role of C-peptide in human physiology. Am. J. Physiol. Endocrinol. Metab. 278 (2000) 759-768
17. Wahren J. C-peptide: new findings and therapeutic implications in diabetes. Clin. Physiol. Funct. Imaging 24 (2004) 180-189
18. Consoli A. Role of liver in pathophysiology of NIDDM. Diabetes Care 15 (1992) 430-441
19. Muller W.A., Faloona G.R., Aguilar-Parada E., and Unger R.H. Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N. Engl. J. Med. 283 (1970) 109-115
20. Reaven G.M., Chen Y.D., Golay A., Swislocki A.L., and Jaspan J.B. Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 64 (1987) 106-110
21. Shah P., Vella A., Basu A., Basu R., Schwenk W.F., and Rizza R.A. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 85 (2000) 4053-4059
22. Woerle H.J., Szoke E., Meyer C., Dostou J.M., Wittlin S.D., Gosmanov N.R., Welle S.L., and Gerich J.E. Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes. Am. J. Physiol: Endocrinol. Metab. 290 (2006) E67-E77
23. Hauge-Evans A.C., Squires P.E., Persaud S.J., and Jones P.M. Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets. Diabetes 48 (1999) 1402-1408
24. Abdollahi M., Zadparvar L., Ayatollahi B., Baradaran M., Nikfar S., Hastaie P., and Khorasani R. Hazard from carbon monoxide poisoning for bus drivers in Tehran, Iran. Bull. Environ. Contam. Toxicol. 61 2 (1998) 210-215
25. Lacy P.E., and Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16 1 (1967) 35-39
26. Gary D.W.R., and Morris P.J. Isolation of rat pancreatic islets by ductal injection of collagenase. Transplantation 42 (1986) 689-691
27. Sutton R., Peters M., and Gray D.W. Improvement in islet yield from a cold-preserved pancreas by pancreatic ductal collagenase distention at the time of harvesting. Transplantation 51 (1991) 566-570
28. Bryla J., Michalik M., Nelson J., and Erecinska M. Regulation of the glutamate dehydrogenase activity in rat islets of Langerhans and its consequence on insulin release. Metabolism 43 (1997) 1187-1195
29. Pluth J.M., Nicklas J.A., O'Neill J.P., and Albertini R.J. Increased frequency of specific genomic deletions resulting from in vitro malathion exposure. Cancer Res. 56 10 (1996) 2393-2399
30. Chen X.Y., Shao J.Z., Xiang L.X., and Liu X.M. Involvement of apoptosis in malathion-induced cytotoxicity in a grass carp (Ctenopharyngodon idellus) cell line. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 142 (2006) 36-45
31. Meyer A., Seidler F.J., Cousins M.M., and Slotkin T.A. Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?. Environ. Health Perspect. 111 (2003) 1871-1876
32. Ren J., Jin P., Wang E., Liu E., M Harlan D., Li1 X., and F Stroncek D. Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation. J. Transl. Med. 5 (2007) 1-15 Review
33. Serup P., Jensen J., Andersen F.G., Jorgensen M.C., Blume N., Holst J.J., and Madsen O.D. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. Proc. Natl. Acad. Sci. USA 93 (1960) 9015-9020
34. Moede T., Leibiger B., Pour H.G., Berggren P., and Leibiger I.B. Identification of a nuclear localization signal RRMKWKK in the homeodomain transcription factor PDX-1. FEBS Lett. 461 (1999) 229-234
35. Jones P.M., and Persaud S.J. (Ca2+)-induced loss of Ca2+/calmodulindependent protein kinase II activity in pancreatic beta-cells. Am. J. Physiol. 274 (1998) E708-E715
36. Osterhoff M., Möhlig M., Schwanstecher M., Seufert J., Ortmann J., Schatz H., and Pfeiffer A.F.H. Ca2+/calmodulin-dependent protein kinase II_2 regulates gene expression of insulin in INS-1 rat insulinoma cells. Cell Calcium 33 (2003) 175-184
37. Ranjbar A., Pasalar P., and Abdollahi M. Induction of oxidative stress and acetylcholinesterase inhibition in organophosphorous pesticide manufacturing workers. Hum. Exp. Toxicol. 21 (2002) 179-182
38. Akhgari M., Abdollahi M., Kebryaeezadeh A., Hosseini R., and Sabzevari O. Biochemical evidence for free radical-induced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats. Hum. Exp. Toxicol. 22 (2003) 205-211
39. Abdollahi M., Ranjbar A., Shadnia S., Nikfar S., and Rezaiee A. Pesticides and oxidative stress: a review. Med. Sci. Monit. 10 (2004) RA144-RA147
40. Matsuoka T.A., Kajimoto Y., Watada H., Kaneto H., Kishimoto M., Umayahara Y., Fujitani Y., Kamada T., Kawamori R., and Yamasaki Y. Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J. Clin. Invest. 99 1 (1997) 144-150
41. Harmon J.S., Gleason C.E., Tanaka Y., Oseid E.A., Hunter-Berger K.K., and Robertson R.P. In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. Diabetes 48 (1999) 1995-2000
42. Robertson R.P., Harmon J., Tran P.O., Tanaka Y., and Takahashi H. Glucose toxicity in beta cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52 (2003) 581-587
43. Burcelin R., Katz E.B., and Charron M.J. Molecular and cellular aspects of the glucagon receptor: role in diabetes and metabolism. Diabetes Metab. 22 (1996) 373-396
44. Unger R.H. Role of glucagon in the pathogenesis of diabetes: the status of the controversy. Metabolism 27 11 (1978) 1691-1709 Review
45. Unger R.H., and Orci L. The essential role of glucagon in the pathogenesis of diabetes mellitus. Lancet 1 7897 (1975) 14-16
46. Ghafour-Rashidi Z., Dermenaki-Farahani E., Aliahmadi A., Esmaily H., Mohammadirad A., Ostad S.N., and Abdollahi M. Protection by cAMP and cGMP phosphodiesterase inhibitors of diazinon-induced hyperglycemia and oxidative/nitrosative stress in rat Langerhans islets cells: molecular evidence for involvement of non-cholinergic mechanisms. Pestic. Biochem. Physiol. 87 (2007) 261-270
47. Teimouri F., Amirkabirian N., Esmaily H., Mohammadirad A., Aliahmadi A., and Abdollahi M. Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxication mechanism in counteracting diazinon-induced oxidative stress. Hum. Exp. Toxicol. 25 (2006) 697-703
48. Theodore A.S., Kathleen K.B., and Frederic J.S. Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood. Environ. Health Perspect. 113 10 (2005) 1291-1294
49. Wang X., Cahill C.M., Pineyro M.A., Zhou J., Doyle M.E., and Egan J.M. Glucagon like peptide-1 regulates the beta cell transcription factor, PDX-1 in insulinoma cells. Endocrinology 140 (1999) 4904-4908
50. Buteau J., Roduit R., Susini S., and Prentki M. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphadylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 42 (1999) 856-864
51. Kalender Y., Kalender S., Uzunhisarcikli M., Ogutcu A., Acikgoz F., and Durak D. Effects of endosulfan on B cells of Langerhans islets in rat pancreas. Toxicology 200 2-3 (2004) 205-211
52. Pluth J.M., Nicklas J.A., O'Neill J.P., and Albertini R.J. Increased frequency of specific genomic deletions resulting from in vitro malathion exposure. Cancer Res. 56 (1996) 2393-2399
53. Jadhav R.K., Sharma V.K., Rao G.J., Saraf A.K., and Chandra H. Distribution of malathion in body tissues and fluids. Forensic Sci. Int. 52 (1992) 223-229